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Cause and potential treatment found for cancer drug's kidney toxicity
Date:6/2/2011

if you remove it, there don't appear to be major negative consequences," Pabla said. The findings point toward using protein kinase C inhibitors as an adjunct therapy for patients experiencing kidney problems and potentially for all cancer patients treated with cisplatin if the enhanced efficacy finding continues to hold up, Dong said.

The scientists note that reducing the cisplatin dose decreases kidney toxicity but also decreases its efficacy and may leave the patient resistant to even higher doses of the drug. In the more than 30-year history with cisplatin, related drugs, such as carboplatin, have been developed to circumvent kidney damage, but those drugs tend to have more limited use, be less effective and/or have additional side effects. In more recent years, the focus has been on trying to protect the kidneys.

Next steps include working with chemists to see if an even more effective inhibitor can be developed.


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Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

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