Navigation Links
Effect of medication is affected by copies of genetic information
Date:4/10/2013

The results may help to explain why certain medications have strong side effects on sperm and eggs, and why certain organisms remain unaffected by environmental changes. This is shown by studies that researchers from the University of Gothenburg, together with researchers from Norway and France, are now publishing in the journal PLOS Genetics.

All cells in our bodies contain copies of the genetic information. However, different cells contain different numbers of the complete genetic information. Normal human cells usually contain two copies of the genetic information, and thus two copies of every gene. Eggs and sperm, however, only contain one set of genes.

"At the same time, the cells of many plants and amphibians contain many more copies of genetic information, and the number of copies can also vary during an organism's development and between different stages of life," explains Jonas Warringer, a researcher at the University of Gothenburg's Department of Chemistry and Molecular Biology.

Research has often overlooked this variation in genetic information. However, Jonas Warringer and his colleagues have now used ordinary baker's yeast to show that the number of copies of genetic information has a decisive effect on the properties of cells.

Jonas and his colleagues collected yeast samples from around the world and created two variants of each yeast culture one with two copies of the genetic information, and the other with just one copy. The researchers then examined the properties of these yeast cells, such as their tolerance to cancer medication and antibiotics. The study, which is reported on in the journal PLOS One, shows that the number of copies of genetic information has a decisive effect on the properties of cells.

"The cells with two copies of genetic information showed greater tolerance to some substances," continues Jonas, "while in other cases those with only one copy had an advantage. Surprisingly enough, these effects were even maintained in species separated by several billions of generations of evolution, suggesting that they are actually of great importance in nature."

The researchers' discovery may be of considerable significance in terms of knowledge about what lies behind differences between organisms in nature.

"It may also help to explain why certain medications have particularly strong side effects on sperm and eggs whereas others do not, and why certain organisms are affected by some environmental changes while others are unaffected," he concludes.


'/>"/>

Contact: Jonas Warringer
jonas.warringer@cmb.gu.se
46-073-022-6322
University of Gothenburg
Source:Eurekalert

Related medicine news :

1. Young girls more likely to report side effects after HPV vaccine
2. Preteens More Likely to Report HPV Vaccine Side Effects
3. In children born with severe heart defect, surgical management has little effect on neuro outcomes
4. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
5. Breast cancer patients suffer treatment-related side effects long after completing care
6. Breast Cancer Treatment Side Effects May Last for Years
7. Baldness Drug May Cause Sexual Side Effects: FDA
8. Study examines adverse effects among different radiation therapies for prostate cancer
9. HIV Prevention Pill Cost-Effective for High-Risk Men: Study
10. Pig stomach mucins are effective as anti-viral agents for consumer products
11. LA BioMeds Dr. John Tsuang examines effects of Ibudilast and metamphetamines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... March 29, 2017 , ... Physicians’ ... a specialized continuing medical education conference for clinicians who manage some of the ... New York. , The program will be led by co- chairs Dr. ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... that in order to improve teacher quality, the field must first improve teacher ... one popular reform to the next” and that decades of input- and outcome-based ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... Ruel Williamson brings his extensive knowledge of appraisals, property values, ad valorem taxation, ... real estate valuation industry for more than 40 years. , “Ruel is a ...
(Date:3/28/2017)... ... March 29, 2017 , ... Dr. Isabella Wentz, PharmD, FASCP, one of ... series titled The Thyroid Secret. Dr. Wentz talked about journey and research recently on ... that medication IS NOT the only solution to deal with thyroid disease. , ...
(Date:3/28/2017)... ... March 28, 2017 , ... Via Oncology, the ... launch of a free, public-facing tool for analyzing the costs of various drug ... provide comparative information to patients, providers, insurers and pharmaceutical companies about the estimated ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... , March 29, 2017  NuVasive, Inc. (NASDAQ: ... transforming spine surgery with minimally disruptive, procedurally-integrated solutions, ... 510(k) clearance of the CoRoent® Small Interbody™ System ... levels in the cervical spine. This marks the ... be used at up to four contiguous levels. ...
(Date:3/29/2017)... 29, 2017   Dynatronics Corporation (NASDAQ: ... of Cynthia L. McHenry (Cyndi) as ... for leading Dynatronics manufacturing, distribution, and purchasing operations ... Dynatronics, CEO Kelvyn H. Cullimore, Jr. ... search process conducted by the company as it ...
(Date:3/29/2017)... 2017 NetworkNewsWire Editorial Coverage  ... There are a ... regulating marijuana, but economic arguments also favor its legalization. The ... enforcement costs. However, to legalize and regulate marijuana requires an ... (OTC: SING) ( SING Profile ), American Cannabis Company (OTC: ...
Breaking Medicine Technology: