Navigation Links
Diabetes Insight Could Lead to Better Treatments
Date:12/21/2009

as a response to high blood sugar. These islet cells are also responsible for secretion of insulin.

To determine if islet production of IL-1b was caused by the interaction of NLRP3 and TXNIP, the researchers exposed islet cells from normal mice and from mice deficient in NLRP3 or TXNIP to high glucose levels. As predicted, the protein-deficient islets made less IL-1b.

What's more, these deficient mice cleared glucose from the bloodstream quicker in response to insulin.

"Our findings predict that type 2 diabetes can be treated by inhibitors of the inflammasome or IL-1b," Tschopp said.

The good news is that these effects of NLRP3 are confined to the insulin-producing beta cells of the pancreas, so compounds to inhibit the pathway should not have systemic effects.

Studies in humans are already under way. According to Tschopp, "clinical studies with type 2 diabetes patients have already been initiated and the first results are again incredibly encouraging. With a single injection of IL-1b inhibitors, glucose levels in diabetes patients are highly reduced during six months. This treatment could replace the standard treatment currently used."'

More information

There's more on type 1 and type 2 diabetes at the American Diabetes Association.



SOURCES: Jurg Tschopp, Ph.D., professor, University of Lausanne, Epalinges, Switzerland; Norma Kenyon, M.D., Martin Kleiman professor of surgery, medicine, microbiology and immunology and biomedical engineering, Diabetes Research Institute, University of Miami Miller School of Medicine; Dec. 21, 2009, online Nature Immunology


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Orameds Dr Roy Eldor was Chosen to Lecture at the First International Conference Held by the Bildirici Center for Diabetes Care Research in Israel.
2. UCSF/SFGH project for diabetes patients wins award for innovation, quality
3. SFGH Project for Diabetes Patients Wins Award for Innovation, Quality
4. Sermo Vitals Report(TM) Quantifies One Year of Physician Conversation About Diabetes
5. TrekDesk: A Potentially Positive Impact on Diabetes & Obesity
6. Coffee, Tea Might Stave Off Diabetes
7. UNC scientists coordinate study of link between insulin use and cancer in people with diabetes
8. Study finds over 90 percent of people with gum disease are at risk for diabetes
9. Study shows how gene action may lead to diabetes prevention, cure
10. Bears Quarterback Jay Cutler and Eli Lilly and Company Will Send 44 Kids to American Diabetes Association Camps Through the Touchdowns for Diabetes Campaign
11. Chinese-American and Korean-American women at highest risk for diabetes in pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Two revolutionary procedures now being utilized by ... disease a far less painful and far more effective ... ever felt electric shock waves surge through your teeth as ... it’s possible you already know the impact of receding gums,” ... dentist in West Palm Beach, and a Fellow in the ...
(Date:9/30/2014)... 30, 2014 (HealthDay News) -- Medicare should cover low-dose ... risk for the disease, a coalition of more than ... which includes the Lung Cancer Alliance, the Society of ... Cancer Society and the American Society of Clinical Oncology, ... the U.S. Centers for Medicare & Medicaid Services (CMS). ...
(Date:9/30/2014)... U.S. Department of Defense has made progress in reducing ... such as depression and post-traumatic stress disorder, but more ... Corporation study. , Despite efforts of both the Defense ... health services, many service members still do not seek ... have made a concerted effort to promote treatment as ...
(Date:9/30/2014)... of a gene mutation that causes a rare premature ... that block the rapid, unstoppable cell division that makes ... of Michigan and the U-M Health System recently discovered ... congenita, in which precious hematopoietic stem cells can,t regenerate ... and are prone to cancer and bone marrow failure. ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 FDA-approved ... hydroxylapatite, Poly-L-lactic acid) are used in several procedures ... loss in patients, but are primarily used for ... skin rejuvenation—in particular, these fillers are being used ... as restoring smoother skin in the hands. (1) ...
Breaking Medicine News(10 mins):Health News:Florida Dentist Battles Gum Disease With Latest Techniques 2Health News:Florida Dentist Battles Gum Disease With Latest Techniques 3Health News:Groups Call for Medicare Coverage of Lung Cancer Screening 2Health News:US military making progress reducing stigma tied to seeking help for mental illness 2Health News:US military making progress reducing stigma tied to seeking help for mental illness 3Health News:Disease decoded: Gene mutation may lead to development of new cancer drugs 2Health News:Nonsurgical Cosmetic How-To: Skinspirations Details Proper Use of FDA-Approved Injectable Fillers for Hand Rejuvenation Procedures 2Health News:Nonsurgical Cosmetic How-To: Skinspirations Details Proper Use of FDA-Approved Injectable Fillers for Hand Rejuvenation Procedures 3Health News:Nonsurgical Cosmetic How-To: Skinspirations Details Proper Use of FDA-Approved Injectable Fillers for Hand Rejuvenation Procedures 4
... care received by vulnerable older people concurrently enrolled in ... it would squeak by with a barely passing mark, ... measurements developed by the Assessing Care of Vulnerable Elders ... only 65 percent of the tests and other diagnostic ...
... as well as the drugs cupboard when it comes to ... the October issue of IJCP, the International Journal of Clinical ... doctors whether they should apply honey to their wounds to ... of the oldest foods in existence and was an ancient ...
... prescription of Traditional Chinese Medicine for SAP was widely ... mechanisms of protective effects on SAP have not been ... Baical skullcap root (an essential Traditional Chinese Medicine of ... renal injury of rats with SAP. The research was ...
... Oct. 17 Clarent Hospital ... October 12, 2007, the Company,s ... a cash distribution to stockholders ... distribution is payable on October ...
... The Channel Islands,Alzheimer,s Institute recently received a $120,000 ... in four payments of $30,000,each beginning now through ... located on the campus of,California State University Channel ... at least two student research,scholarships for $6,000 each ...
... Timely Resource Offers Smart Explanations and Insightful Tips for ... Affordable Health Insurance for ... Health Insurance,Finders http://www.healthinsurancefinders.com, a leading source for ... addition to their impressive library of consumer resources: the,Family ...
Cached Medicine News:Health News:Elderly Medicare, Medicaid patients not receiving quality care 2Health News:Patients should ask surgeons about using honey to heal wounds 2Health News:Baicalin might be a promising therapeutic tool for severe acute pancreatitis 2Health News:Channel Islands Alzheimer's Institute Receives $120,000 Donation 2Health News:Health Insurance Finders Debuts A Comprehensive Guide to Family Health Insurance 2
(Date:9/30/2014)... 30, 2014  Georgia-Pacific Professional is a leading ... for a wide range of away from home ... lines in healthcare, including hospitals, long-term care facilities, ... introducing its healthcare products and solutions to the ... importance of infection control in the dental office," ...
(Date:9/30/2014)... , Sept. 30, 2014 Passport Health, one ... , has launched FluFree.com, a website designed to ... For 20 years, Passport Health has provided ... flu. The launch of FluFree.com is designed to address ... the number of people who actually chose to get ...
(Date:9/30/2014)... September 2014 ... Acutus Medical, Inc. ... 3D-Herzkammer-Bildgebungs- und Dipoldichte-Mappingsystem in Echtzeit zur ... komplexen Herzrhythmusstörungen einschließlich Vorhofflimmern führen bzw. ... zusätzlichen Finanzierung über 26,2 Mio. USD ...
Breaking Medicine Technology:Georgia-Pacific Professional Brings Its Success in Medical Solutions to the Dental Community 2Georgia-Pacific Professional Brings Its Success in Medical Solutions to the Dental Community 3Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 2Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 3Acutus Medical, Inc. schließt zusätzliche Finanzierungsrunde Serie B über 26,2 Mio. USD ab, um Portfolio-Erweiterung zu finanzieren 2Acutus Medical, Inc. schließt zusätzliche Finanzierungsrunde Serie B über 26,2 Mio. USD ab, um Portfolio-Erweiterung zu finanzieren 3
Curved left, Hardy Curettes, bayonet, working distance 120 mm, total length 241 mm....
Toothed pituitary rongeur....
Bateman pituitary forceps, round cup, 5 mm bite, fenestrated crocodile jaws, 150 mm effective....
Bayonet Kerrison Rongeur, ceramic ejector, 9.5 length 40 Fwd, 6.5 working length 165 mm....
Medicine Products: