Navigation Links
Diabetes Insight Could Lead to Better Treatments
Date:12/21/2009

Inhibiting a key inflammatory pathway brought powerful results in mice and people, researchers say

MONDAY, Dec. 21 (HealthDay News) -- Scientists have identified a protein that may be involved in the development of type 2 diabetes, a finding that could lead to new drugs to fight this growing worldwide scourge.

This same group of researchers recently showed that inhibiting this pathway worked to block pain associated with gout, an inflammatory condition affecting the joints.

Inflammation also plays a large role in diabetes.

The authors of this study, published online Dec. 21 in Nature Immunology, started their exploration with the NLRP3 inflammasome, which has been linked with different inflammatory diseases.

Inflammasomes are clusters of proteins that stimulate inflammation and play a role in the body's innate immune response, explained Dr. Norma Kenyon, professor at the Diabetes Research Institute of the University of Miami Miller School of Medicine. She is familiar with the new findings.

"The inflammasome sense situations that are dangerous to our body," added study senior author Jurg Tschopp, a professor at the University of Lausanne in Epalinges, Switzerland. "This includes pathogens (bacteria, viruses), but also endogenous 'danger situations,' such as uric acid crystals found in gout, high circulating glucose found in diabetes or beta-amyloid [plaques] found in Alzheimer's disease."

Until now, scientists were unable to figure how out the NLRP3 inflammasome is activated. With that information now in hand, researchers might have another promising route to developing treatments for type 2 diabetes.

The chain of events seems to start with a protein called TXNIP, which, when exposed to oxidative stress, binds to NLRP3 and leads to the production of interleukin-1 beta or IL-1b, an immune system molecule.

IL-1b is also produced by the pancreas' islet cells
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Orameds Dr Roy Eldor was Chosen to Lecture at the First International Conference Held by the Bildirici Center for Diabetes Care Research in Israel.
2. UCSF/SFGH project for diabetes patients wins award for innovation, quality
3. SFGH Project for Diabetes Patients Wins Award for Innovation, Quality
4. Sermo Vitals Report(TM) Quantifies One Year of Physician Conversation About Diabetes
5. TrekDesk: A Potentially Positive Impact on Diabetes & Obesity
6. Coffee, Tea Might Stave Off Diabetes
7. UNC scientists coordinate study of link between insulin use and cancer in people with diabetes
8. Study finds over 90 percent of people with gum disease are at risk for diabetes
9. Study shows how gene action may lead to diabetes prevention, cure
10. Bears Quarterback Jay Cutler and Eli Lilly and Company Will Send 44 Kids to American Diabetes Association Camps Through the Touchdowns for Diabetes Campaign
11. Chinese-American and Korean-American women at highest risk for diabetes in pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... scientists has shown that more than 80 per cent ... , The study found that medicines called ,JAK inhibitors, ... mutation that is present in more than 80 per ... used, or are in clinical trials, for diseases including ... Bowel cancer is the second-most common cancer in Australia ...
(Date:10/1/2014)... of the human eye, the brain of a rat ... new technology, says a QUT leading robotics researcher. ... Faculty says the new study uses new computer algorithms ... buildings or tunnels. , "This is a very Frankenstein ... two halves of a thing together because we,re taking ...
(Date:10/1/2014)... Philadelphia, PA, October 1, 2014 Patients with ... treatment, have a greatly increased risk of depression. ... therapy for chronic hepatitis C virus infection causes ... Omega-3 fatty acids, more commonly known as fish ... including lowering the risk of heart disease and ...
(Date:10/1/2014)... New research suggests the adage that encourages people to ... target when it comes to exercise. When walking, staying ... distance to it appear shorter and help people walk ... compares this technique to walking while looking around the ... quality of exercise. , "People are less interested in ...
(Date:10/1/2014)... 2014 Marriagelifeinsurance.com has released a ... for retired couples. , Senior citizens can purchase ... for their loved ones. A joint policy is cheaper, ... pass away. , Life insurance can be used ... can even be purchased online, as the application process ...
Breaking Medicine News(10 mins):Health News:Eighty percent of bowel cancers halted with existing medicines 2Health News:Robot researcher combines nature to nurture 'superhuman' navigation 2Health News:Omega-3 fatty acids may prevent some forms of depression 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 3Health News:Elderly Life Insurance - Find Life Insurance for Retired Couples! 2
... , , AUSTIN, Texas, ... processing expert, ThermoGenesis Corp., to deliver the most sophisticated point ... innovative MarrowXpress(TM) (MXP(TM)) System defines a new standard for isolation ... MXP System consistently yields high (> 90%) mononuclear cell recovery ...
... Global health organization PSI helps contestants spread HIV prevention messages throughout ... 21 The Miss Universe contestants continued preparations for Sunday night,s ... condoms to test their strength and playing "Wild Fire Infection" games ... are part of an HIV peer education workshop designed by PSI ...
... , , KUALA LUMPUR, ... Technologies (ICT) is essential for modern healthcare delivery systems if ... and improve patient safety. , , (Logo: ... years, the acquisition of computer technologies by healthcare organizations has ...
... treatment to thousands who need it, experts say ... with patient and therapist texting each other in real-time ... of patients new access to much-needed treatment, researchers say. ... of research and practice involving technology-based treatments for depression ...
... , , , ... (Nasdaq: HTWR - ASX: HIN) today announced that HeartWare has surpassed ... marking an important early enrollment milestone. , , ... at the Texas Heart Institute in Houston, Texas by O.H. Frazier, ...
... N.Y. The Bioproduction Facility at Cornell University has ... vaccinethat will be used in clinical trials for patients ... was developed as a partnership between The Ludwig Institute ... trial is being conducted at New York University Medical ...
Cached Medicine News:Health News:Celling Technologies Sets New Standards With Sophisticated Adult Stem Cell Device 2Health News:Celling Technologies Sets New Standards With Sophisticated Adult Stem Cell Device 3Health News:Miss Universe Contestants Enter Condom Olympics to Tackle HIV 2Health News:Miss Universe Contestants Enter Condom Olympics to Tackle HIV 3Health News:Frost & Sullivan: Medico Legal Implications Related to the Usage of Electronic Health Record 2Health News:Frost & Sullivan: Medico Legal Implications Related to the Usage of Electronic Health Record 3Health News:Frost & Sullivan: Medico Legal Implications Related to the Usage of Electronic Health Record 4Health News:Web-Based Psychotherapy Can Work 2Health News:Web-Based Psychotherapy Can Work 3Health News:HeartWare International Surpasses 50 Implants in the US 2Health News:HeartWare International Surpasses 50 Implants in the US 3Health News:Cornell makes cancer vaccine for clinical use 2Health News:Cornell makes cancer vaccine for clinical use 3
(Date:10/1/2014)... 2014 The Cardinal Health 2014 digital ... can learn about the company,s fiscal year ... the health care continuum by accessing the ... Photo- http://photos.prnewswire.com/prnh/20140930/149504-INFO ... chief executive officer,s letter to shareholders, the ...
(Date:10/1/2014)... NEW YORK , October 1, 2014 ... service provider for the medical industries, announced today the expansion of ... New York City . genae Americas was incorporated in ... strategically centered in one of the highest concentrations of medical innovation ... Kassab , President at genae Americas. "The expansion of genae from ...
(Date:10/1/2014)...  Express Scripts (NASDAQ: ESRX ) today ... Medicare ® Prescription Drug Plans (PDP) will offer ... WAG ) (NASDAQ: WAG ), helping ...  for their Medicare dollars. Medicare beneficiaries who ... or Choice plans for 2015 can save ...
Breaking Medicine Technology:Cardinal Health 2014 Digital Report to Shareholders Now Available 2genae Opens Offices in New York City 2Express Scripts Collaborates with Walgreens to Create Value-Driven Medicare Prescription Drug Plan Pharmacy Network 2Express Scripts Collaborates with Walgreens to Create Value-Driven Medicare Prescription Drug Plan Pharmacy Network 3Express Scripts Collaborates with Walgreens to Create Value-Driven Medicare Prescription Drug Plan Pharmacy Network 4
... EAST RUTHERFORD, N.J., Nov. 1, 2011 Cambrex Corporation ... 2011 financial results will be released on Thursday, November ... The Company will host a conference call to discuss ... Conference CallWhen: , Friday, November 4, 2011 at 8:30 ...
... 2011 Takeda Global Research & Development ... Drug Administration (FDA) has assigned a Prescription Drug User ... for the review of its investigational type 2 diabetes ... combines alogliptin with pioglitazone in a single tablet.   ...
Cached Medicine Technology:Takeda Announces PDUFA Action Date for Investigational Type 2 Diabetes Therapies Alogliptin and the Fixed-Dose Combination Alogliptin/Pioglitazone 2Takeda Announces PDUFA Action Date for Investigational Type 2 Diabetes Therapies Alogliptin and the Fixed-Dose Combination Alogliptin/Pioglitazone 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: