Navigation Links
Cell nucleus protein in brown fat cells governs daily control of body temperature
Date:10/27/2013

PHILADELPHIA - For nearly 300 years, investigators have known that body temperature follows a circadian, or 24-hour, rhythm, with a peak during the day and a low at night. The benefit of this control during evolution may have been to allow conservation of energy while sleeping because keeping body temperature above the surrounding temperature requires heat production from metabolic processes inside the body. But, it is also critical to be able to adapt to changes in ambient temperature, regardless of the time of day.

However, the mechanism responsible for coordinating daily body temperature rhythm and adaptability to environmental challenges is unknown. Now, the laboratory of Mitchell A. Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism at the Perelman School of Medicine, University of Pennsylvania explains in Nature how body temperature rhythms are synchronized while maintaining the ability to adapt to changes in environmental temperature no matter the time of day or night.

"Food is plentiful in our present day society, and for most people there is unlikely to be an advantage of saving calories at night", says Lazar. "If this same mechanism exists in people, and we can target it safely, we could have a new way to combat obesity and its associated conditions such as diabetes and heart disease."

Lazar's team, including lead author Zachary Gerhart-Hines, Ph.D., found that the ability of mice to withstand a cold-temperature challenge was greater at 5:00 AM, when the mice are awake, compared to 5:00 PM when they are normally sleeping. This previously unrecognized circadian susceptibility to cold was found to be controlled by a protein called Rev-erb alpha, which is a molecular component of the body's biological clock mechanism.

Indeed, mice engineered to lack the Rev-erb alpha protein had similar cold tolerance throughout the 24-hour day and also lost the physiological circadian rhythm
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Mercola.com Introduces a New Product: Pure Power Protein Bars
2. New idea for targeting the common cancer protein KRAS
3. Onnit Introduces New Hemp Vanill-Acai Protein
4. Wayne State receives grant to examine exercises effects on proteins in muscles
5. Jekyll-and-Hyde protein offers a new route to cancer drugs
6. Top 55 High Protein Foods Listed in New Video by Fat Loss Expert
7. Fragile X syndrome protein linked to breast cancer progression
8. Birds appear to lack important anti-inflammatory protein
9. Diet Doc Weight Loss Plans Reveals Exclusive Weight Loss Supplements that Make Sticking With Low Fat Foods and High Protein Diets Easy
10. Alzheimers: Newly identified protein pathology impairs RNA splicing
11. Prion-like proteins drive several diseases of aging
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cell nucleus protein in brown fat cells governs daily control of body temperature
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... Crestor Will Remain the Clinical Gold Standard Drug Through 2016, ... to a New Report ... Resources, one of the,world,s leading research and advisory firms focusing ... high-density lipoprotein,cholesterol and has a lower discontinuation rate than that ...
... Medical,Equipment, Inc. (OTC: SHOM) announced today that the ... Industry statistics,suggest a very favorable market into the ... U.S. Bureau of Labor Statistics published in,the November ... new and,replacement nurses will be needed by 2016. ...
... 245-Bed Hospital To Better Track Expensive Assets and ... InfoLogix, Inc.,(Nasdaq: IFLG ), a leading ... tracking solutions for the healthcare and,commercial industries, announced ... Center of Lebanon, TN, to deploy its advanced,HealthTrax(TM) ...
... REDWOOD CITY, Calif., July 29 Genomic Health,Inc. (Nasdaq: ... host a conference,call and webcast on Tuesday, August 5, ... quarter 2008 financial results. The call and webcast,will follow ... close., Conference Call Details, To access the ...
... D sufficiency, new, antimicrobial-susceptibility system/panels for MRSA and other ... and enhanced automated laboratory systems, ... poisoning will also be on view, WASHINGTON, July 29 ... Expo will see Magellan Biosciences, continued,emergence as a new leader ...
... Each summer, as temperature and,humidity rise, mold ... U.S.,population is sensitive to mold, and invisible mold ... infections, according to the,American College of Allergy, Asthma ... building materials. In nature, mold breaks,down decaying organic ...
Cached Medicine News:Health News:A High-Density Lipoprotein Raising Drug That Has a Lower Discontinuation Rate Than That of Extended Release Niaspan Would Earn a 20 Percent Patient Share in the Dyslipidemia Drug Market 2Health News:Southern Home Medical's Encore Medical Staffing Division Poised to Benefit from Major Growth in Nursing Industry 2Health News:InfoLogix Selected by University Medical Center to Deploy Mobile Wireless Asset Tracking Solution 2Health News:InfoLogix Selected by University Medical Center to Deploy Mobile Wireless Asset Tracking Solution 3Health News:Genomic Health to Announce Second Quarter 2008 Financial Results and Host Conference Call on Tuesday, August 5, 2008 2Health News:Magellan Biosciences Companies to Feature Diagnostic Products Designed to Improve Health Outcomes at the Clinical Lab Expo 2Health News:Magellan Biosciences Companies to Feature Diagnostic Products Designed to Improve Health Outcomes at the Clinical Lab Expo 3Health News:Magellan Biosciences Companies to Feature Diagnostic Products Designed to Improve Health Outcomes at the Clinical Lab Expo 4Health News:Magellan Biosciences Companies to Feature Diagnostic Products Designed to Improve Health Outcomes at the Clinical Lab Expo 5Health News:Creating a Healthy Home Environment: Mold and Mildew Free 2
(Date:12/15/2014)... 15, 2014  The Government of Ghana ... Blood Fund (GBF) and Terumo BCT to respond to the emerging ... as provide long-term health system capacity to the citizens of ... The Ghanaian Ebola Readiness and Resilience Initiative (GERRI) is a multi-agency ... preparations for the possible arrival of the Ebola epidemic , ...
(Date:12/13/2014)... December 12, 2014 ... the addition of the  "Global Catheters Market ... Global Trends, Company Profiles, Analysis, Segmentation and ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... up of medical grade material such as ...
(Date:12/13/2014)... 12, 2014 Research ... addition of the  "Global Capnography Market 2015-2019" ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,Capnography is the ... respiratory gasses during the integral part of ... information about CO2 production, alveolar ventilation, and ...
Breaking Medicine Technology:Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 2Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 3Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 4Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 5Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 6Global Catheters Market (Product Types and Geography) - Forecast to 2020 2Global Catheters Market (Product Types and Geography) - Forecast to 2020 3Global Capnography Market 2015-2019: Key Vendors are Covidien, Masimo, Philips Healthcare, Smiths Medical and Welch Allyn 2Global Capnography Market 2015-2019: Key Vendors are Covidien, Masimo, Philips Healthcare, Smiths Medical and Welch Allyn 3
... KemPharm, Inc. today announced that KP106, its clinical candidate ... developed in an oral film dosage form pursuant to ... the development, commercialization and manufacture of KP106.   ... of d -amphetamine, and was identified utilizing KemPharm,s ...
... Mass., April 25, 2011 SynapDx Corporation announced ... directors. Thomas Mac Mahon was President and ... Management Committees of Laboratory Corporation of America (LabCorp) from January ... to LabCorp, Mr. Mac Mahon was Senior Vice President of ...
Cached Medicine Technology:KemPharm, Inc. Announces Plans to Launch KP106 as First Oral Film Dosage Form for ADHD 2KemPharm, Inc. Announces Plans to Launch KP106 as First Oral Film Dosage Form for ADHD 3KemPharm, Inc. Announces Plans to Launch KP106 as First Oral Film Dosage Form for ADHD 4
Finesse electrosurgical generator (100-120 VAC) utilizes a patented design that integrates the electrosurgical generator and smoke evacuation system into a single compact unit....
... the first High Frequency Desiccator with Cut. You ... of the unit is a high frequency desiccator, ... Aaron 900. The other half is a Bovie ... and coag capabilities plenty of power for ...
The Aaron 800-EU is designed and engineered to be the most reliable and durable desiccator available today....
NS2000 Bipolar Generator provides precise coagulation without tissue sticking....
Medicine Products: