Navigation Links
Combined inhibition of VEGF and c-MET can decrease metastasis
Date:2/24/2012

  • Inhibition of VEGF increased c-MET expression in tumors.
  • Invasion and metastasis were blocked by inhibition of VEGF plus c-MET.
  • Dual VEGF/c-MET inhibitors are in late-stage clinical trials.

PHILADELPHIA Dual inhibition of vascular endothelial growth factor and c-MET signaling inhibited tumor invasion and metastasis in a laboratory model of pancreatic neuroendocrine cancer, according to a paper published in Cancer Discovery, the newest journal of the American Association for Cancer Research.

"Inhibition of VEGF signaling plus c-MET signaling results in a synergistic effect on tumors that leads to slowing of tumor growth and decreased invasiveness and metastasis," said lead researcher Donald M. McDonald, M.D., Ph.D., a professor at the University of California San Francisco Comprehensive Cancer Center.

Previous laboratory research had shown that inhibition of VEGF signaling with agents like bevacizumab or sunitinib can give rise to a number of side effects including increased tumor invasion and metastasis.

What was not known was whether anti-VEGF therapy results in elevated c-MET expression, which has been previously shown to promote tumor cell invasiveness and metastasis. To determine this, McDonald and colleagues conducted a two-phase laboratory study. They treated mice engineered to develop pancreatic neuroendocrine tumors with an anti-VEGF antibody, which reduced tumor size but increased invasiveness and metastasis. This treatment also increased tumor hypoxia and expression and activity of c-MET.

However, when both VEGF and c-MET signaling were inhibited simultaneously, there was a reduction in invasion and metastasis. The researchers tested three c-MET inhibitors: crizotinib and PF-04217903, which target c-MET but not VEGF signaling, and cabozantinib, a dual inhibitor that blocks VEGF and c-MET signaling.

McDonald said they conducted their initial study in neuroendocrin
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Combined oral contraceptive pill helps painful periods
2. PSA testing, combined with other relevant patient data can reduce unnecessary prostate biopsies
3. Combined arterial imaging technology reveals both structural and metabolic details
4. Novel combined therapy extends life, diminishes pain in brain cancer patients
5. Ultrasound combined with pre-operative MRI is cost effective in evaluating rotator cuff tears
6. Combined imaging technologies may better identify cancerous breast lesions
7. Combined BRAF-targeted and immunotherapy shows promise for melanoma treatment
8. Vandetanib shows clinical benefit when combined with docetaxel for lung cancer
9. New Laser Technology Combined with Manual Physical Therapy Offer Pain Relief to Chronic Pain Sufferers
10. Singapore Performs Asia's First Combined Heart and Liver Transplant
11. Promega Maxwell 16 IVD System CE Marked to the European Union IVD Directive Delivers Combined Solution for Infectious Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... Alex Kramer HealthDay Reporter ... kids involved in the kitchen, through cooking classes or at ... according to a recent review. Cooking programs and classes ... behaviors, according to the new research. And, although the review ... suggest that such programs might help children develop long-lasting healthy ...
(Date:11/28/2014)... 28, 2014 Mabel’s Labels , ... lose® and an award-winning company established by four moms, ... Esp, and Tricia Mumby have been honored with a ... with the PROFIT Award for Excellence in Entrepreneurship. , ... and Tricia Mumby) accepted the award on behalf of ...
(Date:11/28/2014)... Georgia (PRWEB) November 28, 2014 Patten ... and locally grown. With those passions driving them, they've ... Georgia Grown. Having tried other pecans oils, they've found ... Pitts, Georgia to be exceptionally flavorful, retaining the buttery ... The same nutritional benefits found in pecans ...
(Date:11/28/2014)... ARTAS robotic hair transplant surgical procedures are ... Medical Group hair transplant surgeons Chris Pawlinga, M.D. and ... transplant procedure in the Brentwood office on Monday, December ... Tennessee and one of only three medical centers in ... hair transplantation. Patients benefit from this minimally invasive, no-stitch ...
(Date:11/28/2014)... This report presents a comprehensive investigation ... definite portrayal of the North American commercial center. ... variables driving the development of the business coupled ... of the business. , Complete report available ... the report "Worldwide Dental Report: 2014 Edition", low ...
Breaking Medicine News(10 mins):Health News:Want Kids to Eat Better? Get Them Cooking 2Health News:Want Kids to Eat Better? Get Them Cooking 3Health News:Mabel's Labels’ Co-Founders Named A Winner In The 2014 RBC Canadian Women Entrepreneur Awards Program; A Second-Time Win For The Brand 2Health News:Mabel's Labels’ Co-Founders Named A Winner In The 2014 RBC Canadian Women Entrepreneur Awards Program; A Second-Time Win For The Brand 3Health News:Patten Pecans Goes Local with Nutritious Georgia Pecan Oil 2Health News:First in Tennessee - PAI Medical Group Announces ARTAS - The World’s Most Advanced Medical Robot Used for Hair Transplant Surgery 2Health News:Global Dental Market Report 2014 Edition Now Available at MarketReportsOnline.com 2Health News:Global Dental Market Report 2014 Edition Now Available at MarketReportsOnline.com 3
... YORK, Feb. 19 Medicsight PLC, a subsidiary ... an industry leader in the development of Computer-Aided ... radiologists in the early detection of disease, today ... effective March 19, 2009. Allan Rowley, currently Chief ...
... from the JUPITER study presented today at the International ... of the stroke data according to gender, ethnicity and ... primary analysis of the JUPITER study which demonstrated that ... stroke by nearly half (48%; p=0.002), compared to placebo ...
... Hospice Foundation announces the appointment of Brickson Diamond, ... of Trustees. As Board Chair, Diamond will lead ... to advance quality, compassionate end-of-life care for all.Diamond ... Trust Company,s Personal Investment Management Division and a ...
... A study led by researchers at the University of Illinois ... alerts the body to the infection. , The research, ... led by Illinois physics professor and Howard Hughes Medical Institute ... RIG-I (pronounced rig-EYE), is able to distinguish between viral RNA ...
... can keep problem from advancing, experts say , , THURSDAY, Feb. ... causes poorer brain function in people with type 2 diabetes, ... 55 and older at 52 sites in Canada and the ... larger study on cardiovascular risk in diabetes, underwent cognitive tests ...
... Imprinted Products, a direct marketing promotional products company, offers a ... , ... Lewiston, ME (PRWEB) February 19, ... promotional products company that trades on its easy, customer-friendly ...
Cached Medicine News:Health News:Medicsight PLC Restructures Management Team 2Health News:Medicsight PLC Restructures Management Team 3Health News:CRESTOR Cuts Risk of Stroke by Nearly Half in JUPITER Study 2Health News:CRESTOR Cuts Risk of Stroke by Nearly Half in JUPITER Study 3Health News:CRESTOR Cuts Risk of Stroke by Nearly Half in JUPITER Study 4Health News:Brickson Diamond Appointed Board Chair of National Hospice Foundation 2Health News:Team learns how cellular protein detects viruses and sparks immune response 2Health News:Out-of-Control Blood Sugar May Affect Memory 2Health News:Crestline is the Source for Great Green Giveaways 2Health News:Crestline is the Source for Great Green Giveaways 3
(Date:11/26/2014)... , November 26, 2014 A ... of the organ protrudes through the wall of a weak ... area at birth are some of the causes of hernias. ... hiatal, femoral, and incisional. An inguinal hernia is when part ... umbilical hernia is found in the area of the umbilicus. ...
(Date:11/26/2014)... , Nov. 26, 2014  Aridis Pharmaceuticals, ... produce novel therapies for infectious diseases, announced today ... an internationally recognized key opinion leader in the ... scientific advisory board. Founder and Chief ... "We believe Dr. Opal,s extensive experience investigating bacterial ...
(Date:11/26/2014)... 25, 2014 According to ... Power Source (Electric, Battery, Pneumatic), by Product (Drill, ... Cart), by Application (Orthopedic, ENT, Oral, Thoracic, Neurology) ... global Powered Surgical Instruments Market is estimated to ... 2014 and is expected to grow at a ...
Breaking Medicine Technology:Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 2Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 3Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 4Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4
... Arena Pharmaceuticals, Inc. (NASDAQ: ARNA ) announced ... the Citi 2012 Global Health Care Conference on Wednesday, February ... Time) at the Waldorf=Astoria in New York City. Jack Lief, ... a corporate overview. A live audio webcast of ...
... Switzerland, Feb. 23, 2012  Auxilium Pharmaceuticals, Inc. ... Pharmaceuticals Ltd. (SWX: ATLN.S) announced today that ... for the development, supply and commercialization of ... biologic for the potential treatment of Dupuytren,s ...
Cached Medicine Technology:Arena Pharmaceuticals to Present at the Citi 2012 Global Health Care Conference 2Arena Pharmaceuticals to Present at the Citi 2012 Global Health Care Conference 3Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 2Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 3Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 4Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 5Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 6
These are the Reusable Components (minus cannula), to be used with the VersaStep™ Plus Reposable Short System....
The VersaStep™ 5 mm and VersaStep™ PLUS Reposable system components for creating each access port are supplied in separate packages....
VersaStep™ Reposable Sterilization Trays....
... Instrument for applications in ... ,The VERSASTEP™ Plus instrument ... length is a unique ... radial dilation. It is ...
Medicine Products: