Navigation Links
Cushing's syndrome: A genetic basis for cortisol excess
Date:2/27/2014

An international team of researchers led by an endocrinologist at Ludwig-Maximilians-Universitaet (LMU) in Munich has identified genetic mutations that result in uncontrolled synthesis and secretion of the stress hormone cortisol.

Cortisol is a hormone that is produced by the adrenal gland in response to stressful events, and modulates a whole spectrum of physiological processes. An international research collaboration has now identified genetic mutations that lead to the production and secretion of cortisol in the absence of an underlying stressor.

The discovery emerged from the genetic characterization of benign tumors of the adrenal gland which produce cortisol in excess amounts. Patients who develop such tumors suffer from weight gain, muscle wasting, osteoporosis, diabetes and hypertension. This condition, known as Cushing's syndrome, can be successfully treated by surgical removal of the affected adrenal gland.

Overproduction of cortisol

The team, which included researchers from Germany, France and the US and was led by Professors Felix Beuschlein and Martin Fassnacht of the LMU Medical Center, were able to show that in one-third of a patient population with such adrenal tumors, a mutation in the gene for the enzyme phosphokinase A was specifically associated with the continuous production of cortisol. This mutation had occurred in the adrenal gland and is therefore restricted to the tumor cells. The results have just appeared in the prestigious New England Journal of Medicine.

"The gene for phosphokinase A plays a key role in the regulation of adrenal gland function, and the newly identified mutation causes it to become irreversibly activated, which results in the unrestrained production of cortisol," says Felix Beuschlein. In collaboration with a group at the US National Institutes of Health, the team was also able to identify patients who carry similar genetic alterations in their g
'/>"/>

Contact: Luise Dirscherl
presse@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Metabolic Syndrome: Breaking the Cycle Report and Video Released by Health News Wires
2. Metabolic Syndrome: Understanding the Risk and Treatment Published by Health News Wires
3. Second impact syndrome: A devastating injury to the young brain
4. LA BioMed researchers report on promising new therapy for devastating genetic disorder
5. Gender influences symptoms of genetic disorder
6. Penn study reveals genetics impact risk of early menopause among some female smokers
7. Rare genetic variations may account for severe reaction to LABA drugs in some people
8. Genetic counseling via telephone as effective as in-person counseling
9. New project on psychiatric, neurologic, and behavioral genetics
10. The epigenetics of breast cancer family history
11. Genetic clue to fighting new strains of flu
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... Florida Hospital teamed up with ABC Action ... campaign and live Dr. Oz event, which took place at ... than a thousand people came out to see Dr. Mehmet ... The world renowned cardiothoracic surgeon and Emmy award winning talk ... a panel of experts for the live health expo. Florida ...
(Date:3/26/2015)... 2015 Building off their success ... education, the Cardiometabolic Risk Summit and ... University are proud to announce a pioneering ... interdisciplinary program , which ultimately grants a ... for physicians, nurse practitioners, physician assistants, registered dietitians, ...
(Date:3/26/2015)... (PRWEB) March 26, 2015 Saving Moses ... where it is most needed but least available. As ... milk to six clinics in the Benguela province of ... malnutrition. During a recent visit to their clinics, staff ... the mothers and their babies in a nation the ...
(Date:3/26/2015)... (PRWEB) March 26, 2015 Pacific Medical ... is pleased to be featured on Innovations with Ed ... March 18, 2015. The episode will repeat on ... live on the Pacific Medical home page at: ... threatening emergencies, it is reassuring to trust the integrity ...
(Date:3/26/2015)... DC (PRWEB) March 26, 2015 ... Center for Assessment and Evaluation , has announced ... that enable institutions, organizations, and corporations to accurately ... promote successful learning. , Utilizing Questionmark’s state-of-the-art ... Services will offer improved delivery of the ...
Breaking Medicine News(10 mins):Health News:Florida Hospital Welcome Dr. Oz to Tampa and Invites the Community to Attend Educational Seminars Hosted by Florida Hospital Physicians 2Health News:Florida Hospital Welcome Dr. Oz to Tampa and Invites the Community to Attend Educational Seminars Hosted by Florida Hospital Physicians 3Health News:Certified Culinary Medicine Specialist Program Jointly Launched by Goldring Center for Culinary Medicine at Tulane University and Cardiometabolic Risk Summit 2Health News:Certified Culinary Medicine Specialist Program Jointly Launched by Goldring Center for Culinary Medicine at Tulane University and Cardiometabolic Risk Summit 3Health News:Saving Moses Utilized Photography in an Effort to Engage Mothers and Their Babies on a Recent Visit to Angola 2Health News:Pacific Medical Featured on the Discovery Channel 2Health News:Pacific Medical Featured on the Discovery Channel 3Health News:NLN Testing Services Announces Improved Delivery and Analytics Software and Newly Developed and Revised Exams 2
... were affected by the high court ruling of new ... In the meantime health// authorities began shortlisting doctors, including ... doctors in Britain, adversely affected by the February 9 ... new immigration rules, lodged an appeal against the judgment, ...
... reports the efficacy of a pharmaceutical drug named ... cancer. A comparative study of interferon and// sunitinib ... halting the progress of metastatic kidney cancer. ... prestigious international medical journal, The New England Journal ...
... of March is an auspicious day for all Hindus. ... victory of good over evil. This festival has been ... the enthusiasm to participate and remember our past has ... globalization and economization a lot has changed. Substandard quality ...
... green tea has long been touted for its healthful ... found// that a component of green tea, combined with ... spread of human prostate cancer. ,In the ... University of Wisconsin-Madison demonstrate that low doses of the ...
... graft dysfunction, a common complication that affects up to ... constitutes// a significant risk factor for later deadly bronchiolotis ... in the first issue for March 2007 of the ... by the American Thoracic Society. ,Ramsey R. ...
... need a title change. According to government figures, 5.9 million ... are overweight. ,The figures have got the French ... to the former image of the svelte and cuisine-conscious French. ... down hard on junk food advertisements. Such advertisements will now ...
Cached Medicine News:Health News:Indian Doctors File Appeal Against British Court Ruling 2Health News:A New Drug for Halting Metastatic Kidney Cancer 2Health News:Chemicals Used To Make Synthetic Color Can Cause Cancer And Permanent Blindness 2Health News:Green Tea and COX-2 Inhibitors Combine to Slow Growth of Prostate Cancer 2Health News:Green Tea and COX-2 Inhibitors Combine to Slow Growth of Prostate Cancer 3Health News:Primary Graft Dysfunction Is Risk Factor For Lung Transplant Problem 2
(Date:3/26/2015)... PROSPECT, Illinois , 26. März 2015 ... Pharmacy® (NABP®) wird vom 1. April 2015 an ... von allen abgebenden Apotheken annehmen. Seit dem ... hat der Verband über 275 .pharmacy-Domainnamen zugelassen, ... während dieser Zeiten beantragt wurden. Die NABP ...
(Date:3/26/2015)... , March 26, 2015  CNBC profiled MJ Freeway ... part of a series "How I Did It," which features ... the High Road" released yesterday, illustrates how two tech ... leading IT providers to the marijuana industry. ... describes how Co-Founders Amy Poinsett and Jessica Billingsley ...
(Date:3/26/2015)... a loved relative suffering from cancer - and you ... too expensive. The Austrian Centre of Industrial Biotechnology (acib) ... costs of highly valued drugs significantly. ... pathogens or cancer cells. Therapeutic antibodies are used as ... diseases such as multiple sclerosis. According to "bccresearch.com" the ...
Breaking Medicine Technology:Alle abgebenden Apotheken berechtigt, um ab dem 1. April 2015 .Pharmacy-Domainnamen zu beantragen 2MJ Freeway, Industry-Leading Software Solution for Cannabis Businesses, Featured in CNBC Special "How I Did It" 2World's First Method for Continuous Purification of Valuable Antibodies 2
... SHELTON, Connecticut, February 23, 2012  ... risk of contracting osteoporosis have now been identified as a ... . Women who can now drastically reduce the risk of ... is available.  Increasing numbers of mammography clinics throughout Europe are ...
... (NYSE AMEX: ULU),announced today that an Australian Register ... Therapeutic Goods Administration approving the marketing of Altrazeal® in ... Kerry P. Gray, President and CEO of ULURU, stated, ... of Altrazeal®.  Strategically this is an important market as ...
Cached Medicine Technology:1,000th Woman Identified Using Sectra's Analysis Method - European Mammography Clinics Mark Milestone in the Struggle Against Osteoporosis 21,000th Woman Identified Using Sectra's Analysis Method - European Mammography Clinics Mark Milestone in the Struggle Against Osteoporosis 3ULURU Inc. Announces Approval to Market Altrazeal® in Australia 2ULURU Inc. Announces Approval to Market Altrazeal® in Australia 3
Inquire...
Single-action scissors offer fine-pointed, sharp dissecting jaws to facilitate a partial cut in the cystic duct in preparation for a cholangiogram. They are tapered at the tip for greater visualizati...
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
Single-action, stainless steel micro biopsy forceps....
Medicine Products: