Navigation Links
Distinct niches in bone marrow nurture blood stem cells
Date:2/24/2013

In research that could one day improve the success of stem cell transplants and chemotherapy, scientists have found that distinct niches exist in bone marrow to nurture different types of blood stem cells.

Stem cells in the blood are the precursors to infection-fighting white blood cells and oxygen-carrying red blood cells.

The research, by a team at Washington University School of Medicine in St. Louis, is reported Feb. 24 in the advance online edition of Nature.

The new findings, in mice, suggest that it may be possible to therapeutically target support cells in a particular niche. On the one hand, a drug that nourishes support cells could encourage blood stem cells to establish themselves in the bone marrow, enabling patients who have had stem cell transplants to more quickly rebuild their immune systems.

On the other, tumor cells are known to hide in the bone marrow, and a drug that disrupts the niche environment may drive cancer cells into the bloodstream, where they are more vulnerable to the damaging effects of chemotherapy.

"Our results offer hope for targeting these niches to treat specific cancers or to improve the success of stem cell transplants," says senior author Daniel Link, MD, the Alan A. and Edith L. Wolff Professor of Medicine. "Already, we and others are leading clinical trials to evaluate whether it is possible to disrupt these niches in patients with leukemia or multiple myeloma."

Working in the mice, the researchers selectively deleted a critical gene, CXCL12, which is known to be important for keeping blood stem cells healthy. Rather than knock out the gene in all of the support cells in a niche, the researchers deleted the gene in specific types of support cells. This led to the discovery that each niche holds only certain blood stem cells that are nourished by a unique set of support cells.

"What we found was rather surprising," Link says. "There's not just one
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists discover distinct molecular subtype of prostate cancer
2. Boston Medical Center awarded elite distinction as a 2012 Leapfrog Top Hospital
3. Fertilizing bone marrow helps answer why some cancers spread to bones
4. Markey receives $6.25 million to study deadly blood and bone marrow disease
5. HIV Drug May Prevent Bone Marrow Transplant Complication
6. HIV drug reduces graft-vs.-host disease in bone marrow transplant patients, Penn study shows
7. Clinical trial seeks to cure advanced Crohns disease using bone marrow transplant
8. Bone marrow transplant eliminates signs of HIV infection
9. HIV Undetectable in 2 Men After Bone Marrow Transplants: Study
10. New genetic clues to why most bone marrow transplant patients develop graft-versus-host disease
11. Lack of sleep affects bone health and bone marrow activity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Distinct niches in bone marrow nurture blood stem cells
(Date:7/25/2014)... As reported by Wood TV 8 in the ... has seen a nearly 500-person increase in heroin related overdose ... 271 between 1999 and 2002, the toll increased to 728 ... other states, drug users in Michigan have turned to heroin ... compared the price of both substances, noting that an 80-milligram ...
(Date:7/25/2014)... 25, 2014 (HealthDay News) -- The human brain can ... dehydration, a new study finds. Although dehydration ... England have found that the brain compensates by increasing ... "This research has helped us understand a lot ... exercise in extreme conditions," study first author Steven Trangmar, ...
(Date:7/25/2014)... 25, 2014 Ticket Down is ... Milan tickets in Berkeley at California Memorial Stadium. With ... fans of football, the organizers of the 2014 Guinness International ... teams to North America. With teams representing La Liga, English ... bring some of the best football players from around the ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 This ... current state of the Galactooligosaccharides (GOS) industry ... basic overview of the industry, including definitions, applications ... Chinese domestic market analysis are provided with a ... of the market. A comparison between the international ...
(Date:7/25/2014)... Babies seem to learn even before they,re born, a ... 34 weeks pregnant, their unborn babies can respond to ... nursery rhyme, the researchers report. "The mother,s voice ... developing fetus," Charlene Krueger, nursing researcher and associate professor ... in a university news release. "This research highlights just ...
Breaking Medicine News(10 mins):Health News:Rise in Heroin Use, Overdose Deaths in Michigan 2Health News:Human Brain Has Coping Mechanism for Dehydration 2Health News:Real Madrid vs. Inter Milan Tickets Berkeley: Ticket Down Slashes Ticket Prices on Guinness International Champions Cup Tickets at California Memorial Stadium 2Health News:Real Madrid vs. Inter Milan Tickets Berkeley: Ticket Down Slashes Ticket Prices on Guinness International Champions Cup Tickets at California Memorial Stadium 3Health News:GOS Market (Galacto-oligosaccharides) Development in Global & China Regions Now Available at DeepResearchReports.com 2Health News:GOS Market (Galacto-oligosaccharides) Development in Global & China Regions Now Available at DeepResearchReports.com 3Health News:Rhymes Reveal Evidence of Learning in the Womb 2
... Quigley,Corporation (Nasdaq: QGLY ) today reported net sales ... ended March 31, 2008,compared to $6.1 million reported for ... of 2008 reflects a net sales decrease for the,Company,s ... first quarter,of 2007. The change during 2008 as compared ...
... Company to Host Conference Call at 4:30 p.m. EDT Today ... PCYC ) today reported financial results for its third fiscal,quarter ... quarter of fiscal,2008 was $7.0 million, or $0.27 per share, ... share, in the third quarter of fiscal 2007., Total ...
... Actavis Group, the,international generic pharmaceuticals company, today ... study on the Company and its President,and CEO. ... was presented in an MBA class in international ... made available to business,schools around the world., ...
... Act on Capitol Hill, WASHINGTON, April 24 ... and questions for the patient, their families and,caregivers. ... cancer care by affording the patient the opportunity ... thought the cancer diagnosis, treatment,and follow up care., ...
... April 24 The Asthma and Allergy,Foundation of America ... today -- the most challenging places to live for ... year for many allergy,sufferers from Lexington, KY (ranked #1), ... Allergy Capitals based on the impact that key,environmental and ...
... Association urges Senators Boxer and Feinstein to quickly pass,companion ... April 23 AARP thanked,the supporters and cosponsors of ... passed today in the U.S. House of Representatives. The ... by stopping,harmful cuts proposed by the administration., "Today,s ...
Cached Medicine News:Health News:The Quigley Corporation Reports First Quarter 2008 Results - Increases Investment in Pharmaceutical R&D Future 2Health News:The Quigley Corporation Reports First Quarter 2008 Results - Increases Investment in Pharmaceutical R&D Future 3Health News:The Quigley Corporation Reports First Quarter 2008 Results - Increases Investment in Pharmaceutical R&D Future 4Health News:The Quigley Corporation Reports First Quarter 2008 Results - Increases Investment in Pharmaceutical R&D Future 5Health News:Pharmacyclics Reports Third Quarter 2008 Financial Results 2Health News:Pharmacyclics Reports Third Quarter 2008 Financial Results 3Health News:Pharmacyclics Reports Third Quarter 2008 Financial Results 4Health News:Pharmacyclics Reports Third Quarter 2008 Financial Results 5Health News:Pharmacyclics Reports Third Quarter 2008 Financial Results 6Health News:Harvard Business School Publishes a Case Study on Robert Wessman and Actavis 2Health News:Harvard Business School Publishes a Case Study on Robert Wessman and Actavis 3Health News:Support for Patient Navigation Services to Help Cancer Patients 2Health News:2008 Spring Allergy Capitals Announced 2Health News:AARP Thanks California's Representatives for Supporting Bill to Protect People in Medicaid 2
(Date:7/25/2014)... , July 25, 2014  Depomed, Inc. (NASDAQ: ... second quarter fiscal year 2014 financial results after the ... host a conference call beginning at 4:30 pm EDT, 1:30 ... access the call by dialing 877-317-6789 ( United ... will also be available via a live webcast on ...
(Date:7/25/2014)... LAS VEGAS , July 25, 2014 GrowBLOX ... of a binding Memorandum of Understanding ("MOU") with LaurelCo, LLC, ... to pursue the acquisition of both cultivation and dispensary medical ... . Pursuant to the MOU, GBLX will acquire a 20% ... use our proprietary GrowBLOX TM growing chambers, as well ...
(Date:7/25/2014)... ALBANY, New York , July 25, 2014 /PRNewswire/ ... published by Transparency Market Research "Global and China Insulin ... Insulin) - Industry Analysis, Size, Share, Growth, Trends and ... insulin market was valued at USD 19.99 billion in ... of 6.1% from 2013 to 2019 to reach USD ...
Breaking Medicine Technology:Depomed To Report Second Quarter Fiscal Year 2014 Financial Results On Wednesday, August 6, 2014 2GrowBLOX Sciences, Inc. Partners with LaurelCo, LLC to Obtain Licenses to Cultivate and Dispense Medical Marijuana in Illinois 2GrowBLOX Sciences, Inc. Partners with LaurelCo, LLC to Obtain Licenses to Cultivate and Dispense Medical Marijuana in Illinois 3Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 2Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 3Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 4
... CVS Caremark Corporation (NYSE: CVS ) today announced that Tom Ryan , Chairman, President and CEO, ... to investors at the Barclays Capital 2010 Global Healthcare Conference on March 23, 2010 . The Company is ... ... , ...
... BioSpecifics Technologies Corp. (Nasdaq: BSTC ), a biopharmaceutical company developing first in class collagenase-based products, today announced its financial results for the fourth quarter and full year ended ... ... ... ...
Cached Medicine Technology:CVS Caremark to Present at the Barclays Capital 2010 Global Healthcare Conference 2CVS Caremark to Present at the Barclays Capital 2010 Global Healthcare Conference 3BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2009 Financial Results 2BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2009 Financial Results 3BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2009 Financial Results 4BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2009 Financial Results 5BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2009 Financial Results 6BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2009 Financial Results 7BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2009 Financial Results 8BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2009 Financial Results 9BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2009 Financial Results 10BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2009 Financial Results 11BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2009 Financial Results 12BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2009 Financial Results 13
Stainless steel dull finish....
9 mm diameter pigtail curved blunt probes. Stainless steel. Round knurled handle with polished finish. Includes pre-cut polyethylene tubes. Overall length: 5.9 inches....
12 mm diameter pigtail curved probes with eyes 4mm back of blunt ends. Stainless steel. Round knurled handle with polished finish. Overall length: 5.9 inches....
The Novus 2000 argon laser combines power, size, and versatility. Ideal for the office, clinic and operating room environments, Novus 2000 is the world's most widely accepted ophthalmic laser....
Medicine Products: