Navigation Links
Distinct niches in bone marrow nurture blood stem cells
Date:2/24/2013

In research that could one day improve the success of stem cell transplants and chemotherapy, scientists have found that distinct niches exist in bone marrow to nurture different types of blood stem cells.

Stem cells in the blood are the precursors to infection-fighting white blood cells and oxygen-carrying red blood cells.

The research, by a team at Washington University School of Medicine in St. Louis, is reported Feb. 24 in the advance online edition of Nature.

The new findings, in mice, suggest that it may be possible to therapeutically target support cells in a particular niche. On the one hand, a drug that nourishes support cells could encourage blood stem cells to establish themselves in the bone marrow, enabling patients who have had stem cell transplants to more quickly rebuild their immune systems.

On the other, tumor cells are known to hide in the bone marrow, and a drug that disrupts the niche environment may drive cancer cells into the bloodstream, where they are more vulnerable to the damaging effects of chemotherapy.

"Our results offer hope for targeting these niches to treat specific cancers or to improve the success of stem cell transplants," says senior author Daniel Link, MD, the Alan A. and Edith L. Wolff Professor of Medicine. "Already, we and others are leading clinical trials to evaluate whether it is possible to disrupt these niches in patients with leukemia or multiple myeloma."

Working in the mice, the researchers selectively deleted a critical gene, CXCL12, which is known to be important for keeping blood stem cells healthy. Rather than knock out the gene in all of the support cells in a niche, the researchers deleted the gene in specific types of support cells. This led to the discovery that each niche holds only certain blood stem cells that are nourished by a unique set of support cells.

"What we found was rather surprising," Link says. "There's not just one
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists discover distinct molecular subtype of prostate cancer
2. Boston Medical Center awarded elite distinction as a 2012 Leapfrog Top Hospital
3. Fertilizing bone marrow helps answer why some cancers spread to bones
4. Markey receives $6.25 million to study deadly blood and bone marrow disease
5. HIV Drug May Prevent Bone Marrow Transplant Complication
6. HIV drug reduces graft-vs.-host disease in bone marrow transplant patients, Penn study shows
7. Clinical trial seeks to cure advanced Crohns disease using bone marrow transplant
8. Bone marrow transplant eliminates signs of HIV infection
9. HIV Undetectable in 2 Men After Bone Marrow Transplants: Study
10. New genetic clues to why most bone marrow transplant patients develop graft-versus-host disease
11. Lack of sleep affects bone health and bone marrow activity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Distinct niches in bone marrow nurture blood stem cells
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... first time, researchers at the University of California, San Diego ... processes that power the celebrated health benefits of omega-3 fatty ... be possible to manipulate these processes to short-circuit inflammation before ... it becomes detrimental. The work is published in the ...
... in June,s Journal of Thoracic Oncology says molecular ... be an additional predictive technique for lung cancer screening. ... percent of the positive CT screening results were false positive, ... patients. This research focused on a way to determine if ...
... By Alan Mozes HealthDay Reporter , TUESDAY, May ... a silver bullet when it comes to symptom relief for ... analysis of six prior studies found that the sprays confer ... taken for three weeks at relatively high doses. The ...
... resident Maureen T. Kavanah, MD, an Associate Professor ... (BUSM) and a surgical oncologist at Boston Medical ... Surgical Adjuvant Breast and Bowel Project (NSABP) Distinguished ... and meritorious service to the NSABP in support ...
... for Idiopathic Toe Walking Based on Child,s Age and Severity ... walking pattern, or gait, by age 2. And while some ... the foot or toes, never touching the heel to the ... a neurological disorder. A review article, "Idiopathic Toe Walking," ...
... journal of the American Gastroenterological Association (AGA) Institute, are ... anticipated special 13th issue. Published each May, the 13th ... broad interest; this year,s topic is viral hepatitis. ... PhD, this issue was developed by Gastroenterology,s experts in ...
Cached Medicine News:Health News:Why omega-3 oils help at the cellular level 2Health News:Steroid Nasal Sprays Show Small Benefit for Sinusitis: Study 2Health News:Steroid Nasal Sprays Show Small Benefit for Sinusitis: Study 3Health News:Boston researcher, surgical oncologist receives national award 2Health News:Clinical news alert: Journal of the American Academy of Orthopaedic Surgeons May highlights 2Health News:Gastroenterology special issue focuses on new directions of viral hepatitis care and research 2Health News:Gastroenterology special issue focuses on new directions of viral hepatitis care and research 3
(Date:1/15/2014)... NEW YORK , Jan. 15, 2014 ... market research report is available in its ... and Technologies for Advanced Drug Delivery Systems ... http://www.reportlinker.com/p01940411/Global-Markets-and-Technologies-for-Advanced-Drug-Delivery-Systems----Focus-on-End-Users.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Delivery_Technology STUDY OBJECTIVES ... one of the very important aspects in ...
(Date:1/14/2014)... AUSTIN, Texas , Jan. 14, 2014  Luminex ... it expects to report results for the fourth quarter ... release announcing the results is scheduled for release after ... http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ) Management will hold a conference ... for the fourth quarter and twelve months ended December ...
(Date:1/14/2014)... Jan. 14, 2014 Animal Emergency Critical Care, a LifeCentre ... Leesburg, Virginia is the first in Loudoun ... Dr. Susan M. Barnes , Medical Director, ... and husband, Dr. Cole Taylor , are avid scuba divers. ... for oxygen when air is thin," states Dr Barnes. She goes ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2
... , , JERUSALEM, Israel, January 11 ... systems, today announced that it has filed two registration,statements on ... One registration statement relates to a proposed ... and warrants to purchase 12,million shares of common stock, as ...
... , SAN JOSE, Calif., Jan. 11 Finesse Solutions, ... life sciences process applications, announced the production release of ... oxygen or pH and process temperature, and TruTorr headspace ... accuracy, lifetime, and ease of use. It is available ...
Cached Medicine Technology:Oramed Pharmaceuticals Announces Filing of Two Registration Statements 2Oramed Pharmaceuticals Announces Filing of Two Registration Statements 3Single-Use Sensor Product Family Enters High Volume Production 2
... The new Finnpipette Focus ... specifically to combine ergonomics with ... interchangeable handle plate offers a ... sizes. The new shorter tip ...
500L...
... The new Finnpipette Focus from ... to combine ergonomics with uncompromising ... handle plate offers a custom ... The new shorter tip cones ...
Inquire...
Medicine Products: