Navigation Links
DNA Damage From Chemo May Help Spur Leukemia's Return
Date:1/12/2012

THURSDAY, Jan. 12 (HealthDay News) -- The chemotherapy used to treat a form of adult leukemia sets a trap that can result in the return of the disease within years, a new study suggests.

The finding confirms the suspicions of specialists who thought chemotherapy drugs could disrupt DNA through mutations and ultimately allow tumor cells to avoid the effects of the medications.

"Chemotherapy drugs are absolutely necessary to get leukemia patients into remission, but we also pay a price in terms of DNA damage," study co-author Dr. Timothy Ley, a professor of oncology at Washington University School of Medicine in St. Louis, said in a university news release.

These drugs "may contribute to disease progression and relapse in many different cancers, which is why our long-term goal is to find targeted therapies based on the mutations specific to a patient's cancer, rather than use drugs that further damage DNA," Ley added.

The type of leukemia in question is known as acute myeloid leukemia. While chemotherapy treatment can send the cancer into remission, 80 percent of patients die within five years. In the United States, about 13,000 cases of acute myeloid leukemia are diagnosed annually, most often in people age 60 and older.

The researchers came to their conclusions after studying the genomes -- the entire DNA, both healthy and cancerous cells -- from eight patients with acute myeloid leukemia. They watched to see what happened after the patients received chemotherapy.

The investigators found that tumors essentially reappeared, according to the report published in the Jan. 11 advance online edition of Nature.

"It's the same tumor coming back but with a twist," co-author Richard Wilson, director of university's Genome Institute, explained in the news release. It "comes back with new mutations that give the cells new strategies for surviving attack by whatever drugs are thrown at them. This makes a lot of sense but it's been hard to prove without whole-genome sequencing."

Commenting on the report, Louis DeGennaro, executive vice president and chief mission officer of the Leukemia & Lymphoma Society, said the study "demonstrates the critical need to identify disease-causing mutations in acute myeloid leukemia so that therapies targeted specifically at these mutations can be developed."

Ultimately, he added, "that would allow us to avoid the use of chemotherapy, which may contribute to cancer relapse."

For now, DeGennaro said, "while current chemotherapy regimens have liabilities, they represent the best treatment currently available and may result in complete remission, which would allow eligible patients to receive a stem cell transplant, the only treatment capable of curing acute myeloid leukemia."

More information

For more about acute myeloid leukemia, visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: Louis J. DeGennaro, Ph.D., executive vice president and chief mission officer, Leukemia & Lymphoma Society, White Plains, N.Y.; Washington University School of Medicine in St. Louis, news release, Jan. 11, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Omega-3 fatty acids could prevent and treat nerve damage, research suggests
2. Agent shows ability to suppress brain metastasis and related damage
3. Alzheimers damage occurs early
4. Uncovering how cerebral malaria damages the brain
5. Marathons May Damage Part of Heart: Study
6. Toll-like receptors play role in brain damage in newborns
7. Too Much Acetaminophen Over Time May Damage Liver
8. Improved method of electrical stimulation could help treat damaged nerves
9. The serotonin system in womens brains is damaged more readily by alcohol than that in mens brains
10. Stem Cells Show Promise in Healing Damaged Hearts
11. Stem cell research hopes to repair brain damage of Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
DNA Damage From Chemo May Help Spur Leukemia's Return 
(Date:2/24/2017)... ... February 24, 2017 , ... The Radiology Business Management ... radiology marketing programs at the annual Building Better Radiology Marketing Programs conference, ... Hotel in Fort Worth, Texas. Nine awards are given out in five categories. They ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... ... an official 2017 partnership with The Jensie Gran Fondo of Marin. For the ... UVB rays with Thinksport’s broad-spectrum, mineral-based sunscreen. , “We are thrilled to provide ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rare Disease ... will be participating in Rare Disease Day events, hosted by the Rare Disease ... Disease Report, a website, weekly e-newsletter and quarterly publication, will be conducting interviews ...
(Date:2/23/2017)... ... 23, 2017 , ... Rosica Communications, a national PR ... media management, corporate communications, SEO and cause marketing, is opening an office in ... Hampshire, Massachusetts and Canada, Rosica will focus on expanding its footprint. , ...
(Date:2/23/2017)... ... February 23, 2017 , ... Pink ... publication where generations converge and explore the world from different perspectives. By providing ... enables readers to gain understanding, increase empathy, and find greater happiness. , ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 2017  This report analyzes the worldwide markets for ... Products: Intermediates, Analytical, and Others. The End ... and Agrochemicals. The report provides separate comprehensive analytics for ... Europe , and Rest of World. Annual estimates ... 2022. Also, a six-year historic analysis is provided for ...
(Date:2/24/2017)... , Feb. 24, 2017  Xynomic Pharmaceuticals, Inc., ... announced that it has acquired exclusive worldwide rights ... best-in-class innovative HDAC inhibitor targeting hematological and solid ... 14 Phase 1 and 2 clinical trials of ... have already been completed, demonstrating that ...
(Date:2/23/2017)... 2017  Genesis Healthcare Services has merged with Hospice ... by Bill Monast , President and CEO of ... Nathan Feltman , executives with Home Health Depot, Inc., ... This acquisition helps Hospice Cloud maintain its ... durable medical equipment (DME) solutions for the hospice industry. ...
Breaking Medicine Technology: