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Cell transplantation and cardiac repair
Date:7/1/2009

ded, the leg was also pain-free and usable."

Dr. Amann noted that the patients with limb salvage had better baseline perfusion than the eventually amputated patients. Among the limb-salvaged group, analgesic consumption was reduced by 62 percent and their total walking distance improved from zero to 40 meters.

"This study found that after aBMC, in addition to being spared amputation, a critically ischemic leg can have increased blood flow and support wound healing while patients have reduced pain," concluded Dr. Amann.

Researchers suggested that their results are yet to be confirmed, but a double-blind, placebo controlled study is currently underway.

"Should ours and other studies prove this therapy to be effective, adoption by hospitals other than large academic centers will require a simple method for processing the bone marrow," added Dr. Amann.

Contact: Dr. Berthold Amann, Dept. of Internal Medicine, Franziskuskrankenhaus, Berlin Vascular Center, 10787 Berlin, Germany. Tel: (49) 30-2638-3601 amann@franziskus-berlin.de

"The use of bone marrow derived cells for improvement in ischemic muscle in the heart or leg is very promising," said Amit N. Patel, associate professor of surgery at the University of Utah School of Medicine and the cardiovascular, skin, other tissue section editor of Cell Transplantation. "Both articles demonstrate that the route of delivery is one of the key determinants in having positive outcomes in the early clinical trials."


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Contact: Hans Dohman
Directoria.cientifica@procardiaco.com.br
55-212-131-1584
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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