Navigation Links
Chronic cocaine use triggers changes in brain's neuron structure
Date:5/9/2012

Buffalo, N.Y. Chronic exposure to cocaine reduces the expression of a protein known to regulate brain plasticity, according to new, in vivo research on the molecular basis of cocaine addiction. That reduction drives structural changes in the brain, which produce greater sensitivity to the rewarding effects of cocaine.

The finding suggests a potential new target for development of a treatment for cocaine addiction. It was published last month in Nature Neuroscience by researchers at the University at Buffalo and Mount Sinai School of Medicine.

"We found that chronic cocaine exposure in mice led to a decrease in this protein's signaling," says David Dietz, PhD, assistant professor of pharmacology and toxicology in the School of Medicine and Biomedical Sciences, who did the work while at Mt. Sinai. "The reduction of the expression of the protein, called Rac1, then set in motion a cascade of events involved in structural plasticity of the brain -- the shape and growth of neuronal processes in the brain. Among the most important of these events is the large increase in the number of physical protrusions or spines that grow out from the neurons in the reward center of the brain.

"This suggests that Rac1 may control how exposure to drugs of abuse, like cocaine, may rewire the brain in a way that makes an individual more susceptible to the addicted state," says Dietz. A photo of Dietz is at http://www.buffalo.edu/news/13420.

The presence of the spines demonstrates the spike in the reward effect that the individual obtains from exposure to cocaine. By changing the level of expression of Rac1, Dietz and his colleagues were able to control whether or not the mice became addicted, by preventing enhancement of the brain's reward center due to cocaine exposure.

To do the experiment, Dietz and his colleagues used a novel tool, which allowed for light activation to contro
'/>"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Adjusting Your Attitude About Chronic Pain May Help You Sleep
2. Chronicling pink slimes fall from grace
3. Study suggests new way to treat chronic pain
4. Alternative Medicine May Help Ease Chronic Sinusitis
5. Study determines critical skills for PCPs to safely manage opioid risk in chronic pain patients
6. Where pain lives: Managing chronic pain tougher in poor neighborhoods
7. Web-Based Therapy May Help Teens With Chronic Fatigue
8. Smog Tied to Raised Risk of Chronic Illness in Black Women
9. Chronic Heartburn a Growing Problem in U.S.
10. Journal Retracts Faulty Chronic Fatigue Study
11. Chronic School Absenteeism Linked to Mental Health Problems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chronic cocaine use triggers changes in brain's neuron structure
(Date:8/27/2015)... ... August 27, 2015 , ... Infocast ... for October 27-29, 2015 in San Jose, CA. The first event dedicated ... on the void that exists where battery development and energy storage innovation are ...
(Date:8/27/2015)... ... , ... In addition to its existing Doctor of Philosophy in Leadership and ... its main campus in Reading: Doctor of Nursing Practice. , Alvernia’s Doctor of ... nurses for the highest level of clinical nursing practice. , “Our vision is ...
(Date:8/27/2015)... ... 27, 2015 , ... Florida Hospital North Pinellas, located at 1395 South Pinellas Avenue in Tarpon ... The new facility will be located at US Highway 19 North and Highlands Boulevard, less ... 18, and work on the project is slated to begin in September 2015. ...
(Date:8/27/2015)... ... August 27, 2015 , ... NetDimensions is once ... selected have the platforms required not only to effectively deliver, curate and administer great ... Training Industry, Inc. , For six consecutive years, NetDimensions has maintained its position ...
(Date:8/27/2015)... ... August 27, 2015 , ... Z-Medica®, LLC, a leading developer ... corporate website http://www.Z-Medica.com , to further support the company’s corporate positioning. , ... year. , “We launched a branded website last year to show our ...
Breaking Medicine News(10 mins):Health News:Infocast Hosting First Conference Dedicated to Powering Wearable Devices & the IoT 2Health News:Alvernia University Now Offering Three Doctoral Degree Programs 2Health News:Florida Hospital North Pinellas is Opening a New Free-Standing Emergency Room in Palm Harbor 2Health News:Florida Hospital North Pinellas is Opening a New Free-Standing Emergency Room in Palm Harbor 3Health News:NetDimensions Named Among Top 20 Learning Portal Companies of 2015 2Health News:NetDimensions Named Among Top 20 Learning Portal Companies of 2015 3Health News:Z-Medica® Launches New Corporate Website 2
... Axel Ullrich, Ph.D., is the recipient of the ... his pioneering work in the translation of genomics-based discoveries ... Director of Molecular Biology at the Max Planck Institute ... expert in gene technology and one of the most ...
... of activity helped men, women regardless of family history ... level of aerobic fitness can significantly reduce stroke risk ... study. , The study, expected to be presented Thursday ... New Orleans, showed 30 minutes or more of brisk ...
... connection, experts say , , THURSDAY, Feb. 21 (HealthDay News) ... anywhere else for that matter, may raise your risk ... , "These authors report a potentially important association between ... said Dr. Steven V. Pacia, director of neurology at ...
... similarities, differences in DNA, studies find , , THURSDAY, ... such examination of human genetic diversity yet conducted, an ... to track differences and similarities between people around the ... Science , a team led by Richard Myers, ...
... drugs raises risk of adverse side effects ... take more than one nonsteroidal anti-inflammatory drug (NSAID) may ... suggests. , NSAIDs, which are available in both prescription ... arthritis. , These drugs are widely available, and patients ...
... release is available in Spanish . , ... field of health. However, they are vitally important for patients ... carried out at the Department of Social Anthropology ... lecturer Rafael Briones Gmez, shows that Spanish hospitals are not ...
Cached Medicine News:Health News:Pezcoller Foundation-AACR International Award for Cancer Research recognizes Axel Ullrich 2Health News:Pezcoller Foundation-AACR International Award for Cancer Research recognizes Axel Ullrich 3Health News:Moderate Aerobic Fitness Levels May Cut Stroke Risk 2Health News:Daytime Dozing Might Raise Stroke Risk 2Health News:Global Analysis of Human DNA Tracks Migration, Identity 2Health News:Global Analysis of Human DNA Tracks Migration, Identity 3Health News:Global Analysis of Human DNA Tracks Migration, Identity 4Health News:Taking Multiple Pain Relievers May Cause Complications 2Health News:Patients' relatives are ignored by the health system and suffer emotional stress 2
(Date:8/27/2015)... the leading innovation partner to companies worldwide , ... and anticipates the creation of over 350 new jobs through ... In 2013, the State of Ohio ... to accelerate adoption of open innovation among Ohio ... revenues. To date over 45 middle market companies have worked ...
(Date:8/27/2015)... Mass. and TORONTO , ... ) (OTCQB: GNBT) today announced the issuance of a ... Company,s proprietary buccal insulin spray product.  The white paper ... of the Company,s stockholders by Dr. James H. ... The white paper may be viewed online on the ...
(Date:8/27/2015)... Calif. , Aug. 27, 2015  Mytrus, a technology and ... software platform for electronic informed consent has received approval ... Health Service (NHS). It is the first time e-Consent ... England . Mytrus was ... use in a clinical trial by the U.S. Food ...
Breaking Medicine Technology:State of Ohio and NineSigma Collaborate to Drive Regional Economic Growth and Job Creation 2State of Ohio and NineSigma Collaborate to Drive Regional Economic Growth and Job Creation 3Generex Announces Issuance of Buccal Insulin White Paper 2Generex Announces Issuance of Buccal Insulin White Paper 3Generex Announces Issuance of Buccal Insulin White Paper 4Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 2Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 3Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 4Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 5Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 6Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 7
Fast, accurate SpO2 measurements always within reach....
The Easy Core Biopsy Device offers exceptional performance in automated core biopsy, and provides excellent ergonomics and increased notch size....
Incontinence Pessaries...
The Set comes with a cross reference chart that translates ring size into the correct size of other EvaCare pessaries. The Fitting Set can be disinfected in three ways: autoclaved, boiled or cold ste...
Medicine Products: