Navigation Links
Cold sore linked to mutation in gene, study suggests
Date:9/16/2013

Why some people are troubled by cold sores while others are not has finally been explained by scientists.

Cold sores affect around one in five people but, until now, no one has been sure why some are more prone to the virus that causes them.

Researchers at the University of Edinburgh have found that people affected by cold sores have a mutation in a gene, which means their immune system is not able to prevent them from developing.

Cold sores are caused by a strain of the herpes simplex virus herpes simplex virus type 1 (HSV-1). Between 80 and 90 per cent of people are infected with the virus, but only about a quarter of them get frequent cold sores.

Scientists analysed thousands of genes to identify which ones expressed the proteins needed by the body's immune system to prevent the virus from becoming active and as a result cold sores from developing.

They then looked at blood samples from people with cold sores and found that one of the genes previously identified IL28b was mutated.

This genetic mutation means that the body is not able to mount an adequate immune response to the virus, which results in cold sores.

The gene identified is also linked to treatment responses for hepatitis C patients. If this gene is mutated, patients are less likely to respond as well to treatment. The link is further evidence that a single genetic mutation can be linked to different viruses.

The study, published in the journal Plos Pathogens, was funded by the Medical Research Council, the Biotechnology and Biological Sciences Research Council, the Wellcome Trust and the European Union.

Professor Juergen Haas, of the University of Edinburgh's Division of Pathway Medicine, said: "Most people carry the cold sore strain of the herpes simplex virus, but until now we never knew why only some of them develop cold sores.

"Knowing that susceptibility to the virus involved relates to people's genes reinforces the need to research, not only the evolution of viruses themselves, but also the susceptibility of hosts to infection."


'/>"/>

Contact: Tara Womersley
tara.womersley@ed.ac.uk
44-131-650-9836
University of Edinburgh
Source:Eurekalert

Related medicine news :

1. Antibiotics Linked to Retinal Detachment Risk
2. Pesticides May Be Linked to Slightly Smaller Babies, Shorter Pregnancies
3. Pharmacy Robots Linked to Bacterial Contamination of Drugs
4. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
5. Dental X-Rays May Be Linked to Benign Brain Tumors
6. In Mice, Drug Reverses Symptoms of Condition Linked to Autism
7. Huntingtons Disease Linked to Reduced Cancer Risk in Study
8. Study finds significant skull differences between closely linked groups
9. Researchers Map Brain Regions Linked to Intelligence
10. Swallowing exercises linked with short-term improvement among patients with head and neck cancer
11. Anxiety Linked to Smarts in Brain Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2017)... ... 28, 2017 , ... Shamanic Teacher Anahata Ananda of ... is proud to announce the return of her increasingly popular “Shamanic Wisdom Teachings” ... about the mystical world of shamanism, nature wisdom, the medicine wheel, energy healing ...
(Date:7/27/2017)... , ... July 27, 2017 , ... Standard Process is ... Center of Excellence at the North Carolina Research Campus (NCRC) in Kannapolis, North Carolina ... center will open in the fall of this year, occupying over 10,000 square feet ...
(Date:7/27/2017)... ... July 27, 2017 , ... Somnoware, ... cloud-based polysomnography (PSG) distributed scoring solution to its healthcare management platform. This solution ... management. The speed and functionality of scoring in the cloud is on par ...
(Date:7/27/2017)... ... ... isn’t always easy. Currently, more than 80 percent of Americans fail to eat the recommended ... sugar. This trend may help explain why the obesity rate seems stuck. The most recent ... culture, we seem to have food on the brain more. "We eat two more large ...
(Date:7/27/2017)... ... July 27, 2017 , ... HIMSS announced ... keynote Day 2 of the HIMSS Healthcare Security Forum, the nation’s foremost event ... Boston Hotel, Sept. 11-13, 2017. , Daniel will deliver his keynote, The Evolving ...
Breaking Medicine News(10 mins):
(Date:7/27/2017)... July 27, 2017  Zimmer Biomet Holdings, Inc. (NYSE ... ended June 30, 2017.  The Company reported second quarter ... over the prior year period, and an increase of ... basis points of contribution from the LDR Holding Corporation ... second quarter of 2016, or 0.3% on a constant ...
(Date:7/26/2017)... BEACH, Fla. , July 26, 2017 ... of enrollment of our clinical trial evaluating Altemia TM ... Cell Anemia (SCA) and Sickle Cell Disease (SCD). The ... to evaluate the efficacy and safety of Altemia TM ... trial is conducted under US IND 125274. ...
(Date:7/24/2017)... -- IBM (NYSE: IBM ) has been recognized as ... (SSA) for the fourth year in a row. 1 ... in the Leaders quadrant have the highest scores for their ... the Leaders quadrant has the market share, credibility, and marketing ... technologies. These vendors demonstrate a clear understanding of market needs; ...
Breaking Medicine Technology: