Navigation Links
EGFR protects cancer cells from starvation via a kinase-independent mechanism
Date:5/5/2008

Scientists have uncovered a previously unrealized mechanism by which the epidermal growth factor receptor (EGFR), a tyrosine kinase, promotes survival of cancer cells through a kinase-independent mechanism. The research, published by Cell Press in the May issue of the journal Cancer Cell, provides a rationale for the less than impressive results of recent clinical trials aimed solely at interfering with kinase activity and suggests new directions for potential therapeutic strategies.

The EGFR is closely associated with cell proliferation and survival and excessive expression, and activation of the EGFR is often observed in cancers of epithelial origin. Until now, it was believed that most of EGFRs functions were mediated by its kinase activity, and several compounds that specifically inhibit the kinase activity of the EGFR were developed with the aim of treating these cancers. However, the clinical experience so far has been that blockade of the EGFR tyrosine kinase activity alone does not elicit significant clinical outcomes in most patients.

The expression level of EGFR in cancer tissues is correlated with prognosis, but not with responsiveness to EGFR tyrosine kinase inhibitor treatment, suggesting that, independent of its kinase activity, EGFR may contribute to the progression of cancer, explains study author Dr. Isaiah J. Fidler from the Department of Cancer Biology at The University of Texas M.D. Anderson Cancer Center. Dr. Fidler and colleagues designed a series of studies to investigate the kinase-independent prosurvival function of the EGFR in cancer cells.

The researchers found that the EGFR enables human cancer cells to maintain adequate intracellular glucose levels by stabilizing the sodium/glucose transporter 1 (SGLT1) via a kinase-independent mechanism. Glucose is a major energy substrate for all cells, and without appropriate amounts, cells essentially starve to death through a process called autophagic cell death. Cancer cells are very active metabolically and consume more glucose than normal tissues; moreover, the EGFR overexpression and the associated enhanced stability of SGLT1 allow tumor cells to survive under conditions that would be less than optimal, even for normal cells.

Our results suggest that EGFR, independent of its kinase activity, maintains the basal intracellular glucose level and thereby prevents cancer cells from succumbing to autophagic death. It is possible that this function of the EGFR may even increase the survival capacity of cancer cells in the presence of chemotherapeutic agents, offers study author Dr. Mien-Chie Hung. The researchers suggest that inhibition of both EGFR-mediated SGLT1 stabilization and EGFR kinase activity may be necessary for eradication of epithelial tumors.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. What gives us sunburn protects crayfish against bacteria
2. Broccoli sprout-derived extract protects against ultraviolet radiation
3. Early HRT Protects a Womans Heart
4. Regular Walking Protects the Aging Brain
5. Ovary Removal Protects Some High-Risk Women
6. Cell recycling protects tumor cells from anti-cancer therapy
7. Fasting Before Chemo Protects Healthy Cells
8. Injectable Antibiotic Protects Against Lyme Disease in Mice
9. New Drug Protects Against Radiation Damage
10. Gene Variant Protects Black Heart Failure Patients
11. Treating Stomach Infection Early Protects Against Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history ... The Brink” is the creation of published author, William Nowers. Captain Nowers and ... WWII veteran, he spent thirty years in the Navy. Following his career as ...
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... The American ... Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium ... 8. , In honor of Morris F. Collen, a pioneer in the field of ...
(Date:10/12/2017)... ANGELES (PRWEB) , ... October 12, 2017 , ... ... Parsa Mohebi Hair Restoration, has recently contributed a medical article to the newly ... on cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, the ... by Walgreens and pharmacy benefit manager Prime Therapeutics LLC ... brand, which included the unveiling of new signage at ... as well as at a few other company-owned facilities ... brand to patients, some of whom will begin to ...
(Date:9/27/2017)... 2017  Commended for their devotion to personalized service, SMP ... number one in the South Florida Business Journal,s 50 Fastest-Growing ... yearly list, the national specialty pharmacy has found its niche.  ... will soon be honored by SFBJ as the 2017 Power ... Set to receive his award in October, Bardisa said of ...
Breaking Medicine Technology: