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Cell transplantation and cardiac repair
Date:7/1/2009

issue since the passage (diapedesis) of circulating cells into the adjacent cardiac tissue occurs on the venous side of microcirculation," added Dr. Dohman. "In addition, we found that the grade of obstruction of microcirculation does not correlate with the efficiency of cell delivery to the infarcted tissue."

The research team also found that higher cell retention correlated with better changes in observed ejection fraction from baseline to a six-month follow-up.

"Our data point toward a causal relationship between the total number of cells that participate in infarct repair and the final enhancement of cardiac function," concluded Dr. Dohman.

Contact: Hans Dohman, Hospital Pro-Cardiaco, Rua Dona Mariana 219, Botafogo, Rio de Janeiro, Brasil. CEP: 22280-000 Tel. (55) 21-21311584 Directoria.cientifica@procardiaco.com.br

Bone marrow cell transplants for limb ischemia

Bone marrow cell transplantation has been shown to induce new blood vessel growth (angiogenesis) and foster improvements in patients with ischemic artery disease. This study, conducted by a Berlin-based group, evaluated the long-term effects of intermuscular, autologous bone marrow cell (aBMC) transplants in patients at major risk for amputation due to the loss of blood flow to a limb (limb ischemia) and who have failed or who are not candidates for surgical techniques to remove or bypass blockages. Patients who have failed surgical steps have high rates of amputation. In this study, 90 percent of patients participating in the study had been scheduled for major amputations; their long-term limb salvage rate was 53 percent.

"Our results suggest that aBMC transplants have the potential to treat severely ischemic limbs," said corresponding author Dr. Berthold Amann of the Franziskuskrankenhaus Berlin-Vascular Center. "Among the patients in whom limb salvage was successful and amputation avoi
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Contact: Hans Dohman
Directoria.cientifica@procardiaco.com.br
55-212-131-1584
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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