Navigation Links
Compound shows promise against intractable heart failure
Date:2/11/2010

A chemical compound found normally in the blood has shown promise in treating and preventing an intractable form of heart failure in a mouse model of the disease, report researchers at the University of Illinois at Chicago College of Medicine.

The study is published in the February issue of Circulation.

More than five and half million Americans have heart failure, according to the American Heart Association, and 670,000 new cases are diagnosed each year.

In heart failure the heart is unable to pump effectively and cannot meet the body's need for blood and oxygen. It is really two diseases, each with about half of all patients, says Dr. Samuel Dudley, professor of medicine and physiology at UIC and chair of the section of cardiology. Systolic heart failure occurs when the heart can no longer contract effectively. In diastolic heart failure, the heart is unable to relax after contraction.

"Although we have a number of treatments for systolic heart failure, there are no approved treatments at all for diastolic heart failure, a deadly disease with a 60 percent mortality rate five years after diagnosis," said Dudley.

Hypertension is the cause in the overwhelming majority of diastolic heart failure cases.

"We know from previous studies that nitric oxide (NO) is necessary for blood vessel relaxation," said Dudley, "and that hypertension can lead to a decrease of NO in blood vessels."

Dudley and his colleagues knew that -- in blood vessels -- the problem was depletion of a chemical called tetrahydrobiopterin, or BH4, which is needed for the tissues to make NO.

"We decided to try thinking of the heart as a huge blood vessel that might also be unable to make the NO it needed due to long-term hypertension, and see if adding BH4 could make a difference," said Dudley.

They found that by giving mice BH4 they were not only able to prevent diastolic heart failure from developing, but to
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Coloring Compound in Fruits, Veggies May Cut Colon Cancer Risk
2. Sugary Sodas High in Diabetes-Linked Compound
3. Red wine compound shown to prevent prostate cancer
4. CutisPharma Selected by Medicine Shoppe International as Preferred Vendor for Unit-of-Use Compounding Kits
5. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
6. VioQuest to Present Data on Oncology Compounds VQD-002 and Lenocta(TM) at AACR-NCI-EORTC International Meeting
7. Organon Signs an Exclusive, Worldwide Licence Agreement on Advanced Antithrombotic Compounds With Endotis Pharma
8. Primus Innovations and Health Robotics Launch Strategic Partnership to Accelerate Transformation in Chemotherapy Compounding
9. Cannabis Compound May Stop Metastatic Breast Cancer
10. Prostate Cancer Treatments Often Compound Existing Health Problems
11. Pharmacopeia and GlaxoSmithKline Collaboration Identifies Two Additional Lead Compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Colic affects about one in five infants in the ... during the first several months after birth. Research into ... promise; however, the April 1, 2014 issue of the ... on a study, "Probiotics and Infant Colic," concluding that ... for infant colic did not reduce crying or ...
(Date:4/17/2014)... of Medicine (BUSM) have discovered that the anti-seizure ... model. The findings, reported in the American ... lead to more effective treatments for alcoholism. , ... leading causes of illness and death in the ... limiting the productivity of workers and necessitating huge ...
(Date:4/17/2014)... Calif.) An international team led by researchers at ... complex, which plays a key role in cell division, ... This is the first time the complex has been ... make cyclin B1/Cdk1 an excellent target to control cellular ... The research was published online today in the journal ...
(Date:4/17/2014)... by Cesar A. Arias, M.D., Ph.D., at The University ... identified a new superbug that caused a bloodstream infection ... April 17 issue of The New England Journal ... of a class of highly-resistant bacteria known as methicillin-resistant ... major cause of hospital and community-associated infections. The superbug ...
(Date:4/17/2014)... ribbon representing a disease. A pink ribbon is well known ... think of with lung cancer?, Although white has been identified ... black may be the only one they think fits., A ... smokers between the ages of 51 to 79 years old, ... these patients, the emotional toll it can have and how ...
Breaking Medicine News(10 mins):Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2Health News:Dual role: Key cell division proteins also power up mitochondria 2Health News:New MRSA superbug emerges in Brazil 2Health News:Unraveling the 'black ribbon' around lung cancer 2
... Solutions Founder, Joins Schooner Healthcare Consulting Team, ... RN, CCM, a,leading thought leader in the case ... "I am delighted that Ms. Craig, architect of ... as Chief Knowledge Officer,",notes Mr. Garry Carneal, SHS ...
... may explain why some nonsmokers contract the disease, study says ... variant increases the risk of lung cancer, even in nonsmokers, ... the alpha1-antitrypsin gene double someones risk of developing lung cancer, ... help explain why some nonsmokers develop the disease, said study ...
... TransforMED Names Kevin Hutchinson to Inaugural Board of ... president and chief,executive officer, Kevin Hutchinson, has been ... for TransforMED LLC, a wholly owned subsidiary of ... provide,support and consulting services to primary care physicians ...
... Dermatology Clinic (ADC),Tustin announces today the appointment of Dr. ... Board of the American College of,Veterinary Dermatology (ACVD). The ... is the decision making body for the specialty College.,This ... Dr.,Muse being a liaison between the ACVD Executive Board ...
... the June issue of the Journal of Dental Research ... and Craniofacial Research (NIDCR) in expanding the understanding of, ... NIDCR Director Lawrence A. Tabak and Deputy Director A. ... the traditional research community can be best positioned for ...
... May 27 Family,Health International,s staff will make ... number of new publications at the annual,Global Health ... Shoreham Hotel in Washington, DC., Join FHI ... public health,impact of the recent violence in Kenya, ...
Cached Medicine News:Health News:Acuity Workflow Solutions(TM) Enhances Medical Case Management Process: 2Health News:Common Genetic Variant Tied to Lung Cancer Risk 2Health News:Common Genetic Variant Tied to Lung Cancer Risk 3Health News:Prematics CEO Joins Initiative to Advance More Coordinated, Connected Health Care 2Health News:Prematics CEO Joins Initiative to Advance More Coordinated, Connected Health Care 3Health News:Animal Dermatology Clinic Tustin Announces Dr. Russell Muse's Appointment as the Member-At-Large for the Executive Board of the American College of Veterinary Dermatology 2Health News:NIDCR strategies for future scientific success 2Health News:Family Health International Featured at Global Health Council Conference 2Health News:Family Health International Featured at Global Health Council Conference 3Health News:Family Health International Featured at Global Health Council Conference 4
(Date:1/15/2014)... , Jan. 15, 2014 ... research report is available in its ... Markets and Technologies for Advanced Drug ... of Administration ...
(Date:1/14/2014)... , Jan. 14, 2014 InformEx, North America,s ... of high-value chemistry, will hold the 30 th edition ... Convention Center from January 21-24. (Logo: ... from top pharmaceutical, fine chemical and specialty chemical companies will ...
(Date:1/14/2014)... , Jan. 14, 2014   NuAire , a manufacturer of ergonomically ... with Hitachi Koki of Japan ... North America . NuAire will utilize its network of ... Canada to offer assistance in application use, ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2NuAire announces sales and service of Hitachi Koki centrifuges in North America 2
... Technologies®, a leading provider of radio frequency identification ... a three-year strategic partnership with HPSI® Purchasing Services ... security solutions for the long-term care market. ... Alert® Wandering Management, Quick Response® Wireless Call systems ...
... 2011 ThermoGenesis Corp. (NASDAQ: KOOL ), a ... store adult stem cells, said today that Mahendra Rao, M.D., ... "Dr. Rao has been appointed to a position ... to resign as a director of the Company, pursuant to ...
Cached Medicine Technology:ThermoGenesis Names Former Applied Imaging CEO Robin Stracey to Board of Directors, Replacing Dr. Mahendra Rao 2ThermoGenesis Names Former Applied Imaging CEO Robin Stracey to Board of Directors, Replacing Dr. Mahendra Rao 3
All the advantages of Dr. Roy P. Finney's classic stent design with an open tip....
... Chlamydia Culture Confirmation provides ... of intracellular inclusions (elementary ... in tissue culture. ... in this kit is ...
... direct fluorescent assays (DFA) kit ... to provide clear, easy-to-read and ... Chlamydia antigens are detected ... the C. trachomatis major outer ...
... rubella IgG antibody in women prior to ... possible rubella viral infection during pregnancy. ... reduced the incidence of rubella epidemics, but ... of immune status, especially for women of ...
Medicine Products: