Navigation Links
Combined inhibition of VEGF and c-MET can decrease metastasis
Date:2/24/2012

  • Inhibition of VEGF increased c-MET expression in tumors.
  • Invasion and metastasis were blocked by inhibition of VEGF plus c-MET.
  • Dual VEGF/c-MET inhibitors are in late-stage clinical trials.

PHILADELPHIA Dual inhibition of vascular endothelial growth factor and c-MET signaling inhibited tumor invasion and metastasis in a laboratory model of pancreatic neuroendocrine cancer, according to a paper published in Cancer Discovery, the newest journal of the American Association for Cancer Research.

"Inhibition of VEGF signaling plus c-MET signaling results in a synergistic effect on tumors that leads to slowing of tumor growth and decreased invasiveness and metastasis," said lead researcher Donald M. McDonald, M.D., Ph.D., a professor at the University of California San Francisco Comprehensive Cancer Center.

Previous laboratory research had shown that inhibition of VEGF signaling with agents like bevacizumab or sunitinib can give rise to a number of side effects including increased tumor invasion and metastasis.

What was not known was whether anti-VEGF therapy results in elevated c-MET expression, which has been previously shown to promote tumor cell invasiveness and metastasis. To determine this, McDonald and colleagues conducted a two-phase laboratory study. They treated mice engineered to develop pancreatic neuroendocrine tumors with an anti-VEGF antibody, which reduced tumor size but increased invasiveness and metastasis. This treatment also increased tumor hypoxia and expression and activity of c-MET.

However, when both VEGF and c-MET signaling were inhibited simultaneously, there was a reduction in invasion and metastasis. The researchers tested three c-MET inhibitors: crizotinib and PF-04217903, which target c-MET but not VEGF signaling, and cabozantinib, a dual inhibitor that blocks VEGF and c-MET signaling.

McDonald said they conducted their initial study in neuroendocrin
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Combined oral contraceptive pill helps painful periods
2. PSA testing, combined with other relevant patient data can reduce unnecessary prostate biopsies
3. Combined arterial imaging technology reveals both structural and metabolic details
4. Novel combined therapy extends life, diminishes pain in brain cancer patients
5. Ultrasound combined with pre-operative MRI is cost effective in evaluating rotator cuff tears
6. Combined imaging technologies may better identify cancerous breast lesions
7. Combined BRAF-targeted and immunotherapy shows promise for melanoma treatment
8. Vandetanib shows clinical benefit when combined with docetaxel for lung cancer
9. New Laser Technology Combined with Manual Physical Therapy Offer Pain Relief to Chronic Pain Sufferers
10. Singapore Performs Asia's First Combined Heart and Liver Transplant
11. Promega Maxwell 16 IVD System CE Marked to the European Union IVD Directive Delivers Combined Solution for Infectious Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2015)... 2015 Burke Rehabilitation Hospital will ... in New York City, to speak at Burke on Wednesday, ... ongoing Legacy Lobby Lecture series, will take place at 4:30 ... the great grandson of Stanford White of McKim, Mead and ... Burke’s campus 100 years ago. , “We are thrilled to ...
(Date:5/24/2015)... Michigan (PRWEB) May 24, 2015 ... concerns about hair loss. Although it is unclear about ... there are environmental factors such as metabolism, nutritional deficiencies, ... Since they offer a comprehensive approach to evaluating the ... post-menopausal woman, they can help patients find a cause ...
(Date:5/24/2015)... NH (PRWEB) May 24, 2015 ... leather, launches “InkGard™ Plus” – a classic, rugged ... the polymer allowing difficult stains, including ink, to ... 16 different colors suitable for corporate, healthcare, hospitality ... in line with EnviroLeather’s goal of developing products ...
(Date:5/24/2015)... Medicx Media Solutions http://www.medicxmedia.com ... Krihak as its head of programmatic strategy and ... expertise and leadership position in the data driven ... , Krihak is an experienced, award-winning agency and ... sales planning teams for mobile platform Jumptap. ...
(Date:5/23/2015)... On May 13, Nithyananda Yoga Foundation organized ... power learned through meditation and initiation at Special Holistic ... , Yogamaatha, a nine-year-old girl from North Carolina, stunned ... attending the 2015 Business Advocacy Summit at Capitol Hill ... , In a demonstration that lasted three hours, Yogamaatha ...
Breaking Medicine News(10 mins):Health News:Burke Rehabilitation Hospital Welcomes Architect Samuel White, Descendant of McKim, Mead and White, for Legacy Lobby Lecture 2Health News:Burke Rehabilitation Hospital Welcomes Architect Samuel White, Descendant of McKim, Mead and White, for Legacy Lobby Lecture 3Health News:Women's Excellence Now Treats Menopausal Hair Loss 2Health News:EnviroLeather By LDI Launches "InkGard Plus" - Stain Resistant Faux Leather 2Health News:Medicx Media Solutions Expands Executive Team 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3
... problem , , THURSDAY, June 19 (HealthDay News) -- Due ... oral rapid HIV test was recently halted by the ... which operates 10 sexually transmitted disease walk-in clinics. , ... testing of finger-stick, whole-blood specimens using the OraQuick test. ...
... DC (Thursday, June 19, 2008) Healthy individuals who gain ... risk for developing chronic kidney disease (CKD), according to a ... Journal of the American Society Nephrology (JASN). The study ... conditions that are associated with weight gain, including diabetes and ...
... reveals in detail how breast cells produce new cells that ... action of the CHFR gene. , CHFR expression is ... of this gene is also a hot area of interest ... forms of cancer. , The new study reveals how ...
... June 19 Pastillas para la,diabetes tipo 2, a ... 2,diabetes and need information to help them compare various ... Agency for Healthcare Research,and Quality., Diabetes is one ... United States. AHRQ data show that nearly one in ...
... research company,s database, AUBURN HILLS, Mich., ... Plexus Online on-demand software for the manufacturing,enterprise, ... SC) is using Plexus Online to facilitate ... governmental,industrial and academic., (Logo: http://www.newscom.com/cgi-bin/prnh/20070627/CLW071LOGO ...
... York, NY-- The Damon Runyon Cancer Research Foundation ... May 2008 Fellowship Award Committee review. The ... postdoctoral scientists conducting basic and translational cancer research ... the country. The Fellowship is specifically intended ...
Cached Medicine News:Health News:False Positives in Oral HIV Test Halt Use in NYC 2Health News:Weight gain within the normal range increases risk of chronic kidney disease 2Health News:Lack of CHFR gene expression sets stage for breast cancer 2Health News:Lack of CHFR gene expression sets stage for breast cancer 3Health News:New Spanish-Language Consumer Guide Compares Oral Diabetes Medications 2Health News:Plexus Online Enables Business-Government-Academic Collaboration for Advanced Technology Institute 2Health News:Plexus Online Enables Business-Government-Academic Collaboration for Advanced Technology Institute 3Health News:Plexus Online Enables Business-Government-Academic Collaboration for Advanced Technology Institute 4Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators 2Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators 3Health News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators 4
(Date:5/21/2015)... May 21, 2015  CryoLife, Inc. (NYSE: CRY ... focused on cardiac and vascular surgery, announced today that ... dividend for the second quarter 2015 of $0.03 per ... of $0.03 per share will be paid on June ... of June 12, 2015.  The ex-dividend date for the ...
(Date:5/21/2015)... , May 21, 2015  (MUSE Booth # ... Health Record (EHR) is invaluable in any hospital ... are now a requirement and mainstream in healthcare, ... into the EHR is gaining traction in MEDITECH ... Holmes, RN, Site Project Manager & Clinical Analyst ...
(Date:5/21/2015)... 21. Mai 2015 Dipexium ... ein Unternehmen für Arzneimittel im fortgeschrittenen ... und Vermarktung von Locilex® (Pexiganan-Creme 0,8 %) ... eine wissenschaftliche Posterpräsentation an, welche das ... vorstellt, OneStep-1 und OneStep-2, in der ...
Breaking Medicine Technology:CryoLife Announces Quarterly Cash Dividend for the Second Quarter 2015 2Hospital Streamlines ICU Efficiency with Timely Data Integration 2Hospital Streamlines ICU Efficiency with Timely Data Integration 3Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 2Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 3Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 4Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 5Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 6Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 7
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: