Navigation Links
Compounds outsmart solid tumors' malfunctioning machinery
Date:7/17/2013

SAN ANTONIO (July 17, 2013) Molecular biologists in the School of Medicine at The University of Texas Health Science Center San Antonio have found a novel way to fine-tune the activity of cells' protein-disposing machinery, with potentially cancer-fighting effects.

This machinery, the proteasome, is deregulated in cancer. Agents called protease inhibitors are viewed as potential anti-cancer therapies, but they indiscriminately curb proteasome activity, which also includes protein recycling. Such strategy is effective to kill cells in aggressive blood cancers but leads to drug resistance and excessive toxicity in solid tumors.

Fine-tuning

The new strategy may change that. By basically outsmarting the cell's machinery, compounds called allosteric regulators are able to fine-tune the proteasome actions instead of block them. "The result is that cell lines from solid tumors, which are resistant to existing therapy, are sensitive to these agents," said Pawel Osmulski, Ph.D., assistant professor of molecular medicine at the Health Science Center. He and Maria Gaczynska, Ph.D., associate professor of molecular medicine, co-authored a report in Molecular Pharmacology that provides a basis for this approach.

'Highly beneficial'

Deregulation of the proteasome's actions is noted in cancer or during aging and contributes to intracellular pathologies. "It is easy to envision that precise adjusting of the proteasome activities with therapeutic molecules would be highly beneficial in many human conditions," Dr. Osmulski said.

Inhibition and activation

"Allosteric regulators are better than proteasome-affecting agents used in clinics because they do not induce classical drug resistance," Dr. Gaczynska said. "They bind to sites on the proteasome molecule used by natural regulatory proteins. They are more specific and are not restricted to proteasome inhibition but can activate the proteasome under certain conditions."

The new strategy was serendipitously found during experiments with rapamycin, a drug that in a highly publicized study by the UT Health Science Center's Barshop Institute for Longevity and Aging Studies was found to extend life span in mice.

Potential

The Molecular Pharmacology report and follow-up studies describe the unexpected and highly desired effects that rapamycin and similar compounds elicit on the proteasome. Based on these studies, it would be possible to design a new line of proteasome regulators with anti-cancer properties, Drs. Osmulski and Gaczynska said. This work is in progress in their laboratory. Drs. Osmulski and Gaczynska are affiliated with the Barshop Institute and with the Cancer Therapy & Research Center at The University of Texas Health Science Center San Antonio.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Related medicine news :

1. Natural Sciences Repository Publishes Chromatography and Acidic Compounds Resources
2. Compounds activate key cancer enzyme to interfere with tumor formation
3. Taiho Pharmaceutical unveils data on 8 novel anticancer compounds
4. Dirty Drugs and We Know It: Attorneys at Console & Hollawell Comment on ISMP Survey Relating to Contaminated Drug Compounds and the Risks to Consumers
5. Advance in re-engineering photosynthesis to make drugs, compounds or ingredients
6. NIH-supported researchers identify new class of malaria compounds
7. Ginger compounds may be effective in treating asthma symptoms
8. Many solid tumors carry genetic changes targeted by existing compounds
9. Some Whooping Cough Strains Now Outsmarting Vaccine
10. AvePoint Outsmarts the Chaos with Interactive Meetings App for Microsoft SharePoint 2013
11. OHSU research highlights promising strategy to help vaccines outsmart HIV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2017)... ... 2017 , ... Wondering where to go this Valentine's Day? Well, there is ... a romantic, lobster feast in the comfort of your own home. Lobster Gram is ... will be featured until February 15th, 2017. , Romantic Dinner one is Lobster ...
(Date:1/14/2017)... Glendale, CA (PRWEB) , ... January 13, 2017 ... ... published on Body and Soul, incorporating a magnesium-rich Mediterranean diet may lower the ... Leon Café and Lounge notes that the many health and wellness benefits linked ...
(Date:1/13/2017)... ... January 13, 2017 , ... The 18th European Congress: Perspectives in Lung ... 3-4, 2017. This Congress is expertly designed to meet the educational needs of ... lung cancer. , Chaired by Dr. Giorgio V. Scagliotti, Professor of Oncology at the ...
(Date:1/13/2017)... ... ... Pahrump, Nev., used an unsavory medical experience to think of a way to improve the ... for a half year due to lazy bladder," he said. "Keeping these things on my ... to do this." , He then designed and created a prototype of the FOLEY CRADLE, ...
(Date:1/13/2017)... (PRWEB) , ... January 13, 2017 , ... Friday, January ... area of the game room, increasing the size of the location to 90,000 square ... an 8-hole mini golf course that takes customers on an educational tour of the ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)...   JDRF , the leading global organization ... to announce that after more than a decade ... Medicaid Services (CMS) has recognized continuous glucose monitoring ... in making diabetes treatment decisions as durable medical ... for coverage under Medicare. JDRF has been the ...
(Date:1/13/2017)... 13, 2017 Research and Markets has announced ... Analysis" report to their offering. ... Cystic fibrosis (CF) is a progressive genetic ... cystic fibroses transmembrane conductance regulator (CFTR) gene from both parents. The ... cells, and result in the buildup of a thick and sticky ...
(Date:1/13/2017)... Jan. 12, 2017  Albertsons Companies proudly announces ... for Health Care (ACHC) for its specialty care ... and drug chain with this accreditation and its ... Accreditation by ACHC reflects Albertsons Companies, ... facilitate a higher level of performance and patient ...
Breaking Medicine Technology: