Navigation Links
'Fishy Smell' May Keep Patients From Diabetes Drug
Date:2/15/2010

Research letter reports what medical literature hasn't: metformin's odor is off-putting

MONDAY, Feb. 15 (HealthDay News) -- The commonly used diabetes medication metformin sometimes has such an unpleasant odor that people may stop taking it, experts say.

But they recommend that people let their doctors know if the smell of this oral drug is an issue for them, because different formulations -- especially the extended-relief version -- tend to have a milder odor, if any at all, reports a letter in the Feb. 16 issue of the Annals of Internal Medicine.

"Metformin is an excellent drug, but the immediate-release formulation may have an odor to it. The smell is fishy or like the inside of an inner tube, and in a patient's mind, because it smells like something that has gone bad, they may think the drug isn't good," explained one of the letter's authors, J. Russell May, a clinical professor at the University of Georgia College of Pharmacy at the Medical College of Georgia.

However, May said, "some metformin products on the market are extended-release and the drug is embedded and released slow, over time. These products have much less smell, if any."

May and his colleagues wrote the letter to the journal to raise awareness of this issue, especially because nausea is a commonly reported side effect of metformin. "Is it nausea from the medication, or is it because it smells bad?" May said.

Physicians at the Medical College of Georgia had two adult male patients with type 2 diabetes complain of the "dead fish" odor of metformin. The smell was significant enough that both of the men stopped taking the medication. One of the men switched to the extended-release version of the drug and no longer had any problems; the second man refused to try the extended-release version.

May and his colleagues searched the medical literature to see whether problems with the smell of metformin were common, but they found no reports.

Then they searched the Internet and found reports on hundreds of posts to message boards about the smell of metformin, and in an informal survey of pharmacists, several said they could easily identify metformin by its unique "old locker-room sweat sock" odor.

Bristol-Myers Squibb is one of a number of companies that manufacture metformin, and although the company won't comment on drugs made by others, a spokesman, Ken Dominski, released this statement on metformin's odor:

"Bristol-Myers Squibb is aware that the inherent characteristics of metformin have been associated with a mild odor upon opening of the bottle, so these type of reports are not unexpected. It's important to note there has been no correlation between an odor and the efficacy of metformin, which has been on the market in the U.S. since 1995."

"Patients actually put up with a lot of side effects and discomfort from medications, and most doctors would like to know that, because there are probably some underreported experiences with medications that we don't know about, and this may be one of them," said Dr. Elbert Huang, assistant professor of medicine at the University of Chicago. "As doctors, we can't take every medication, so we don't always understand what it's like. But, one thing is clear, if we make people miserable, we've defeated the purpose of the medication."

If the smell of metformin bothers you, Huang added, you shouldn't discontinue the medication, but you should definitely let your doctor know. A different formulation may be available to you.

One easy solution May proposed is simply to hold your nose while taking the drug.

More information

Learn more about oral diabetes medications from the American Diabetes Association.



SOURCES: J. Russell May, Pharm.D., clinical professor, University of Georgia College of Pharmacy, Medical College of Georgia, Augusta, Ga.; Elbert S. Huang, M.D., M.P.H., assistant professor of medicine, University of Chicago; statement, Bristol-Myers Squibb; Feb. 16, 2010, Annals of Internal Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Eniva USA Efacor(R) Fish Oil (Non-Fishy Lemon Taste) Receives ConsumerLab.com Seal of Approval
2. White House Launches Fishy Expedition
3. Penn study suggests professional welders at risk for loss of sense of smell
4. Subliminal smells bias perception about a persons likeability
5. Why some depressed girls cant smell the roses
6. Impaired sense of smell may be early indicator of Parkinsons disease
7. Poor Sense of Smell May Be Early Sign of Parkinsons
8. Weizmann Institute scientists produce the first smell map
9. Brains Olfactory Bulb Grows With Sense of Smell
10. New combination of tests measures childs ability to taste and smell
11. New Tests Assess Kids Sense of Smell, Taste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ?This conference will prominently feature 150+ Hospital ... President and Director, AMN Healthcare: Susan Salka , 43rd President of the United ... The Big Fight My Life In and Out of the Ring: Sugar Ray Leonard , ...
(Date:3/23/2017)... Kennett Square, PA (PRWEB) , ... March 23, 2017 , ... ... sunny days. That means many students are thinking about summer internships , which ... (or lack thereof). , The pros at Garden Media Group, a boutique public relations ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... non-steroidal skincare products, was awarded as winners of American Dreams & Good Housekeeping ... was hosted jointly by HSN and Good Housekeeping. , Steven Wang, MD ...
(Date:3/23/2017)... Washington, DC (PRWEB) , ... March 23, 2017 , ... ... for Dental Choice has helped score a major victory in Europe for public health ... lead. , Based on rigorous scientific research and the overwhelming support of ...
(Date:3/23/2017)... ... March 23, 2017 , ... “A ... God. “A Respectful Response To Atheist Manifesto” is the creation of published author ... wife, Nancy, for sixty years. He holds graduate degrees from Kent State University ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... 23, 2017  Interpace Diagnostics Group, Inc. (NASDAQ: ... integrated commercial company that provides clinically useful molecular ... it has entered into agreements to successfully restructure ... ("RedPath") and concurrently terminate its royalty and milestone ... debt to RedPath amounting to $9.34 million is ...
(Date:3/23/2017)... March 23, 2017 CENTRO DE IMAGEM DIAGNOSTICOS ... paragraph 4 of Law 6,404/76 and Instruction 358/02 of ... its shareholders and the market in general that it ... Centro de Diagnosticos por Imagem Ltda. (" CDI "), ... in RADIOLOGISTAS ASSOCIADOS LTDA. (" Partnership " and " ...
(Date:3/23/2017)... 23, 2017  The goal of the pilot ... and track prescription drugs as they are distributed in ... to requirements from US FDA to better protect consumers ... medicines. Blockchain startup Chronicled, which links ... and blockchain technology and recently raised $6.25M, and the ...
Breaking Medicine Technology: