Navigation Links
DNA Damage From Chemo May Help Spur Leukemia's Return
Date:1/12/2012

THURSDAY, Jan. 12 (HealthDay News) -- The chemotherapy used to treat a form of adult leukemia sets a trap that can result in the return of the disease within years, a new study suggests.

The finding confirms the suspicions of specialists who thought chemotherapy drugs could disrupt DNA through mutations and ultimately allow tumor cells to avoid the effects of the medications.

"Chemotherapy drugs are absolutely necessary to get leukemia patients into remission, but we also pay a price in terms of DNA damage," study co-author Dr. Timothy Ley, a professor of oncology at Washington University School of Medicine in St. Louis, said in a university news release.

These drugs "may contribute to disease progression and relapse in many different cancers, which is why our long-term goal is to find targeted therapies based on the mutations specific to a patient's cancer, rather than use drugs that further damage DNA," Ley added.

The type of leukemia in question is known as acute myeloid leukemia. While chemotherapy treatment can send the cancer into remission, 80 percent of patients die within five years. In the United States, about 13,000 cases of acute myeloid leukemia are diagnosed annually, most often in people age 60 and older.

The researchers came to their conclusions after studying the genomes -- the entire DNA, both healthy and cancerous cells -- from eight patients with acute myeloid leukemia. They watched to see what happened after the patients received chemotherapy.

The investigators found that tumors essentially reappeared, according to the report published in the Jan. 11 advance online edition of Nature.

"It's the same tumor coming back but with a twist," co-author Richard Wilson, director of university's Genome Institute, explained in the news release. It "comes back with new mutations that give the cells new strategies for surviving attack by whatever drugs are thrown at them. This
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Omega-3 fatty acids could prevent and treat nerve damage, research suggests
2. Agent shows ability to suppress brain metastasis and related damage
3. Alzheimers damage occurs early
4. Uncovering how cerebral malaria damages the brain
5. Marathons May Damage Part of Heart: Study
6. Toll-like receptors play role in brain damage in newborns
7. Too Much Acetaminophen Over Time May Damage Liver
8. Improved method of electrical stimulation could help treat damaged nerves
9. The serotonin system in womens brains is damaged more readily by alcohol than that in mens brains
10. Stem Cells Show Promise in Healing Damaged Hearts
11. Stem cell research hopes to repair brain damage of Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
DNA Damage From Chemo May Help Spur Leukemia's Return 
(Date:3/4/2015)... March 04, 2015 FDA’s New Inspection ... **FDAnews Webinar**, March 24, 2015 — 1:30 p.m. – ... generally know within four hours of an inspection whether ... is on their “good” list, they’ll merely ask for ... manufacturer is on the “bad” list, the manufacturer must ...
(Date:3/4/2015)... Concord, NH (PRWEB) March 04, 2015 ... the natural frozen food category, will attend this year’s ... from its newest product line. With this new line, ... meals in the natural channel, continues its commitment to ... the fastest growing frozen brand in the natural channel, ...
(Date:3/4/2015)... 04, 2015 The print component of ... San Francisco Chronicle with a circulation of approximately 173,000 ... digital component is distributed nationally through a vast social ... sites and partner outlets. To explore the digital version ... Milorganite is composed of heat-dried microbes that have digested ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 The New ... and lyrical music, will be performed by the award-winning ... Estates, CA, this March 6-22, 2015, on Fridays, Saturdays ... at Peninsula High School (27118 Silver Spur Road, ... hour before the program or may be purchased on-line ...
(Date:3/4/2015)... Columbus is no stranger to drug addiction. The ... addiction, and suffers from the potential threat of Kratom. In ... DEA revealed that Kratom is a “drug of concern.” Although ... introduced herb from Southeast Asia acts as a stimulant in ... kratom foments symptoms similar to heroin withdrawal, and includes tremors, ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces: FDA’s New Inspection Approach: What Your Inspector Knows in Four Hours Webinar, March 24, 2015 2Health News:FDAnews Announces: FDA’s New Inspection Approach: What Your Inspector Knows in Four Hours Webinar, March 24, 2015 3Health News:FDAnews Announces: FDA’s New Inspection Approach: What Your Inspector Knows in Four Hours Webinar, March 24, 2015 4Health News:Fastest Growing Frozen Brand in Natural Channel Showcases New Line at Expo West 2015 2Health News:Fastest Growing Frozen Brand in Natural Channel Showcases New Line at Expo West 2015 3Health News:The New Mel Brooks Musical Young Frankenstein Performance March 6-March 22, 2015, by the Award Winning Drama Department at Peninsula High School, Rolling Hills 2Health News:Columbus, OH Combats the Sale of Kratom as a Drug, Harbor Village Detox Stresses Caution 2
... , BATESVILLE, Ind., and ANDOVER, Mass., Sept. ... strategic partnership agreement to integrate the Radianse real-time location system ... this move, Hill-Rom intends to extend its leadership in health ... obstacles for health care customers as they consider high-precision, enterprise-wide ...
... ... Association (DIA) Study Endpoints Special Interest Area Community (SIAC) will host Measuring Study Endpoints ... Caregiver from October 26-27, 2009 in New Orleans, LA. , ... Horsham, PA (Vocus) September 2, 2009 ...
... Sept. 2 The following is an updated GlaxoSmithKline Consumer Healthcare statement ... orlistat: , , On August 24th the FDA ... serious adverse events. , , To view the Multimedia ... It,s important consumers know that alli is safe and effective ...
... , , , ... Sept. 2 /PRNewswire-FirstCall/ -- ... that is developing and marketing Levulan(R) Photodynamic Therapy (PDT) and other ... Doman, President and Chief Executive Officer, will present a corporate overview ...
... on their calls , TUESDAY, Sept. 1 (HealthDay ... research suggests they can appreciate music inspired by the ... similar to soothing monkey calls, the animals moved less ... distress calls, they became anxious. , This may not ...
... N.C., Sept. 2 Anpath Group, Inc. (OTC Bulletin Board: ANPG), ... joined the Board of Directors. , , Dr. ... care, specifically with HIV treatment and immunology. Currently he is ... Academy of HIV Medicine. In 2000, he founded his current ...
Cached Medicine News:Health News:Hill-Rom and Radianse Announce Partnering Agreement to Integrate Location-Sensing Technology into NaviCare(R) Nurse Call 2Health News:Hill-Rom and Radianse Announce Partnering Agreement to Integrate Location-Sensing Technology into NaviCare(R) Nurse Call 3Health News:Hill-Rom and Radianse Announce Partnering Agreement to Integrate Location-Sensing Technology into NaviCare(R) Nurse Call 4Health News:Key Stakeholders to Discuss Regulatory Issues Related to the Use of Study Endpoints in Multinational Clinical Trials 2Health News:Key Stakeholders to Discuss Regulatory Issues Related to the Use of Study Endpoints in Multinational Clinical Trials 3Health News:Video: FDA States Consumers Should Continue to Use alli 2Health News:DUSA Pharmaceuticals to Present at the Rodman & Renshaw 11th Annual Healthcare Conference 2Health News:Scientists Make Sweet Monkey Music 2Health News:Dr. William J. Robbins Joins Anpath Group, Inc. Board of Directors 2Health News:Dr. William J. Robbins Joins Anpath Group, Inc. Board of Directors 3
(Date:3/4/2015)... WASHINGTON , March 4, 2015  Vanda ... today announced top-line results of the Phase II ... and efficacy of tradipitant as a monotherapy in ... atopic dermatitis. Despite a highly significant and clinically ... from baseline, p<0.0001) as measured on a 100mm ...
(Date:3/4/2015)... 2015 Asterias Biotherapeutics, Inc. (NYSE MKT: AST), ... regenerative medicine, today announced that Pedro Lichtinger , ... Bell ® of the New York Stock Exchange ... as an NYSE MKT listed company on October 8, ... a trusted partner to Asterias Biotherapeutics, and we are ...
(Date:3/4/2015)... InfuSystem Holdings, Inc. (NYSE MKT: INFU), a ... for the U.S. healthcare industry, today announced that it ... results on Monday, March 9, 2015 after the market ... conference call for investors on Monday, March 9, 2015 ... and full year 2014 performance and results.  To participate ...
Breaking Medicine Technology:Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 2Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 3Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 4Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 5Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 6Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 7Asterias Biotherapeutics to Ring Opening Bell at New York Stock Exchange 2Asterias Biotherapeutics to Ring Opening Bell at New York Stock Exchange 3
... Market to Demonstrate Test,s Potential for ... Rapid ... DIAG) and Applied Biosystems Inc. (NYSE: ABI ) today,announced the launch ... searches for a unique gene expression signature,identified by DiaGenic using a custom ...
... Have Other Important Benefits, Says CRN-, WASHINGTON, ... Study II, to be released at the American ... the November 12,issue of the Journal of the ... vitamin E and C supplementation on cardiovascular,events in ...
Cached Medicine Technology:Diagenic Announces Launch of First Breast Cancer Gene-Expression Blood Test 2Diagenic Announces Launch of First Breast Cancer Gene-Expression Blood Test 3Physicians' Health Study II Finds No Magic Bullet for Preventing Cardiovascular Disease 2Physicians' Health Study II Finds No Magic Bullet for Preventing Cardiovascular Disease 3Physicians' Health Study II Finds No Magic Bullet for Preventing Cardiovascular Disease 4
McIntyre-Binkhorst Cannula have a smooth blunt tip end opening....
Army navy retractor set....
Sharp. 4 mm wide. Hand-Held...
Adsons bayonet forceps....
Medicine Products: