Navigation Links
'Fertilizing' bone marrow helps answer why some cancers spread to bones
Date:5/14/2012

ANN ARBOR, Mich.Researchers found that administering a common chemotherapy drug before bone tumors took root actually fertilized the bone marrow, enabling cancer cells, once introduced, to seed and grow more easily.

The findings provide valuable insight as to why some cancers metastasize to bone, and could eventually result in new metastasis-prevention drugs, said Laurie McCauley, professor in the Department of Periodontics and Oral Medicine at the University of Michigan School of Dentistry and principal investigator on the study.

The really good news is that researchers reversed the tumor-friendly effect of the drug, called cyclophosphamide, by inhibiting another cell-communicating protein in the bone marrow, called CCL2.

"This work is early and still at the pre-clinical level," said McCauley, who also has an appointment in the Department of Pathology at the U-M Health System. "However, the biggest potential impact is in metastasis preventive strategies.

"If we better understood the specific mediators, or conditions, in the bone marrow that support tumors, we could develop more effective therapeutics to prevent local cancers from spreading and hence reduce metastasis to the bone."

The study highlights the potential for the bone marrow to provide the right environment for tumors to metastasize, said Serk In Park, first author and a postdoctoral fellow in McCauley's lab. Many cancers, such as prostate and breast cancer, are fond of spreading, or metastasizing, to bones.

Researchers administered the chemotherapy drug cyclophosphamide experimentally to manipulate the environment inside the bone marrow prior to exposing experimental tumors. Cyclophosphamide therapy is used in certain cancers to slow cell growth, and McCauley's group experimented with its use in a pre-metastatic mode using a prostate cancer model.

While effective at attacking tumor cells, a side effect of cyclophosphamide (and many
'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. New Drug May Help Fight Rare Bone Marrow Disorder
2. Survival rates for pediatric bone marrow transplants top in nation
3. Bone marrow and blood stem cell transplant survival rates equal, when donor is unrelated to patient
4. Biomarker detects graft-versus-host-disease in cancer patients after bone marrow transplant
5. Bone marrow cells migrate to tumors and can slow their growth
6. New half-match bone marrow transplant procedure yields promising outcomes for cancer patients
7. Bone marrow transplantation may increase cancer resistance in patients
8. Stem cell mobilization therapy found to be safe for bone marrow donors
9. Bone marrow transplant survival more than doubles for young high-risk leukemia patients
10. Gene-modified stem cells help protect bone marrow from toxic side effects of chemotherapy
11. Study reveals origins of a cancer affecting the blood and bone marrow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... 2013 MinuteHound, a leading time and ... save businesses up to 8% on payroll costs. MinuteHound’s ... time card systems. Their biometric system is simple: Employees ... clocks them in and out automatically. Employee time ... and buddy punching. , Because the fingerprint data ...
(Date:6/19/2013)... 19, 2013 Over the past five ... industry has been growing at an annualized rate ... Many factors have supported the development of the industry ... by drugstores; relatively higher drug prices in hospitals; and ... support for the development of chain drug retailing enterprises ...
(Date:6/18/2013)... 19, 2013 "What if adding one ... could boost your health and well-being? Well, there is ... Sublime Beauty®. "It is called Skin Brushing ." ... became a lost art. Now, people are rediscovering this ... Brushing, and so do certain health conscious people. Sublime ...
(Date:6/18/2013)... York, NY (PRWEB) June 18, 2013 Cheap ... tickets for the tournament which gets underway in July. ... savings on any CONCACAF ticket order. , The ... and cranny of the globe.    In fact, the hype of the ... Its popularity also trickled down the veins of fans ...
(Date:6/18/2013)... 2013 The Temp1000IS temperature data ... device which can be used to automatically record temperatures ... of the Temp1000IS comes with the serial number and ... IFC400 (sold separately) docking station and can be ... No more removal of end-caps to download data. The ...
Breaking Medicine News(10 mins):Health News:MinuteHound Announces How Cloud Computing Technology Boosts Savings 2Health News:MinuteHound Announces How Cloud Computing Technology Boosts Savings 3Health News:Pharmacies and Drug Retailers in China Industry Research Report – Now Available from IBISWorld 2Health News:Pharmacies and Drug Retailers in China Industry Research Report – Now Available from IBISWorld 3Health News:The Easiest Way to Contribute to Better Health and Well-Being Starting Today and for Under $20, Says Sublime Beauty® 2Health News:CONCACAF Tickets Have Been Released for Martinique, Mexico, Panama, El Salvador, Trinidad, Tobago, Haiti, Honduras, Costa Rica, Cuba, Belize, US, Canada, Honduras & Cuba 2Health News:CONCACAF Tickets Have Been Released for Martinique, Mexico, Panama, El Salvador, Trinidad, Tobago, Haiti, Honduras, Costa Rica, Cuba, Belize, US, Canada, Honduras & Cuba 3Health News:MadgeTech, Inc. Introduces the New Temp1000IS Intrinsically Safe High Temperature Data Logger 2
... in the outbreak is a good time to get vaccinated, ... -- As the current wave of H1N1 swine flu continues ... get vaccinated in case another outbreak strikes this winter. , ... eased, it,s an ideal time to get vaccinated, Secretary of ...
... , , NEW YORK, Dec. 17 ... available in its catalogue: , India Healthcare IT ... http://www.reportlinker.com/p0169911/India-Healthcare-IT-Investment-Opportunities-Analysis-and-Forecasts-to-2015.html , India Healthcare IT Investment Opportunities, ... , This report is an essential source for in-depth ...
... Dec. 17 Today, CDC,s Morbidity and Mortality Weekly ... of state-level epidemiologists has decreased steadily since 2004, with ... was also a substantial decrease in core epidemiology capacity ... and emergency response. For some important subject ...
... , , , ... high-tech,healthcare group, Golden Meditech Company Limited ("Golden Meditech" or ... the interim results for,Financial Year 2009/10. During the period ... on the New York Stock Exchange and NASDAQ;,its key ...
... teenagers are among the largest consumers of cannabis worldwide. ... brains are worse than originally thought, according to new ... the Research Institute of the McGill University Health Centre. ... , suggests that daily consumption of cannabis in teens ...
... ... Health Resources hospital clients Rutherford Hospital Inc. (Rutherfordton, N.C.), a management client since ... recognized as top-ranked Community Value Providers by Cleverley + Associates. , ... Brentwood, Tenn. (PRWEB) ...
Cached Medicine News:Health News:Swine Flu Wanes, But Future Uncertain 2Health News:Reportlinker Adds India Healthcare IT Investment Opportunities, Analysis and Forecasts to 2015 2Health News:Reportlinker Adds India Healthcare IT Investment Opportunities, Analysis and Forecasts to 2015 3Health News:Reportlinker Adds India Healthcare IT Investment Opportunities, Analysis and Forecasts to 2015 4Health News:Reportlinker Adds India Healthcare IT Investment Opportunities, Analysis and Forecasts to 2015 5Health News:Reportlinker Adds India Healthcare IT Investment Opportunities, Analysis and Forecasts to 2015 6Health News:Reportlinker Adds India Healthcare IT Investment Opportunities, Analysis and Forecasts to 2015 7Health News:Reportlinker Adds India Healthcare IT Investment Opportunities, Analysis and Forecasts to 2015 8Health News:CSTE National Assessment Finds Critical Public Health Disease Surveillance Capacity Lacking 2Health News:Golden Meditech Announces Interim Results of FY2009/10 2Health News:Golden Meditech Announces Interim Results of FY2009/10 3Health News:QHR Client Hospitals in North Carolina, Michigan Lauded for Providing Community Value 2
(Date:6/18/2013)... MPR is excited to unveil a new ... all part of an ongoing effort to freshen the look ... over 28 years. (Photo: http://photos.prnewswire.com/prnh/20130618/NY33937 ... MPR has expanded upon its foundation as a concise ... an increasing array of clinical and practice management tools including ...
(Date:6/18/2013)... June 18, 2013 New-generation electronic designs ... portable and lightweight. Simultaneously, circuitry is increasing the ... speed to which it performs at. Connecting cables ... and military equipment, such as cameras or detectors, ... and nano-circular connectors include custom cable designs for ...
(Date:6/18/2013)... Apama Medical, a privately held medical ... atrial fibrillation technologies, today announced the issuance of ... and Trademark Office (USPTO), titled "Low Profile Electrodes". ... use on expandable structures such as balloons used ... "We are grateful to the NSF SBIR ...
Breaking Medicine Technology:MPR Sports a Bold New Look 2Omnetics Circular Connectors Offer Both Micro and Nano Interconnects for Highly Portable Electronic Systems, Meeting the Needs of Designers Looking for Size Reduction Options and Cable Flexibility 2
... SALT LAKE CITY , May 11 Dynatronics Corporation (Nasdaq: DYNT ... during the morning of Monday, May 17, 2010 .   , ... Dynatronics has scheduled a conference call for investors later that ...  Those interested in participating should call 800-861-4084 and use passcode: 9921511. , ...
... 11 RF Technologies®, a leading provider of healthcare safety and ... use with Safe Place® Infant Security Solutions. The soft, stretchy banding material ... staff when a Safe Place bracelet is loose, tampered with or is ... Smart Sense ...
Cached Medicine Technology:Smart Sense(TM) From RF Technologies Upgrades Safe Place(R) Bracelets Using Industry-Leading Infant Security Technology, Fit and Comfort 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: