Navigation Links
Faulty DNA repair could be a risk factor for lung cancer in nonsmokers
Date:6/26/2008

PHILADELPHIA People who have never smoked but whose cells cannot efficiently repair environmental insults to DNA are at higher risk of developing lung cancer than those with effective genomic repair capability, according to researchers from the Department of Epidemiology at The University of Texas M. D. Anderson Cancer Center.

"About 15 percent of lung cancers occur in lifetime never smokers. Risk factors for lung cancer in people who have never smoked are poorly understood, but this study demonstrates that poor DNA repair capacity is an important predictor of lung cancer risk in never smokers," said the study's lead author, Olga Gorlova, Ph.D., an assistant professor in the Department of Epidemiology.

In the June issue of Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research, the researchers say that, overall, nonsmokers with suboptimal DNA repair capacity (DRC) are almost twice as likely to develop lung cancer, compared with nonsmokers with normal DRC. Study participants with the lowest ability to repair their DNA had a more than a threefold increased risk, compared with individuals with efficient DRC.

Secondhand smoke exposure is another established risk factor; in participants with inefficient DRC who also reported such exposure, the risk of lung cancer was almost fourfold.

Although the research team has not pinpointed the gene or genes that cause suboptimal DRC, their data suggest that the trait is heritable to some degree. Notably they found that first-degree relatives of those with lowest DRC were 2.5 times more likely to develop lung cancer than were first-degree relatives of people with efficient DRC.

"Our findings demonstrate that suboptimal DNA repair capacity together with secondhand smoke exposure are strong lung cancer risk factors in lifetime never smokers," Gorlova said.

This is the first study that has looked at functional DNA rep
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Faulty brain connections may be responsible for social impairments in autism
2. St. Jude Finds Mechanism for Faulty Protein Disposal
3. St. Jude finds mechanism for faulty protein disposal
4. Pedophilia may be the result of faulty brain wiring
5. Evalve MitraClip: Clinical trial of nonsurgical repair for severe mitral valve regurgitation
6. 2nd Option Improves Abdominal Aorta Repair Outcomes
7. Joint distraction promotes structural repair in patients with severe knee osteoarthritis
8. Industrial Control Repair Named Honda of America Manufacturings 2007 Supplier of the Year
9. Finding clues for nerve cell repair
10. New stem cell therapy may aid the repair of damaged brains
11. Collaborative Drug Discovery and Myelin Repair Foundation Announce Partnership
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... (PRWEB) October 25, 2014 More than ... President’s Circle Reception on Monday at the home of ... and hear from guest speaker Dr. Winifred Lender on ... , Dr. Lender, a Santa Barbara psychologist, author and ... and benefits of living in the digital age. Our ...
(Date:10/25/2014)... October 25, 2014 QueenBeeTickets.com has a ... great selection at affordable prices. Bob Seger & The ... Center and Nationwide Arena are going on sale October ... Click Here to browse the selection of tickets ... QueenBeeTickets.com. , The famous singer is touring North America ...
(Date:10/25/2014)... FRIDAY, Oct. 24, 2014 (HealthDay News) -- Interrupting blood supply ... help reduce the risks associated with the surgery, according to ... to stop the blood supply to the heart to be ... blood, the heart will reduce its ability to produce energy ... blood flow to another large muscle, such as an arm ...
(Date:10/25/2014)... -- Current osteoporosis screening guidelines and tools fail ... for osteoporosis-related fractures, a new study says. ... tools that help us accurately predict who will ... target these at-risk people for preventive measures," study ... the division of general internal medicine and health ...
(Date:10/22/2014)... Austin, TX (PRWEB) October 22, 2014 ... Criminal Minds featuring skin diseases both fictional ... Foundation (CEHMDF), a nonprofit organization committed to advocacy ... wondering if CBS will take the opportunity to impart ... disease. , There are many misconceptions about ...
Breaking Medicine News(10 mins):Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 2Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 3Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 4Health News:QueenBeeTickets.com Features Bob Seger & The Silver Bullet Band Tickets for Charleston Civic Center, Huntington Center, and Nationwide Arena at Reduced Prices 2Health News:Brief Interruption of Blood Supply to Limb Might Aid Heart Surgery: Study 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 3
... Governors,University (http://www.wgu.edu ) is now offering its ... managers and nurse educators. These,scholarships are designed to ... become educators, managers, and leaders in various healthcare,settings. ... and,M.S. in Nursing-Leadership and Management degree programs., ...
... Oct. 17 Collaborative Drug Discovery,Inc. (CDD, Inc.) ... of,recent publications focused on the fight against Chagas, ... available to researchers free of charge, via,the CDD ... Chemistry, Bioorganic &,Medicinal Chemistry, the Journal of American ...
... Looks to Add Even More Space in the ... W.Va., ReBuilder Medical Technologies,Inc. (Pink Sheets: RBRM), ... device inventor David B. Phillips, Ph.D., today,announced it ... demand,of it cutting edge medical devices and products. ...
... Pacific Design ... WEST HOLLYWOOD, Calif., Oct. 17 Charles S. Cohen,visionary ... to support AIDS Walk Los Angeles and the City of ... Angeles, in addition to,providing Pacific Design Center as the official ...
... consumers manage costs and adopt healthier ... ... in Virginia is now offering new health plan options for employers,and individuals ... healthier lives and gain control over the rising,cost of care. These consumer ...
... the Way Toward Malaria ... Eradication U.S. Presidential Candidates Urged to Sustain and Expand President,s ... Malaria Initiative, SEATTLE, Oct. ... - to reach a,day when no human being has malaria, and no mosquito on earth ...
Cached Medicine News:Health News:Nursing Scholarships Offered by Western Governors University for Master's Degree Programs 2Health News:Free Access to Literature Data on Chagas' Disease Offered Online: Collaborative Drug Discovery, Inc. provides Neglected Disease researchers with 'archive mine and collaborate' access to small molecule bioactivity SAR data on parasitic disease 2Health News:ReBuilder Medical Technologies, Inc. Increases Manufacturing Space to Meet Demand 2Health News:ReBuilder Medical Technologies, Inc. Increases Manufacturing Space to Meet Demand 3Health News:Charles S. Cohen, Pacific Design Center Augment Their Support for AIDS Walk Los Angeles 2Health News:Charles S. Cohen, Pacific Design Center Augment Their Support for AIDS Walk Los Angeles 3Health News:Anthem Blue Cross and Blue Shield in Virginia Introduces New Generation of Consumer Driven Health Products 2Health News:Anthem Blue Cross and Blue Shield in Virginia Introduces New Generation of Consumer Driven Health Products 3Health News:Anthem Blue Cross and Blue Shield in Virginia Introduces New Generation of Consumer Driven Health Products 4Health News:Bill and Melinda Gates Call for New Global Commitment to Chart a Course for Malaria Eradication 2Health News:Bill and Melinda Gates Call for New Global Commitment to Chart a Course for Malaria Eradication 3
(Date:10/25/2014)... 2014 Best Practices designed the Medical ... a forum for sharing insights about the key ... mechanism for creating and sharing solutions through three ... from the Medical Affairs Consortium survey. ... the first roundtable of the 2014-2015 Medical Affairs ...
(Date:10/22/2014)... 22, 2014  Rescheduling of hydrocodone combination products ... pain market, according to a new primary market ... providing market research and consultation exclusively in the ... http://photos.prnewswire.com/prnh/20141021/153440 In August, ... combination products from Schedule III to Schedule II ...
(Date:10/22/2014)... HOUSTON , Oct. 22, 2014  Charlene Vernak, RPh, ... York , recently was awarded the George Roentsch ... Vernak received the award in Houston ... The scholarship is awarded annually to an independent pharmacist ... nature of George Roentsch , a well-known pharmacist ...
Breaking Medicine Technology:Strong Participation in Best Practices' Medical Affairs Consortium Survey 2Hydrocodone: Rescheduled, Repositioned & Reinvented 2Hydrocodone: Rescheduled, Repositioned & Reinvented 3PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2
... HOUSTON, Sept. 29 The Gulf Coast Regional Center ... three companies who will receive up to a total ... Emerging Technology Fund (TETF).   (Logo:   ... The TETF program was established by ...
... Luminex Corporation (Nasdaq: LMNX ), today ... USA Award for its innovative xTAG® Respiratory Viral Panel ... Technology at the Prix Galien USA and International awards ... American Museum of Natural History in New York City. ...
Cached Medicine Technology:Gulf Coast Regional Center of Innovation and Commercialization and Houston Technology Center Announce Recipients of TETF Awards 2Gulf Coast Regional Center of Innovation and Commercialization and Houston Technology Center Announce Recipients of TETF Awards 3Luminex Corporation Wins Prestigious 2010 Prix Galien USA Award 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: