Navigation Links
Fat associated with chemical changes in DNA that may help explain obesity-related disease
Date:1/20/2011

AUGUSTA, Ga. Fat appears to associate with some distinctive chemical changes in the DNA a finding that may help explain why obesity can increase the risk for chronic problems such as cardiovascular disease and diabetes, researchers report.

The finding, published in BMC Medicine, may one day help identify those at risk and reduce it, according to Dr. Xiaoling Wang, genetic epidemiologist at the Medical College of Georgia's Georgia Prevention Institute.

"Losing fat is very difficult; we know that. We also know it causes many diseases so we want to identify and target pathways to reduce those diseases," Wang said.

Fat used to be viewed as essentially padding and a ready energy source but scientists are learning it's more like a factory that makes chemicals and compounds such as hormones and proteins. Studies comparing two groups of obese versus lean teens found higher levels of chemical change, or methylation, in a portion of the UBASH3A gene and lower levels in part of the TRIM3 gene.

Both genes are known to have roles in regulating the immune system, which is often dysregulated in obese individuals. Dysregulation can result in a level of chronic inflammation that contributes to diseases such as cardiovascular disease, diabetes and cancer. Methylation can impact immune function by affecting gene expression levels which ultimately impacts downstream functions of the proteins produced by genes.

"You need to know disease pathways to find novel medications," Wang said. "We generally know they have a dysregulation of the immune function, but we didn't know the specific site." She believes she found at least two sites in the UBASH3A and TRIM3 gene. Her initial search was broad: a genome-wide screen of seven obese and seven lean teens that enabled her to identify genes most different between the two. She ranked the differences and, in a much larger study of 46 obese and 46 lean controls, looked at the same sites in
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Discovery of a gene associated with a leukemia mostly affecting children
2. Blood Type O Associated With Less Risk for Heart Attack
3. Abstinence, heavy drinking, binge drinking associated with increased risk of cognitive impairment
4. Malfunctioning gene associated with Lou Gehrigs disease leads to nerve-cell death in mice
5. Extreme obesity associated with higher risk of death for 2009 H1N1 patients
6. Consistent exercise associated with lower risk of colon cancer death
7. Poor breast cancer prognosis associated with presence of circulating tumor, cancer stem cells
8. Lower levels of education are associated with increased risks of heart failure
9. Low and high vitamin D levels in older women associated with increased likelihood of frailty
10. Early physical therapy for low back pain associated with less subsequent health care utilization
11. Genetic mutations associated with increased PSA and prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fat associated with chemical changes in DNA that may help explain obesity-related disease
(Date:5/22/2015)... Power Systems is proud to announce the sponsorship of Elite ... in his second year of racing in the professional division ... Department in Missoula, MT. He entered the triathlon scene in ... he has had 15 1st Place finishes. In his first ... all seven of his 2014 races, including two 2nd Place ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 According to ... hub for drug related death, totaling almost 2,500 confirmed drug ... reported by state officials, totals 2,489 deaths stemming from legal ... out, Pennsylvania loses seven people every day to fatal overdoses ... been singled out as one of the most rife with ...
(Date:5/22/2015)... New York, NY (PRWEB) May 22, 2015 ... abstract entitled “Positivity Rates and Genotype Results in ‘Baby ... Action: Results from a Nationwide Lab Test Database” at Digestive ... conducted by Medivo’s Clinical Affairs and Analytics team members Carol ... Dhaliwal, MD; and Andrea Parker, MSI, along with Nancy Reau, ...
(Date:5/22/2015)... Raton, FL (PRWEB) May 22, 2015 ... which provides vascular, electrocardiogram (EKG), echocardiogram and NCV ... David Sempier, a highly respected All American National athlete, ... multi-sport athlete, I find the high level of testing ... both the athlete and their athletic trainers, this way ...
(Date:5/22/2015)... In an effort to support the athletes of ... donate $5 dollars for every maintenance call, and $25 ... system. Customers have their needs serviced, and donations contributed ... the Special Olympics receives money. Hence the name Everybody ... million athletes, and boasts a myriad of events. This ...
Breaking Medicine News(10 mins):Health News:Philadelphia Ranks Among the Tops Cities in Penn. for Drug Deaths 2Health News:Medivo Study Finds HCV Positivity Rates are 250% Higher Among Baby Boomers 2Health News:Wimbledon Athletics Recruits Team USA Athlete 2Health News:Wimbledon Athletics Recruits Team USA Athlete 3Health News:Parker and Sons is Proud to Support the Special Olympics with Their Everybody Wins Program 2
... (MRI) technique called arterial spin can distinguish// between ... is often mistaken for Alzheimer’s disease in patients ... its behavior manifestations. The disease is characterized by ... repetitive or compulsive behavior, lack of inhibition or ...
... of new disease like SARS, Ebola, Marburg and Avian influenza ... from a global perspective. ,In an article in the ... suggested that instead of tackling these epidemics from the standpoint ... tackled with a common health program for the entire world. ...
... licensed the use of strontium ranelate to be used for ... the drug it is important to observe the changes in ... Medical Journal has said that the drug strontium ranelate have ... this effect can be used in advantage of the treatment ...
... children in the age group of 4 to 6 years of ... single helping. ,New research on pediatric behavior suggests that preschool ... in any one time. Till date it was accepted that these ... last meals, or how calorie rich the last meals were. New ...
... in maintaining the proper structure// and function of cell ... In fact animal studies have shown that high intake ... A cataract is a clouding of the normally clear ... leading cause of blindness in the world today. Besides ...
... anti cancer drug that is used to treat cancers of ... labor. The drug acts on the function of a hormone ... process of delivery. ,Researchers from the University of Newcastle ... also known as TSA, affects the human smooth muscle cells ...
Cached Medicine News:Health News:PUFA reduces risk of cataract 2
(Date:5/22/2015)... -- The Assistance Fund announces the addition of its ... for copay to individuals diagnosed with Melanoma. ... the Melanoma Copay Assistance Program to our portfolio of ... "With each additional program we are closer to achieving ... one is denied access to medications due to an ...
(Date:5/22/2015)...  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX), a clinical-stage drug ... today announced that J.J. Finkelstein , chief executive ... overview at two upcoming investor conferences. ... Annual Microcap Conference on Thursday May 28, 2015 ... 11:00 am EDT.  A webcast will be available at ...
(Date:5/22/2015)... May 22, 2015  The Mesothelioma Victims Center ... of mesothelioma get the best possible compensation, and they ... with this rare cancer caused by exposure to ... information related to treatment options such as a ... the Mesothelioma Victims Center anytime at 866-714-6466. ...
Breaking Medicine Technology:The Assistance Fund Adds Melanoma Assistance Program 2RegeneRx to Present at 2 Investor Conferences 2RegeneRx to Present at 2 Investor Conferences 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 2Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 5
... pause of a heartbeat. The bodys warmth ... breathing. These vital signs are yours to ... line of Temperature Monitoring products helps you ... needed to provide the most comfortable and ...
... is a portable, compact, lightweight system with ... emitting the same intensity (50 mW/cm) of ... smaller treatment area (30 cm). Excilite- possesses ... satisfy the most demanding professional users. The ...
... HIRO 3.0 is the most advanced system for ... system features a patented optical fiber handpiece that ... precision, recovering up to the 20% of the ... are averted thanks to a special gel which ...
... which can remove any undesired hair (except ... of large areas thus reducing operating time. ... light system for faster and extensive treatments ... skins. These characteristics make it a real ...
Medicine Products: