Navigation Links
Commonly used drug can limit radiation damage to lungs and heart for cancer patients
Date:4/21/2013

Geneva, Switzerland: Unavoidable damage caused to the heart and lungs by radiotherapy treatment of tumours in the chest region can be limited by the administration of an ACE inhibitor, a drug commonly used in the treatment of cardiovascular disease, a group of Dutch researchers have found. [1]

Common cancers such as breast, oesophagus, lung, and Hodgkin's lymphoma are frequently treated with radiotherapy, but the radiation dose that can be given safely is limited by the sensitivity of the health lung tissue which is also irradiated.

The lung is a particularly complex and sensitive organ and strategies for protecting it from radiotherapy damage, apart from limiting the dose given and, therefore, the efficacy of the treatment, are few. Presenting the research to the 2nd Forum of the European Society for Radiotherapy and Oncology (ESTRO) today (Sunday), Dr Sonja Van der Veen, MSc, from the University Medical Centre, Groningen, The Netherlands, said that she had set out with colleagues to see whether the use of an ACE inhibitor could protect against early radiation-induced lung toxicity (RILT). Previous studies had shown that damage to blood vessels can play an important role in the development of RILT [2], so the researchers irradiated the lungs, heart, or heart and lungs of rats and administered the ACE inhibiter captopril immediately after treatment. The rats' lung functions were then measured at two-weekly intervals.

"After eight weeks, when early lung toxicity is usually at its height, we found that captopril improved the rats' heart and lung functions, but we were surprised to find that this only occurred when the heart was included in the irradiation field," said Dr Van der Veen. "This was not due to protection of the lung blood vessels, which were equally damaged with or without captopril. So we investigated further and found that the captopril treatment improved the heart's function and decreased the level of fibrosis in the heart soon after irradiation. So these new findings show that ACE inhibition decreases RILT by reducing direct acute heart damage."

Irradiating the heart leads to the development of fibrosis, which stiffens it, and this in turn leads to problems in the relaxation of the left ventricle. Due to this, blood flow from the lungs into the heart is hindered, and this can cause pulmonary damage. However, after treatment with captopril, the researchers observed an improvement in ventricular relaxation in the irradiated hearts.

Dr Van der Veen and her colleagues are now collaborating with a research group from the Mayo Clinic, Rochester, Minnesota (USA), in order to design a randomised clinical trial where patients who are treated with radiation to the thoracic area including the heart will be treated with either an ACE inhibitor or a placebo after irradiation.

Much progress has been made in radiation treatment over recent years, but in breast cancer, for example, most women still receive high doses to the heart, and this is known to increase the risk of heart disease. A recent study [3] has shown that for each Gray (Gy) [4] of radiation, there is a 7.4% increase in the occurrence of a subsequent major coronary event.

"Given that most women will receive a dose of between 1 and 5 Gray, and that the dangers are even greater for women with existing cardiac risk factors or coronary disease, this is still a big problem," said Dr Van der Veen.

Rats were chosen for the study because, unlike mice, they are big enough for researchers to be able to irradiate different part of the lungs and heart. The researchers believe that the way in which ACE inhibition works in both animals and humans is similar.

"We are confident that our clinical trial will see the same protective effect in humans as that which we have seen in rats," said Dr Van der Veen. "We will also now begin to study the late effects of ACE inhibition on RILT to see whether it affords similar protection. We believe that our results suggest a promising strategy for shielding patients from radiation damage and improving their quality of life, while at the same time allowing them to receive a high enough dose to ensure the effective treatment of their cancer."

President of ESTRO, Professor Vincenzo Valentini, a radiation oncologist at the Policlinico Universitario A. Gemelli, Rome, Italy, said: "This study underlines the importance of translational research. The understanding of anti-cancer mechanisms, as well as of protective opportunities discovered in the experimental environment, is of upmost importance in the era of personalised medicine. This research provides further evidence of the importance of testing experimental theories in the clinical environment to the ultimate benefit of patients."


'/>"/>

Contact: Mary Rice
mary.rice@riceconseil.eu
European Society for Radiotherapy and Oncology (ESTRO)
Source:Eurekalert

Related medicine news :

1. Commonly used cholesterol calculation underestimates heart disease danger for many
2. UV Flash Infection Control Unit Steps onto the Healthcare Market, with a Quick and Effective Way to Disinfect Virtually any Item Commonly Found in Medical Facilities
3. New UAlberta research shows commonly prescribed medications could have adverse effects
4. Condition Commonly Seen in Aging May Alter Brain Function
5. Commonly used painkillers may protect against skin cancer
6. Memory, the adolescent brain and lying: The limits of neuroscientific evidence in the law
7. Career Confidential Announces Their Cover Letter Podcast Viewing Complimentary for a Limited Time
8. Asia-Pacific Seasonal Influenza Vaccine Market to 2018 - Positive Impact of Government Support Offset by Limited Production Capacity : MarketResearchReports.biz
9. Ability to think about thinking not limited to humans
10. iPad Ultra Thin Aluminum Bluetooth Keyboard Case Released by iGearUnlimited
11. Kwiksure Discovers Uses and Limitations of Vehicle GPS in Hong Kong
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... ... Mother Nature isn’t the only mom that loves the garden. Mothers everywhere love ... women with more than just a bouquet of flowers. Give mom, or any special ... Vibrant, Edible, Compact Plants from BrazelBerries: , For a gift that adds year-round color ...
(Date:5/4/2016)... ... May 04, 2016 , ... World ... the Everlasting Glove, a sports invention that aids in the improvement of the ... industry is worth $9 billion," says Scott Cooper, CEO and Creative Director of ...
(Date:5/4/2016)... CO (PRWEB) , ... May 04, 2016 , ... ... of observational and interview techniques, seeks to add a deeper understanding of the ... strengths and weaknesses, and each answers different yet important questions. , In a ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... ... children has donated 100 of its innovative kicking trainers to St. Jude Children’s ... The SOCKIT is a durable, lightweight rubber band designed to teach children how ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... ... million in grants to identify, fund and implement ideas aimed at improving care ... Medicaid. , “Part of our vision for Trinity Health is to drive ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)...  Compass Diversified Holdings (NYSE: CODI ) ... leading middle market businesses, announced today its consolidated operating ... First Quarter 2016 Highlights , Generated ... "Cash Flow") of $13.6 million for the first quarter ... million for the first quarter of 2016; , ...
(Date:5/4/2016)... According to a new market ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... (BCI) market  is expected to reach a value of ... expand at a CAGR of 14.9 % during the ... BCI device provides collaboration between the brain and an ...
(Date:5/4/2016)... , May 4, 2016  It,s time for an upgrade. There are many medical ... brilliant 3.5 inch LCD, the illustrious DVMAXX HD  offers unparalleled connectivity and functionality.  ... as a world class manufacturer of innovative technology.  Photo - http://photos.prnewswire.com/prnh/20160503/363416 ... ... ...
Breaking Medicine Technology: