Navigation Links
Counting copy numbers characterises prostate cancer
Date:4/4/2013

Non-invasive 'liquid biopsies' can find metastatic or recurrent prostate cancer, in a low cost assay suitable for most healthcare systems, finds research published in BioMed Central's open access journal Genome Medicine. Genomic signatures of prostate cancer, isolated from plasma DNA, display abnormal copy numbers of specific areas of chromosomes. It is even possible to separate out patients who develop resistance against hormone deprivation therapy, which is the most common form of treatment in men with metastatic prostate cancer.

Prostate cancer is the most common cancer in men with 2.6 million new cases being diagnosed each year in Europe alone. PSA testing means that many cancers are found and treated at an early stage. However some men still have recurrent or metastatic disease despite treatment which appears to have destroyed the cancer.

Testing for metastasis remains a challenge requiring repeated biopsies. A team of researchers from the Medical University of Graz and the University Medical Center Hamburg Eppendorf investigated the possibility of testing for the presence of disease in a less invasive manner.

Using whole genome analysis of plasma DNA, plus targeted sequencing of genes known to be involved in prostate cancer, the team discovered that there are abnormal copy numbers (some losses, some gains) of specific prostate cancer related sequences. Although this was a small scale study the presence of prostate cancer was flagged by copy number mistakes in sequences such as NCOA2, PHLPP1 and TMPRSS2-ERG. As expected each person's cancer signature was slightly different, however patients whose cancer did not respond to castration all had increased copy numbers of genes for the androgen receptor (AR).

Discussing the value of this research Dr Jochen Geigl and Prof Michael Speicher, who led this study commented, "The simplicity and low cost of 'liquid biopsies' make these genetic tests an attractive alternative
'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Page: 1 2

Related medicine news :

1. MileAgeAds.com Invites Blog Owners in Accounting Niche to their Ad Network
2. 1 week and counting: Dont cut the research that fuels the US economy
3. Plastic Surgery up 5% in 2012 - Celebrity Doctor Looks Behind the Numbers
4. HealthCompare Urges the Newly Increasing Numbers of 1099 Employees to Seek Health Insurance Coverage They Need
5. Five Companies and Agencies Celebrate Award-Wins Showcasing Their Advertising Expertise with Vanity 800 Numbers
6. Stink Bugs will Reach Record Numbers in 2013
7. US Drug Watchdog Now Fears the Numbers of Transvaginal Mesh Product Failure Victims Will Grow and They Offer Victims the Names of the Best Lawyers-Who Will All Be Women
8. Treating disease by the numbers
9. Terrorism and the Olympics by-the-numbers: Analysis from UMD-based START
10. Numbers of blind are falling
11. Hepatitis C Causing Liver Damage in Greater Numbers: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... Rochelle, NY -- New guidelines on cholesterol treatment and ... double the risk of dying from atherosclerotic cardiovascular disease ... do women with a similar risk profile (based on ... The implications of this finding for when and how ... Editorial in Journal of Men,s Health , a ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 The Beryl ... and third annual Institute Scholar Program. These offerings reinforce ... the patient experience in healthcare and the need for ... The grant and scholar programs are intended ... , Value of focusing on the patient experience ...
(Date:7/22/2014)... The Pennsylvania judge overseeing hundreds ... in the Philadelphia Court of Common Pleas won’t ... cases alleging the medication caused plaintiffs to develop ... In an Order dated July 18, 2014, Judge ... certify the matter for an immediate appeal to ...
(Date:7/22/2014)... July 22, 2014 The park is ... the Kendalltown Homeowners Association, Inc., made a ... residential community with the purchase of playground equipment from ... located in beautiful Miami Florida, and is a 475-unit ... of the surrounding landscape has created a tropical paradise ...
(Date:7/22/2014)... TUESDAY, July 22, 2014 (HealthDay News) -- One of ... of a psychiatric disorder has uncovered 83 new sites ... The findings, made by an international team of ... variants linked to the disorder to 108. ... used as a test to predict who will or ...
Breaking Medicine News(10 mins):Health News:The Beryl Institute Opens Applications for 2014 Patient Experience Grant and Scholar Programs 2Health News:The Beryl Institute Opens Applications for 2014 Patient Experience Grant and Scholar Programs 3Health News:Risperdal Lawsuit News: Pennsylvania Judge Won’t Reconsider Denial of Punitive Damages for Risperdal Gynecomastia Plaintiffs, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuit News: Pennsylvania Judge Won’t Reconsider Denial of Punitive Damages for Risperdal Gynecomastia Plaintiffs, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuit News: Pennsylvania Judge Won’t Reconsider Denial of Punitive Damages for Risperdal Gynecomastia Plaintiffs, Bernstein Liebhard LLP Reports 4Health News:Fun in the Florida Sun: Kendalltown Homeowners Association Inc. Expands Outdoor Recreation with American Parks Company™ 2Health News:Fun in the Florida Sun: Kendalltown Homeowners Association Inc. Expands Outdoor Recreation with American Parks Company™ 3Health News:Gene Discoveries Could Shed New Light on Schizophrenia 2
... to lack a particular protein in the brain have ... they say, for exploring the hereditary causes of deafness ... provides an entry point for gaining new insight into ... the protein, says the team, led by scientists at ...
... ATSI ) is looking forward to its ... of Thoracic Surgeons (STS). The event runs January,28-30, ... one of the year,s,key gatherings of cardiovascular surgeons ... ), ATS Medical continues to broaden its ...
... Rochester,Medical Corporation (Nasdaq: ROCM ) will announce quarterly ... The Company will then,hold a quarterly conference call to ... p.m. central standard time (5:00 p.m. eastern time)., ... be accessed at,Rochester Medical,s website at http://www.rocm.com . ...
... PRINCETON, N.J., Jan. 24 The final ... Care Resources,provides a thorough and candid explanation of ... short on delivering solutions to address,the healthcare system,s ... consensus of the New Jersey Hospital Association, the,state,s ...
... Personalizing ones nutrition for maximum health benefits is becoming ... help health professions learn more about this trend at ... Nutrition" is the theme for the 35th annual Texas ... The event, at the Rudder Tower, is from 8 ...
... on healthy living, healthy aging, healthy ... communities, ... million investment in three initiatives that will help,Silicon Valley become the healthiest ... strides in achieving the goals,of healthy living, healthy aging, and healthy communities ...
Cached Medicine News:Health News:Deafness and seizures result when mysterious protein deleted in mice 2Health News:Deafness and seizures result when mysterious protein deleted in mice 3Health News:ATS Medical Participating in 44th Annual STS Annual Meeting 2Health News:ATS Medical Participating in 44th Annual STS Annual Meeting 3Health News:Rochester Medical Announces First Quarter 2008 Earnings Conference Call February 4, 2008 2Health News:NJHA: State Report Provides Thorough Examination of Hospital Fiscal Woes 2Health News:The Health Trust Announces $30 Million Investment Towards Making Silicon Valley Healthiest Region in America 2Health News:The Health Trust Announces $30 Million Investment Towards Making Silicon Valley Healthiest Region in America 3
(Date:7/22/2014)... , July 22, 2014  Decision Resources Group finds ... Canada will remain relatively stagnant at a ... the fact that percutaneous coronary intervention (PCI) volumes are growing ... developed markets, such as the United States ... be largely driven by the increase in penetration of PCI ...
(Date:7/22/2014)... 22, 2014 Research and Markets  has ... 2014-2018" report to their offering. ... used to diagnose, monitor, and assess medical conditions, diseases, ... provide outcomes for earlier and more targeted treatment. These ... provide accurate results. This kind of diagnostics provides early ...
(Date:7/22/2014)... VIEW, Calif. , July 22, 2014 /PRNewswire/ ... resonance imaging (MRI) market, Frost & Sullivan recognizes ... for Product Leadership. Siemens Healthcare,s FREEZEit solution, which ... the need for robust and motion-insensitive imaging. The ... boosted the evolution of body MRI imaging in ...
Breaking Medicine Technology:The Canadian Interventional Cardiology Device Market Will Remain Relatively Stagnant Through 2022 at Around $80 Million 2The Canadian Interventional Cardiology Device Market Will Remain Relatively Stagnant Through 2022 at Around $80 Million 3Global IVD Market 2014-2018: Key Vendors are Abbott Laboratories, Johnson & Johnson, Roche Diagnostics and Siemens Healthcare 2Global IVD Market 2014-2018: Key Vendors are Abbott Laboratories, Johnson & Johnson, Roche Diagnostics and Siemens Healthcare 3Frost & Sullivan Recognizes Siemens Healthcare with the Product Leadership Award for Innovative Techniques in Abdominal Imaging 2Frost & Sullivan Recognizes Siemens Healthcare with the Product Leadership Award for Innovative Techniques in Abdominal Imaging 3Frost & Sullivan Recognizes Siemens Healthcare with the Product Leadership Award for Innovative Techniques in Abdominal Imaging 4
... DIEGO, June 10, 2011 Volcano Corporation (NASDAQ: ... precision intravascular diagnosis and therapy guidance tools designed to ... said today that it will be participating in the ... on Thursday, June 16. The presentation by ...
... jury awarded $625,000 to the estate of a 63 year ... blood thinner that contained a contaminated ingredient Baxter sourced from ... on Baxter contaminated Chinese heparin to go to trial.  The ... in Chicago, Illinois before Judge Jennifer Duncan-Brice and in the ...
Cached Medicine Technology:Nolan Law Group: Jury Finds Against Baxter Healthcare In Nation's First Contaminated Chinese Heparin Case 2
Cushing-landolt bi-valve speculum for trans-sphenoidal hypophysectomie....
Hardy pituitary spoon, bayonet, malleable....
... the T.L.I.F. market as the premium banana-shaped implant. ... history and the amazing success of the Devex ... to be king of the jungle amongst T.L.I.F. ... in height. The footprint is 28 mm x ...
... The Stackable Cage System provides anterior ... or total vertebrectomies from T1 to L5. ... Peek Carbon Fiber Polymer cages that are ... patient needs. The Peek Carbon Fiber Reinforced ...
Medicine Products: