Navigation Links
Fat associated with chemical changes in DNA that may help explain obesity-related disease
Date:1/20/2011

AUGUSTA, Ga. Fat appears to associate with some distinctive chemical changes in the DNA a finding that may help explain why obesity can increase the risk for chronic problems such as cardiovascular disease and diabetes, researchers report.

The finding, published in BMC Medicine, may one day help identify those at risk and reduce it, according to Dr. Xiaoling Wang, genetic epidemiologist at the Medical College of Georgia's Georgia Prevention Institute.

"Losing fat is very difficult; we know that. We also know it causes many diseases so we want to identify and target pathways to reduce those diseases," Wang said.

Fat used to be viewed as essentially padding and a ready energy source but scientists are learning it's more like a factory that makes chemicals and compounds such as hormones and proteins. Studies comparing two groups of obese versus lean teens found higher levels of chemical change, or methylation, in a portion of the UBASH3A gene and lower levels in part of the TRIM3 gene.

Both genes are known to have roles in regulating the immune system, which is often dysregulated in obese individuals. Dysregulation can result in a level of chronic inflammation that contributes to diseases such as cardiovascular disease, diabetes and cancer. Methylation can impact immune function by affecting gene expression levels which ultimately impacts downstream functions of the proteins produced by genes.

"You need to know disease pathways to find novel medications," Wang said. "We generally know they have a dysregulation of the immune function, but we didn't know the specific site." She believes she found at least two sites in the UBASH3A and TRIM3 gene. Her initial search was broad: a genome-wide screen of seven obese and seven lean teens that enabled her to identify genes most different between the two. She ranked the differences and, in a much larger study of 46 obese and 46 lean controls, looked at the same sites in
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Discovery of a gene associated with a leukemia mostly affecting children
2. Blood Type O Associated With Less Risk for Heart Attack
3. Abstinence, heavy drinking, binge drinking associated with increased risk of cognitive impairment
4. Malfunctioning gene associated with Lou Gehrigs disease leads to nerve-cell death in mice
5. Extreme obesity associated with higher risk of death for 2009 H1N1 patients
6. Consistent exercise associated with lower risk of colon cancer death
7. Poor breast cancer prognosis associated with presence of circulating tumor, cancer stem cells
8. Lower levels of education are associated with increased risks of heart failure
9. Low and high vitamin D levels in older women associated with increased likelihood of frailty
10. Early physical therapy for low back pain associated with less subsequent health care utilization
11. Genetic mutations associated with increased PSA and prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fat associated with chemical changes in DNA that may help explain obesity-related disease
(Date:11/28/2014)... a leader in the wig industry, has announced a great ... promotion features: , > 400 pieces of FOUR ... (no coupon code needed), > 10% off for ... $49 , Visit http://www.uniwigs.com for more details , The ... 1st and the first 100 shoppers each day will receive our ...
(Date:11/28/2014)... Georgia (PRWEB) November 28, 2014 Patten ... and locally grown. With those passions driving them, they've ... Georgia Grown. Having tried other pecans oils, they've found ... Pitts, Georgia to be exceptionally flavorful, retaining the buttery ... The same nutritional benefits found in pecans ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 An inventor from ... day to day. "I got this idea while lying in ... the bathroom," he said. , The Bed Buddy provides a ... go to the bathroom. It eliminates the need to leave ... promotes comfort and dignity. Easy to use and producible in ...
(Date:11/28/2014)... Before that Thanksgiving meal even had time to ... shopping season. Today, people will stand in line for hours ... retail shopping day of the year. , But instead ... Albany dentist Dr. Ronald Receveur is asking the public ... literally brighten a few smiles. , The gifts he suggests ...
(Date:11/28/2014)... Colorado (PRWEB) November 28, 2014 talklocal ... connect consumers to the right service professionals by phone in ... week after at least two tornadoes were reported to have ... Although no damage was reported following the tornadoes, Denver residents ... for the unexpected. Having TalkLocal is like having local pros ...
Breaking Medicine News(10 mins):Health News:Pre-X'mas Crazy Sale Starts from $0 at UniWigs.com 2Health News:Patten Pecans Goes Local with Nutritious Georgia Pecan Oil 2Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 2Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 3Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 4Health News:TalkLocal Launches In Denver A Week After Multiple Tornadoes Hit Near City 2
... Yet another Major Rise in Listeners. Affordable Health Insurance and ... ... Kansas City, MO (PRWEB) August 28, 2008 -- The Health Insurance ... September 6th on 1260 AM and 104.1 FM KSGF. The ...
... RDYN ) today announced the restructuring of ... 80% to 5 employees in,actions that are scheduled ... As a result of these actions Replidyne will ... for the,treatment of Clostridium difficile (C. difficile) bacteria ...
... Oncology has selected renowned pediatric oncologist Audrey Evans, M.D., ... recognized during the Awards Ceremony held Tuesday, September 23, ... Boston., Dr. Evans has been on the forefront of ... She was one of the co-founders of the original ...
... longer to see positive effect, researchers say , , WEDNESDAY, Aug. ... not lower the rate of stroke, cardiovascular events or diabetes ... stroke, a new study finds. , Telmisartan is an angiotensin ... chemicals that constrict the blood vessels enabling the blood to ...
... wages and benefits, HEMET, Calif., Aug. 27 The ... against the,board of directors of Valley Health System (VHS) for ... already voted to agree to., "I do this job ... said,Lisa Howell, a registered nurse at Menifee Valley Medical Center. ...
... use 7 simple variables to gauge in-hospital mortality ... News) -- A new scoring system for assessing ... been confirmed to be effective, according to Mayo ... The Mayo Clinic Risk Score (MCRS) uses seven ...
Cached Medicine News:Health News:The Health Insurance Advocate Radio Show Expands to Springfield, Missouri, and Reaches a New All-Time Ratings High for Female Listenership 2Health News:The Health Insurance Advocate Radio Show Expands to Springfield, Missouri, and Reaches a New All-Time Ratings High for Female Listenership 3Health News:Replidyne Announces Restructuring of Operations 2Health News:ASTRO selects pediatric oncologist as 2008 honorary member 2Health News:Newer Blood Pressure Drug No Better Than Placebo in Preventing Stroke 2Health News:Newer Blood Pressure Drug No Better Than Placebo in Preventing Stroke 3Health News:State Board Issues Complaint: VHS Board Should Have Signed Contract With Caregivers 2Health News:Angioplasty Scoring System Predicts Risk of Death 2
(Date:11/26/2014)... -- Cohen, Placitella & Roth, PC is investigating potential ... Pharmaceutical Corporation ("Nymox" or "Company") (NASDAQ: ... 2011 through November 2, 2014 ("Class Period").  The ... officers and directors publically disseminated materially false and/or ... 20(a) of the Securities Exchange Act of 1934 ...
(Date:11/26/2014)... Md. , Nov. 26, 2014  Over 100 ... of those suffer from this pain daily. Chronic and ... of pain management is born to fulfill the need ... all types of pain. On October 28th, ... the Cumberland, Maryland community.  This ...
(Date:11/26/2014)... -- Zynerba Pharmaceuticals , Inc., a specialty pharmaceutical ... cannabinoid treatments, today announced that the company will present ... The conference will be held December 2 to 3, ... York . Zynerba,s Chairman and CEO, Armando ... December 2. To listen to a webcast ...
Breaking Medicine Technology:Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 3New Pain Management Center Opens in Cumberland, Md. 2Zynerba Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2014 2
... Inc. ("Oncolytics") (TSX:ONC, NASDAQ: ONCY ) announced ... a Phase 2 clinical trial using intravenous administration ... in patients with non-small cell lung cancer (NSCLC) ... is Dr. Miguel Villalona-Calero, Professor, Division of Hematology/Oncology ...
... quantitative imaging endpoints from MRI analysesROCHESTER, N.Y., March ... ), a leading provider of quantitative imaging for ... Canadian medical device company based in Laval, Quebec, ... pivotal clinical trial for its cartilage repair device ...
Cached Medicine Technology:Oncolytics Biotech(R) Inc. Announces Start of Enrolment in U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours 2VirtualScopics' Quantitative Imaging Provides Primary Endpoint in Cartilage Repair Pivotal Clinical Trial 2VirtualScopics' Quantitative Imaging Provides Primary Endpoint in Cartilage Repair Pivotal Clinical Trial 3
20 g MVR knife. Dimensions: 31.8 mm x 1.18 mm x 2.7 mm....
Full Handle Laseredge Spoon Blade Knife, 3.0 mm angled double bevel. Blade dimension: 11.0 mm (L) x 3.0 mm (W). Cut: 320....
Full Handle Laseredge Slit Blade Knife, 3.2 mm angled double bevel. Blade tip dimension: 14.4 mm x 3.2 mm x 4.0 mm....
Full Handle Laseredge Slit Blade Knife, 3.0 mm angled bevel up. Blade tip dimension: 14.4 mm x 3.0 mm x 3.7 mm....
Medicine Products: