Navigation Links
Drug combination shrinks breast cancer metastases in brain
Date:12/17/2007

SAN ANTONIO, Texas--A combination of a "targeted" therapy and chemotherapy shrank metastatic brain tumors by at least 50 percent in one-fifth of patients with aggressive HER2-positive breast cancer, according to data presented by Dana-Farber Cancer Institute investigators at the San Antonio Breast Cancer Symposium.

Lapatinib (Tykerb) and capecitabine (Xeloda) were paired in an extension of a Phase 2 clinical trial in which lapatinib given alone shrank brain metastases significantly in six percent of 241 patients.

In the extension trial, capecitabine was added to lapatinib in 49 patients whose metastases -- cancerous colonies in the brain spread from their primary cancer -- had progressed while on treatment. With the combination therapy, brain metastases shrank by 20 percent or more in 18 patients (37 percent) and shrank by at least 50 percent in 10 patients (20 percent), reported Nancy Lin, MD, of Dana-Farber's Breast Oncology Center.

"Very few medications have shown activity in the treatment of brain metastases, particularly in HER-2-positive metastatic breast cancer patients," said Lin, who led the study with Eric Winer, MD, director of the Dana-Farber Breast Oncology Center. "Therefore, these data are quite encouraging, and further studies are warranted."

The data (abstract 6076) will be presented on Sunday, Dec. 16 at 7 a.m. CT.

Lapatinib is an oral small-molecule drug from GlaxoSmithKline that is approved along with capecitabine for treating patients with advanced or metastatic breast cancer whose tumors are driven by the abnormal growth signal, HER-2, and who have already undergone therapy including trastuzumab (Herceptin), a taxane drug, and an anthracycline compound. Lapatinib, like trastuzumab, blocks the HER-2 signal.

Up to one-third of women with advanced, HER-2-positive breast cancer may develop metastases to the brain.

"Although radiation treatment is often effective, as women live long
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Promising drug combination may help those with ocular melanoma that has spread
2. Combination therapy reverses effects of portal hypertension in rats
3. Combination vaccines okay for infants, study shows
4. Antidepressants and painkillers - a dangerous combination
5. Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
6. U.S. Oncology Initiates Complete Phase Ib Trial of Brostallicin Combination Therapy in Advanced Solid Tumors
7. Drug combination might offer hope for patients deadly brain tumors
8. EpiCept to Present Preclinical Studies of EPC2407 in Combination With Anti-Angiogenic and Chemotherpeutic Agents at the AACR-NCI-EORTC International Conference
9. Combination targets: some drugs may work best when they work together
10. MAP Pharmaceuticals Initiates Phase 2a Clinical Trial of Combination Therapy in Adult Patients with Asthma
11. Quality Control: Nissan Quest to Feature micronAir(R) Combination Cabin Air Filters
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... One of ... interviews to discuss his new book, The Pain Antidote , which provides strategies ... of Las Vegas Recovery Center’s Chronic Pain Treatment Program, wrote the book in conjunction ...
(Date:8/4/2015)... ... 04, 2015 , ... 24/7 Care At Home , a provider of ... today announced that the U.S. Department of Veteran’s Affairs (VA) has awarded its agency ... is well on the path to meeting the aspirational goals the VA promotes each ...
(Date:8/4/2015)... ... 04, 2015 , ... Increasingly, patients are researching online to ... In an effort to share more and better information with these savvy and ... share patient satisfaction ratings and comments about its doctors and advanced practice providers. ...
(Date:8/4/2015)... ... August 04, 2015 , ... SanusEO, the healthcare industry ... its executive leadership team as Senior Vice President of Sales and Marketing. Mr. ... expanding global markets with a special emphasis on the healthcare industry. , Today, ...
(Date:8/4/2015)... NJ (PRWEB) , ... August 04, 2015 , ... Montclair ... Arts and Health, the first of its kind in New Jersey, which starting this ... of the Arts and Graduate School partnered with Atlantic Health System, one of the ...
Breaking Medicine News(10 mins):Health News:Medical Expert's New Book Offers Help for Chronic Pain Sufferers 2Health News:Medical Expert's New Book Offers Help for Chronic Pain Sufferers 3Health News:24/7 Care At Home Receives Two Stars from the VA 2Health News:24/7 Care At Home Receives Two Stars from the VA 3Health News:UPMC 1st in Pa. to Share Provider Ratings 2Health News:UPMC 1st in Pa. to Share Provider Ratings 3Health News:SanusEO Hires Healthcare Technology Executive Bruce McCalley As Senior Vice President of Sales & Marketing 2Health News:SanusEO Hires Healthcare Technology Executive Bruce McCalley As Senior Vice President of Sales & Marketing 3Health News:Atlantic Health System & Montclair State University Launch Graduate Program in Arts & Health 2Health News:Atlantic Health System & Montclair State University Launch Graduate Program in Arts & Health 3
... all Sites from a Single ... ... chosen multiple products from Sage Software - including the,Intergy by Sage Practice ... the,patient experience. Previously, Digestive Specialists used The Medical,Manager by Sage., "We ...
... Biosciences, Inc.,(Nasdaq: RDEA ), a company focused ... for the treatment of HIV, cancer and,inflammatory diseases, ... key milestones in 2008 for its clinical,development programs, ... provided financial guidance for 2008., "During 2007, ...
... from Stanford University, ... Diego State University, CENTER VALLEY, Pa., March ... opto-digital solutions in healthcare,life science and consumer electronics ... Innovation Award Program: Tom Byers, Ph.D. and Tina,Seelig, ...
... CHICAGO, March 24 Linden LLC, a health care ... of a controlling,interest in its portfolio company, Ranir LLC, ... P. Kiphart. In addition to being a private,investor, Mr. ... Company.,Linden acquired Ranir in April 2005 and will maintain ...
... HealthMEDX, Inc. (HMX),the leading provider of Web-based ... has partnered with Silverchair Learning Systems to,offer ... Silverchair,s Learning Management System is a ... that delivers, tracks,and reports on educational programs ...
... finds they,re not getting needed screenings for breast and cervical ... review of 32 studies suggests that obese women -- particularly ... screenings for breast and cervical cancer. , No one ... avoid mammograms or Pap smears. And it,s not known why ...
Cached Medicine News:Health News:Multi-site Gastro Practice Chooses Intergy by Sage Practice Management System 2Health News:Ardea Biosciences Reports Progress of Clinical Development Programs; Provides 2008 Outlook; Announces 2007 Financial Results and Provides 2008 Financial Guidance 2Health News:Ardea Biosciences Reports Progress of Clinical Development Programs; Provides 2008 Outlook; Announces 2007 Financial Results and Provides 2008 Financial Guidance 3Health News:Ardea Biosciences Reports Progress of Clinical Development Programs; Provides 2008 Outlook; Announces 2007 Financial Results and Provides 2008 Financial Guidance 4Health News:Ardea Biosciences Reports Progress of Clinical Development Programs; Provides 2008 Outlook; Announces 2007 Financial Results and Provides 2008 Financial Guidance 5Health News:Ardea Biosciences Reports Progress of Clinical Development Programs; Provides 2008 Outlook; Announces 2007 Financial Results and Provides 2008 Financial Guidance 6Health News:Olympus Announces 2008 Winners of Olympus Innovation Awards 2Health News:Olympus Announces 2008 Winners of Olympus Innovation Awards 3Health News:Olympus Announces 2008 Winners of Olympus Innovation Awards 4Health News:Linden Announces Sale of Ranir to Kayak Holdings 2Health News:Linden Announces Sale of Ranir to Kayak Holdings 3Health News:HealthMEDX Partners With Silverchair Learning Systems 2Health News:Obese Women Less Likely to Be Tested for Some Cancers 2
(Date:8/4/2015)... -- Research and Markets ( ... PharmaBiotech,s new report "Animal Biotechnology - Technologies, ... This report describes and evaluates animal biotechnology ... as well as improvement in food production. Knowledge ... of biotechnology to manage genetic disorders and improve ...
(Date:8/4/2015)... Pa. , Aug. 4, 2015 Among ... prescription medications, yet only half of consumers surveyed are ... percent have ever used use them, according to findings ... , a community service partnership focused on improving the ... The online survey polled 1,000 men and women, ...
(Date:8/3/2015)... 4, 2015   The Intellectual Property and ... leading provider of intelligent information for businesses and ... CMR Pharmaceutical R&D Factbook , the biopharmaceutical industry,s ... around declines in R&D, the analysis identifies a ... milestone and forecasts sales to reach $1.3 trillion ...
Breaking Medicine Technology:Animal Biotechnology 2014-2024 - 2015 Technologies, Markets and Companies Analysis 2Animal Biotechnology 2014-2024 - 2015 Technologies, Markets and Companies Analysis 3New Study Finds Consumers are Leaving Money at the Pharmacy 2New Study Finds Consumers are Leaving Money at the Pharmacy 3Pharma Sales to Grow Beyond $1 Trillion 2
... FRANCISCO, Jan. 25, 2012 Medizone International, Inc. (MZEI:OB) ... veterinarian supply company , jointly announce the signing ... new division of Canmedical will become an AsepticSure ... have formed a joint venture to establish, fund and ...
... FARMINGDALE, N.Y., Jan. 25, 2012  Misonix, Inc. (NasdaqGM: ... and markets innovative therapeutic ultrasonic products worldwide for ... surgery and other surgical applications, announced today the ... national investor relations program. Michael ...
Cached Medicine Technology:Canmedical Secures AsepticSure Distribution Rights For Canadian Veterinary Market 2Canmedical Secures AsepticSure Distribution Rights For Canadian Veterinary Market 3Misonix, Inc. Retains Lytham Partners for Investor Relations 2Misonix, Inc. Retains Lytham Partners for Investor Relations 3
... individually adjusted for perfect focus where it's ... paper. This, along with Keeler's wide angle ... whatever the patient's pupil size, you will ... view. Lithium-ion technology provides a longer life ...
... individually adjusted for perfect focus where it's ... paper. This, along with Keeler's wide angle ... whatever the patient's pupil size, you will ... view. Lithium-ion technology provides a longer life ...
A full function instrument at an economical price....
... superior aspherical optics. Includes XHL halogen bulb. ... by means of the aspherical optical system ... Beta 200 allows you to view the ... retina even with a small pupil. Conventional ...
Medicine Products: