Navigation Links
Cushing's syndrome: A genetic basis for cortisol excess
Date:2/27/2014

An international team of researchers led by an endocrinologist at Ludwig-Maximilians-Universitaet (LMU) in Munich has identified genetic mutations that result in uncontrolled synthesis and secretion of the stress hormone cortisol.

Cortisol is a hormone that is produced by the adrenal gland in response to stressful events, and modulates a whole spectrum of physiological processes. An international research collaboration has now identified genetic mutations that lead to the production and secretion of cortisol in the absence of an underlying stressor.

The discovery emerged from the genetic characterization of benign tumors of the adrenal gland which produce cortisol in excess amounts. Patients who develop such tumors suffer from weight gain, muscle wasting, osteoporosis, diabetes and hypertension. This condition, known as Cushing's syndrome, can be successfully treated by surgical removal of the affected adrenal gland.

Overproduction of cortisol

The team, which included researchers from Germany, France and the US and was led by Professors Felix Beuschlein and Martin Fassnacht of the LMU Medical Center, were able to show that in one-third of a patient population with such adrenal tumors, a mutation in the gene for the enzyme phosphokinase A was specifically associated with the continuous production of cortisol. This mutation had occurred in the adrenal gland and is therefore restricted to the tumor cells. The results have just appeared in the prestigious New England Journal of Medicine.

"The gene for phosphokinase A plays a key role in the regulation of adrenal gland function, and the newly identified mutation causes it to become irreversibly activated, which results in the unrestrained production of cortisol," says Felix Beuschlein. In collaboration with a group at the US National Institutes of Health, the team was also able to identify patients who carry similar genetic alterations in their g
'/>"/>

Contact: Luise Dirscherl
presse@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Metabolic Syndrome: Breaking the Cycle Report and Video Released by Health News Wires
2. Metabolic Syndrome: Understanding the Risk and Treatment Published by Health News Wires
3. Second impact syndrome: A devastating injury to the young brain
4. LA BioMed researchers report on promising new therapy for devastating genetic disorder
5. Gender influences symptoms of genetic disorder
6. Penn study reveals genetics impact risk of early menopause among some female smokers
7. Rare genetic variations may account for severe reaction to LABA drugs in some people
8. Genetic counseling via telephone as effective as in-person counseling
9. New project on psychiatric, neurologic, and behavioral genetics
10. The epigenetics of breast cancer family history
11. Genetic clue to fighting new strains of flu
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2015)... Vegas, Nevada (PRWEB) May 30, 2015 ... treatment of acne scars, large pores, deep wrinkles, stretch ... a licensed medical professional, such as Dr. F. Victor ... some of the clinical trials in Las Vegas. This ... SmartScan technology into a system that delivers proven results ...
(Date:5/29/2015)... CA (PRWEB) May 29, 2015 Displays and ... that has lowered the price of hanging signs ; ... Hanging signs that hang down from ceiling rigging points at ... over the trade show floor. These signs are very ... there are additional costs for installation and dismantle labor and ...
(Date:5/29/2015)... May 29, 2015 Based in St. Louis, ... awareness shirts for a couple of months now and ... latest release, which reads “I’m not misbehaving, I have Autism, ... the parent’s of an autistic child in order to start ... , Not only are they raising awareness through the autism ...
(Date:5/29/2015)... What does community do? , According to ... together to plant gardens, to teach young people, to ... critical issues. Community invites everyone to help improve lives ... Community Does" was commissioned by The Denver Foundation, the ... during the foundation’s Annual Celebration in May. At just ...
(Date:5/29/2015)... Washington, PA (PRWEB) May 29, 2015 ... ” quiz-based learning in 14 medical specialties, now offers ... includes a wide spectrum of rheumatology disorders ranging from ... Alfred Saint Jacques, editorial director of MDLinx, and Caroline ... excited about the impact it will have on the ...
Breaking Medicine News(10 mins):Health News:Announcing Ground-Breaking Technology for Anti-Aging, FDA Approved, Venus Viva. 2Health News:Announcing Ground-Breaking Technology for Anti-Aging, FDA Approved, Venus Viva. 3Health News:Displays and Exhibits Announces New Hanging Sign Supplier 2Health News:La La Land Shirts Is Busy Spreading Autism Awareness with Complimentary Shipping on Their New Shirt 2Health News:What Community Does: A New Video from The Denver Foundation 2Health News:MDLinx Launches Smartest Rheumatologist 2
... Academy of Sciences and the Shanghai Institutes of Biomedical Sciences ... world of the progress made by China in the field ... SARS, the H5N1 bird flu virus and the prevalence of ... 100 scientists from China, the U.S., Europe and other parts ...
... of Indian origin to receive a license to practice privately in ... He sees as many as 100 patients per day starting from ... His practice is estimated at US$ 5 million. // ... it has happened in a ‘non-immigration country’ that permits expatriate doctors, ...
... to stay has made it necessary for health teams to ... University Medical Center has pioneered the use of a baby ... quickly to infants in distress from any chemical weapons attacks ... Health and the Health Resources and Services Administration (HRSA) has ...
... the Indian State of Kerala leads the rest of the nation. ... where life expectancy, infant mortality and birth rate are concerned. //The ... while it is at 24.80 for the entire nation. Likewise, the ... the country and infant mortality is at 11, far lower than ...
... officer, Sir Liam Donaldson, has announced the introduction of ... , with a motive to prevent children from falling ... ,The pneumococcal infection, upon entering the blood stream, can ... poisoning) and pneumonia. Almost 50 young lives under age ...
... levels fall after the removal of a diseased liver from ... return even after a healthy liver transplant, which can even ... results published in the American Association for the Study of ... most liver transplantations is Hepatitis C. ,As ...
Cached Medicine News:Health News:East And West Meet Under The Aegis of NY Academy Of Sciences' 2Health News:Pneumococcal Vaccine: Childhood Immunization Programme has a new recruit 2
(Date:5/29/2015)... Ill. , May 29, 2015  Today, ... MasterControl, a leading global provider of electronic quality ... a collaborative agreement which will leverage the strengths ... with both quality system implementation and comprehensive advice ... Adding MasterControl,s EQMS capabilities to UL,s strength ...
(Date:5/29/2015)... 29, 2015  Fair Rate Funding, a leader in ... in Delaware found Thursday that ... treat pelvic organ prolapse (POP) and Stress Urinary Incontinence ... executives hid the design flaws from the plaintiff, ... Transvaginal mesh, also known as ...
(Date:5/29/2015)... , May 29, 2015  Dr. Yair Walzer ... resolve vaginal health issues often caused by menopause. The MonaLisa ... no anesthesia, received FDA clearance in 2014. Dr. Walzer is ... to offer the special fractional CO 2 laser ... cancer survivors. In 2010 there were greater ...
Breaking Medicine Technology:UL and MasterControl collaborate to provide medical manufacturers full service QMS and Regulatory Submissions support 2UL and MasterControl collaborate to provide medical manufacturers full service QMS and Regulatory Submissions support 3TV Mesh Lawsuit Funding Firm, Fair Rate Funding, Reports Delaware Woman Awarded $100 Million Against Boston Scientific in Pelvic Mesh Verdict. 2TV Mesh Lawsuit Funding Firm, Fair Rate Funding, Reports Delaware Woman Awarded $100 Million Against Boston Scientific in Pelvic Mesh Verdict. 3The Newest FDA-Cleared Breakthrough In Women's Health Treatments 2
... , SOUTH SAN FRANCISCO, Calif., Dec. 9 Anesiva, Inc. ... 2009, Anesiva entered into an Asset Purchase Agreement which assigned ... Ltd., dated November 30, 2009, and sold certain assets related ... Virgin Island LLC, and Lee,s Pharmaceuticals (HK) Limited (Lee,s Pharma), ...
... , , , WESTCHESTER, Ill., ... for targeted, less-invasive medical treatments, announced today that St. ... flex, a powerful computer-assisted surgery (CAS) system featuring Digital ... software solution. St. Luke,s is the first in North ...
Cached Medicine Technology:Anesiva Completes Sale of its Zingo(TM) Assets to Powder Pharmaceuticals and Lee's Pharmaceuticals 2St. Luke's Hospital Acquires Pioneering Technology From BrainLAB 2St. Luke's Hospital Acquires Pioneering Technology From BrainLAB 3
... Collection Tubes are 100% plastic capillary blood ... of applications, the Capillary Collection Tubes are ... and a micro tube.,The capillary tube uses ... the micro tube thereby eliminating the tendency ...
... SAFE-T-FILL Capillary Blood Collection Tubes are 100% ... a wide range of applications, the Capillary ... tube, attached cap and a micro tube.,The ... the blood into the micro tube thereby ...
... is an enzyme immunoassay test in a microwell ... 90-minute incubation. The results are objective and ... The Bio-Rad Mumps IgG test is intended ... IgG antibodies to mumps virus in human serum ...
... for Toxoplasmosis has progressed from ... dye test to immunoflourescence, latex ... In addition to Toxo ... both Toxo IgM immunocapture and ...
Medicine Products: