Navigation Links
Cell transplantation and cardiac repair
Date:7/1/2009

Tampa, Fla. (July 1, 2009) The frontiers of cell transplantation for cardiac repair are discussed in the current issue of Cell Transplantation (Vol. 18 No.3), now available on-line without charge at http://www.ingentaconnect.com/content/cog/ct.

Two studies are highlighted, one by a Brazil-based research team who looked at two different bone marrow cell delivery methods following myocardial infarction, and a second study from a team of researchers in Germany who used bone marrow stem cell transplants to repair limb ischemia with a goal of preventing amputations.

Two delivery techniques for stem cells

With evidence mounting that cell-based therapies can repair the injured myocardium following acute infarction, a Brazil-based research team addressed questions of the best way to safely deliver bone-marrow mononuclear cells (BMMNC) derived from the same patient (autologous cells) to the heart, following a heart attack caused by a prolonged interruption of blood flow leading to changes in the electrocardiogram (ST elevation myocardial infarction). They compared two different delivery techniques through the anterograde intra-coronary (ICA) or via the retrograde intra-coronary artery vein (ICV). Researchers used radiolabeled cells to evaluate cell distribution patterns in the heart and their relationship with left ventricle function improvement.

"BMMNC retention by damaged heart tissue was apparently higher when the anterograde approach was used, although further studies are required to confirm this data," said corresponding author Dr. Hans Dohman of the Hospital Pro-Cardiaco in Rio de Janeiro, Brazil.

While previous reports observed that microvascular obstruction impairing cell uptake by the heart could be an issue, the team hypothesized that an intravenous approach may overcome that potential.

"We hypothesized that an intravenous approach might overcome this issue since the passage (diapedesis) of circulating cells into the adjacent cardiac tissue occurs on the venous side of microcirculation," added Dr. Dohman. "In addition, we found that the grade of obstruction of microcirculation does not correlate with the efficiency of cell delivery to the infarcted tissue."

The research team also found that higher cell retention correlated with better changes in observed ejection fraction from baseline to a six-month follow-up.

"Our data point toward a causal relationship between the total number of cells that participate in infarct repair and the final enhancement of cardiac function," concluded Dr. Dohman.

Contact: Hans Dohman, Hospital Pro-Cardiaco, Rua Dona Mariana 219, Botafogo, Rio de Janeiro, Brasil. CEP: 22280-000 Tel. (55) 21-21311584 Directoria.cientifica@procardiaco.com.br


Bone marrow cell transplants for limb ischemia

Bone marrow cell transplantation has been shown to induce new blood vessel growth (angiogenesis) and foster improvements in patients with ischemic artery disease. This study, conducted by a Berlin-based group, evaluated the long-term effects of intermuscular, autologous bone marrow cell (aBMC) transplants in patients at major risk for amputation due to the loss of blood flow to a limb (limb ischemia) and who have failed or who are not candidates for surgical techniques to remove or bypass blockages. Patients who have failed surgical steps have high rates of amputation. In this study, 90 percent of patients participating in the study had been scheduled for major amputations; their long-term limb salvage rate was 53 percent.

"Our results suggest that aBMC transplants have the potential to treat severely ischemic limbs," said corresponding author Dr. Berthold Amann of the Franziskuskrankenhaus Berlin-Vascular Center. "Among the patients in whom limb salvage was successful and amputation avoided, the leg was also pain-free and usable."

Dr. Amann noted that the patients with limb salvage had better baseline perfusion than the eventually amputated patients. Among the limb-salvaged group, analgesic consumption was reduced by 62 percent and their total walking distance improved from zero to 40 meters.

"This study found that after aBMC, in addition to being spared amputation, a critically ischemic leg can have increased blood flow and support wound healing while patients have reduced pain," concluded Dr. Amann.

Researchers suggested that their results are yet to be confirmed, but a double-blind, placebo controlled study is currently underway.

"Should ours and other studies prove this therapy to be effective, adoption by hospitals other than large academic centers will require a simple method for processing the bone marrow," added Dr. Amann.

Contact: Dr. Berthold Amann, Dept. of Internal Medicine, Franziskuskrankenhaus, Berlin Vascular Center, 10787 Berlin, Germany. Tel: (49) 30-2638-3601 amann@franziskus-berlin.de

"The use of bone marrow derived cells for improvement in ischemic muscle in the heart or leg is very promising," said Amit N. Patel, associate professor of surgery at the University of Utah School of Medicine and the cardiovascular, skin, other tissue section editor of Cell Transplantation. "Both articles demonstrate that the route of delivery is one of the key determinants in having positive outcomes in the early clinical trials."


'/>"/>

Contact: Hans Dohman
Directoria.cientifica@procardiaco.com.br
55-212-131-1584
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related medicine news :

1. American Society of Transplantations Past President Testifies Before Congress at Forum on Organ Donation
2. Patients over age 60 do well after liver transplantation
3. No racial differences seen in outcomes after liver transplantation
4. Predicting survival after liver transplantation
5. Study on Plasma-Depleted Cord Blood Transplantation Receives Best Abstract Award From The National Marrow Donor Program
6. Optimal systemic and splanchnic hemodynamic state after living-donor liver transplantation
7. Thoratec Announces Unanimous FDA Advisory Panel Recommendation for Approval of HeartMate II(R) for Bridge-to-Transplantation
8. American Society of Transplantation Applauds Rep. Inslee for His Efforts to Pass the Charlie W. Norwood Living Organ Donation Act
9. VELCADE(R) (Bortezomib) for Injection Based Therapy Produced Significant Complete Remission Rates Pre- and Post-Transplantation in IFM Phase III Front-Line Multiple Myeloma Trial
10. Extreme obesity affects chances of kidney transplantation
11. Former substance abusers rarely relapse after organ transplantation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... ... June 20, 2017 , ... This year, ... focused on finding product improvements that could reduce the occurrence of unplanned ... they need help breathing or to provide medication. Sometimes, patient movement can cause ...
(Date:6/20/2017)... ... , ... Uniform Advantage (UA), a multi-channel retailer of medical apparel ... tailored looks and athleisure-inspired outfits. UA Flex fabric is breathable, wrinkle resistant and durable ... trendy looks hitting the medical community, UA Flex is for the medical professional who ...
(Date:6/20/2017)... ... June 20, 2017 , ... John D'Eri, CEO of Rising ... in Adult Autism Award during the Autism Society of America 's 49th ... The Daniel Jordan Fiddle Foundation (DJFF) was founded in 2002 as the nation's ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... radio program, The Sharon Kleyne Hour Power of Water, Global Climate Change and ... to the world’s water crisis and how it affects the human eyes. ...
(Date:6/20/2017)... ... June 20, 2017 , ... As part of an effort ... Professional Benefit Administrators (SPBA) has provided input to the U.S. Senate on health care ... (R - KY), Charles E. Schumer (D - NY) and all other Senate members. ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... N.J. , June 16, 2017 Datascope Corp. is ... by Datascope Corp. for a potential electrical test failure code.     ... PART NUMBER ... CS100 IABP CS300 IABP ... ...
(Date:6/14/2017)... CALABASAS, Calif. , June 14, 2017 ... with the City of Fremont ... chain of the bio-pharma industry in California ... sharing technology, enabling executive networking, and fostering workforce development. ... the development and growth of start-ups, as well as ...
(Date:6/12/2017)... 2017 Kineta, Inc., a biotechnology company focused on ... Vice President of R&D and Head of Virology Kristin Bedard ... for the Northwest and Beyond meeting sponsored by Life ... 2017 from 8:30-10:30 AM PDT at the Agora Conference Center ... Dr. Bedard will be joined by other leaders in infectious ...
Breaking Medicine Technology: