Navigation Links
Counting copy numbers characterises prostate cancer
Date:4/4/2013

Non-invasive 'liquid biopsies' can find metastatic or recurrent prostate cancer, in a low cost assay suitable for most healthcare systems, finds research published in BioMed Central's open access journal Genome Medicine. Genomic signatures of prostate cancer, isolated from plasma DNA, display abnormal copy numbers of specific areas of chromosomes. It is even possible to separate out patients who develop resistance against hormone deprivation therapy, which is the most common form of treatment in men with metastatic prostate cancer.

Prostate cancer is the most common cancer in men with 2.6 million new cases being diagnosed each year in Europe alone. PSA testing means that many cancers are found and treated at an early stage. However some men still have recurrent or metastatic disease despite treatment which appears to have destroyed the cancer.

Testing for metastasis remains a challenge requiring repeated biopsies. A team of researchers from the Medical University of Graz and the University Medical Center Hamburg Eppendorf investigated the possibility of testing for the presence of disease in a less invasive manner.

Using whole genome analysis of plasma DNA, plus targeted sequencing of genes known to be involved in prostate cancer, the team discovered that there are abnormal copy numbers (some losses, some gains) of specific prostate cancer related sequences. Although this was a small scale study the presence of prostate cancer was flagged by copy number mistakes in sequences such as NCOA2, PHLPP1 and TMPRSS2-ERG. As expected each person's cancer signature was slightly different, however patients whose cancer did not respond to castration all had increased copy numbers of genes for the androgen receptor (AR).

Discussing the value of this research Dr Jochen Geigl and Prof Michael Speicher, who led this study commented, "The simplicity and low cost of 'liquid biopsies' make these genetic tests an attractive alternative
'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Page: 1 2

Related medicine news :

1. MileAgeAds.com Invites Blog Owners in Accounting Niche to their Ad Network
2. 1 week and counting: Dont cut the research that fuels the US economy
3. Plastic Surgery up 5% in 2012 - Celebrity Doctor Looks Behind the Numbers
4. HealthCompare Urges the Newly Increasing Numbers of 1099 Employees to Seek Health Insurance Coverage They Need
5. Five Companies and Agencies Celebrate Award-Wins Showcasing Their Advertising Expertise with Vanity 800 Numbers
6. Stink Bugs will Reach Record Numbers in 2013
7. US Drug Watchdog Now Fears the Numbers of Transvaginal Mesh Product Failure Victims Will Grow and They Offer Victims the Names of the Best Lawyers-Who Will All Be Women
8. Treating disease by the numbers
9. Terrorism and the Olympics by-the-numbers: Analysis from UMD-based START
10. Numbers of blind are falling
11. Hepatitis C Causing Liver Damage in Greater Numbers: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 2014 Best Cheap Hosting USA is ... The site has recently announced that iPower ( http://www.best-cheap-hosting-usa.com/go/iPower/ ... people from around the world. , “iPower is one ... and is providing various kinds of useful products for ... on offering excellent customer service and a number of ...
(Date:10/22/2014)... 22, 2014 Lintelus, Inc., an event ... President of Sales, will be speaking on the subject ... Expo on October 28, at the Holiday Inn in ... booth as well as a Tech Demo at 12:45pm, ... create a more engaging event experience. , The Annual ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, 2014 (HealthDay ... only about half as likely as white women to become ... and the racial disparity persists even when donor eggs are ... patients became pregnant after IVF, compared to about 17 percent ... over two years to tease out the impact of race, ...
(Date:10/22/2014)... 2014 (HealthDay News) -- Measures taken by Firestone officials ... Liberia may have limited the spread of the disease ... The Firestone Natural Rubber Co. provides health services to ... nearby densely populated communities. Between Aug. 1 and ... cases among those 80,000 people. That incidence rate of ...
(Date:10/20/2014)... With a mere 19 days to November 4, ... fundraising stop at the  Law Offices of Dan ... debate last night with his opponent Gov. Rick Scott, ... seven minutes because Crist had an electric fan underneath ... one word: "weird." , Before touching on his well-known ...
Breaking Medicine News(10 mins):Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3
... Industry often advertises during shows watched by typical U.S. ... -- Cable TV shows that attract a significant proportion ... most ads for alcohol, new research has found. , ... 600,000 ads for alcohol that aired on cable TV ...
... a reduced risk of stroke afterwards , FRIDAY, Aug. ... longest-running study yet confirm that surgery is better than ... the carotid artery, the largest vessel carrying blood to ... surgical patients had about half the rate of strokes ...
... ... discusses how to integrate the color blue for to calm the body and clear the ... professional communications. , ... 29, 2009 -- ColorAlchemy is featured on HeartandHome radio show (heartandhomehealing.com/upcoming_shows.htm) and discusses how to ...
... Officials at ... applauding the recent TIME magazine cover story that reveals exercise won,t help you lose weight ... ... at Diet-to-Go, a national leader in deliciously healthy, ready to heat and eat meals, ...
... , MORRISTOWN, N.J., Aug. 28 ... specialty pharmaceutical company, today announced that its subsidiary, Watson Laboratories, ... and Drug Administration (FDA) on its Abbreviated New Drug Application ... women ages 17 and above, as well as for prescription ...
... fiber to ward off the disease , FRIDAY, Aug. 28 ... and dairy products should not boost her risk for breast ... been debated as either boosting or reducing the risk of ... new research, scientists could not conclude that meat, eggs or ...
Cached Medicine News:Health News:Alcohol Ads on Cable TV Reach Young Audiences 2Health News:Alcohol Ads on Cable TV Reach Young Audiences 3Health News:Surgery Better Than Angioplasty for Narrowed Neck Artery 2Health News:Surgery Better Than Angioplasty for Narrowed Neck Artery 3Health News:ColorAlchemy is Featured on HeartandHome Radio Show and Shares the Secret Color for Instant Calm and Clarity 2Health News:ColorAlchemy is Featured on HeartandHome Radio Show and Shares the Secret Color for Instant Calm and Clarity 3Health News:ColorAlchemy is Featured on HeartandHome Radio Show and Shares the Secret Color for Instant Calm and Clarity 4Health News:Diet-to-Go Asks: Isn't it TIME You Listened to the Facts About Weight Loss? 2Health News:Diet-to-Go Asks: Isn't it TIME You Listened to the Facts About Weight Loss? 3Health News:Watson Pharmaceuticals Receives FDA Approval for Generic PLAN B(R) for Over-the-Counter Use 2Health News:Meat, Dairy Won't Up Odds for Breast Cancer 2Health News:Meat, Dairy Won't Up Odds for Breast Cancer 3
(Date:10/22/2014)... , Oct. 22, 2014  Rescheduling of ... transformation in the pain market, according to a ... Inc., a firm providing market research and consultation ... Photo - http://photos.prnewswire.com/prnh/20141021/153440 ... change for hydrocodone combination products from Schedule III ...
(Date:10/22/2014)... Calif. , Oct 22, 2014 Antigen ... Irvine, California , announced the receipt of ... Business Innovation Research award (SBIR) from the National Institute of Dental ... fund the development of a Pan-HIV Protein Microarray Chip, ... HIV-1 and HIV-2 subtypes and aid in the development ...
(Date:10/22/2014)... Oct. 22, 2014 Moms are ready to ... for themselves and their kids, according to the results ... & Fitness Go Mobile for Moms, the latest installment ... the number 1 pregnancy and parenting web and mobile ... percent of moms surveyed say they can,t think of ...
Breaking Medicine Technology:Hydrocodone: Rescheduled, Repositioned & Reinvented 2Hydrocodone: Rescheduled, Repositioned & Reinvented 3Biomarker Discovery Company, Antigen Discovery Inc., Awarded an NIH Phase I Small Business Innovation Research Grant to Develop a Pan-HIV Protein Microarray Chip 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4
... OAKS, Calif., Sept. 8, 2011 Amgen (NASDAQ: ... Conference on Tuesday, Sept. 13, 2011 at the Grand Hyatt ...  Jim Daly, senior vice president of North America Commercial Operations ... be accessed from the Events Calendar on Amgen,s website, ...
... 2011 Positive results from the initial Phase 1 clinical ... the Sanaria® PfSPZ Vaccine are published today in the online ... "This is the first indication that a highly effective ... eliminate Plasmodium falciparum malaria in geographically defined areas ...
Cached Medicine Technology:Initial Trial of Sanaria's Malaria Vaccine Yields Positive Results 2Initial Trial of Sanaria's Malaria Vaccine Yields Positive Results 3Initial Trial of Sanaria's Malaria Vaccine Yields Positive Results 4
... a single lumen or dual lumen catheter. ... ,Trac-Wedge™ device, and patient label with ... label. Dual swivel elbow kits do not ... systems are latex-free. , ...
... Minimize Patient Trauma and Increase Staff ... Kits (10 Fr, 12 Fr, 14 Fr, ... Depth-Marked Suction Catheters with Contro-Vac Valves and ... the potential for inflammation,during suctioning. Each catheter ...
SAFE-T-VAC Coil Packed Suction Catheters Kits, Sterile without Solution...
Sterile, Coil Packed Suction Catheter Mini Tray with (2) Walleted SAFESKIN PURPLE NITRILE Latex-Free Exam Gloves...
Medicine Products: