Navigation Links
Diabetes Insight Could Lead to Better Treatments
Date:12/21/2009

as a response to high blood sugar. These islet cells are also responsible for secretion of insulin.

To determine if islet production of IL-1b was caused by the interaction of NLRP3 and TXNIP, the researchers exposed islet cells from normal mice and from mice deficient in NLRP3 or TXNIP to high glucose levels. As predicted, the protein-deficient islets made less IL-1b.

What's more, these deficient mice cleared glucose from the bloodstream quicker in response to insulin.

"Our findings predict that type 2 diabetes can be treated by inhibitors of the inflammasome or IL-1b," Tschopp said.

The good news is that these effects of NLRP3 are confined to the insulin-producing beta cells of the pancreas, so compounds to inhibit the pathway should not have systemic effects.

Studies in humans are already under way. According to Tschopp, "clinical studies with type 2 diabetes patients have already been initiated and the first results are again incredibly encouraging. With a single injection of IL-1b inhibitors, glucose levels in diabetes patients are highly reduced during six months. This treatment could replace the standard treatment currently used."'

More information

There's more on type 1 and type 2 diabetes at the American Diabetes Association.



SOURCES: Jurg Tschopp, Ph.D., professor, University of Lausanne, Epalinges, Switzerland; Norma Kenyon, M.D., Martin Kleiman professor of surgery, medicine, microbiology and immunology and biomedical engineering, Diabetes Research Institute, University of Miami Miller School of Medicine; Dec. 21, 2009, online Nature Immunology


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Orameds Dr Roy Eldor was Chosen to Lecture at the First International Conference Held by the Bildirici Center for Diabetes Care Research in Israel.
2. UCSF/SFGH project for diabetes patients wins award for innovation, quality
3. SFGH Project for Diabetes Patients Wins Award for Innovation, Quality
4. Sermo Vitals Report(TM) Quantifies One Year of Physician Conversation About Diabetes
5. TrekDesk: A Potentially Positive Impact on Diabetes & Obesity
6. Coffee, Tea Might Stave Off Diabetes
7. UNC scientists coordinate study of link between insulin use and cancer in people with diabetes
8. Study finds over 90 percent of people with gum disease are at risk for diabetes
9. Study shows how gene action may lead to diabetes prevention, cure
10. Bears Quarterback Jay Cutler and Eli Lilly and Company Will Send 44 Kids to American Diabetes Association Camps Through the Touchdowns for Diabetes Campaign
11. Chinese-American and Korean-American women at highest risk for diabetes in pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... The popular television program VOICES IN AMERICA, ... that it will be devoting an entire short segment to the subject of diabetes. ... the globe on a daily basis, but recent advancements in medical science may prove ...
(Date:8/28/2015)... ... August 28, 2015 , ... Joining ... County Memorial Hospital recently transitioned management companies to partner with Wound Care Advantage ... their outpatient wound center. , Transitioning wound care management providers can be ...
(Date:8/28/2015)... Port Richey, FL (PRWEB) , ... August 28, 2015 , ... ... while many potential workers are qualified for the position they are applying for, they ... Because of this, many employers are considering altering drug testing policies in order to ...
(Date:8/28/2015)... ... August 28, 2015 , ... For Dallas, the time is nearing ... their subsidiary USPI Tenet Health. , The American Heart Association hosts their well-known Heart ... They believe that together, a difference can be made. Walkers can participate in the ...
(Date:8/28/2015)... MA (PRWEB) , ... August 28, 2015 , ... The ... benefitting the renowned Brain Aneurysm Foundation has added yet another accolade to its cadre ... Rahm Emanuel. , “With the help of the medical community and the ...
Breaking Medicine News(10 mins):Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 4Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3
... research shows physical symptoms may predict survival in patients ... such as nausea and shortness of breath, predicted shorter ... of breath increased the risk of death by 50 ... and vomiting at the early stages of their terminal ...
... ulcers is one side effect people with diabetes face. Diabetic ... blood sugar // levels, which cause poor blood circulation. When ... findings researchers say people with diabetic foot ulcers suffer from ... life. ,For the study, 60 diabetic patients were given ...
... shows success reducing pain in patients with multiple sclerosis, ... known as Marinol, has been used to soothe nausea ... Dronabinol on pain in patients with multiple sclerosis. ... participated in the study . They were given up ...
... about 10 percent of cancer deaths each year.Researchers say ... for patients who have colorectal cancer that resists standard ... known as Erbitux, may be a promising new therapy. ... the drug irinotecan (Camptosar) that can be given alone ...
... New research shows while obesity may increase a person’s risk ... have the opposite effect.// ,In a recent study conducted, ... They found those who were obese in middle age were ... patients who had high cholesterol and high blood pressure in ...
... commonest cancer effecting men. Benefits of Lycophene- an anti-oxidant ... grapefruit( most lycopene in processed //tomato products including paste, ... preventing the aging process and improve skin health ... looked at for preventing and treating cancers such as ...
Cached Medicine News:
(Date:8/27/2015)... , Aug. 27, 2015 ieCrowd™ today ... the commercial development of the company,s supplemental oxygen ... Oxygen device, being developed by ieCrowd,s subsidiary Smart ... patient,s changing demand for oxygen based on level ... (k) submission for the Smart Oxygen device would ...
(Date:8/27/2015)... Lilly and Company (NYSE: LLY ) will attend ... 17, 2015. Sue Mahony , Ph.D., senior vice ... Gaynor , M.D., senior vice president of product development ... a fireside chat at 3:30 p.m., Eastern Daylight Time. ... available on the "Webcasts & Presentations" section of Lilly,s ...
(Date:8/27/2015)... , Aug. 27, 2015   Women Grow , the ... industry, is partnering with the Cannabis World Congress & ... to produce 15 business-focused educational sessions. CWCBExpo in LA ... Los Angeles Convention Center in Los ... on the West Coast for the marijuana industry. ...
Breaking Medicine Technology:Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 2Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 3Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 4Lilly to Participate in Morgan Stanley Global Healthcare Conference 2Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 2Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 3Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 4
... April 6, 2012 The 99 Cents Only Stores is ... campaign by promoting to the broader LA community the ... carried regularly in 99 Cents Only Stores. In the ... and the American Red Cross are urging the Los ...
... 6, 2012 Ameritox(SM), the nation,s leader in pain ... Inc. (Operation UNITE), the organizers of the inaugural National ... national forum to address the prescription drug abuse epidemic. ... Florida. "As the nation,s leader in ...
Cached Medicine Technology:99 Cents Only Stores Partners with the Red Cross to Help Local Residents Prepare for the Big One 2Ameritox Commends Operation UNITE on Its Inaugural National Rx Drug Abuse Summit 2Ameritox Commends Operation UNITE on Its Inaugural National Rx Drug Abuse Summit 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: