Navigation Links
Cold sore linked to mutation in gene, study suggests
Date:9/16/2013

Why some people are troubled by cold sores while others are not has finally been explained by scientists.

Cold sores affect around one in five people but, until now, no one has been sure why some are more prone to the virus that causes them.

Researchers at the University of Edinburgh have found that people affected by cold sores have a mutation in a gene, which means their immune system is not able to prevent them from developing.

Cold sores are caused by a strain of the herpes simplex virus herpes simplex virus type 1 (HSV-1). Between 80 and 90 per cent of people are infected with the virus, but only about a quarter of them get frequent cold sores.

Scientists analysed thousands of genes to identify which ones expressed the proteins needed by the body's immune system to prevent the virus from becoming active and as a result cold sores from developing.

They then looked at blood samples from people with cold sores and found that one of the genes previously identified IL28b was mutated.

This genetic mutation means that the body is not able to mount an adequate immune response to the virus, which results in cold sores.

The gene identified is also linked to treatment responses for hepatitis C patients. If this gene is mutated, patients are less likely to respond as well to treatment. The link is further evidence that a single genetic mutation can be linked to different viruses.

The study, published in the journal Plos Pathogens, was funded by the Medical Research Council, the Biotechnology and Biological Sciences Research Council, the Wellcome Trust and the European Union.

Professor Juergen Haas, of the University of Edinburgh's Division of Pathway Medicine, said: "Most people carry the cold sore strain of the herpes simplex virus, but until now we never knew why only some of them develop cold sores.

"Knowing that susceptibility to the virus involved relates to people's genes reinforces the need to research, not only the evolution of viruses themselves, but also the susceptibility of hosts to infection."


'/>"/>

Contact: Tara Womersley
tara.womersley@ed.ac.uk
44-131-650-9836
University of Edinburgh
Source:Eurekalert

Related medicine news :

1. Antibiotics Linked to Retinal Detachment Risk
2. Pesticides May Be Linked to Slightly Smaller Babies, Shorter Pregnancies
3. Pharmacy Robots Linked to Bacterial Contamination of Drugs
4. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
5. Dental X-Rays May Be Linked to Benign Brain Tumors
6. In Mice, Drug Reverses Symptoms of Condition Linked to Autism
7. Huntingtons Disease Linked to Reduced Cancer Risk in Study
8. Study finds significant skull differences between closely linked groups
9. Researchers Map Brain Regions Linked to Intelligence
10. Swallowing exercises linked with short-term improvement among patients with head and neck cancer
11. Anxiety Linked to Smarts in Brain Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... 25, 2016 , ... Today American University of Antigua (AUA) ... announced the AUA-FIU Global MD Program. Students in the Global MD Program ... a Certificate of Completion from the FIU Herbert Wertheim College of Medicine Clinical ...
(Date:5/25/2016)... ... May 25, 2016 , ... CloudLIMS, joins an elite number of companies ... Solution Providers list of 2016 by CIOReview. , In a deliberate session with the ... Solution Providers 2016 has been concluded with. The positioning is based on evaluation of ...
(Date:5/25/2016)... , ... May 25, 2016 , ... Cheryl Bowker of ... to bestow: the Dick McKenna Good Hands Legacy Award. McKenna ran one of Allstate’s ... which continues to inspire all those who knew him. The award named for him ...
(Date:5/25/2016)... ... 2016 , ... Afrimesure specializes in providing clients with ideal ... and HVAC facilities. Their knowledgeable staff also takes care of the installation, IQ/OQ/PQ ... offers a variety of MadgeTech systems available for sterilization and temperature monitoring, including ...
(Date:5/25/2016)... , ... May 25, 2016 , ... ... results of its annual Medical and Prescription Drug survey , an ... , The survey, which was conducted in December 2015, indicates that employers are ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... May 24, 2016 Cirujanos holandeses ... ayudar a los médicos a compartir sus mejores prácticas ... escala mundial. Profesionales médicos de Europa, África, ... apuntado a la aplicación, que combina la transmisión en ... totalmente seguro. Educación   "Imagine un ...
(Date:5/24/2016)...   , Study met both ... in , Excellent plus Good ... of the ascending colon   ,      ... announced new positive data from the phase III MORA study for ... litre PEG with ascorbate. The study met both primary endpoints showing ...
(Date:5/24/2016)... May 24, 2016 ARANZ Medical ... the healthcare sector, has been named the Coretex Hi-Tech Emerging ... 2016. Dr Bruce Davey , CEO of ... team.  It,s really good to be recognised for the work ... products are used in 35 countries around the world from ...
Breaking Medicine Technology: