Navigation Links
Commonly used drug can limit radiation damage to lungs and heart for cancer patients
Date:4/21/2013

art soon after irradiation. So these new findings show that ACE inhibition decreases RILT by reducing direct acute heart damage."

Irradiating the heart leads to the development of fibrosis, which stiffens it, and this in turn leads to problems in the relaxation of the left ventricle. Due to this, blood flow from the lungs into the heart is hindered, and this can cause pulmonary damage. However, after treatment with captopril, the researchers observed an improvement in ventricular relaxation in the irradiated hearts.

Dr Van der Veen and her colleagues are now collaborating with a research group from the Mayo Clinic, Rochester, Minnesota (USA), in order to design a randomised clinical trial where patients who are treated with radiation to the thoracic area including the heart will be treated with either an ACE inhibitor or a placebo after irradiation.

Much progress has been made in radiation treatment over recent years, but in breast cancer, for example, most women still receive high doses to the heart, and this is known to increase the risk of heart disease. A recent study [3] has shown that for each Gray (Gy) [4] of radiation, there is a 7.4% increase in the occurrence of a subsequent major coronary event.

"Given that most women will receive a dose of between 1 and 5 Gray, and that the dangers are even greater for women with existing cardiac risk factors or coronary disease, this is still a big problem," said Dr Van der Veen.

Rats were chosen for the study because, unlike mice, they are big enough for researchers to be able to irradiate different part of the lungs and heart. The researchers believe that the way in which ACE inhibition works in both animals and humans is similar.

"We are confident that our clinical trial will see the same protective effect in humans as that which we have seen in rats," said Dr Van der Veen. "We will also now begin to study the late effects of ACE inhibition on RILT to see whe
'/>"/>

Contact: Mary Rice
mary.rice@riceconseil.eu
European Society for Radiotherapy and Oncology (ESTRO)
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Commonly used cholesterol calculation underestimates heart disease danger for many
2. UV Flash Infection Control Unit Steps onto the Healthcare Market, with a Quick and Effective Way to Disinfect Virtually any Item Commonly Found in Medical Facilities
3. New UAlberta research shows commonly prescribed medications could have adverse effects
4. Condition Commonly Seen in Aging May Alter Brain Function
5. Commonly used painkillers may protect against skin cancer
6. Memory, the adolescent brain and lying: The limits of neuroscientific evidence in the law
7. Career Confidential Announces Their Cover Letter Podcast Viewing Complimentary for a Limited Time
8. Asia-Pacific Seasonal Influenza Vaccine Market to 2018 - Positive Impact of Government Support Offset by Limited Production Capacity : MarketResearchReports.biz
9. Ability to think about thinking not limited to humans
10. iPad Ultra Thin Aluminum Bluetooth Keyboard Case Released by iGearUnlimited
11. Kwiksure Discovers Uses and Limitations of Vehicle GPS in Hong Kong
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... (HealthDay News) -- Children and teens who lose a parent ... adulthood, a new study suggests. People who were children ... greater risk of death during the study period than those ... to the report. Although the study found an association ... premature death, it wasn,t designed to prove cause-and-effect. Also, ...
(Date:7/23/2014)... 2014 SafeUseNow? , a ... developed by Principled Strategies , today announced ... California . Utilizing SafeUseNow’s patent-pending risk model, Partnership ... misusing and abusing controlled substance drugs, particularly prescription ... its members. , The agreement with Partnership HealthPlan ...
(Date:7/23/2014)... Texas (PRWEB) July 23, 2014 ... 2020?, provides key market data on the North ... value, in millions of US dollars, and volume ... dollars), within market categories Cardiac Valve Repairs and ... shares and distribution shares data for each of ...
(Date:7/23/2014)... By using brightly hued dyes, George Mason University ... proteins touch each other, possibly leading to new ... lung disease. , George Mason researchers unraveled the ... touch each other. "One protein interlocks with another ... and this sends a signal down the line ...
(Date:7/23/2014)... 2014 Splashtop , a ... that it has joined the RSA Ready Technology ... Enterprise and RSA SecurID® multi-factor authentication solution from ... , Splashtop also announced that leading Japanese ... Splashtop Enterprise, the industry’s only on-premise remote access ...
Breaking Medicine News(10 mins):Health News:Parent's Death May Raise Risk of Early Death for Grown Children, Study Suggests 2Health News:Partnership HealthPlan of California Signs Program Participation Agreement with SafeUseNow 2Health News:Partnership HealthPlan of California Signs Program Participation Agreement with SafeUseNow 3Health News:Partnership HealthPlan of California Signs Program Participation Agreement with SafeUseNow 4Health News:Cardiovascular Prosthetic Devices Market in North America to 2020 Report Available at MarketOptimizer.org 2Health News:Cardiovascular Prosthetic Devices Market in North America to 2020 Report Available at MarketOptimizer.org 3Health News:Cardiovascular Prosthetic Devices Market in North America to 2020 Report Available at MarketOptimizer.org 4Health News:Cardiovascular Prosthetic Devices Market in North America to 2020 Report Available at MarketOptimizer.org 5Health News:Researchers unlock the protein puzzle 2Health News:Splashtop Joins RSA® Ready Technology Partner Program; Announces Adoption by Leading Japan Insurance Group Nissei Asset Management 2Health News:Splashtop Joins RSA® Ready Technology Partner Program; Announces Adoption by Leading Japan Insurance Group Nissei Asset Management 3
... , COLUMBUS, Ohio, Dec. 14 Skilled nursing ... services in order to deal with a 92 percent increase in ... $12.01 per bed per day, scheduled for December 15. The ... to the state each month, or $210,240 per year, for a ...
... , DENVER, Dec. 14 On December 9, 2009, ... government,s position that private insurance companies are "plans" and therefore subject ... have held that contracts issued by insurance companies may be subject ... Frost is the first case an insurance company itself has ...
... study finds, , MONDAY, Dec. 14 (HealthDay News) -- Here,s good ... or two of java: Coffee and tea consumption may decrease the ... of an Australian study that also found the more coffee you ... was associated with a 7 percent reduction in the risk of ...
... age to physical, mental functioning , , MONDAY, Dec. 14 ... tend to live longer than those who look older than ... from research that involved 1,826 Danish twins, aged 70 and ... had their faces photographed. Three groups of volunteers looked at ...
... , AAHC Urges Congress to Ensure ... Congressional leaders must ensure that health reform includes a ... of an integrated, coordinated national health workforce policy, according to ... of Academic Health Centers (AAHC). "With each step in ...
... Dec. 14 Anthem Blue Cross announced today that the ... the Tri-County Commercial contract renewal to provide Medi-Cal benefits to ... is the second largest expansion and the third largest renewal ... contract allows Anthem Blue Cross, State Sponsored Business to continue ...
Cached Medicine News:Health News:Survey Shows Tax Increase Forcing Ohio Skilled Nursing Facilities to Make Cuts 2Health News:Survey Shows Tax Increase Forcing Ohio Skilled Nursing Facilities to Make Cuts 3Health News:Insurance Now Subject to Federal Jurisdiction 2Health News:Coffee, Tea Might Stave Off Diabetes 2Health News:Coffee, Tea Might Stave Off Diabetes 3Health News:Looking Younger Than Your Age May Mean Longer Life 2Health News:Health Reform Needs Enforceable National Workforce Strategy 2Health News:Anthem Blue Cross Wins Third Largest Medicaid Managed Care Contract Renewal in the Country 2
(Date:7/23/2014)... -- Use of Risk Evaluation and Mitigation Strategies (REMS) ... entry results in $5.4 billion in lost savings annually, ... by economic consulting firm Matrix Global Advisors ... Required by the Food and Drug Administration (FDA) ... intended to improve drug safety by ensuring that the ...
(Date:7/23/2014)... 2014 /PRNewswire-iReach/ -- Top Staten Island Pediatrician Dr. ... on article, which discusses tips for parents about pool safety ... According to US News article, "Drowning ... American children aged 1 to 4, and can occur in ... expert in the article says that watching a child in ...
(Date:7/23/2014)... , July 23, 2014 PositiveID Corp. (OTCQB: ... , is an emerging player in the ... for bio-threat detection and rapid medical testing. The ... (Microfluidic Bio-agent Autonomous Networked Detector), was developed under ... ("DHS") Science & Technology directorate, and $30 million ...
Breaking Medicine Technology:New Analysis Finds $5.4 Billion In Annual Lost Savings From Strategies Geared Toward Delaying Generic Drug Entry 2Premier Staten Island Pediatrician Dr. Michael Gabriel Comments On Article Discussing Pool Safety Tips for Parents 2PositiveID Analyst Inspection: Emerging Contender in BioThreat Detection - First Ever Revenue Guidance and Backlog Position Company for Increased Visibility and Traction - by SmallCapTraders.com 2
... Oramed,Pharmaceuticals, Inc. (OTCBB: ORMP.OB) ( http://www.oramed.com ), ... that its abstract, entitled "Open,Label Study to ... of Five Oral Insulin Formulations in Healthy,Subjects," ... upcoming 44th Annual,Meeting of the European Association ...
... Industry Leader with Strong Clinical Research Relationships and ... Organizations to Lead Commercialization, SANTA CLARA, Calif., ... a cardiac diagnostic and services company, today,announced that ... president. Mr.,Renz will oversee the Company,s commercialization effort, ...
Cached Medicine Technology:Oramed Pharmaceuticals Chosen to Present Oral Insulin Trial Results at EASD Conference (September 7-11, Rome) 2Vincent W. Renz Joins NewCardio as President 2Vincent W. Renz Joins NewCardio as President 3Vincent W. Renz Joins NewCardio as President 4
For the direct quantitative determination of low density lipoprotein cholesterol (LDL-C) in human serum or plasma. For in vitro diagnostic use only....
Storage temperature: 15 - 30C, linearity: 0 - 20 mg/dL, expected value: male: 3.0 - 7.0 mg/dL and female: 2.2 - 6.2 mg/dL. Available with calibrator and number of tests 125....
Intended for the quantitative determination of uric acid in serum or plasma. Reaction: endpoint. Wavelength: 520 nm. Linearity: 20 mg/dL (1190 mol/L). Single vial, dry powder reagent....
... A fully automated, random ... over 50 assays available ... tumor marker, therapeutic drug, ... testing can be performed ...
Medicine Products: