Navigation Links
Fat associated with chemical changes in DNA that may help explain obesity-related disease
Date:1/20/2011

AUGUSTA, Ga. Fat appears to associate with some distinctive chemical changes in the DNA a finding that may help explain why obesity can increase the risk for chronic problems such as cardiovascular disease and diabetes, researchers report.

The finding, published in BMC Medicine, may one day help identify those at risk and reduce it, according to Dr. Xiaoling Wang, genetic epidemiologist at the Medical College of Georgia's Georgia Prevention Institute.

"Losing fat is very difficult; we know that. We also know it causes many diseases so we want to identify and target pathways to reduce those diseases," Wang said.

Fat used to be viewed as essentially padding and a ready energy source but scientists are learning it's more like a factory that makes chemicals and compounds such as hormones and proteins. Studies comparing two groups of obese versus lean teens found higher levels of chemical change, or methylation, in a portion of the UBASH3A gene and lower levels in part of the TRIM3 gene.

Both genes are known to have roles in regulating the immune system, which is often dysregulated in obese individuals. Dysregulation can result in a level of chronic inflammation that contributes to diseases such as cardiovascular disease, diabetes and cancer. Methylation can impact immune function by affecting gene expression levels which ultimately impacts downstream functions of the proteins produced by genes.

"You need to know disease pathways to find novel medications," Wang said. "We generally know they have a dysregulation of the immune function, but we didn't know the specific site." She believes she found at least two sites in the UBASH3A and TRIM3 gene. Her initial search was broad: a genome-wide screen of seven obese and seven lean teens that enabled her to identify genes most different between the two. She ranked the differences and, in a much larger study of 46 obese and 46 lean controls, looked at the same sites in
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Discovery of a gene associated with a leukemia mostly affecting children
2. Blood Type O Associated With Less Risk for Heart Attack
3. Abstinence, heavy drinking, binge drinking associated with increased risk of cognitive impairment
4. Malfunctioning gene associated with Lou Gehrigs disease leads to nerve-cell death in mice
5. Extreme obesity associated with higher risk of death for 2009 H1N1 patients
6. Consistent exercise associated with lower risk of colon cancer death
7. Poor breast cancer prognosis associated with presence of circulating tumor, cancer stem cells
8. Lower levels of education are associated with increased risks of heart failure
9. Low and high vitamin D levels in older women associated with increased likelihood of frailty
10. Early physical therapy for low back pain associated with less subsequent health care utilization
11. Genetic mutations associated with increased PSA and prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fat associated with chemical changes in DNA that may help explain obesity-related disease
(Date:4/18/2014)... 21, 2014) -- A group of scientists from ... the Sanders-Brown Center on Aging has found interesting ... neuropsychological function in Parkinson,s disease (PD). , ... the study, which assessed cognitive function in depressed ... dopamine replacement therapy commonly used to treat motor ...
(Date:4/18/2014)... Medicine researchers have been awarded two-year grants for their ... this month. Of the 110 initial submissions to the ... Program, only four projects were funded, three of which ... Powell, M.D., Ph.D.; G. William Wong, Ph.D.; and Elias ... of oncology, will use his $500,000 proof of principle ...
(Date:4/18/2014)... Calif. (April 18, 2014) ― A new study in ... weekly patterns in health-related Google searches reveals a recurring ... strategies. , Investigators from San Diego State ... the Monday Campaigns, analyzed "healthy" Google searches (searches that ... "healthy diet") originating in the U.S. from 2005 to ...
(Date:4/17/2014)... who show signs of chronic inflammation in non-cancerous prostate ... having prostate cancer than those with no inflammation, according ... from the Johns Hopkins Kimmel Cancer Center. , The ... for men with so-called high-grade prostate cancer those ... indicating the presence of the most aggressive and rapidly ...
(Date:4/17/2014)... to a study published today in PLOS Pathogens ... where malaria is common can mount an immune response ... to avoid repeated bouts of high fever and illness ... their bloodstream. The findings may help researchers develop future ... the malaria parasite. , Each year, approximately 200 million ...
Breaking Medicine News(10 mins):Health News:Treating depression in PD patients: New research 2Health News:New research shows people are thinking about their health early in the week 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Study sheds light on how the immune system protects children from malaria 2
... BlueShield Give 40 in District Opportunity to Help Community Prevent HIV/AIDS ... ... Education ( SHIRE ), Inc., is reaching out to 40 young men ... prevent the spread of HIV and AIDS and childhood obesity. The ...
... Manhattan Cross Cultural Group is now offering at ... CME cultural competency training course for physicians in New ... by June 30, 2009. New Jersey physicians can sign ... by visiting: http://www.qualityinteractions.org/index.new.html ...
... BETHESDA, Md., May 11 The American College of ... four new directors, following its 2009 annual meeting. The ... for the Foundation and for advancing the policies and ... a term of 5 years, are: Wayne W. Grody, ...
... Karen Ignagni, President and CEO of America,s Health Insurance ... containment framework presented to President Obama:"Health plans are honored ... framework for cost containment, which is essential to make ... and preserve the competitiveness of our country. We strongly ...
... Massachusetts, May 11 ,Optasia Medical Ltd., a ... has received certification for the successful,registration of ... 9001:2008 and ISO,13485:2003. The certification audit was ... 2009. The Intertek auditor examined all elements ...
... northwest region with more hires planned throughout the ... The Pennsylvania Patient Safety Authority has hired ... to help healthcare facilities that report through the ... safety for Pennsylvania citizens. The Patient Safety Liaison ...
Cached Medicine News:Health News:Stepping Up: D.C. Wards 7 and 8 Teens to Teach Prevention of HIV, Obesity in Summer Youth Program 2Health News:Stepping Up: D.C. Wards 7 and 8 Teens to Teach Prevention of HIV, Obesity in Summer Youth Program 3Health News:Stepping Up: D.C. Wards 7 and 8 Teens to Teach Prevention of HIV, Obesity in Summer Youth Program 4Health News:Attention New Jersey Physicians Still Needing to Meet Cultural Competency Requirement by June 30 2Health News:New Board Members Join American College of Medical Genetics Foundation (ACMGF): Distinguished Executive, Medical and Philanthropic Leaders Bring Additional Perspectives to the ACMGF Board 2Health News:New Board Members Join American College of Medical Genetics Foundation (ACMGF): Distinguished Executive, Medical and Philanthropic Leaders Bring Additional Perspectives to the ACMGF Board 3Health News:AHIP Statement on Cost Containment Framework 2Health News:Pennsylvania Patient Safety Authority Hires Patient Safety Liaison to Help Healthcare Facilities Implement Guidance 2Health News:Pennsylvania Patient Safety Authority Hires Patient Safety Liaison to Help Healthcare Facilities Implement Guidance 3
(Date:1/15/2014)...  Novation, the leading health care supply chain expertise, analytics ... (VAR) national contracts that expand its portfolio to provide ... costs. These include manufacturer product and service agreements, as ... ongoing IT consulting support. New Novation ...
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces that ... to the announced tender offer for all of the outstanding shares ... of the waiver, the transaction is no longer conditional on OFT ... 24, 2014 following the currently scheduled expiration time, subject to the ...
(Date:1/15/2014)... , Jan. 15, 2014  Manufacturers, suppliers and distributors ... able to protect their most important business assets, ... ) Because of the highly-competitive ... remains one of the most litigious industry sectors ...
Breaking Medicine Technology:New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Intellectual Property Insurance for Medical-related Products and Services 2
... The ACS:180 SE is a ... PLUS, consisting of important physical ... simplify routine operation and increase ... the "Next Generation" ACS:180. The ...
... range of Platelet aggregometers allows to ... particular needs. Single, dual and four ... recorder outputs or digital computer outputs. ... aggregometers, which measure platelet aggregation in ...
... in achieving improved cost efficiency in ... cut costs is constantly increasing. Optimize ... unnecessary manual interactions. Ensuring security of ... mechanisms like pipetting integrity check. Right ...
... The Advia 2400 ... sample volume (as low ... water consumption (40 L/hour) ... The optional universal rack ...
Medicine Products: