Navigation Links
Fat associated with chemical changes in DNA that may help explain obesity-related disease
Date:1/20/2011

AUGUSTA, Ga. Fat appears to associate with some distinctive chemical changes in the DNA a finding that may help explain why obesity can increase the risk for chronic problems such as cardiovascular disease and diabetes, researchers report.

The finding, published in BMC Medicine, may one day help identify those at risk and reduce it, according to Dr. Xiaoling Wang, genetic epidemiologist at the Medical College of Georgia's Georgia Prevention Institute.

"Losing fat is very difficult; we know that. We also know it causes many diseases so we want to identify and target pathways to reduce those diseases," Wang said.

Fat used to be viewed as essentially padding and a ready energy source but scientists are learning it's more like a factory that makes chemicals and compounds such as hormones and proteins. Studies comparing two groups of obese versus lean teens found higher levels of chemical change, or methylation, in a portion of the UBASH3A gene and lower levels in part of the TRIM3 gene.

Both genes are known to have roles in regulating the immune system, which is often dysregulated in obese individuals. Dysregulation can result in a level of chronic inflammation that contributes to diseases such as cardiovascular disease, diabetes and cancer. Methylation can impact immune function by affecting gene expression levels which ultimately impacts downstream functions of the proteins produced by genes.

"You need to know disease pathways to find novel medications," Wang said. "We generally know they have a dysregulation of the immune function, but we didn't know the specific site." She believes she found at least two sites in the UBASH3A and TRIM3 gene. Her initial search was broad: a genome-wide screen of seven obese and seven lean teens that enabled her to identify genes most different between the two. She ranked the differences and, in a much larger study of 46 obese and 46 lean controls, looked at the same sites in
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Discovery of a gene associated with a leukemia mostly affecting children
2. Blood Type O Associated With Less Risk for Heart Attack
3. Abstinence, heavy drinking, binge drinking associated with increased risk of cognitive impairment
4. Malfunctioning gene associated with Lou Gehrigs disease leads to nerve-cell death in mice
5. Extreme obesity associated with higher risk of death for 2009 H1N1 patients
6. Consistent exercise associated with lower risk of colon cancer death
7. Poor breast cancer prognosis associated with presence of circulating tumor, cancer stem cells
8. Lower levels of education are associated with increased risks of heart failure
9. Low and high vitamin D levels in older women associated with increased likelihood of frailty
10. Early physical therapy for low back pain associated with less subsequent health care utilization
11. Genetic mutations associated with increased PSA and prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fat associated with chemical changes in DNA that may help explain obesity-related disease
(Date:7/31/2014)... July 31, 2014 T.E.N., a ... firm, honored finalists and winners Wednesday evening, July ... and Awards Gala at the Westin St. Francis ... of information security for the BlackLine Systems, was ... Year Award winner for the ISE® West Region. ...
(Date:7/31/2014)... HealthDay Reporter , WEDNESDAY, July ... cigarettes isn,t warranted based on current evidence, a team ... to compete with regular cigarettes might cut tobacco-related deaths ... studies on the use and safety of the nicotine-emitting ... is a potential for smokers to reduce their health ...
(Date:7/31/2014)... July 31, 2014 Ethane Web ... has introduced a new service named ‘Java Development’. ... Web Technologies has designed the service after doing ... and Java Development service being provided by other ... a confidence to promise outstanding Java Development service. ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Bedros Keuilian’s Fit ... and in several other countries. At his annual Fitness Business ... to Keuilian for their marketing strategies. But in his latest ... strategies for marketing a personal training business is ... , “Almost every personal trainer has a certain area that ...
(Date:7/31/2014)... TX (PRWEB) July 31, 2014 Dallas ... Main Street, Dallas, Texas to 3821 Ross Avenue, also in ... for current and potential members to burn fat and get ... for this move because he believes that the new space ... loss and fitness results they want as well as accommodate ...
Breaking Medicine News(10 mins):Health News:Max Solonski, Caesars Entertainment Claim Top Awards at ISE® West Ralph Johnson (King County, WA) named People’s Choice Award Winner 2Health News:Max Solonski, Caesars Entertainment Claim Top Awards at ISE® West Ralph Johnson (King County, WA) named People’s Choice Award Winner 3Health News:Max Solonski, Caesars Entertainment Claim Top Awards at ISE® West Ralph Johnson (King County, WA) named People’s Choice Award Winner 4Health News:Benefits of E-Cigarettes May Outweigh Harms, Study Finds 2Health News:Benefits of E-Cigarettes May Outweigh Harms, Study Finds 3Health News:Ethane Web Technologies Announces Java Development Service at Pocket Friendly Cost 2Health News:Bedros Keuilian’s New Post Explains the Value of Fitness Information Products in Marketing a Personal Training Business 2Health News:Bedros Keuilian’s New Post Explains the Value of Fitness Information Products in Marketing a Personal Training Business 3Health News:Dallas Fit Body Boot Camp Moves to New Location, Announces Grand Opening Set for Saturday August 9th 2
... Partnerships with Minority Banks in Washington ... , Los Angeles , Calif. ... Intended to Spur Economic Growth and Revitalization , WASHINGTON, Nov. 23 ... nationwide Minority Bank Initiative designed to create jobs and spur revitalization in ...
... , WASHINGTON, Nov. 23 ... largest individual membership association of state legislators, congratulates South Carolina ... constitutional amendment to protect the right of individuals to ... the 24th state where legislators have introduced, or will introduce, ...
... , , NEW YORK, Nov. 23 ... 2009 Survey by Saatchi & Saatchi Wellness on Wellness & the ... focus shifts from a healthy lifestyle of exercise and diet to ... economic climate. , The survey,s most dramatic finding was the ...
... 2009 -- Exposure shortly after birth to ambient metals ... emissions are associated with respiratory symptoms in young inner ... at the Columbia Center for Children,s Environmental Health (CCCEH) ... The study is the first to analyze the effects ...
... , ... Reconstructive Surgery...In Brief is distributed monthly and designed to keep you updated on the ... of the full studies highlighted here, or to arrange an interview with a spokesperson, ... ...
... , NEW ... announces that a new market research report ... http://www.reportlinker.com/p0165298/Childrens-Food-and-Drinks-in-Europe---A-Guide-to-Markets-Products-and-Innovation-2nd-Edition.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=prnewswire , Despite the ... ageing population, children remain a significant consumer ...
Cached Medicine News:Health News:DaVita Launches Minority Bank Initiative with $5 Million Investment in Underserved Communities Across the Country 2Health News:DaVita Launches Minority Bank Initiative with $5 Million Investment in Underserved Communities Across the Country 3Health News:South Carolina Now 24th State to Defend Health Care Choice 2Health News:Being Well Is About Reinvention - Not Health 2Health News:Being Well Is About Reinvention - Not Health 3Health News:Exposures to metals and diesel emissions in air linked to respiratory symptoms in children 2Health News:Plastic and Reconstructive Surgery...In Brief 2Health News:Plastic and Reconstructive Surgery...In Brief 3Health News:Reportlinker Adds Children's Food and Drinks in Europe - A Guide to Markets, Products and Innovation 2nd Edition 2Health News:Reportlinker Adds Children's Food and Drinks in Europe - A Guide to Markets, Products and Innovation 2nd Edition 3Health News:Reportlinker Adds Children's Food and Drinks in Europe - A Guide to Markets, Products and Innovation 2nd Edition 4Health News:Reportlinker Adds Children's Food and Drinks in Europe - A Guide to Markets, Products and Innovation 2nd Edition 5Health News:Reportlinker Adds Children's Food and Drinks in Europe - A Guide to Markets, Products and Innovation 2nd Edition 6Health News:Reportlinker Adds Children's Food and Drinks in Europe - A Guide to Markets, Products and Innovation 2nd Edition 7Health News:Reportlinker Adds Children's Food and Drinks in Europe - A Guide to Markets, Products and Innovation 2nd Edition 8
(Date:7/31/2014)... July 31, 2014 Endo International plc (NASDAQ: ... quarter 2014 revenues of $719 million, an increase of ... $712 million. Endo reported net income of $21 million ... of $35 million in the second quarter of 2013.  ... net income for the three months ended June 30, 2014 ...
(Date:7/31/2014)... Auxilium Pharmaceuticals, Inc. (NASDAQ: ... today announced that the Company will receive a ... Asahi Kasei Pharma Corporation (Asahi Kasei). The payment ... a regulatory application to the Japanese Pharmaceutical and ... (collagenase clostridium histolyticum) for the treatment of Dupuytren,s ...
(Date:7/30/2014)... Advanced Photonix ® (NYSE MKT: API) will ... results on Monday, August 11, 2014. A press release announcing ... the market and the Company will host a live audio ... on the same day. Participating in the call ... Rob Risser (COO and Director), and Jeff Anderson ...
Breaking Medicine Technology:Endo Reports Second Quarter Financial Results 2Endo Reports Second Quarter Financial Results 3Endo Reports Second Quarter Financial Results 4Endo Reports Second Quarter Financial Results 5Endo Reports Second Quarter Financial Results 6Endo Reports Second Quarter Financial Results 7Endo Reports Second Quarter Financial Results 8Endo Reports Second Quarter Financial Results 9Endo Reports Second Quarter Financial Results 10Endo Reports Second Quarter Financial Results 11Endo Reports Second Quarter Financial Results 12Endo Reports Second Quarter Financial Results 13Endo Reports Second Quarter Financial Results 14Endo Reports Second Quarter Financial Results 15Endo Reports Second Quarter Financial Results 16Endo Reports Second Quarter Financial Results 17Endo Reports Second Quarter Financial Results 18Endo Reports Second Quarter Financial Results 19Endo Reports Second Quarter Financial Results 20Endo Reports Second Quarter Financial Results 21Endo Reports Second Quarter Financial Results 22Endo Reports Second Quarter Financial Results 23Endo Reports Second Quarter Financial Results 24Endo Reports Second Quarter Financial Results 25Endo Reports Second Quarter Financial Results 26Endo Reports Second Quarter Financial Results 27Endo Reports Second Quarter Financial Results 28Endo Reports Second Quarter Financial Results 29Endo Reports Second Quarter Financial Results 30Endo Reports Second Quarter Financial Results 31Endo Reports Second Quarter Financial Results 32Auxilium Pharmaceuticals, Inc. Announces XIAFLEX Milestone: Partner Asahi Kasei Pharma Corporation Completes Regulatory Submission For Dupuytren's Contracture In Japan 2Auxilium Pharmaceuticals, Inc. Announces XIAFLEX Milestone: Partner Asahi Kasei Pharma Corporation Completes Regulatory Submission For Dupuytren's Contracture In Japan 3Auxilium Pharmaceuticals, Inc. Announces XIAFLEX Milestone: Partner Asahi Kasei Pharma Corporation Completes Regulatory Submission For Dupuytren's Contracture In Japan 4Auxilium Pharmaceuticals, Inc. Announces XIAFLEX Milestone: Partner Asahi Kasei Pharma Corporation Completes Regulatory Submission For Dupuytren's Contracture In Japan 5
... COLLEGEVILLE, Pa., and TARRYTOWN, N.Y., May 22 ... ), and Progenics,Pharmaceuticals, Inc. (Nasdaq: PGNX ), ... with investigational oral and,intravenous formulations of RELISTOR(TM) (methylnaltrexone ... phase 2 trial, evaluated the effects of,an oral ...
... LAS VEGAS, May 22 CardioVascular,BioTherapeutics, Inc. (OTC Bulletin ... Christopher Moore to be the sponsor and general,partner of ... of,$1 million and up to $10 million of the ... am extremely impressed with CVBT,s wound healing drug, which ...
Cached Medicine Technology:Wyeth and Progenics Announce Preliminary Clinical Trial Results for RELISTOR Oral and Intravenous Formulations 2Wyeth and Progenics Announce Preliminary Clinical Trial Results for RELISTOR Oral and Intravenous Formulations 3Wyeth and Progenics Announce Preliminary Clinical Trial Results for RELISTOR Oral and Intravenous Formulations 4Wyeth and Progenics Announce Preliminary Clinical Trial Results for RELISTOR Oral and Intravenous Formulations 5Wyeth and Progenics Announce Preliminary Clinical Trial Results for RELISTOR Oral and Intravenous Formulations 6Wyeth and Progenics Announce Preliminary Clinical Trial Results for RELISTOR Oral and Intravenous Formulations 7Dr. Christopher Moore to Form ProDerm LP to Fund CVBT Wound Healing Trial 2Dr. Christopher Moore to Form ProDerm LP to Fund CVBT Wound Healing Trial 3
... True/Flex technology which has revolutionized the treatment ... unique fluted titanium construct was used in ... The biology of the tibia, with its ... presents special challenges to the healing process. ...
... 3080/3085 SP Bariatric Foot Extension provides extraordinary ... surgical capabilities for Amsco 3080 and 3085 ... Extension is rated for patients up to ... and easy attachment and full positioning capability. ...
... care you can provide to your patients, ... including innovative products, standardization and reimbursement guidelines, ... lavage systems deliver the performance needed for ... and foreign material. Each provides controlled pressure ...
... Pulsavac Wound Debridement System ... for pulsatile irrigation,and debridement. ... range of fluid pressure ... lavage to a penetrating ...
Medicine Products: