Navigation Links
Fat cells in breast may connect social stress to triple-negative breast cancer
Date:6/18/2013

ng this observation.

Conzen worked closely with colleague Martha McClintock, PhD, professor of psychology at the University of Chicago, to carefully model chronic social stress exposure in female mice. In previous joint projects they showed that a measurable chronic stress response could reliably be induced in mice by raising them in isolation after weaning, rather than housing them in small groups.

In this study, Conzen also worked with colleague, Matthew Brady, PhD, associate professor of medicine and a specialist in fat cell biology, to decipher the effect of stress on the mammary fat.

"By separating fat cells in the breast from the other cell types, we were able to measure expression of genes involved in metabolism in those fat cells and not other fat cells or different cell types from the breast tissue," Brady said.

The researchers looked for differences in gene expression in multiple tissues and circulating hormones between group-housed and isolated mice. To their surprise, there were no significant differences in circulating hormones.

They found a dramatic change, however, in fat cells located within mammary glands. Measurements of those cells taken at 15 weeks of age showed that social isolation stimulated significant increases in the expression of three genesHk2 (hexokinase), Acly (ATP citrate lyase) and Acaca (acetyl-CoA carboxykase).

All three are crucial to the uptake and metabolism of glucose, the primary source of cellular energy. Mammary fat cells in the stressed mice took up about twice as much glucose as the same fat cells from unstressed mice, indicating a significant increase in metabolic activity.

These cells use glucose to synthesize lipidsfatty substances, often used to convey biological signals. Increased fat cell metabolism was associated with increased local secretion of substances such as leptin, an important chemical messenger produced by fat cells. Leptin can stimulate pro
'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. New drug prevents spread of human prostate cancer cells
2. Tiny hitchhikers attack cancer cells
3. To prevent leukemias dreaded return, go for the stem cells
4. Scientists identify major source of cells defense against oxidative stress
5. Therapy exploits addiction of leukemia cells
6. IBN discovers human neural stem cells with tumor targeting ability
7. Leukaemia cells have a remembrance of things past
8. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
9. Research yields new clues to how brain cancer cells migrate and invade
10. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
11. Researchers Rejuvenate Blood-Forming Stem Cells in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014 Luxury Linen purveyor Peacock ... of Dallas to provide logistics and support for one ... Alley has a long history of giving back to the ... of this year's Toy Drive were Whataburger® and 99.5 The ... than the holidays. Providing gifts to children who would otherwise ...
(Date:12/22/2014)... NAPW honors Cheryl A. ... Year. She is recognized with this prestigious distinction for ... organization of professional women in the country, spanning virtually ... Women is a vibrant networking community with over 600,000 ... is passionate and committed to best practices that support ...
(Date:12/22/2014)... Washington, DC (PRWEB) December 22, 2014 ... Nursing Leadership Conference, next month in San ... strategies to address dynamics that often stand in ... authority, and competition. , This premier faculty ... Center for Transformational Leadership, whose mission is to ...
(Date:12/21/2014)... (PRWEB) December 22, 2014 Recently, BambooFlooringChina.com, ... durable strand woven bamboo flooring collection , and launched ... 25%. The promotion is valid until Jan. 30, 2015. ... woven bamboo is the hardest bamboo flooring available today; ... resembling that of traditional teak hardwoods. Strand woven bamboo ...
(Date:12/21/2014)... Khanna Vision Institute is pleased to announce ... Helicopters holiday event for underprivileged kids. The highlight was ... by an aspen helicopter pilot. In the cover of ... was visible.(please see accompanying video). Helicopter pilots require great ... many pilots with Pi in eye vision correction. ...
Breaking Medicine News(10 mins):Health News:Peacock Alley and Community Partners of Dallas Fulfill an Estimated 12,000 Holiday Wishes for Deserving Children 2Health News:National Association of Professional Women Announces Cheryl A. Kreider, President / CEO of Kreider Health Solutions, LLC, a 2014 Professional Woman of the Year 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 3Health News:BambooFlooringChina.com Announced Its Durable Strand Woven Bamboo Flooring Collection 2
... for many with low risk disease, researchers find , ... prostate cancer that has a low risk of progression, ... a suitable treatment option, according to a large-scale study ... to treat localized prostate cancer is controversial because, especially ...
... ... Ridgway, MD is now performing a new procedure at Baptist Medical Center in Jackson, ... is referred to as a myomectomy, or fibroidectomy. , ... Jackson, MS (Vocus) June 18, 2010 -- Baptist ...
... families need extra support, study says , FRIDAY, June ... are at increased risk for falling behind in reading ... the American Speech-Language-Hearing Association. , Parents should provide these ... ASHA, which offers the following tips: , Talk ...
... 18 June 2010: There is significant disparity between ,richer, ... to biological treatments for rheumatoid arthritis (RA), according to ... today at EULAR 2010, the Annual Congress of the ... from a separate study show that RA patients report ...
... ... environment, many Adult Learners contact a “For Profit” Online University or ... about returning to school to earn their online degree. What most ... certificates, licenses earned and college level exams successfully completed can all ...
... cost increased, consumption dropped, study found , FRIDAY, June ... soft drinks may reduce consumption and help lower levels ... new study suggests. , Researchers examined what happened during ... Women,s Hospital in Boston increased the price of regular ...
Cached Medicine News:Health News:'Watchful Waiting' Often Best Strategy for Slow-Moving Prostate Cancer 2Health News:GYN Oncologist Uses da Vinci Surgical Robot to Preserve Fertility 2Health News:Country economy is a stronger predictor of therapy initiation 2Health News:College Equalizer Takes College Counseling Beyond the Status Quo to Help Adult Learners Find the Best School 2Health News:College Equalizer Takes College Counseling Beyond the Status Quo to Help Adult Learners Find the Best School 3Health News:People May Skip Soft Drinks Rather Than Pay More 2
(Date:12/19/2014)... and CARDIFF-BY-THE-SEA, Calif. ... (NASDAQ: SRNE ;  Sorrento), an oncology ... pain, and Conkwest, Inc., a privately-held immuno-oncology company ... Killer (NK) cell-line based therapy, announced today that ... to jointly develop next generation CAR-TNK™ (pronounced as ...
(Date:12/19/2014)... , Dec. 18, 2014  Sage Analytics ( ... of equipment for the testing of marijuana potency ... the new Luminary™ Profiler, the industry,s first product ... in a cost-effective, portable unit. Designed ... needs of the cannabis industry, the Luminary™ Profiler ...
(Date:12/19/2014)... , Dec. 18, 2014 Baptist Health Lexington is ... to receive full Atrial Fibrillation with Electrophysiology Services (EPS) ... Atrial fibrillation is the most common cardiac arrhythmia ... some cases can lead to stroke and possible death. More ... have atrial fibrillation and the numbers are rapidly ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3
... organiser UBM Live , a division of UBM ... China 2011 and co-located events ICSE China for contract and ... BioPh China to cater to the biopharmaceuticals market, held from ... a 36% increase in attendance from the 2010 events. Over ...
... HOPKINTON, Mass., July 12, 2011 Roche (SIX: ... Inc. (NASDAQ: CALP ) today announced ... of automated protocols for the NimbleGen SeqCap EZ ... Workstation.  The collaboration aims to simplify high throughput ...
Cached Medicine Technology:China Pharma Events Attract Over 27,000 Visitors 2China Pharma Events Attract Over 27,000 Visitors 3Roche NimbleGen and Caliper Collaborate to Offer Automated Target Enrichment Pipeline Solution for Next-Generation Sequencing 2Roche NimbleGen and Caliper Collaborate to Offer Automated Target Enrichment Pipeline Solution for Next-Generation Sequencing 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: