Navigation Links
Fat associated with chemical changes in DNA that may help explain obesity-related disease
Date:1/20/2011

AUGUSTA, Ga. Fat appears to associate with some distinctive chemical changes in the DNA a finding that may help explain why obesity can increase the risk for chronic problems such as cardiovascular disease and diabetes, researchers report.

The finding, published in BMC Medicine, may one day help identify those at risk and reduce it, according to Dr. Xiaoling Wang, genetic epidemiologist at the Medical College of Georgia's Georgia Prevention Institute.

"Losing fat is very difficult; we know that. We also know it causes many diseases so we want to identify and target pathways to reduce those diseases," Wang said.

Fat used to be viewed as essentially padding and a ready energy source but scientists are learning it's more like a factory that makes chemicals and compounds such as hormones and proteins. Studies comparing two groups of obese versus lean teens found higher levels of chemical change, or methylation, in a portion of the UBASH3A gene and lower levels in part of the TRIM3 gene.

Both genes are known to have roles in regulating the immune system, which is often dysregulated in obese individuals. Dysregulation can result in a level of chronic inflammation that contributes to diseases such as cardiovascular disease, diabetes and cancer. Methylation can impact immune function by affecting gene expression levels which ultimately impacts downstream functions of the proteins produced by genes.

"You need to know disease pathways to find novel medications," Wang said. "We generally know they have a dysregulation of the immune function, but we didn't know the specific site." She believes she found at least two sites in the UBASH3A and TRIM3 gene. Her initial search was broad: a genome-wide screen of seven obese and seven lean teens that enabled her to identify genes most different between the two. She ranked the differences and, in a much larger study of 46 obese and 46 lean controls, looked at the same sites in
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Discovery of a gene associated with a leukemia mostly affecting children
2. Blood Type O Associated With Less Risk for Heart Attack
3. Abstinence, heavy drinking, binge drinking associated with increased risk of cognitive impairment
4. Malfunctioning gene associated with Lou Gehrigs disease leads to nerve-cell death in mice
5. Extreme obesity associated with higher risk of death for 2009 H1N1 patients
6. Consistent exercise associated with lower risk of colon cancer death
7. Poor breast cancer prognosis associated with presence of circulating tumor, cancer stem cells
8. Lower levels of education are associated with increased risks of heart failure
9. Low and high vitamin D levels in older women associated with increased likelihood of frailty
10. Early physical therapy for low back pain associated with less subsequent health care utilization
11. Genetic mutations associated with increased PSA and prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fat associated with chemical changes in DNA that may help explain obesity-related disease
(Date:11/21/2014)... (PRWEB) November 21, 2014 TopConsumerReviews.com ... Lift, an industry leader in the relief ... have significant feelings of sadness and depression each ... traditional pharmaceutical choices. Often, prescription drugs can produce ... Prescription drugs are expensive and require regular follow-up ...
(Date:11/21/2014)... 21, 2014 According to a National ... June 11th, 2014, the inflating system found in certain ... airbag inflates. The force of inflation may cause the ... metal shards may pierce the airbag’s fabric and potentially ... , According to a Bloomberg Business Week article ...
(Date:11/21/2014)... London, UK (PRWEB) November 21, 2014 ... world’s only ISO verified healthcare professional panel, today announced two ... the appointment of Roni DasGupta as President of Market Research, ... of Market Research, Europe. , Ms. DasGupta joined ... Vice President and most recently Head of Sales. Roni ...
(Date:11/21/2014)... HealthDay Reporter THURSDAY, Nov. 20, 2014 (HealthDay ... a still-beating heart has the potential to improve the health ... study. Heart patients who received the gel implant had ... of feet farther during a six-minute walk test, said senior ... division at Washington University School of Medicine and a cardiologist-in-chief ...
(Date:11/21/2014)... Serena Gordon HealthDay ... Two U.S. government agencies have proposed new rules that ... clinical trial was successful or not. The proposed ... to publish summaries of their results to ClinicalTrials.gov -- a ... Health (NIH) and the U.S. Department of Health and Human ...
Breaking Medicine News(10 mins):Health News:Depression Relief Product Receives Top 5-Star Rating from TopConsumerReviews.com 2Health News:Takata Airbag Recall Class Action Lawsuit Resource Released by Florida Injury Attorney 2Health News:Takata Airbag Recall Class Action Lawsuit Resource Released by Florida Injury Attorney 3Health News:M3 Global Research Announces Leadership Team Promotions in US and EU 2Health News:Gel Implant Might Help Fight Heart Failure 2Health News:Gel Implant Might Help Fight Heart Failure 3Health News:U.S. Proposes Greater Public Access to Data From Clinical Trials 2
... HealthDay Reporter , WEDNESDAY, July 7 (HealthDay News) -- ... is less accurate when done in the summer than in ... Although the particular brand of test used in the study ... United States, the findings are of interest to U.S. researchers ...
... HealthDay Reporter , TUESDAY, July 6 (HealthDay News) -- The ... of chronic lower back pain caused by osteoarthritis, a new ... knock against glucosamine, with other recent studies showing similar results. ... back pain for a long time (more than 6 months), ...
... ... Today Construction of a State-of-the-Art Hospital in Rural Kenya. Founded by a Kaiser ... The Foundation,s Investment Management Approach to African Philanthropy is a Departure from Traditional ... ...
... ... applying for SSDI with spinal cord impairments , ... Belleville, Ill. (Vocus) -- Every 41 minutes a person ... each year, according to the United Spinal Association. Allsup, a nationwide provider of ...
... In ... with a free upgrade to their Celloxylin® skincare products!, , ... Laguna Hills, CA (PRWEB) July 7, 2010 ... one of their products is encouraged to upgrade an anti-aging product they didn’t like, ...
... ... can seek out cutting-edge stem cell treatments designed to enhance their quality of ... Austin, TX (Vocus) ... CELLING Treatment Center is newly open in Austin, providing stem cell therapies for common ...
Cached Medicine News:Health News:Could Hot Weather Affect Results of a Colorectal Cancer Test? 2Health News:Could Hot Weather Affect Results of a Colorectal Cancer Test? 3Health News:Could Hot Weather Affect Results of a Colorectal Cancer Test? 4Health News: Glucosamine Ineffective for Lower Back Pain Linked to Arthritis 2Health News: Glucosamine Ineffective for Lower Back Pain Linked to Arthritis 3Health News:State of the Art Hospital for Rural Kenya Announced by California Foundation 2Health News:State of the Art Hospital for Rural Kenya Announced by California Foundation 3Health News:Social Security Disability Benefits Can Be Crucial to Surviving With Spinal Cord Injury, Allsup Reports 2Health News:Social Security Disability Benefits Can Be Crucial to Surviving With Spinal Cord Injury, Allsup Reports 3Health News:Social Security Disability Benefits Can Be Crucial to Surviving With Spinal Cord Injury, Allsup Reports 4Health News:Apriori Beauty Offers Free Anti-Aging Product Upgrade 2Health News:CELLING Treatment Centers New Clinic Revolutionizes Spinal Care with Adult Stem Cells 2
(Date:11/21/2014)... Ill. , Nov. 21, 2014  Heated dialogue ... drug prices – from cancer treatments to Gilead,s new ... pharmaceutical leaders around the world questioning what it means ... of care. And while drug pricing ... pharmaceutical industry – from both a general business and ...
(Date:11/21/2014)... 21, 2014  PTC Therapeutics, Inc. (NASDAQ: PTCT ... Technology Award for Vision, Innovation, and Leadership has been awarded ... This award recognizes an individual who has had a significant ... for several decades. "I am honored ... Stuart Peltz , Ph.D., CEO of PTC Therapeutics, Inc. "When ...
(Date:11/21/2014)... , Nov. 21, 2014 ... the European Medicines Agency (EMA) has granted ... company,s lead product candidate, for the treatment ... a rare, severely disabling genetic disease characterized ... swelling (flare-ups) and new abnormal bone formation. ...
Breaking Medicine Technology:"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 2"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 3"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 4"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 5PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 2PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 3Clementia Pharmaceuticals Receives EMA Orphan Medicinal Product Designation for Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva 2Clementia Pharmaceuticals Receives EMA Orphan Medicinal Product Designation for Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva 3
... , ST. LOUIS , Feb. 1 ... The TODAY Show featured Dr. Mauricio Arruda ... Heart & Vascular Institute in Cleveland, Ohio , performing ... its broadcast this morning.  The patient was a 69 year ...
... DIEGO , Feb. 1 CareFusion (NYSE: ... today that it has entered into a 5-year sole source ... top ten Catholic health systems in the U.S., to upgrade ... further into the operating rooms and cath labs. , CareFusion,s ...
Cached Medicine Technology:Stereotaxis System Procedure Featured on NBC's The TODAY Show 2CareFusion Announces 5-Year, Sole Source Pyxis(R) Perioperative Solutions Agreement With CHRISTUS Health 2CareFusion Announces 5-Year, Sole Source Pyxis(R) Perioperative Solutions Agreement With CHRISTUS Health 3CareFusion Announces 5-Year, Sole Source Pyxis(R) Perioperative Solutions Agreement With CHRISTUS Health 4
... The Finnpipette Digital Multichannel, ... even lighter work of routine ... all these advanced features: Soft-touch ... micro volume pipetting (0.5-10ul models), ...
... Multichannel, with it's streamlined design, ... routine laboratory tasks. The multichannel ... Soft-touch tip ejection, Super blow-out ... models), Entire pipette autoclavable, streamlined ...
... Designed with 96-well plates in mind, ... for molecular biology applications: PCR* sequencing, ... plates, etc. Used with Diamond Tips ... this product will maximize performance and ...
... to operate in a wide variety of applications. ... The manifold can be freely rotated against the ... always at an optimum angle towards the microtiter ... the use of most common pipette tips, and ...
Medicine Products: