Navigation Links
Chronic cocaine use triggers changes in brain's neuron structure
Date:5/9/2012

Buffalo, N.Y. Chronic exposure to cocaine reduces the expression of a protein known to regulate brain plasticity, according to new, in vivo research on the molecular basis of cocaine addiction. That reduction drives structural changes in the brain, which produce greater sensitivity to the rewarding effects of cocaine.

The finding suggests a potential new target for development of a treatment for cocaine addiction. It was published last month in Nature Neuroscience by researchers at the University at Buffalo and Mount Sinai School of Medicine.

"We found that chronic cocaine exposure in mice led to a decrease in this protein's signaling," says David Dietz, PhD, assistant professor of pharmacology and toxicology in the School of Medicine and Biomedical Sciences, who did the work while at Mt. Sinai. "The reduction of the expression of the protein, called Rac1, then set in motion a cascade of events involved in structural plasticity of the brain -- the shape and growth of neuronal processes in the brain. Among the most important of these events is the large increase in the number of physical protrusions or spines that grow out from the neurons in the reward center of the brain.

"This suggests that Rac1 may control how exposure to drugs of abuse, like cocaine, may rewire the brain in a way that makes an individual more susceptible to the addicted state," says Dietz. A photo of Dietz is at http://www.buffalo.edu/news/13420.

The presence of the spines demonstrates the spike in the reward effect that the individual obtains from exposure to cocaine. By changing the level of expression of Rac1, Dietz and his colleagues were able to control whether or not the mice became addicted, by preventing enhancement of the brain's reward center due to cocaine exposure.

To do the experiment, Dietz and his colleagues used a novel tool, which allowed for light activation to contro
'/>"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Adjusting Your Attitude About Chronic Pain May Help You Sleep
2. Chronicling pink slimes fall from grace
3. Study suggests new way to treat chronic pain
4. Alternative Medicine May Help Ease Chronic Sinusitis
5. Study determines critical skills for PCPs to safely manage opioid risk in chronic pain patients
6. Where pain lives: Managing chronic pain tougher in poor neighborhoods
7. Web-Based Therapy May Help Teens With Chronic Fatigue
8. Smog Tied to Raised Risk of Chronic Illness in Black Women
9. Chronic Heartburn a Growing Problem in U.S.
10. Journal Retracts Faulty Chronic Fatigue Study
11. Chronic School Absenteeism Linked to Mental Health Problems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chronic cocaine use triggers changes in brain's neuron structure
(Date:1/22/2015)... York (PRWEB) January 22, 2015 Thousand ... Fresenius Medical Care recalled its GranuFlo and NaturaLyte dialysis ... litigation underway in U.S. District Court, District of Massachusetts, ... January 20th, the Court has remanded a case filed ...
(Date:1/22/2015)... Plainsboro, NJ (PRWEB) January 22, 2015 ... advocate and keynote speaker at the upcoming 32nd ... by ACCME-accredited Physicians’ Education Resource®, LLC (PER®) , ... breast would have gone undetected if she had not ...
(Date:1/22/2015)... IsoComforter, Inc. has introduced the most innovative and ... to treat specific body parts and muscle groups. , ... to use patented cold therapy machine with the innovative IsoTube ... muscle injuries. IsoComforter has become the industry leader in ...
(Date:1/22/2015)... As interest in the value of spiritual support ... Rev. Eric J. Hall , president and CEO of ... be the keynote speaker on January 27 at an international ... , The conference, “Hope and Resilience: Innovative and Interdisciplinary Spiritual ...
(Date:1/22/2015)... 22, 2015 Step into a macabre ... Science Museum of Virginia. Wicked Plants, the Museum’s latest ... unearths 75 poisonous, carnivorous and diabolical plants inside of ... to uncover the biochemical, physical and neurological processes between ...
Breaking Medicine News(10 mins):Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Wicked Plants are taking over the Science Museum of Virginia 2
... Aug. 26 (HealthDay News) -- Two new European reports should ... diagnosing possible heart attacks in emergency room patients, cardiologists say. ... of the New England Journal of Medicine , looked ... cells. Standard practice in most hospitals now calls for a ...
... Tenn., Aug. 26 HCA today announced the start of its ... HCA CEO Richard Bracken, 125 not-for-profit agencies and more than 1,000 ... employee giving campaign this morning in Centennial Park. , , ... com.com/cgi-bin/prnh/20050825/CLTH069LOGO ) , , Last year, ...
... ... Generation and Gender Impact Physician Engagement", , ... Charlotte, NC (Vocus) August 26, 2009 -- Morehead , the human capital ... Engagement." The free hour-long webinar will be broadcast on Wednesday, September 16, 2009 at ...
... , , , , ... , , Medical group-specific cost information available at ... MINNEAPOLIS, Aug. 26 In a significant step toward bringing cost ... health care, MN Community Measurement has published new information about how much ...
... CHICAGO, Aug. 26 Paul S. Boulis, president ... retirement today, effective December 31, 2009. In his role ... has been responsible for all operations, including consumer and group ... medical policy, medical and disease management, government relations and public ...
... early diagnostic test , WEDNESDAY, Aug. 26 (HealthDay News) ... renal failure could offer a noninvasive and fairly inexpensive ... most treatable stages, according to Israeli researchers who developed ... volatile organic compounds in the exhaled breath of laboratory ...
Cached Medicine News:Health News:Newer, Better Tests for Heart Attacks 2Health News:Newer, Better Tests for Heart Attacks 3Health News:HCA Kicks Off 2009 'Caring for the Community' Campaign 2Health News:Morehead Presents Webinar on 'He Said…She Said: How Gender Differences Impact Physician Engagement' 2Health News:MN Community Measurement Brings Cost and Quality Information Together For Consumers 2Health News:MN Community Measurement Brings Cost and Quality Information Together For Consumers 3Health News:Paul S. Boulis, President, Blue Cross and Blue Shield of Illinois, Announces His Retirement 2Health News:'Electronic Nose' Could Spot Kidney Disease 2
(Date:1/22/2015)... , Jan. 22, 2015  ViewRay™, a privately held medical ... an exclusive distributor agreement with ITOCHU Corporation (Tokyo Stock ... system for the treatment of cancer in ... is the world,s first and only MRI-guided radiation therapy ...
(Date:1/22/2015)... Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the "Company"), a specialty ... disease and overall health is pleased to provide you with ... outlook for 2015 from the CEO, Mr. Eugene Bortoluzzi ... like to take this opportunity to share with you the ...
(Date:1/22/2015)... 2015 Increasing sophistication among enterprise buyers of language ... in 2015, says Moravia CMO, Renato ... by market research firm Common Sense Advisory, 15 percent ... translation and localization needs. "From a language industry perspective, ...
Breaking Medicine Technology:ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
... Feb. 28, 2011 PolyOne Corporation (NYSE: POL ... in SunBelt Chlor Alkali Partnership to Olin Corporation.   ... venture formed in 1996 between PolyOne (formerly The Geon Company) ... for $175 million, including $132 million in cash and the ...
... LOUIS, Feb. 28, 2011 Stereotaxis, Inc. (Nasdaq: ... full year and fourth quarter ended December 31, 2010. ... capital orders, record recurring revenue and record gross margins. ... the year, which helped to drive decreases in both ...
Cached Medicine Technology:PolyOne Announces Sale of SunBelt Investment 2PolyOne Announces Sale of SunBelt Investment 3Stereotaxis Reports 2010 Financial Results, Provides 2011 Financial Outlook 2Stereotaxis Reports 2010 Financial Results, Provides 2011 Financial Outlook 3Stereotaxis Reports 2010 Financial Results, Provides 2011 Financial Outlook 4Stereotaxis Reports 2010 Financial Results, Provides 2011 Financial Outlook 5Stereotaxis Reports 2010 Financial Results, Provides 2011 Financial Outlook 6Stereotaxis Reports 2010 Financial Results, Provides 2011 Financial Outlook 7
...
...
Ascent Primary Knee System with cruciate retaining, posterior stabilized and constrained components...
... The Consensus knee system continues the ... intelligent engineering with the diversified experience of ... an affordable knee system that incorporates state-of-the-art ... provide both joint and implant stability and ...
Medicine Products: