Navigation Links
Counting copy numbers characterises prostate cancer
Date:4/4/2013

Non-invasive 'liquid biopsies' can find metastatic or recurrent prostate cancer, in a low cost assay suitable for most healthcare systems, finds research published in BioMed Central's open access journal Genome Medicine. Genomic signatures of prostate cancer, isolated from plasma DNA, display abnormal copy numbers of specific areas of chromosomes. It is even possible to separate out patients who develop resistance against hormone deprivation therapy, which is the most common form of treatment in men with metastatic prostate cancer.

Prostate cancer is the most common cancer in men with 2.6 million new cases being diagnosed each year in Europe alone. PSA testing means that many cancers are found and treated at an early stage. However some men still have recurrent or metastatic disease despite treatment which appears to have destroyed the cancer.

Testing for metastasis remains a challenge requiring repeated biopsies. A team of researchers from the Medical University of Graz and the University Medical Center Hamburg Eppendorf investigated the possibility of testing for the presence of disease in a less invasive manner.

Using whole genome analysis of plasma DNA, plus targeted sequencing of genes known to be involved in prostate cancer, the team discovered that there are abnormal copy numbers (some losses, some gains) of specific prostate cancer related sequences. Although this was a small scale study the presence of prostate cancer was flagged by copy number mistakes in sequences such as NCOA2, PHLPP1 and TMPRSS2-ERG. As expected each person's cancer signature was slightly different, however patients whose cancer did not respond to castration all had increased copy numbers of genes for the androgen receptor (AR).

Discussing the value of this research Dr Jochen Geigl and Prof Michael Speicher, who led this study commented, "The simplicity and low cost of 'liquid biopsies' make these genetic tests an attractive alternative to traditional biopsies. Better genetic information resulting from these tests may also help target treatment, especially of castration-resistant prostate cancer and aid personalised therapy in the clinic."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Related medicine news :

1. MileAgeAds.com Invites Blog Owners in Accounting Niche to their Ad Network
2. 1 week and counting: Dont cut the research that fuels the US economy
3. Plastic Surgery up 5% in 2012 - Celebrity Doctor Looks Behind the Numbers
4. HealthCompare Urges the Newly Increasing Numbers of 1099 Employees to Seek Health Insurance Coverage They Need
5. Five Companies and Agencies Celebrate Award-Wins Showcasing Their Advertising Expertise with Vanity 800 Numbers
6. Stink Bugs will Reach Record Numbers in 2013
7. US Drug Watchdog Now Fears the Numbers of Transvaginal Mesh Product Failure Victims Will Grow and They Offer Victims the Names of the Best Lawyers-Who Will All Be Women
8. Treating disease by the numbers
9. Terrorism and the Olympics by-the-numbers: Analysis from UMD-based START
10. Numbers of blind are falling
11. Hepatitis C Causing Liver Damage in Greater Numbers: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2017)... ... July 27, 2017 , ... HIMSS ... will keynote Day 2 of the HIMSS Healthcare Security Forum, the nation’s foremost ... Sheraton Boston Hotel, Sept. 11-13, 2017. , Daniel will deliver his keynote, The ...
(Date:7/26/2017)... Madison, WI (PRWEB) , ... July 26, 2017 ... ... launch of Talent Management Solutions as part of their continued efforts to provide ... retain, and develop the best IT resources and build dynamic, high-performing teams to ...
(Date:7/26/2017)... , ... July 27, 2017 , ... It's time to sign up for ... with great benefits," says Kathy Heshelow, founder of Sublime Naturals and author of numerous books ... essential oil each month, mailed by the 5th. , Two items are ...
(Date:7/26/2017)... ... July 26, 2017 , ... IDC-Eating Disorder Care ... for the treatment program located in Royal Oak, Michigan. IDC, formerly known ... are focused on providing the highest standards in the field of eating disorder treatment ...
(Date:7/26/2017)... ... July 26, 2017 , ... The number of adults 65 ... States, but ways to improve asthma control in the population are not well described. ... (JACI: In Practice), an official journal of the American Academy of Allergy, Asthma & ...
Breaking Medicine News(10 mins):
(Date:7/15/2017)... 2017 Enterin Inc., a Philadelphia ... (PD), today announced the completion of a $12.7 million Series ... III, as well as the participation of existing investors. ... have the support of New Ventures III and our current ... of the potential of our platform technology to transform the ...
(Date:7/14/2017)... , July 13, 2017 It should come as ... is in the midst of a crippling opioid ... since 1999, the number of overdose deaths from opiate-based medications ... over half a million dead from 2001 to 2015". During ... and hydrocodone has similarly quadrupled, drawing a compelling link between ...
(Date:7/13/2017)... , July 13, 2017 RK Logistics Group, ... of Pharmacy certification for its Fremont, CA ... solutions in the Tri-Valley and San Jose ... City of Fremont , with its Fremont Innovation ... to provide such a powerful resource to the hundreds of ...
Breaking Medicine Technology: