Navigation Links
Cleveland Clinic researchers identify urgent need for Alzheimer's drug development
Date:7/2/2014

THURSDAY, July 3, 2014, Las Vegas: Researchers at the Cleveland Clinic Lou Ruvo Center for Brain Health have conducted the first-ever analysis of clinical trials for Alzheimer's disease (AD), revealing an urgent need to increase the number of agents entering the AD drug development pipeline and progressing successfully towards new therapy treatments. The paper, "Alzheimer's Disease Drug Development Pipeline: Few Candidates, Frequent Failures," was published today in the journal Alzheimer's Research & Therapy.

A comprehensive look at all clinical trials underway shows:

  • There are relatively few drugs in development for Alzheimer's disease.
  • The failure rate for AD drug development is 99.6 percent for the decade 2002-2012.
  • The number of drugs has been declining since 2009.

"Our goal was to examine historical trends to help understand why Alzheimer's disease treatment development efforts so often fail," said Jeffrey L. Cummings, M.D., ScD, Director of the Cleveland Clinic Lou Ruvo Center for Brain Health. "With an estimated 44 million people living worldwide with the condition, the study shows that the Alzheimer's disease drug development ecosystem needs more support given the magnitude of the problem."

Using the advanced search mechanisms of ClinicalTrials.gov, a government website that records all ongoing clinical trials, Dr. Cummings, along with Kate Zhong, M.D., Senior Director of Clinical Research and Development, and Touro University medical student Travis Morstorf, constructed a comprehensive analysis to examine all trials since 2002.

"By analyzing both completed as well as on-going trials and currently active compounds, we were able to provide insight into longitudinal trends in drug development," said Dr. Zhong. "What we found was that the investment in AD drugs and therapies is relatively low compared to the challenge posed by the disease. The pipeline is almost dry."

T
'/>"/>

Contact: Megan Pruce
prucem@ccf.org
216-445-7452
Cleveland Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cleveland Clinic selected to participate in National MDS Clinical Research Consortium
2. Cleveland Clinic researchers discover molecule that may prevent atherosclerosis
3. Cleveland Clinic Florida receives approval for transplant programs at Weston Facilities
4. Cleveland Clinic researchers investigating potential drug for treatment of Alzheimers disease
5. Cleveland Clinic study shows vitamin E may decrease cancer risk in Cowden syndrome patients
6. University Hospitals & Philips Healthcare to showcase imaging technology at Cleveland Medical Mart
7. Cleveland Clinic researcher identifies 2 new genetic mutations associated with Cowden syndrome
8. Redskins Quarterback & Lynx Shreds Athlete Kirk Cousins will Start Today vs. Cleveland Browns for Injured RG3
9. Cleveland Clinic researcher receives grant to fund autism research
10. Cleveland Clinic study shows bariatric surgery restores pancreatic function by targeting belly fat
11. Vein Expert in Winston-Salem, NC Participates in Elite Cleveland Clinic Seminar
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... The typical Thanksgiving dinner table is ... of gravy and a myriad of mouthwatering desserts. Who ... of year to begin losing weight? Listen closely. With ... secret to losing unhealthy, embarrassing and uncomfortable fat while ... The insight to Diet Doc’s calorie loading holiday ...
(Date:11/21/2014)... Florida (PRWEB) November 21, 2014 TruDenta, ... chronic headaches and other jaw-related symptoms, has ... seeking relief from chronic head pain, neck pain, TMJ ... , “This year we have seen a 52% increase ... Our network of over 300 doctors and their teams ...
(Date:11/21/2014)... Even with years of experience under his belt, Kirk ... growth, participating in two recent events for his State Farm ... networking event with the leaders of State Farm and thousands ... and greatest in insurance news and products for his clients. ... (Stacy, Anthony, Reina and Jacob) as exhibitors at the recent ...
(Date:11/21/2014)... 2014 First Choice Emergency Room ... The new facility is located at 225 E. Parkwood ... “We are pleased to join the Friendswood community and ... care here,” said Dr. Siddiqi, Facility Medical Director of ... celebrate the opening, First Choice Emergency Room made a ...
(Date:11/21/2014)... HealthDay Reporter THURSDAY, Nov. 20, 2014 ... of a still-beating heart has the potential to improve the ... new study. Heart patients who received the gel implant ... hundreds of feet farther during a six-minute walk test, said ... cardiovascular division at Washington University School of Medicine and a ...
Breaking Medicine News(10 mins):Health News:Diet Doc Releases New Calorie Loading Diet Plans - the Perfect Way to Jump Start the Metabolism and Begin Weight Loss During Thanksgiving 2Health News:Diet Doc Releases New Calorie Loading Diet Plans - the Perfect Way to Jump Start the Metabolism and Begin Weight Loss During Thanksgiving 3Health News:Diet Doc Releases New Calorie Loading Diet Plans - the Perfect Way to Jump Start the Metabolism and Begin Weight Loss During Thanksgiving 4Health News:National Rise In Patients Seeking Headache Relief 2Health News:Kirk Martin Insurance Agency Goes Local and National with State Farm 2Health News:First Choice Emergency Room Opens New Facility in Friendswood, Texas 2Health News:Gel Implant Might Help Fight Heart Failure 2Health News:Gel Implant Might Help Fight Heart Failure 3
... Reporter , THURSDAY, March 31 (HealthDay News) -- Almost three ... reactors in Japan, American public opinion on the risks and ... years earlier, a new Harris Interactive/HealthDay poll finds. ... or not more nuclear power plants should be built on ...
... By Steven Reinberg HealthDay Reporter , THURSDAY, March 31 ... States has dropped by almost 1 percent a year and the ... a new report shows. These declines, seen between 2003 and ... added. Importantly, this is the first time a drop ...
... Salamon HealthDay Reporter , THURSDAY, March 31 (HealthDay ... service, American kids always seem to have plenty to keep ... a tipping point detrimental to their mental and physical health ... overscheduled children has been on scientists, radar for at least ...
... Dr. Leona Cuttler, a pediatric endocrinologist and growth hormone expert ... co-author of an editorial in the New England Journal ... giving girls with Turner syndrome low doses of estrogen, as ... increases their height and offers other benefits. With her ...
... More than 250 leaders from Chinese and U.S. academic ... Emory University to examine and compare healthcare reform in ... to care. The symposium is being co-hosted by the ... and the China Medical Board. "Healthcare reform is ...
... -- There may be a link between certain types of migraines ... suggests. U.S. researchers looked at 109 children aged 6 to ... Children,s Medical Center in Salt Lake City, Utah, between 2008 and ... foramen ovale (PFO) -- a defect in the wall between the ...
Cached Medicine News:Health News:Despite Radiation in Japan, Little Shift in Americans' Views on Nuke Power: Poll 2Health News:Despite Radiation in Japan, Little Shift in Americans' Views on Nuke Power: Poll 3Health News:U.S. Cancer Rates Continue to Fall 2Health News:U.S. Cancer Rates Continue to Fall 3Health News:Are Some Kids Overscheduled? 2Health News:Are Some Kids Overscheduled? 3Health News:Assessing the value of treatments to increase height 2Health News:Healthcare Reform in China and the US: Forum examines similarities, differences and challenges 2
(Date:11/21/2014)... NEW YORK , Nov. 20, 2014  Market research ... as the "Year of The Buy, in the medical ... market for medical devices will produce just 3% growth ... competitive actions, including acquisitions of product lines and entrance ... an annual survey of medical devices, The Global ...
(Date:11/21/2014)... Nov. 20, 2014  The acceptance of two ... AAGL Global Congress demonstrates continued interest in the ... provide bowel control. One of the abstracts, presented by ... Division Chief of Urogynecology and Reconstructive Pelvic Surgery ... Award for Best Written Abstract on Urogynecology/Pelvic Floor ...
(Date:11/21/2014)... Nov. 20, 2014 Oxis International, Inc. (OXIS) (OXI.PA) ... election of Anthony J. Cataldo as Chief Executive ... Effective November 19, 2014, Ken Eaton resigned his ... of Directors of Oxis International, Inc. to pursue new opportunities. ... named Chief Executive Officer of Oxis International, Inc. Mr. Cataldo ...
Breaking Medicine Technology:Kalorama: 2014 The "Year of The Buy" in Medical Device Industry 2LIFE Study Prominently Featured at Minimally Invasive Gynecology Conference 2LIFE Study Prominently Featured at Minimally Invasive Gynecology Conference 3OXIS International, Inc. announces Changes in Management Team 2OXIS International, Inc. announces Changes in Management Team 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: