Navigation Links
'Fertilizing' bone marrow helps answer why some cancers spread to bones
Date:5/14/2012

ANN ARBOR, Mich.Researchers found that administering a common chemotherapy drug before bone tumors took root actually fertilized the bone marrow, enabling cancer cells, once introduced, to seed and grow more easily.

The findings provide valuable insight as to why some cancers metastasize to bone, and could eventually result in new metastasis-prevention drugs, said Laurie McCauley, professor in the Department of Periodontics and Oral Medicine at the University of Michigan School of Dentistry and principal investigator on the study.

The really good news is that researchers reversed the tumor-friendly effect of the drug, called cyclophosphamide, by inhibiting another cell-communicating protein in the bone marrow, called CCL2.

"This work is early and still at the pre-clinical level," said McCauley, who also has an appointment in the Department of Pathology at the U-M Health System. "However, the biggest potential impact is in metastasis preventive strategies.

"If we better understood the specific mediators, or conditions, in the bone marrow that support tumors, we could develop more effective therapeutics to prevent local cancers from spreading and hence reduce metastasis to the bone."

The study highlights the potential for the bone marrow to provide the right environment for tumors to metastasize, said Serk In Park, first author and a postdoctoral fellow in McCauley's lab. Many cancers, such as prostate and breast cancer, are fond of spreading, or metastasizing, to bones.

Researchers administered the chemotherapy drug cyclophosphamide experimentally to manipulate the environment inside the bone marrow prior to exposing experimental tumors. Cyclophosphamide therapy is used in certain cancers to slow cell growth, and McCauley's group experimented with its use in a pre-metastatic mode using a prostate cancer model.

While effective at attacking tumor cells, a side effect of cyclophosphamide (and many
'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Drug May Help Fight Rare Bone Marrow Disorder
2. Survival rates for pediatric bone marrow transplants top in nation
3. Bone marrow and blood stem cell transplant survival rates equal, when donor is unrelated to patient
4. Biomarker detects graft-versus-host-disease in cancer patients after bone marrow transplant
5. Bone marrow cells migrate to tumors and can slow their growth
6. New half-match bone marrow transplant procedure yields promising outcomes for cancer patients
7. Bone marrow transplantation may increase cancer resistance in patients
8. Stem cell mobilization therapy found to be safe for bone marrow donors
9. Bone marrow transplant survival more than doubles for young high-risk leukemia patients
10. Gene-modified stem cells help protect bone marrow from toxic side effects of chemotherapy
11. Study reveals origins of a cancer affecting the blood and bone marrow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... (PRWEB) , ... September 04, 2015 , ... ... Consumer Health Products Association (CHPA) joint meeting of its Product, Quality and Manufacturers, ... hazardous waste handling rules constantly evolving in the consumer goods industry, it can ...
(Date:9/4/2015)... ... September 04, 2015 , ... Keeping mold top of mind ... home is quite common. Mold can grow anywhere - on carpet, clothing, food, paper, ... for excessive moisture and water in the home is key to preventing mold growth, ...
(Date:9/4/2015)... ... September 04, 2015 , ... Mike Day, a former Navy ... compete in the Ironman World Championships in Kona on October 10th. , Mike is ... Brain Injury (TBI) through combat and the cutting-edge treatments that restore their quality of ...
(Date:9/4/2015)... ... September 04, 2015 , ... The USC Eye Institute is ... 9 nationwide by Doximity. Faculty, residents and staff are honored to have contributed ... the quality of our ophthalmology residency program. Our faculty places a high priority on ...
(Date:9/4/2015)... , ... September 04, 2015 , ... ... development of its first neighborhood created specifically for adults with intellectual, developmental and ... Phoenix Metro area and feature 30 cottage or “pocket” homes. In this community, ...
Breaking Medicine News(10 mins):Health News:Inmar Experts To Address OTC Manufacturers’ Session on Hazardous Waste and Handling at CHPA Meeting 2Health News:Inmar Experts To Address OTC Manufacturers’ Session on Hazardous Waste and Handling at CHPA Meeting 3Health News:September is Mold Awareness Month 2Health News:September is Mold Awareness Month 3Health News:September is Mold Awareness Month 4Health News:Navy SEAL Shot 27 Times Competes in Ironman World Championship in Kona to Raise Money for Veteran's Suffering from TBI and PTSD 2Health News:USC Ophthalmology Residency Program Ranked in Top 10 by Doximity 2Health News:USC Ophthalmology Residency Program Ranked in Top 10 by Doximity 3Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 2Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 3Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 4
... its latest study has indicated that the culprit to most ... fuels used for cooking and heating. According to the ... by the indoor air pollution. ,This study is ... ,Indoor air pollution is the physical, chemical, and biological ...
... new cancer research study that may be the last best ... States to discover the genetic and environmental factors that cause ... (CPS-3) aims to enroll a geographically and ethnically diverse group ... help pave the way for the next generation of American ...
... glaucoma awareness among Mexican-Americans, who have a higher risk for ... reports. ,Mexican-Americans over age 60, blacks over ... all face a higher risk for the disease. Five percent ... glaucoma. ,The rate increases to 8% among ...
... study in The American Journal of Gastroenterology suggests that ... is attacked in those who suffer from Crohns ... the patient will eventually require surgical treatment. ... more frequently in the small intestine, rather than the ...
... tau helped in the reduction of Alzheimers symptoms in mice. ... treatment to a deadly brain disorder, scientists hope. ... Francisco said, If this strategy also works in humans, it ... ,The researchers, whose work is published in the journal ...
... While the field of transplantation is quite young, substantial advancements ... supply of organs and the demand for them. The ... system through a point system based primarily on wait time, ... occurs, the kidney is offered to the person at the ...
Cached Medicine News:Health News:American Cancer Society Launches Major New Study 2Health News:American Cancer Society Launches Major New Study 3Health News:Who Receives a Kidney Transplant First? 2
(Date:9/3/2015)... YORK , Sept. 3, 2015 ... Your New Guide to that Market, its R&D and Sales ... to assess the future of cancer-treating medicines? Visiongain,s new report ... you stay ahead. There you discover financial data, R&D trends, ... In our analysis you see forecasted sales to ...
(Date:9/3/2015)... YORK , Sept. 3,  2015 /PRNewswire/ ... are human-made bio-artificial devices, which are implanted ... support natural organs. These include artificial heart, ... such as polymers (polyurethane, polysulfone, and porous ... to develop artificial organs. These organs are ...
(Date:9/3/2015)... Calif. , Sept. 3, 2015 Nevro ... company that is providing innovative evidence-based solutions for the ... will be presenting at the Morgan Stanley Global Healthcare ... City.  Nevro management is scheduled to ... accessible via a live audio webcast, accessible in the ...
Breaking Medicine Technology:World Cancer-Treating Drugs Industry and Market: Companies, Therapies, R&D and Forecasts 2015-2025 2World Cancer-Treating Drugs Industry and Market: Companies, Therapies, R&D and Forecasts 2015-2025 3World Cancer-Treating Drugs Industry and Market: Companies, Therapies, R&D and Forecasts 2015-2025 4World Cancer-Treating Drugs Industry and Market: Companies, Therapies, R&D and Forecasts 2015-2025 5World Cancer-Treating Drugs Industry and Market: Companies, Therapies, R&D and Forecasts 2015-2025 6World Cancer-Treating Drugs Industry and Market: Companies, Therapies, R&D and Forecasts 2015-2025 7Global Artificial Organ Market 2015-2019 2
... 2011 CardioFocus announced that two "live cases" ... The first live case was a satellite transmission ... broadcast to the 16th Annual Boston Symposium on ... the treatment of atrial fibrillation served as moderators ...
... More than 300 million Americans get the common cold, and ... the 60 million people who also have asthma and allergies, ... these respiratory diseases take a devastating toll on public health, ... of life, lowering workplace and school performance, and can even ...
Cached Medicine Technology:Two Laser Balloon 'Live Cases' Shed New Light on Direct Visualization and PV Ablation 2Survey Finds Patients Oppose Prescription Mandate for OTC Medicines Containing Pseudoephedrine 2Survey Finds Patients Oppose Prescription Mandate for OTC Medicines Containing Pseudoephedrine 3Survey Finds Patients Oppose Prescription Mandate for OTC Medicines Containing Pseudoephedrine 4Survey Finds Patients Oppose Prescription Mandate for OTC Medicines Containing Pseudoephedrine 5
... Pipettor is the #1 Pipettor for ... comfort, and reliability. Continuously adjustable. Features ... sub-micrometer. Easy interchangeable ejector buttons to ... Adjustable rapid pipet tip ejector with ...
... The new Finnpipette Focus from Thermo Labsystems ... uncompromising performance. Advanced features such as ... fine volume adjustment on microvolumes help to ... single channel pipettes. The new interchangeable handle ...
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (Z71,408-9) or contact custom...
This adjustable-volume digital micropipet is used to accurately measure and transfer small solution volumes in the 0.5-10 microliter range....
Medicine Products: