Navigation Links
'Fertilizing' bone marrow helps answer why some cancers spread to bones
Date:5/14/2012

ANN ARBOR, Mich.Researchers found that administering a common chemotherapy drug before bone tumors took root actually fertilized the bone marrow, enabling cancer cells, once introduced, to seed and grow more easily.

The findings provide valuable insight as to why some cancers metastasize to bone, and could eventually result in new metastasis-prevention drugs, said Laurie McCauley, professor in the Department of Periodontics and Oral Medicine at the University of Michigan School of Dentistry and principal investigator on the study.

The really good news is that researchers reversed the tumor-friendly effect of the drug, called cyclophosphamide, by inhibiting another cell-communicating protein in the bone marrow, called CCL2.

"This work is early and still at the pre-clinical level," said McCauley, who also has an appointment in the Department of Pathology at the U-M Health System. "However, the biggest potential impact is in metastasis preventive strategies.

"If we better understood the specific mediators, or conditions, in the bone marrow that support tumors, we could develop more effective therapeutics to prevent local cancers from spreading and hence reduce metastasis to the bone."

The study highlights the potential for the bone marrow to provide the right environment for tumors to metastasize, said Serk In Park, first author and a postdoctoral fellow in McCauley's lab. Many cancers, such as prostate and breast cancer, are fond of spreading, or metastasizing, to bones.

Researchers administered the chemotherapy drug cyclophosphamide experimentally to manipulate the environment inside the bone marrow prior to exposing experimental tumors. Cyclophosphamide therapy is used in certain cancers to slow cell growth, and McCauley's group experimented with its use in a pre-metastatic mode using a prostate cancer model.

While effective at attacking tumor cells, a side effect of cyclophosphamide (and many
'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Drug May Help Fight Rare Bone Marrow Disorder
2. Survival rates for pediatric bone marrow transplants top in nation
3. Bone marrow and blood stem cell transplant survival rates equal, when donor is unrelated to patient
4. Biomarker detects graft-versus-host-disease in cancer patients after bone marrow transplant
5. Bone marrow cells migrate to tumors and can slow their growth
6. New half-match bone marrow transplant procedure yields promising outcomes for cancer patients
7. Bone marrow transplantation may increase cancer resistance in patients
8. Stem cell mobilization therapy found to be safe for bone marrow donors
9. Bone marrow transplant survival more than doubles for young high-risk leukemia patients
10. Gene-modified stem cells help protect bone marrow from toxic side effects of chemotherapy
11. Study reveals origins of a cancer affecting the blood and bone marrow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... Spring, Md. (PRWEB) , ... July 02, 2015 , ... ... mark in his solo cross-country walk to raise awareness and money for the ... and expects to arrive at PHA’s headquarters near Washington, D.C. by mid-September. He left ...
(Date:7/2/2015)... CA (PRWEB) , ... July 02, 2015 , ... ActiveBunch.com ... a passion for social fitness. Built to function as a lifestyle community, Active Bunch ... them the opportunity to network, meet, and participate in discussions or group events. ...
(Date:7/2/2015)... (PRWEB) , ... July 02, ... ... wound therapy (NPWT) - pipeline review 2015” provides comprehensive information on the ... development. Complete report on negative pressure wound therapy (NPWT) with 22 market ...
(Date:7/2/2015)... , ... July 02, 2015 ... ... janitorial supply company , announced today that it has reached an ... acquisition will make CleanItSupply.com the largest distributor of Rubbermaid Commercial Products on ...
(Date:7/2/2015)... ... 2015 , ... Real Time Pain Relief (RTPR), makers of the popular rub-on pain ... PBR to sponsor The Fifth Annual Big Sky Professional Bull Riders Event being held ... of their popular pain relief lotion and products at the family friendly event that features ...
Breaking Medicine News(10 mins):Health News:79-Year-old ‘Pacing Parson’ Passes 1,000-Mile Mark in Cross-Country Walk for Pulmonary Hypertension Association 2Health News:79-Year-old ‘Pacing Parson’ Passes 1,000-Mile Mark in Cross-Country Walk for Pulmonary Hypertension Association 3Health News:ActiveBunch.com Launches as a Social Community for People with Active Lifestyles 2Health News:Negative Pressure Wound Therapy (System, Wound Care, Tissue Cooling NPWT) Pipeline Review 2015 Market Research Report Available at RnRMarketResearch.com 2Health News:Negative Pressure Wound Therapy (System, Wound Care, Tissue Cooling NPWT) Pipeline Review 2015 Market Research Report Available at RnRMarketResearch.com 3Health News:Negative Pressure Wound Therapy (System, Wound Care, Tissue Cooling NPWT) Pipeline Review 2015 Market Research Report Available at RnRMarketResearch.com 4Health News:CleanItSupply.com Acquires eRubbermaid.com 2Health News:Real Time Pain Relief Sponsors The Fifth Annual Big Sky Professional Bull Riders Event at Big Sky Town Center in July 2Health News:Real Time Pain Relief Sponsors The Fifth Annual Big Sky Professional Bull Riders Event at Big Sky Town Center in July 3
... already used for high blood pressure and prostate problems ... in veterans with posttraumatic stress disorder (PTSD). ... been demonstrated effective for PTSD nightmares and sleep disruption," ... mental health service at the Veterans Affairs Puget Sound ...
... simpler than what scientists// had been assuming. A new study ... livers. It could significantly affect the way physicians make livers ... or cancer. ,"The human liver is ... regenerate from as little as 25 percent of its tissue," ...
... Britain’s junior doctors,// reports show. ,It ... street in protest of the lack of suitable jobs. This was ... pounds to train for government programs that would make them eligible ... to the Department of Health ‘s scheme, the Medical Training Application ...
... National Cancer Institute (NCI) has commended Novartis' anti-cancer tablet, ... GISTs, metastatic gastro-intestinal tumors. ,These tumours ... found in the digestive system - the gastrointestinal tract. ... control the movements of the gut. ...
... A report has come out with the suggestion that Britain’s ... curb the binge-drinking spree that is threatening to knock out ... journal published by the Institute for Public Policy Research (IPPR), ... over the regulation of alcohol. ,Gerard purports "tough ...
... on. Is Hormone Replacement Therapy (HRT), good or bad? ... which targets menopausal women by giving them measured doses of ... Its risks such as breast cancer, and heart disease often ... This was mainly due to a 2002 study conducted for ...
Cached Medicine News:Health News:BP and Prostate Problems Drug Effective in Treating PTSD Nightmares 2Health News:BP and Prostate Problems Drug Effective in Treating PTSD Nightmares 3Health News:Liver Regeneration may Be Simpler Than Previously Thought 2Health News:Liver Regeneration may Be Simpler Than Previously Thought 3Health News:UK’s Junior Doctors Losing Hop 2Health News:Novartis Gleevec Found Effective in Treating Gastro-intestinal Tumors 2Health News:Drinking Age Must Be Raised to Curb Binge Drinking-Voices Warn 2Health News:Hormone Replacement Therapy – To Choose Or No 2
(Date:7/2/2015)... Research and ... of the "2015 New Frontiers in ... Technologies, Competitive Landscape" report to their ... Clinical Chemistry and Immunodiagnostics: Global Challenges, Emerging ... strategic analysis of major business opportunities emerging ...
(Date:7/2/2015)... julio de 2015 BGI anunció hoy que ... alto rendimiento en Hong Kong ... (CAP). La instalación de BGI en Hong Kong ... próxima generación que recibe la certificación CAP en ... en prácticas de laboratorio clínico. Junto con el exitoso ...
(Date:7/2/2015)... SEOUL , South Korea, July 2, 2015 ... of a new E-CUBE Series ultrasound system. Developed to ... of clinical areas, the E-CUBE 15 EX produces superb ... outstanding clinical performance in women,s health, general imaging, and ... The latest in the renowned E-CUBE Series, ...
Breaking Medicine Technology:New Frontiers in 2015 Global Clinical Chemistry and Immunodiagnostics Market: Challenges, Emerging Technologies, Competitive Landscape 2BGI recibe la acreditación del College of American Pathologists (CAP) 2E-CUBE 15 EX from ALPINION Enhances User Experience and Patient Care 2E-CUBE 15 EX from ALPINION Enhances User Experience and Patient Care 3
... University of Bari, Italy, concluded that treating patients after ... (SVR) and protects them from liver-related deaths. The purpose ... outcomes of patients posttransplant who underwent antiviral therapy for ... graft. The use in clinical practice ...
... SPRING, Md., Oct. 29 The U.S. Food ... an injectable antibiotic to treat adults with community ... and skin structure infections (ABSSSI), including methicillin-resistant ...   http://photos.prnewswire.com/prnh/20090824/FDALOGO ) (Logo:   http://www.newscom.com/cgi-bin/prnh/20090824/FDALOGO ...
Cached Medicine Technology:Achieving Sustained Viral Response for Patients with Recurrent Hepatitis C After Transplantation is Key for Long-Term Outcomes 2FDA Approves Teflaro for Bacterial Infections 2FDA Approves Teflaro for Bacterial Infections 3