Navigation Links
Cocaine's effects on brain metabolism may contribute to abuse
Date:2/18/2008

UPTON, NY - Many studies on cocaine addiction - and attempts to block its addictiveness - have focused on dopamine transporters, proteins that reabsorb the brain's "reward" chemical once its signal is sent. Since cocaine blocks dopamine transporters from doing their recycling job, it leaves the feel-good chemical around to keep sending the pleasure signal. Now a new study conducted at the U.S. Department of Energy's Brookhaven National Laboratory suggests that cocaine's effects go beyond the dopamine system. In the study, cocaine had significant effects on brain metabolism, even in mice that lack the gene for dopamine transporters.

"In dopamine-transporter-deficient mice, these effects on metabolism are clearly independent of cocaine's effects on dopamine," said Brookhaven neuroscientist Panayotis (Peter) Thanos, who led the research. "These metabolic factors may be a strong regulator of cocaine use and abuse, and may also suggest new avenues for addiction treatments." The study will appear in the May 2008 issue of the journal Synapse, and will be available online on Monday, February 18, 2008.

The scientists used positron emission tomography, or PET scanning, to measure brain metabolism in dopamine-transporter deficient mice (known as DAT knockouts) and in littermates that had normal dopamine transporter levels. In this technique, the scientists administer a radioactively labeled form of sugar (glucose) - the brain's main "fuel" - and use the PET scanner to track its site-specific concentrations in various brain regions. They tested the mice before and after cocaine administration, and compared the results to mice treated with saline instead of the drug.

Before any treatment, mice lacking dopamine transporters had significantly higher metabolism in the thalamus and cerebellum compared with normal mice. This elevated metabolism may be linked to chronically high levels of dopamine in the DAT knockout mice. It also suggests that dopamine
'/>"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New study may explain Vioxx side-effects
2. 13 percent of women stop taking breast cancer drug because of side effects, U-M study finds
3. Natural aorta grafts have few side effects for infection-prone patients
4. New Report: Dangerous Drug Side Effects and Deaths Doubled Since 1998... Seniors Hit Hardest
5. Detroit Metro Tower Air Traffic Controllers File Lawsuit Alleging Improper Mold Removal and Health Effects
6. Empowerment Program Gets Patients on the PATH to Managing the Physical and Emotional Effects of Psoriatic Arthritis
7. Shaking may cause brain damage and serious long-term effects to infants
8. Smoking can harm the long-term effects of some oral surgery procedures
9. ECLIPSE data on effects of Otsukas investigational novel treatment, Tolvaptan
10. Combination therapy reverses effects of portal hypertension in rats
11. Fighting the Gassy Effects of Good Eating, From the Harvard Health Letter
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... December 20, 2014 DePuy Pinnacle ... metal-on-metal version of the artificial hip system was ... and federal courts, Bernstein Liebhard LLP reports. According ... County Superior Court on December 2nd, counsel in ... deposition of plaintiffs on November 19, 2014, with ...
(Date:12/20/2014)... December 20, 2014 Recently, VogueQueen.com, a ... VogueQueen Big Sale Online for 2015. Great ... All new and old consumers can get a discount, ... at the company’s website before January 30, 2015. , ... dresses and launched a prom dress promotion. Many customers ...
(Date:12/20/2014)... York, New York (PRWEB) December 20, 2014 ... continue to move forward in U.S. courts, ... new study which suggests that children treated with ... a hormone linked to breast development and lactation. ... looked at 34 children and adolescents who began ...
(Date:12/20/2014)... Recently, AngelWeddingDress.com has introduced its special offer (called ... Christmas. In the promotion, all buyers worldwide can enjoy ... something special for the women who are looking for ... new collections of 2015 dresses have been unveiled recently. ... discounted prices. Visit our website now before they are ...
(Date:12/20/2014)... Twin Cities DI Day is recognized as the premier ... financial professionals come together each year to hear up ... to protect their clients and to be inspired by ... of disability. , On September 23rd, 2014, financial professionals ... The 13th Annual Twin Cities DI Day where they ...
Breaking Medicine News(10 mins):Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 3Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 4Health News:VogueQueen Big Sale Online For The Coming 2015 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 3Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 4Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3
... 31 The following,is being released by the Campaign ... from across New Jersey express strong support,for 100 percent ... to 28 percent), voters support extending the statewide Smoke-Free,Air ... from a,broad-based coalition of voters across the state, including ...
... data finds no link to most common illnesses , ... do not increase the risk of cancers, connective tissue ... researchers. , A team from the International Epidemiology Institute ... in Nashville, Tenn., reviewed available research on the safety ...
... 31, 2007 A new study appearing in International ... anti-cancer agent that prevents tumor growth by interfering with ... potential to improve the efficacy of standard combination chemotherapy ... most common cancer in women, accounting for nearly 14,000 ...
... month of November,American Diabetes Month, the Erectile Dysfunction ... (ED) to ask,their doctor about being screened for ... under-discussed complication of,diabetes," states Dr. Ananda Basu, an ... don,t realize is that coronary heart disease,is the ...
... LAKE FOREST, Ill, Oct. 31 Hospira, Inc.,(NYSE: ... today,that Thomas E. Werner, senior vice president, Finance, and ... Credit Suisse Phoenix,Health Care Conference on Tuesday, Nov. 13, ... to all interested parties at noon,Mountain Time on Tuesday, ...
... wellness ... options, CAMP HILL, ... linked to lifestyle. In fact, half of the two,million premature deaths that ... poor nutrition, and lack of,exercise -- are a primary reason for rising ...
Cached Medicine News:Health News:New Poll Finds Nearly Seven in 10 New Jersey Voters Support Smoke-Free Casinos 2Health News:New Poll Finds Nearly Seven in 10 New Jersey Voters Support Smoke-Free Casinos 3Health News:Little Evidence Silicone Breast Implants Harm Health 2Health News:Diabetic Men With Erectile Dysfunction Urged to Consult Their Doctors During November - American Diabetes Month 2Health News:Hospira to Present at the Credit Suisse Phoenix Health Care Conference on November 13 2Health News:Highmark Blue Shield Program Rewards Members for Enhancing their 'Healthstyle' 2Health News:Highmark Blue Shield Program Rewards Members for Enhancing their 'Healthstyle' 3
(Date:12/19/2014)... HILL, N.C. , Dec. 19, 2014 /PRNewswire/ ... to optimize a product,s web presence to reflect ... Brand websites, in particular, must meet the needs ... regulations and culture. According to ... more than half of the participating companies averaged ...
(Date:12/19/2014)... Dec. 19, 2014  Monarch America Inc. (OTCQB: CANK) ... is pleased to provide this review of the Company,s ... 2015. "Over this past year, we achieved ... am extremely proud to say that Monarch America is ... it has ever been," stated Eric Hagen , ...
(Date:12/19/2014)... WORTH, Texas , December 18, 2014 /PRNewswire/ ... a networked software application/module that is used to ... related images. RIS comprises a patient tracking and ... system. The integration of RIS with HIS and ... used for patient registration and patient scheduling, patient ...
Breaking Medicine Technology:Building a Best-in-Class Pharma Global Brand Website 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3
... For Judith Talnadge, a power wheelchair provided through Medicare ... with opportunities to visit with friends and engage in ... Those starkly different living environments are ... who suffers from muscular dystrophy and spina bifida.  These ...
... Optimer Pharmaceuticals, Inc. (NASDAQ: OPTR ) today announced its ... Optimer reported net income for the first quarter of 2011 of ... respectively, as compared to a net loss for the first quarter ... a basic and diluted basis.  The increase in net income was ...
Cached Medicine Technology:Power Wheelchairs Keep Medicare Beneficiaries Out of Nursing Homes, While Reducing Government Costs and Providing More Freedom and Independence 2Power Wheelchairs Keep Medicare Beneficiaries Out of Nursing Homes, While Reducing Government Costs and Providing More Freedom and Independence 3Power Wheelchairs Keep Medicare Beneficiaries Out of Nursing Homes, While Reducing Government Costs and Providing More Freedom and Independence 4Optimer Pharmaceuticals Reports First Quarter 2011 Financial Results 2Optimer Pharmaceuticals Reports First Quarter 2011 Financial Results 3Optimer Pharmaceuticals Reports First Quarter 2011 Financial Results 4Optimer Pharmaceuticals Reports First Quarter 2011 Financial Results 5Optimer Pharmaceuticals Reports First Quarter 2011 Financial Results 6
This high technology cast plaster cutter saw is very easy and comfortable to use....
... a minimum results in less emotional trauma ... the clinician. The innovative motor plus saw ... lighter package. In addition, the unique design ... more user comfort. Plus automated multi-speed controls ...
The True/Fix Cannulated Bone Screw System contains 7.0mm large cannulated bone screws and 3.5mm cortical and 4.0mm cannulated cancellous bone screws....
LEMAIRE stapes are stainless steel staples indicated for ligament fixation....
Medicine Products: