Navigation Links
'Fishy Smell' May Keep Patients From Diabetes Drug
Date:2/15/2010

Research letter reports what medical literature hasn't: metformin's odor is off-putting

MONDAY, Feb. 15 (HealthDay News) -- The commonly used diabetes medication metformin sometimes has such an unpleasant odor that people may stop taking it, experts say.

But they recommend that people let their doctors know if the smell of this oral drug is an issue for them, because different formulations -- especially the extended-relief version -- tend to have a milder odor, if any at all, reports a letter in the Feb. 16 issue of the Annals of Internal Medicine.

"Metformin is an excellent drug, but the immediate-release formulation may have an odor to it. The smell is fishy or like the inside of an inner tube, and in a patient's mind, because it smells like something that has gone bad, they may think the drug isn't good," explained one of the letter's authors, J. Russell May, a clinical professor at the University of Georgia College of Pharmacy at the Medical College of Georgia.

However, May said, "some metformin products on the market are extended-release and the drug is embedded and released slow, over time. These products have much less smell, if any."

May and his colleagues wrote the letter to the journal to raise awareness of this issue, especially because nausea is a commonly reported side effect of metformin. "Is it nausea from the medication, or is it because it smells bad?" May said.

Physicians at the Medical College of Georgia had two adult male patients with type 2 diabetes complain of the "dead fish" odor of metformin. The smell was significant enough that both of the men stopped taking the medication. One of the men switched to the extended-release version of the drug and no longer had any problems; the second man refused to try the extended-release version.

May and his colleagues searched the medical literature to see whether problems with the smell of metformin were common, but they found no reports.

Then they searched the Internet and found reports on hundreds of posts to message boards about the smell of metformin, and in an informal survey of pharmacists, several said they could easily identify metformin by its unique "old locker-room sweat sock" odor.

Bristol-Myers Squibb is one of a number of companies that manufacture metformin, and although the company won't comment on drugs made by others, a spokesman, Ken Dominski, released this statement on metformin's odor:

"Bristol-Myers Squibb is aware that the inherent characteristics of metformin have been associated with a mild odor upon opening of the bottle, so these type of reports are not unexpected. It's important to note there has been no correlation between an odor and the efficacy of metformin, which has been on the market in the U.S. since 1995."

"Patients actually put up with a lot of side effects and discomfort from medications, and most doctors would like to know that, because there are probably some underreported experiences with medications that we don't know about, and this may be one of them," said Dr. Elbert Huang, assistant professor of medicine at the University of Chicago. "As doctors, we can't take every medication, so we don't always understand what it's like. But, one thing is clear, if we make people miserable, we've defeated the purpose of the medication."

If the smell of metformin bothers you, Huang added, you shouldn't discontinue the medication, but you should definitely let your doctor know. A different formulation may be available to you.

One easy solution May proposed is simply to hold your nose while taking the drug.

More information

Learn more about oral diabetes medications from the American Diabetes Association.



SOURCES: J. Russell May, Pharm.D., clinical professor, University of Georgia College of Pharmacy, Medical College of Georgia, Augusta, Ga.; Elbert S. Huang, M.D., M.P.H., assistant professor of medicine, University of Chicago; statement, Bristol-Myers Squibb; Feb. 16, 2010, Annals of Internal Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Eniva USA Efacor(R) Fish Oil (Non-Fishy Lemon Taste) Receives ConsumerLab.com Seal of Approval
2. White House Launches Fishy Expedition
3. Penn study suggests professional welders at risk for loss of sense of smell
4. Subliminal smells bias perception about a persons likeability
5. Why some depressed girls cant smell the roses
6. Impaired sense of smell may be early indicator of Parkinsons disease
7. Poor Sense of Smell May Be Early Sign of Parkinsons
8. Weizmann Institute scientists produce the first smell map
9. Brains Olfactory Bulb Grows With Sense of Smell
10. New combination of tests measures childs ability to taste and smell
11. New Tests Assess Kids Sense of Smell, Taste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from PsychTests.com ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of ... Forecast to 2022" report to their offering. ... date financial data derived from varied research sources to present ... impact on the market during the next five years, including ... sub markets, regional and country level analysis. The report provides ...
(Date:6/23/2016)... , , , WHEN: ... , , , , LOCATION: , , , Online, with ... , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice ... Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... industry is witnessing an exceptional era. Several new demand spaces, such ...
(Date:6/23/2016)... June 23, 2016  Guerbet announced today that it ... Supplier Horizon Award . One of 12 ... recognized for its support of Premier members through exceptional ... excellence, and commitment to lower costs. ... recognition of our outstanding customer service from Premier," says ...
Breaking Medicine Technology: