Navigation Links
Faulty DNA repair could be a risk factor for lung cancer in nonsmokers
Date:6/26/2008

PHILADELPHIA People who have never smoked but whose cells cannot efficiently repair environmental insults to DNA are at higher risk of developing lung cancer than those with effective genomic repair capability, according to researchers from the Department of Epidemiology at The University of Texas M. D. Anderson Cancer Center.

"About 15 percent of lung cancers occur in lifetime never smokers. Risk factors for lung cancer in people who have never smoked are poorly understood, but this study demonstrates that poor DNA repair capacity is an important predictor of lung cancer risk in never smokers," said the study's lead author, Olga Gorlova, Ph.D., an assistant professor in the Department of Epidemiology.

In the June issue of Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research, the researchers say that, overall, nonsmokers with suboptimal DNA repair capacity (DRC) are almost twice as likely to develop lung cancer, compared with nonsmokers with normal DRC. Study participants with the lowest ability to repair their DNA had a more than a threefold increased risk, compared with individuals with efficient DRC.

Secondhand smoke exposure is another established risk factor; in participants with inefficient DRC who also reported such exposure, the risk of lung cancer was almost fourfold.

Although the research team has not pinpointed the gene or genes that cause suboptimal DRC, their data suggest that the trait is heritable to some degree. Notably they found that first-degree relatives of those with lowest DRC were 2.5 times more likely to develop lung cancer than were first-degree relatives of people with efficient DRC.

"Our findings demonstrate that suboptimal DNA repair capacity together with secondhand smoke exposure are strong lung cancer risk factors in lifetime never smokers," Gorlova said.

This is the first study that has looked at functional DNA rep
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Faulty brain connections may be responsible for social impairments in autism
2. St. Jude Finds Mechanism for Faulty Protein Disposal
3. St. Jude finds mechanism for faulty protein disposal
4. Pedophilia may be the result of faulty brain wiring
5. Evalve MitraClip: Clinical trial of nonsurgical repair for severe mitral valve regurgitation
6. 2nd Option Improves Abdominal Aorta Repair Outcomes
7. Joint distraction promotes structural repair in patients with severe knee osteoarthritis
8. Industrial Control Repair Named Honda of America Manufacturings 2007 Supplier of the Year
9. Finding clues for nerve cell repair
10. New stem cell therapy may aid the repair of damaged brains
11. Collaborative Drug Discovery and Myelin Repair Foundation Announce Partnership
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... 2014 In its latest blog post, ... that having family close by during a stay in rehab ... process is successful, is focusing on a topic that is ... addiction-related dialogues: opiate abuse facts. , The Best Drug Rehabilitation ... An overview of opiates, and why they’re considered “the ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 The Europe Drilling ... drilling fluid and completion fluid market in Europe with analysis ... market in Europe is estimated to grow from around $1.3 ... CAGR of 6.1%, for the given period. , Browse through ... Market Report, to get an idea of the in-depth analysis ...
(Date:7/23/2014)... 2014 AidJoy is delighted to announce that ... Zen on September 5, 2014 from 7:00 to 11:00 ... are expected to attend this semi-formal event. , "We are ... past six years," says Jess Dennis, Director of Operations and ... on this moment in AidJoy’s history before we launch into ...
(Date:7/23/2014)... 2014 "I wanted a better way to ... my blood sugar, blood pressure and pulse rate," said an ... have to carry along a bunch of different devices, so ... developed the Master III to make it easier to monitor ... convenient unit. The accessory enables the user to have more ...
(Date:7/23/2014)... shown that some high-profile athletes who suffered repeated blows ... clumps in their brains. Those clumps suggest the athletes ... scientists are working on tests that might be able ... an article in Chemical & Engineering News (C&EN) ... Society. , In the article, Lauren Wolf, a senior ...
Breaking Medicine News(10 mins):Health News:Latest Best Drug Rehabilitation Blog Post Focuses on Opiate Abuse Facts 2Health News:Europe Drilling Fluid & Completion Fluid Market is Expected to Reach $1.7 Billion in 2018 - New Report by MicroMarket Monitor 2Health News:Europe Drilling Fluid & Completion Fluid Market is Expected to Reach $1.7 Billion in 2018 - New Report by MicroMarket Monitor 3Health News:Europe Drilling Fluid & Completion Fluid Market is Expected to Reach $1.7 Billion in 2018 - New Report by MicroMarket Monitor 4Health News:Europe Drilling Fluid & Completion Fluid Market is Expected to Reach $1.7 Billion in 2018 - New Report by MicroMarket Monitor 5Health News:Europe Drilling Fluid & Completion Fluid Market is Expected to Reach $1.7 Billion in 2018 - New Report by MicroMarket Monitor 6Health News:AidJoy’s Inaugural Gala to be Held September 5, 2014 2
... who regularly complain of fatigue can increase their energy levels ... by engaging in regular, low intensity exercise, according to a ... that a quick workout will leave us worn out ... Puetz, who recently completed his doctorate at UGA and is ...
... Launch New Accreditation Program This Spring, LOVELAND, ... (PHII), a non-profit 501(c)(3) organization that promotes,credible, transparent, ... announces the election of Joel V.,Brill, MD; Garry ... to the PHII,Board of Directors. They will join ...
... Philadelphia, PA, February 28, 2008 There is a ... adults diagnosed with schizophrenia. However, there is a ... and adolescents with schizophrenia. Although the U.S. Food ... of aripiprazole and risperidone for adolescents with schizophrenia, few ...
... of dermatologist endorsed moisturizers, MEMPHIS, Tenn., Feb. ... full line of dermatologist endorsed moisturizers especially,created to ... launching its 2008,"Prepare to Unveil Yourself" initiative with ... skin. Four Theraplex(R) solutions:,HydroLotion, ClearLotion, Emollient, and Theraplex ...
... (NEWARK, N.J., Feb. 28, 2008) New Jersey State ... Administration Research Education) Award for Excellence in Research to ... Flynn, assistant professor at the College of Nursing at ... honored with three other C.A.R.E. award recipients during the ...
... Feb. 28 Boston Scientific,Corporation (NYSE: ... implants of its,COGNIS(TM) cardiac resynchronization therapy defibrillator ... began,performing implants earlier this week. Forty implants ... countries., When choosing a high-energy device, ...
Cached Medicine News:Health News:Low-intensity exercise reduces fatigue symptoms by 65 percent, study finds 2Health News:Population Health Impact Institute Announces New Board Members 2Health News:Comparison of antipsychotic treatments in adolescents with schizophrenia 2Health News:Prepare to Unveil Yourself with Theraplex(R) for Spring and Summer 2008 2Health News:Prepare to Unveil Yourself with Theraplex(R) for Spring and Summer 2008 3Health News:Prepare to Unveil Yourself with Theraplex(R) for Spring and Summer 2008 4Health News:Boston Scientific Announces First European Implants of New Devices to Treat Heart Failure and Sudden Cardiac Death 2Health News:Boston Scientific Announces First European Implants of New Devices to Treat Heart Failure and Sudden Cardiac Death 3Health News:Boston Scientific Announces First European Implants of New Devices to Treat Heart Failure and Sudden Cardiac Death 4
(Date:7/23/2014)... MINNEAPOLIS , July 23, 2014 ... they have added 14 new vendors so far ... Creekridge,s newest vendors are from both ... mid-size domestic organizations to large, well-known multi-national companies. ... Creekridge,s diversified suite of financing products including: standard ...
(Date:7/23/2014)... South Korea , July 23, 2014  Mezzion ... clinical program to evaluate the use of udenafil to ... for single ventricle heart defects. The clinical program will ... representatives of the Pediatric Heart Network (PHN), a multi-center ... and Blood Institute (NHLBI) of the National Institutes of ...
(Date:7/23/2014)... LONDON , July 23, 2014  Lightlake ... developing addiction treatments based on its expertise in ... an investigational new drug application ("IND") with respect ... Lightlake also announced today that it has received ... Drug Abuse ("NIDA"), part of the National Institutes ...
Breaking Medicine Technology:Creekridge Capital Signs Several New Vendor Partners 2Mezzion Pharma Initiates Clinical Development Program To Evaluate Udenafil In Adolescents With Single Ventricle Heart Defects 2Lightlake Therapeutics Inc. Files Investigational New Drug Application For Naloxone Nasal Spray For Reversing Opioid Overdose And Announces A Further Collaboration With The National Institute On Drug Abuse 2Lightlake Therapeutics Inc. Files Investigational New Drug Application For Naloxone Nasal Spray For Reversing Opioid Overdose And Announces A Further Collaboration With The National Institute On Drug Abuse 3
Surgical Stainless Steel Adult 16.5....
Ultra-Slip™ endotracheal tube guide for single-patient use only., ,Caution: Not MRI Compatible....
FlexiSlip™ Plastic coated malleable metal core. Single use, Sterile, Latex Free. Soft distal tip flexes to reduce risk of trauma to patient. Malleable metal core is easy to shape. Low friction ...
FlexiSlip™ Plastic coated malleable metal core. Single use, Sterile, Latex Free. Soft distal tip flexes to reduce risk of trauma to patient. Malleable metal core is easy to shape. Low friction ...
Medicine Products: