Navigation Links
Diabetes Insight Could Lead to Better Treatments
Date:12/21/2009

as a response to high blood sugar. These islet cells are also responsible for secretion of insulin.

To determine if islet production of IL-1b was caused by the interaction of NLRP3 and TXNIP, the researchers exposed islet cells from normal mice and from mice deficient in NLRP3 or TXNIP to high glucose levels. As predicted, the protein-deficient islets made less IL-1b.

What's more, these deficient mice cleared glucose from the bloodstream quicker in response to insulin.

"Our findings predict that type 2 diabetes can be treated by inhibitors of the inflammasome or IL-1b," Tschopp said.

The good news is that these effects of NLRP3 are confined to the insulin-producing beta cells of the pancreas, so compounds to inhibit the pathway should not have systemic effects.

Studies in humans are already under way. According to Tschopp, "clinical studies with type 2 diabetes patients have already been initiated and the first results are again incredibly encouraging. With a single injection of IL-1b inhibitors, glucose levels in diabetes patients are highly reduced during six months. This treatment could replace the standard treatment currently used."'

More information

There's more on type 1 and type 2 diabetes at the American Diabetes Association.



SOURCES: Jurg Tschopp, Ph.D., professor, University of Lausanne, Epalinges, Switzerland; Norma Kenyon, M.D., Martin Kleiman professor of surgery, medicine, microbiology and immunology and biomedical engineering, Diabetes Research Institute, University of Miami Miller School of Medicine; Dec. 21, 2009, online Nature Immunology


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Orameds Dr Roy Eldor was Chosen to Lecture at the First International Conference Held by the Bildirici Center for Diabetes Care Research in Israel.
2. UCSF/SFGH project for diabetes patients wins award for innovation, quality
3. SFGH Project for Diabetes Patients Wins Award for Innovation, Quality
4. Sermo Vitals Report(TM) Quantifies One Year of Physician Conversation About Diabetes
5. TrekDesk: A Potentially Positive Impact on Diabetes & Obesity
6. Coffee, Tea Might Stave Off Diabetes
7. UNC scientists coordinate study of link between insulin use and cancer in people with diabetes
8. Study finds over 90 percent of people with gum disease are at risk for diabetes
9. Study shows how gene action may lead to diabetes prevention, cure
10. Bears Quarterback Jay Cutler and Eli Lilly and Company Will Send 44 Kids to American Diabetes Association Camps Through the Touchdowns for Diabetes Campaign
11. Chinese-American and Korean-American women at highest risk for diabetes in pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/14/2014)... Top10BestSEOHosting.com always offers truly reliable information for ... carefully, the site has announced that Arvixe ( ... WordPress Hosting suppliers in the current market. , ... hosting provider, and the company’s reputation for reliability ... known for its flexible hosting packages, decent uptime ...
(Date:9/14/2014)... September 14, 2014 Final Cut Pro ... the production of the Flip Flop Theme template for ... Flop is a simple-to-use and simplistic template that allows ... ease in Final Cut Pro X," said Christina Austin, ... and On-Screen controls, the user has controls of the ...
(Date:9/13/2014)... Recently, an experienced supplier of wedding ... its new collection of eggplant evening dresses . ... discounted rates, up to 58% off. According to the ... September 23. , The company’s new items are ... vintage, plus size, modest, sexy outfits and so on. ...
(Date:9/13/2014)... Ticket Down is a dependable ... beloved pop-rock group that originally formed in 1994 in Los ... of the group had been anticipating a new album since ... excited yet about the release of their new album, they ... a massive worldwide tour beginning in the United States in ...
(Date:9/13/2014)... (PRWEB) September 13, 2014 MillionaireSinglesDating.com ... by Successful Match, the leading niche dating services ... site PositiveSingles.com, the leading sugar daddy site ... site , InterracialMatch.com. The site has recently reached ... millionaire singles and admirers. The members include CEOs, ...
Breaking Medicine News(10 mins):Health News:Top10BestSEOHosting.com: The Best Linux Web Hosting Suppliers Now Unveiled 2Health News:Pixel Film Studios Releases Flip Flop Theme for Final Cut Pro X Users 2Health News:Cheap Eggplant Evening Dresses Now Announced By Experienced Company iFitDress.com 2Health News:Maroon 5 Tickets Now on Sale in Philadelphia, Washington DC, Nashville, San Jose, Chicago, Dallas, Los Angeles, Tacoma, Saint Paul, Vancouver, San Diego & New York 2Health News:Maroon 5 Tickets Now on Sale in Philadelphia, Washington DC, Nashville, San Jose, Chicago, Dallas, Los Angeles, Tacoma, Saint Paul, Vancouver, San Diego & New York 3Health News:MillionaireSinglesDating.com Reaches 2 Million Users Milestone 2
... Adults with type 2 diabetes who eat unhealthy, ... this can be offset by taking antioxidant vitamins with ... There is already growing evidence linking diabetes to cognitive ... are especially vulnerable to acute meal-induced memory deficits after ...
... Form 10-Q,s for First Three Quarters of Fiscal 2008 ... for Fiscal 2008 Ended March 31, 2008 Points to ... ... ST. LOUIS, June 25 KV Pharmaceutical Company,(NYSE: KVa/KVb), a ...
... in Oral Biology Award will be presented to Dr. ... Pediatric Dentistry, University of Alabama at Birmingham School of ... for Dental Research (IADR) at its 86th General Session ... Dr. Childers, research has contributed to the understanding of ...
... Canada As part of the Opening Ceremonies of ... Metro Toronto Convention Centre, the International Association for Dental ... follow: , IADR Honorary Membership ... may select an Honorary Member who has made significant ...
... N.C., June 25 New research that explores,the tactics ... management is now available in the Best Practice Database, ... Best,Practices, LLC., To review sample key findings and ... with links to each study at this address:, http://www3.best-in-class.com/dr319.htm ...
... there,s a new infant formula that blocks transmission of ... status during pregnancy will affect her baby,s future dental ... prevents early-childhood tooth decay? ,These are but a few ... be presented when the International,Association for Dental Research (IADR) ...
Cached Medicine News:Health News:Seniors with type 2 diabetes may experience memory declines immediately after eating unhealthy meal 2Health News:Seniors with type 2 diabetes may experience memory declines immediately after eating unhealthy meal 3Health News:KV Pharmaceutical Company Completes Fiscal 2008 Filings With Securities and Exchange Commission 2Health News:KV Pharmaceutical Company Completes Fiscal 2008 Filings With Securities and Exchange Commission 3Health News:KV Pharmaceutical Company Completes Fiscal 2008 Filings With Securities and Exchange Commission 4Health News:International Association for Dental Research presents awards and fellowships 2Health News:International Association for Dental Research presents awards and fellowships 3Health News:International Association for Dental Research presents awards and fellowships 4Health News:International Association for Dental Research presents awards and fellowships 5Health News:Best Practice Database Adds Research on New Product Commercialization 2Health News:International Dental Research Association meets in Toronto 2Health News:International Dental Research Association meets in Toronto 3Health News:International Dental Research Association meets in Toronto 4
(Date:9/12/2014)... LAUSANNE , Switzerland , September ... Genetics, leader européen de la médecine basée sur les ... son premier contrat avec le National Health Service au ... Cela fait suite à une forte hausse de la ... cliniques émanant des laboratoires et hôpitaux en Allemagne, en ...
(Date:9/12/2014)...  WellStar Paulding Hospital is the first hospital in ... in the U.S. to offer a new, innovative procedure ... System, Paulding Hospital is on the cutting edge of ... Inspire Therapy offers relief for moderate to ... to use traditional treatments, like Continuous Positive Airway Pressure ...
(Date:9/12/2014)... , Sept. 12, 2014 ... of the "Global Medical Technologies Market 2014-2018" ... Medical technology is a collective term for software ... to ensure good health. The Global Medical Technologies ... and respiratory technology, In vitro diagnostics technology, dental ...
Breaking Medicine Technology:Sophia Genetics annonce son premier contrat avec le National Health Service britannique et un grand laboratoire turc, élargissant ainsi sa clientèle européenne 2WellStar Pioneers New Sleep Apnea Treatment 2Global Medical Technologies Market 2014-2018: Key Vendors are GE, Johnson & Johnson, Medtronic, Roche and Siemens 2Global Medical Technologies Market 2014-2018: Key Vendors are GE, Johnson & Johnson, Medtronic, Roche and Siemens 3
... Transgenomic, Inc. (OTC/BB: TBIO) today announced the ... Results and Business Update Conference CallWhen: , Thursday, August ... How: , Live over the Internet -- Simply log ... Investor Relations, 402-452-5400To access the call via telephone, call ...
... 11, 2011 /PRNewswire-Asia/ -- ShangPharma Corporation (NYSE: ... pharmaceutical and biotechnology research and development outsourcing company, today ... two multi-staged projects in its biologics division, which portends ... The initial milestones were achieved for two oncology ...
Cached Medicine Technology:Transgenomic to Hold Second Quarter Financial Results Conference Call Today 2ShangPharma's Biologics Division Announces Accelerated Achievement of Milestones for Two Multi-Stage Projects 2
PDA-version of the leading portable drug reference....
PDA formatted guide containing outlines and detailed information on the diagnosis and treatment of HIV infection and AIDS....
PDA application contains 15,000+ ICD-9-CM Diagnosis codes....
Information on diagnosis and management of 500 common or important medical and surgical disorders....
Medicine Products: