Navigation Links
Diabetes Insight Could Lead to Better Treatments
Date:12/21/2009

Inhibiting a key inflammatory pathway brought powerful results in mice and people, researchers say

MONDAY, Dec. 21 (HealthDay News) -- Scientists have identified a protein that may be involved in the development of type 2 diabetes, a finding that could lead to new drugs to fight this growing worldwide scourge.

This same group of researchers recently showed that inhibiting this pathway worked to block pain associated with gout, an inflammatory condition affecting the joints.

Inflammation also plays a large role in diabetes.

The authors of this study, published online Dec. 21 in Nature Immunology, started their exploration with the NLRP3 inflammasome, which has been linked with different inflammatory diseases.

Inflammasomes are clusters of proteins that stimulate inflammation and play a role in the body's innate immune response, explained Dr. Norma Kenyon, professor at the Diabetes Research Institute of the University of Miami Miller School of Medicine. She is familiar with the new findings.

"The inflammasome sense situations that are dangerous to our body," added study senior author Jurg Tschopp, a professor at the University of Lausanne in Epalinges, Switzerland. "This includes pathogens (bacteria, viruses), but also endogenous 'danger situations,' such as uric acid crystals found in gout, high circulating glucose found in diabetes or beta-amyloid [plaques] found in Alzheimer's disease."

Until now, scientists were unable to figure how out the NLRP3 inflammasome is activated. With that information now in hand, researchers might have another promising route to developing treatments for type 2 diabetes.

The chain of events seems to start with a protein called TXNIP, which, when exposed to oxidative stress, binds to NLRP3 and leads to the production of interleukin-1 beta or IL-1b, an immune system molecule.

IL-1b is also produced by the pancreas' islet cells
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Orameds Dr Roy Eldor was Chosen to Lecture at the First International Conference Held by the Bildirici Center for Diabetes Care Research in Israel.
2. UCSF/SFGH project for diabetes patients wins award for innovation, quality
3. SFGH Project for Diabetes Patients Wins Award for Innovation, Quality
4. Sermo Vitals Report(TM) Quantifies One Year of Physician Conversation About Diabetes
5. TrekDesk: A Potentially Positive Impact on Diabetes & Obesity
6. Coffee, Tea Might Stave Off Diabetes
7. UNC scientists coordinate study of link between insulin use and cancer in people with diabetes
8. Study finds over 90 percent of people with gum disease are at risk for diabetes
9. Study shows how gene action may lead to diabetes prevention, cure
10. Bears Quarterback Jay Cutler and Eli Lilly and Company Will Send 44 Kids to American Diabetes Association Camps Through the Touchdowns for Diabetes Campaign
11. Chinese-American and Korean-American women at highest risk for diabetes in pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... NY (PRWEB) December 21, 2014 The ... 1,400 in a consolidated litigation underway in New Jersey, ... a total of 1,375 claims involving the birth control ... Court. These lawsuits were filed by women who allege ... have led to uterine perforations and other complications they ...
(Date:12/21/2014)... Parker & Sons, Inc. a market ... and other similar home contractor services announces a record ... its expert contracting services. The company is considered by ... serving Arizona for well over 40 years. Parker and ... in quality customer service to the residents and business ...
(Date:12/21/2014)... Theme and plugin developers ... plugin for Final Cut Pro X entitled ProMotion. , ... more with absolute ease.” Said Christiana Austin, CEO of ... needed to easily animate their media inside FCPX.” , ... users to animate pictures, videos, logos, and more with ...
(Date:12/21/2014)... December 21, 2014 The Oncology Institute of ... the Santa Ana and Whittier offices. The Hope for the ... lives of patients and their families during the holiday season. ... to approximately 70 children between both offices. This event continues ... of Target’s community service team, store managers and assistant managers ...
(Date:12/20/2014)... BambooIndustry.com is a leading eco-friendly bamboo flooring ... bamboo flooring promotion for the coming 2015. , ... and offers the best bamboo products and services ... all customers can enjoy a special discount, up ... BambooIndustry.com from press releases. , The bamboo flooring ...
Breaking Medicine News(10 mins):Health News:Mirena Lawsuits Approach 1,400 in Bergen County Litigation, Bernstein Liebhard LLP Reports 2Health News:Mirena Lawsuits Approach 1,400 in Bergen County Litigation, Bernstein Liebhard LLP Reports 3Health News:Parker & Sons Announces Record Number Of Favorable Reviews In 2014 With Regard To Its Expert Contracting Services 2Health News:Parker & Sons Announces Record Number Of Favorable Reviews In 2014 With Regard To Its Expert Contracting Services 3Health News:Announcing a new plugin for Final Cut Pro X ProMotion from Pixel Film Studios. 2Health News:Eco-friendy Bamboo Flooring Manufacturer BambooIndustry.com Introduces Its Bamboo Flooring Promotion for 2015 2
... up running is a good way to boost your fitness level ... to the sport -- or exercise in general -- should have ... "Running is very accepting of beginners. It,s a great way ... for those who have set a New Year,s resolution to get ...
... (HealthDay News) -- New research suggests that in addition to ... damages the part of the brain that affects thinking skills, ... central area that relates to the rest of the brain ... an associate professor at University of Texas Health Science Center ...
... Reporter , FRIDAY, Dec. 30 (HealthDay News) -- Doctors have ... fuel a diabetes epidemic. Study results have now underscored ... time a person carries excess weight directly contributes to an ... because today,s children are expected to receive a larger lifetime ...
... 30 (HealthDay News) --Among 9/11 responders at the World ... stress disorder (PTSD) seems to be strongly correlated, with ... development of breathing issues, a new study finds. ... and physical diseases that WTC responders suffer," study co-author ...
... -- There are many ways to prevent spreading germs and ... also one of the most important: proper hand-washing. ... and get together for parties and other celebrations, researchers at ... "Hand-washing is the single most effective way to prevent the ...
... THURSDAY, Dec. 29 (HealthDay News) -- Nations with open trade ... rates of obesity than those with more trade controls, a ... countries with the highest obesity rates and fast food restaurants ... the United States, the United Kingdom, Australia, New Zealand and ...
Cached Medicine News:Health News:Tips to Start Running and Stay Motivated in 2012 2Health News:Multiple Sclerosis May Cause Changes in Thalamus: Study 2Health News:Obesity, Diabetes Pose 1-2 Threat to Young Americans 2Health News:Obesity, Diabetes Pose 1-2 Threat to Young Americans 3Health News:PTSD, Respiratory Problems May Be Linked in 9/11 Responders 2Health News:Hand-Washing Key to Stopping Spread of Disease 2Health News:Are Global Market Forces Linked to Obesity Epidemic? 2
(Date:12/19/2014)...  Monarch America Inc. (OTCQB: CANK) ("Monarch America" or ... provide this review of the Company,s recent achievements and ... "Over this past year, we achieved many of our ... to say that Monarch America is in a stronger ... been," stated Eric Hagen , CEO of Monarch ...
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/942kh3/micro_market ... "Micro Market Monitor: North American Dermatology Diagnostic Devices ... http://photos.prnewswire.com/prnh/20130307/600769 Cosmetic ... has resulted in fueling the overall demand of ... of these dermatology devices is to assist in ...
(Date:12/19/2014)... DIEGO , Dec. 18, 2014  RESMED INC. (NYSE: ... its second quarter of fiscal year 2015 results on Thursday, ... close. A press release with ResMed,s results will be issued ... host a webcast to discuss operating results and future outlook. ... 1:30 p.m. US Pacific Time and the live webcast of ...
Breaking Medicine Technology:Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3ResMed To Announce Second Quarter 2015 Results 2
... Inc. (Nasdaq: IDIX ), a biopharmaceutical company engaged ... of human viral diseases, today announced that two abstracts have ... the European Association for the Study of the Liver (EASL, ... can now be viewed at the EASL website at www.easl.eu. ...
... (Nasdaq: IDIX ) announced today that management will ... Stock Conference on Monday, March 14, 2011 at 12:00 p.m. ... California and at the Barclays Capital 2011 Global Healthcare Conference ... the Loews Miami Hotel, Florida. The live and ...
Cached Medicine Technology:Idenix Announces Data Presentations at the 46th Annual Meeting of the European Association for the Study of the Liver (EASL) 2Idenix Announces Data Presentations at the 46th Annual Meeting of the European Association for the Study of the Liver (EASL) 3
Modular Specimen Filing System has five cells that can hold either slides or tissue cassettes....
... an expanded database containing over 330 ... cards, VITEK 2 Compact offers enhanced ... of time (2 to 14 hours), ... microorganisms that contaminate production areas and ...
... is a comprehensive hemodynamic monitoring and ... lab. Patient demographics, clinical hemodynamic ... procedural information all flow seamlessly into ... repetitive data entry. Both ...
... generation product is a patient monitoring system ... parameters, sensed at the tissue level, reflecting ... tissue by low power light and detects ... tissue. The light is guided to the ...
Medicine Products: