Navigation Links
Chronic cocaine use triggers changes in brain's neuron structure
Date:5/9/2012

Buffalo, N.Y. Chronic exposure to cocaine reduces the expression of a protein known to regulate brain plasticity, according to new, in vivo research on the molecular basis of cocaine addiction. That reduction drives structural changes in the brain, which produce greater sensitivity to the rewarding effects of cocaine.

The finding suggests a potential new target for development of a treatment for cocaine addiction. It was published last month in Nature Neuroscience by researchers at the University at Buffalo and Mount Sinai School of Medicine.

"We found that chronic cocaine exposure in mice led to a decrease in this protein's signaling," says David Dietz, PhD, assistant professor of pharmacology and toxicology in the School of Medicine and Biomedical Sciences, who did the work while at Mt. Sinai. "The reduction of the expression of the protein, called Rac1, then set in motion a cascade of events involved in structural plasticity of the brain -- the shape and growth of neuronal processes in the brain. Among the most important of these events is the large increase in the number of physical protrusions or spines that grow out from the neurons in the reward center of the brain.

"This suggests that Rac1 may control how exposure to drugs of abuse, like cocaine, may rewire the brain in a way that makes an individual more susceptible to the addicted state," says Dietz. A photo of Dietz is at http://www.buffalo.edu/news/13420.

The presence of the spines demonstrates the spike in the reward effect that the individual obtains from exposure to cocaine. By changing the level of expression of Rac1, Dietz and his colleagues were able to control whether or not the mice became addicted, by preventing enhancement of the brain's reward center due to cocaine exposure.

To do the experiment, Dietz and his colleagues used a novel tool, which allowed for light activation to contro
'/>"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Adjusting Your Attitude About Chronic Pain May Help You Sleep
2. Chronicling pink slimes fall from grace
3. Study suggests new way to treat chronic pain
4. Alternative Medicine May Help Ease Chronic Sinusitis
5. Study determines critical skills for PCPs to safely manage opioid risk in chronic pain patients
6. Where pain lives: Managing chronic pain tougher in poor neighborhoods
7. Web-Based Therapy May Help Teens With Chronic Fatigue
8. Smog Tied to Raised Risk of Chronic Illness in Black Women
9. Chronic Heartburn a Growing Problem in U.S.
10. Journal Retracts Faulty Chronic Fatigue Study
11. Chronic School Absenteeism Linked to Mental Health Problems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chronic cocaine use triggers changes in brain's neuron structure
(Date:2/27/2015)... Dr. Andrew Campbell, one of the ... to announce the expansion of Quintessa Aesthetic Center with ... has begun seeing patients on February 18, 2015. , ... offer a variety of state-of-the-art surgical and non-surgical ... laser peels, chemical peels, microdermabrasion, ProFractional Laser, Broad Band ...
(Date:2/27/2015)... Daytona Beach, FL (PRWEB) February 27, 2015 ... marketing medical companies, devices and pharmaceuticals, Benedict Advertising ... FL as its newest client. The company’s patented ... is a pain-free, no-stress method of sedation. , ... taking medical patient comfort to a new level, ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 Victorian Hotel ... deals for couples who wanted to spend the auspicious ... opportunity to get a jump on Valentine’s Day with ... stay in one of their luxurious rooms. , ... 13, inviting guests for a mouthwatering 3 course meal ...
(Date:2/27/2015)... February 27, 2015 The UC Davis ... expertise have made it a beacon of hope for ... has been acknowledged by the national society committed to ... Huntington’s Disease Society of America — as a Level ... acknowledgement recognizes the center’s service to over 300 families ...
(Date:2/27/2015)... 27, 2015 “ Logical Operations ” ... Tech Report, which takes a look at the latest ... Mallory Sofastaii, a special reporter for NewsWatch and a ... how this company helps companies avoid cyber security threats. ... they’ll probably see cyber security somewhere in the headlines. ...
Breaking Medicine News(10 mins):Health News:Dr. Andrew Campbell Expands Quintessa Aesthetic Center into Delafield 2Health News:Dr. Andrew Campbell Expands Quintessa Aesthetic Center into Delafield 3Health News:Benedict Advertising & Marketing Signs Sedation Systems 2Health News:Victorian Hotel Celebrated Valentine’s Day in 2015 With Unique Overnight Deal 2Health News:UC Davis Huntington's Disease Center Receives Level 1 Designation 2Health News:UC Davis Huntington's Disease Center Receives Level 1 Designation 3Health News:A Way for Companies to Avoid Cyber Security Threats was Featured on NewsWatch Television on January 30, 2015 2
... Ga., Feb. 24 As part of the ... search and recovery duties for fallen servicemen overseas, ... historical and practical importance of their mission from ... establishment of Biotrauma, Inc. - a death scene ...
... Inc. (TSX: NRI), a Canadian drug development company focused ... to and through the skin using its topical and ... platform, developed by its San Diego based research and ... of four finalists in the Science and Medical category ...
... Sheets: BEDA), a medical imaging and diagnostic Company launches new Physician ... out sourced billing services as part of its commitment to synergistically ... ... February 24, 2009 -- Bederra Corporation (Pink Sheets: BEDA), ...
... Protect Healthcare Workers from Hazardous Drug ExposureCOLUMBUS, Ohio, Feb. ... surrounding the safe handling of hazardous drugs in the ... National Safe Handling Awareness Month with Monday, April 20, ... Day. The proclamation of National Safe Handling Awareness ...
... leading IP Call -Management Software, Call-Shadow V5.0 will now support ... ... Hertfordshire, UK (PRWEB) February 24, 2009 -- Shadow Technology today ... V5.0 will now support the following new platforms:, , , ...
... rising costs of making funeral arrangements for your loved ones. It ... families to try to cut costs where ever possible. , ... West ... in New York, recently announced the launch of this new business to ...
Cached Medicine News:Health News:USMC Crime Scene Cleaners Draw On Iraq Experience as Biotrauma, Inc. 2Health News:Nuvo's High Throughput Experimentation Platform Selected as 2009 Edison Award Finalist 2Health News:Nuvo's High Throughput Experimentation Platform Selected as 2009 Edison Award Finalist 3Health News:Bederra Corporation Launches New Billing Services Division Expected to Add up to $500,000 in Revenue 2Health News:Bederra Corporation Launches New Billing Services Division Expected to Add up to $500,000 in Revenue 3Health News:April 2009 Declared National Safe Handling Awareness Month 2Health News:April 2009 Declared National Safe Handling Awareness Month 3Health News:April 2009 Declared National Safe Handling Awareness Month 4Health News:Call-Shadow IP Call Management Software Now With Increased Platform Support 2Health News:Call-Shadow IP Call Management Software Now With Increased Platform Support 3Health News:Grief Counseling Services Battles Rising Costs of Funeral Expenses 2Health News:Grief Counseling Services Battles Rising Costs of Funeral Expenses 3
(Date:2/27/2015)... , Feb. 27, 2015  Pomerantz LLP is ... Inc. ("Vitae" or the "Company") (NASDAQ: VTAE ... S. Willoughby at rswilloughby@pomlaw.com or 888-476-6529, ... and certain of its officers and/or directors have violated ... of 1934.  On February 27, 2015, ...
(Date:2/27/2015)...  Pharmacyclics, Inc. (NASDAQ: PCYC ) ... in the Proceedings of the National Academy ... when ibrutinib (IMBRUVICA ® ) was combined with ... tumor growth was enhanced suggesting a greater response ... and solid tumors with the combination. IMBRUVICA is ...
(Date:2/27/2015)...  Acsis Inc., the market leader for supply chain ... John DiPalo , Acsis, Chief Strategy Officer, has ... Executive 2015 Provider Pro to Know. The award ... help prepare their companies, and customers, supply chains for ... list of Provider Pros to Know is featured in ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Vitae Pharmaceuticals, Inc. - VTAE 2In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 2In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 3In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 4In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 5In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 6In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 7In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 8In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 9Acsis CSO John DiPalo Named Supply & Demand Chain Executive 2015 Pro to Know 2
... AcelRx Pharmaceuticals, Inc. announced today that results ... of its oral transmucosal NanoTab(TM) formulation of sufentanil ... the upcoming American Society of Anesthesiologists Annual Meeting ... Officer of AcelRx, will present in the following ...
... Oct. 15 Azopharma Product Development Group, LLC, ... services and PharmaNet Development Group, Inc., a leading ... biotechnology, generic drug and medical device companies, are ... development and co-promotion alliance to leverage complementary services, ...
Cached Medicine Technology:Azopharma and PharmaNet Development Group Enter Preclinical Strategic Alliance 2
... Hip Stabilizer Abduction and ... replacements, revisions and fractures. ... abduction with adjustable flexion ... settings. Adjustabelt back panel. ...
... low cost walker features a non-skid rocker ... low profile design minimizes leg length discrepancies. ... makes strapping quick and easy. Steel uprights ... swollen ankles and extra bandaging. This extra ...
... and Cronin, Inc. is ... Patient Footwear, Orthopedic Softgoods, ... Products. Our products are ... and available in the ...
... Walker is a short pneumatic walking brace ... Because of its shorter height it is ... calf circumference prohibits them from using a ... for patient comfort while providing superior injury ...
Medicine Products: