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DNA Damage From Chemo May Help Spur Leukemia's Return
Date:1/12/2012

makes a lot of sense but it's been hard to prove without whole-genome sequencing."

Commenting on the report, Louis DeGennaro, executive vice president and chief mission officer of the Leukemia & Lymphoma Society, said the study "demonstrates the critical need to identify disease-causing mutations in acute myeloid leukemia so that therapies targeted specifically at these mutations can be developed."

Ultimately, he added, "that would allow us to avoid the use of chemotherapy, which may contribute to cancer relapse."

For now, DeGennaro said, "while current chemotherapy regimens have liabilities, they represent the best treatment currently available and may result in complete remission, which would allow eligible patients to receive a stem cell transplant, the only treatment capable of curing acute myeloid leukemia."

More information

For more about acute myeloid leukemia, visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: Louis J. DeGennaro, Ph.D., executive vice president and chief mission officer, Leukemia & Lymphoma Society, White Plains, N.Y.; Washington University School of Medicine in St. Louis, news release, Jan. 11, 2012


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