Navigation Links
Fat associated with chemical changes in DNA that may help explain obesity-related disease
Date:1/20/2011

AUGUSTA, Ga. Fat appears to associate with some distinctive chemical changes in the DNA a finding that may help explain why obesity can increase the risk for chronic problems such as cardiovascular disease and diabetes, researchers report.

The finding, published in BMC Medicine, may one day help identify those at risk and reduce it, according to Dr. Xiaoling Wang, genetic epidemiologist at the Medical College of Georgia's Georgia Prevention Institute.

"Losing fat is very difficult; we know that. We also know it causes many diseases so we want to identify and target pathways to reduce those diseases," Wang said.

Fat used to be viewed as essentially padding and a ready energy source but scientists are learning it's more like a factory that makes chemicals and compounds such as hormones and proteins. Studies comparing two groups of obese versus lean teens found higher levels of chemical change, or methylation, in a portion of the UBASH3A gene and lower levels in part of the TRIM3 gene.

Both genes are known to have roles in regulating the immune system, which is often dysregulated in obese individuals. Dysregulation can result in a level of chronic inflammation that contributes to diseases such as cardiovascular disease, diabetes and cancer. Methylation can impact immune function by affecting gene expression levels which ultimately impacts downstream functions of the proteins produced by genes.

"You need to know disease pathways to find novel medications," Wang said. "We generally know they have a dysregulation of the immune function, but we didn't know the specific site." She believes she found at least two sites in the UBASH3A and TRIM3 gene. Her initial search was broad: a genome-wide screen of seven obese and seven lean teens that enabled her to identify genes most different between the two. She ranked the differences and, in a much larger study of 46 obese and 46 lean controls, looked at the same sites in
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Discovery of a gene associated with a leukemia mostly affecting children
2. Blood Type O Associated With Less Risk for Heart Attack
3. Abstinence, heavy drinking, binge drinking associated with increased risk of cognitive impairment
4. Malfunctioning gene associated with Lou Gehrigs disease leads to nerve-cell death in mice
5. Extreme obesity associated with higher risk of death for 2009 H1N1 patients
6. Consistent exercise associated with lower risk of colon cancer death
7. Poor breast cancer prognosis associated with presence of circulating tumor, cancer stem cells
8. Lower levels of education are associated with increased risks of heart failure
9. Low and high vitamin D levels in older women associated with increased likelihood of frailty
10. Early physical therapy for low back pain associated with less subsequent health care utilization
11. Genetic mutations associated with increased PSA and prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fat associated with chemical changes in DNA that may help explain obesity-related disease
(Date:8/23/2014)... 23, 2014 Professional kitchen employees, prospective ... aid in preparing for Food Safety Certification exams thanks ... by Dynamic Path. , Dynamic Path announced the release ... more than 200 review questions for culinary industry students ... to cover requirements of the ServSafe® Food Safety Certification, ...
(Date:8/23/2014)... Teen drug and alcohol abuse is ... in Wilmington, NC. Substance abuse can happen to people ... drug and alcohol dependency in higher numbers than ever ... substance abuse, but don’t know where to find professional ... be a challenge because most treatment options are designed ...
(Date:8/22/2014)... 2014 Deep Research Report on ... in-depth research report on the Glucose Meter market. ... Glucose Meter definition, classification, application, and industry chain ... covers the international market analysis, including domestic market ... environment & economic situation analysis. The report on ...
(Date:8/22/2014)... 23, 2014 Top 10 Best ... web hosting companies and highly recommended FatCow ( ... The manager of Top 10 Best SEO Hosting ... dedicated server hosting supplier. Actually, these companies have ... speed and customer support. People can get the ...
(Date:8/22/2014)... 2014 With the stage set for ... Store Expo - which will be held in Boston ... op-ed in its online opinion section, Podium. The ... is co-authored by Steven C. Anderson, IOM, CAE, president ... of the MCPHS University School of Pharmacy – Worcester/Manchester. ...
Breaking Medicine News(10 mins):Health News:Food Handler Safety Certification Made Easy with Dynamic Path 2Health News:Troubled Teens Wilmington Helpline Guides Adolescents to the Path of Recovery 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 3Health News:FatCow Reviews Released by Top10BestSEOHosting.com 2Health News:The Boston Globe Publishes Value of Pharmacy Op-ed as NACDS Total Store Expo Begins 2Health News:The Boston Globe Publishes Value of Pharmacy Op-ed as NACDS Total Store Expo Begins 3
... led by Dr. Bernhard Hering have reported the arrival of ... new $6.2 million, 21,000-square-foot Islet Resource Facility in Minneapolis, U.S. ... project- the Spring Point Project, a non- profit organization for ... ,This project will focus on the testing of ...
... 36-year-old professional body-builder who used growth hormone to boost his ... to a report. ,He was admitted with chest ... 12 months, during which he had also experienced excessive urination, ... for 15 years and artificial growth hormone for the past ...
... - The FDA has permitted the use of a ... drug known as Vyvanse//, is manufactured by Shire PLC. ... have a smooth transition from the older ADHD medications ... that the present drug is promising because it is ...
... doctors in Srinagar are quite frustrated by the large number ... bite cases// recorded by the main SMHS hospital here last ... in the last two months. 'The situation is alarming. We ... cases the victims are suspected to have been bitten by ...
... are under the impression that ovarian cancer can be detected ... that this wrong notion is more dangerous to the lives ... 610 women, out of which 305 thought that pap smear ... Breast Cancer Centre said that pap smear is not the ...
... education programme on cervical cancer prevention and the new vaccine ... organized by a team of doctors from Obstetrics and Gynecology ... ,Dr Rihab Awad of the hospital insisted on ... tests once a year. Any aberration detected in cervix can ...
Cached Medicine News:Health News:Pigs Arrive at Bio-secure Center 2
(Date:8/22/2014)... 2014  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) today announced ... of common stock and warrants at a price of ... prior to deducting underwriting discounts and commissions and offering ... are immediately separable and will be issued separately.  The ... on The NASDAQ Stock Market under the ticker symbol ...
(Date:8/21/2014)... --  Memorial Hermann Health System and The University ... new partnership to provide a new level of specialized breast ... the greater Houston area. ... provider of professional breast radiology services for five of Memorial ... The Woodlands , Northeast, Southwest and ...
(Date:8/21/2014)... , Aug. 21, 2014 Nektar ... International Inc. today announced positive results from its ... an investigational, extended half-life recombinant factor VIII (rFVIII) ... Factor (Recombinant)], which met its primary endpoint in ... arm compared to the on-demand arm. ...
Breaking Medicine Technology:WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 3WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 4Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 3Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 2Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 3Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 5
... Johnson & Johnson Pharmaceutical,Research & Development, ... demonstrate doripenem (DORIBAX(TM), doripenem for injection), a,carbapenem ... in vitro against certain,strains of Enterobacteriaceae, including ... Enterobacteriaceae is a large group of ...
... A doctor who is,internationally recognized for her ... DHA, an omega-3 fatty acid, has received the,March ... in the field,of maternal-fetal nutrition., Susan E. ... that infants,receiving breast milk had higher DHA (dietary ...
Cached Medicine Technology:New Data Show In Vitro Potency of Doripenem Against Resistant Bacteria 2New Data Show In Vitro Potency of Doripenem Against Resistant Bacteria 3New Data Show In Vitro Potency of Doripenem Against Resistant Bacteria 4New Data Show In Vitro Potency of Doripenem Against Resistant Bacteria 5March of Dimes Honors Dr. Susan Carlson for Outstanding Work In Maternal-Fetal Nutrition 2
... a new generation Spectrophotometer for near ... nm to 1020 nm with built-in ... and printer. It features four digit ... transmittance, absorption and concentration with excellent ...
... 400 Series Spectrophotometer is ... to UV-VIS instrumentation. The ... incorporated into a radically ... features and performance unprecedented ...
... 520 General Purpose UV/Vis Spectrophotometer. Beckman ... proven technology for a wide range ... 500 Scanning Spectrophotometers, with easily interchangeable ... use. A totally affordable, completely modular ...
... user to quickly and accurately count bacteria colonies. ... or manual counting. An optional 1.5X auxiliary lens ... 3.0X. The adjustable focusing rod allows the 1.5X ... lens also rotates a full 360 for ready ...
Medicine Products: