Navigation Links
Cause and potential treatment found for cancer drug's kidney toxicity
Date:6/2/2011

AUGUSTA, Ga. Scientists may have a way to make the powerful cancer drug cisplatin less toxic to the kidneys and more effective against some cancers.

The chemotherapeutic agent used in combination with other drugs for a variety of cancers, results in kidney damage or failure in about 30 percent of users, although the mechanism has been unclear. The most physicians can do today to protect the kidneys is advise patients to drink more water.

The relatively simple, highly reactive compound tends to accumulate in the kidneys, said Dr. Navjotsingh Pabla, postdoctoral fellow at Georgia Health Sciences University and first author on the study in The Journal of Clinical Investigation. "The kidneys can take it up, but they have trouble removing it, so it just accumulates," he said.

The kidneys' endless workload of filtering some substances while resorbing others leaves them vulnerable to injury, one of the reasons the kidneys are the first organ to shut down when a patient is critically ill, said Dr. Zheng Dong, GHSU cell biologist, Career Research Scientist at the Charlie Norwood Veterans Affairs Medical Center in Augusta and the study's senior author. "Any stress to the cell can injure it," Dong said.

The scientists have shown in mice with tumors as well as human cancer cells in culture that cisplatin highly activates protein kinase C delta; protein kinases regulate other proteins by adding phosphates to them that can change their function. They've further shown that protein kinase C delta is a key mediator of cell death in kidneys and important to cancer cell survival.

The dichotomy appears useful because they've also shown that a drug, already in clinical trials for its potential in protecting brain cells following stroke, blocks the kidney destruction. In fact, protein kinase inhibitors in mice with tumors, enhanced breast and ovarian cancer treatment.

"Normal cells may not depend on this protein for survival and growth so
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. GW researchers show host Mta1 gene is required for optimal survival of schistosome parasites, a leading global cause of cancer
2. Cosmetics can cause serious adverse effects
3. Heart scientists discover protein that may be 1 cause of heart failure
4. Dietary inorganic nitrate may reduce heart dysfunction caused by powerful anti-cancer drug
5. Newer Epilepsy Meds Less Likely to Cause Birth Defects: Study
6. A gene that fights cancer, but causes it too
7. Chiropractic Spinal Manipulation Wont Cause Chest Injuries, Study Contends
8. Mayo Clinic finds new genetic cause of neurodegeneration
9. Morning Heart Attacks Cause More Damage, Study Finds
10. Increased computer use by adolescents cause for concern
11. Wrestlers Quick Weight Loss May Cause Mental Confusion
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cause and potential treatment found for cancer drug's kidney toxicity
(Date:4/25/2015)... Sports controversies continue to revolve around issues of abuse and violence. ... the Miami Dolphins and Richie Incognito, or off the field and ... abuse case. In a recent episode of SCI TV , ... locker room culture on teams. He examines what worked for the ... improve the locker room as a work place. , Steele ...
(Date:4/24/2015)... NY (PRWEB) April 24, 2015 Constellations ... living residence in Westchester County. Just 35 miles from ... transition individuals back into everyday life while recovering from ... May 7, 2015, will allow therapists, doctors and treatment ... and learn more about the opportunities offered by Constellations ...
(Date:4/24/2015)... April 24, 2015 Carvers' goal ... have a successful biking day in Breck. , ... five minutes walking distance from Breckenridge, this family-owned ... in both Breckenridge bike rentals ( http://www.breckenridgeskishop.com/en/rent-equipment ) ... offer extensive bike rentals in May 2015. With ...
(Date:4/24/2015)... CA (PRWEB) April 24, 2015 On ... sitting down in an interview with ItsNotAboutMe.TV contributor Karen ... Recovery, a holistic treatment center for addiction, of which ... ceremonies and festivals throughout the year, the EcoLuxe Lounge ... providers of eco-friendly and socially conscious products and services. ...
(Date:4/24/2015)... Anchor Health Administrators (Anchor), specialists in Long-Term Care ... exclusive agreement with LTC Solutions for All LLC (SFA) ... , Anchor has more than 18 years of experience ... and is currently the designated advocate for the American ... member benefit. , “I am very pleased to be ...
Breaking Medicine News(10 mins):Health News:David Steele Discusses Locker Room Culture on SCI TV 2Health News:David Steele Discusses Locker Room Culture on SCI TV 3Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 3Health News:Carvers Breckenridge Bike Rentals Offers Demo Mountain, Tandem, Bike Path Cruiser & JR. Bikes in May 2015 2Health News:Karen Salkin Talks with Per Wickstrom at the 2015 EcoLuxe Lounge and the "Salute to the Oscars" Celebration 2
... Maureen Salamon HealthDay Reporter , THURSDAY, Sept. 29 ... every corner of the globe, new research suggests that folks ... the workday progresses, regardless of where they live. The ... of 2.4 million people in 84 countries over two years, ...
... FRIDAY, Sept. 30 (HealthDay News) -- Unspoken clues -- ... according to a new study. Researchers from the University ... an impact on how patients view their relationship with ... The findings could help doctors better understand how they ...
... Franklin was right, at least on the healthy part. "Early to ... of early-bird Australian youths keep slimmer and more physically active than ... of sleep. A study in the Oct. 1 issue of ... of 2,200 Australian participants, ages 9 to 16, and compared their ...
... Picky eating is normal in children, but a pediatric feeding ... a child,s physical and mental development, an expert says. ... clinical director of the Pediatric Feeding Disorders Program at the ... reject certain foods but still has a nourishing diet. Children ...
... , THURSDAY, Sept. 29 (HealthDay News) --,New ... in a large-scale analysis of genetic data related to ... Philadelphia examined six large databases for DNA data from ... healthy people. In addition to validating results from ...
... LOS ANGELES (Sept. 29, 2011) Six leaders in ... will be key presenters at the world,s largest interdisciplinary ... The World Stem Cell Summit, co-sponsored by the ... the global stem cell and regenerative medicine community. ...
Cached Medicine News:Health News:Twitter Reflects World's Changing Moods 2Health News:Twitter Reflects World's Changing Moods 3Health News:Doctors Consider Nonverbal Cues in Medical Decisions 2Health News:Early to bed and early to rise -- study suggests it's keeping kids leaner 2Health News:Does Your Picky Eater Have a 'Feeding Disorder'? 2Health News:Cedars-Sinai scientists, physicians to be key presenters at World Stem Cell Summit 2Health News:Cedars-Sinai scientists, physicians to be key presenters at World Stem Cell Summit 3
(Date:4/24/2015)... - T-Bird Pharma Inc. (TSXV:TPI) ("T-Bird" or the "Company"), ... marijuana products and a licensed producer ("LP") to cultivate ... Canada ) ("MMPR"), is pleased to announce ... closed the transaction announced on March 11, 2015 with ... Transfer") a total of 20,156,790 common shares of T-Bird ...
(Date:4/24/2015)... , April 24, 2015  Blueprint Medicines ... a selective and potent inhibitor of fibroblast growth ... in models of hepatocellular carcinoma (HCC) that are ... candidate, BLU-554 induced complete tumor regression in a ... FGFR4-activating ligand at the highest dose levels. These ...
(Date:4/23/2015)... 2015  ResMed Inc. (NYSE: RMD ) today ... Revenue for the quarter was $422.5 million, a 6 ... 2014 (a 13 percent increase on a constant currency ... 1 percent compared to the quarter ended March 31, ... $0.64, an increase of 2 percent compared to the ...
Breaking Medicine Technology:T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 2T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 3Blueprint Medicines Presents New Preclinical Data Demonstrating Its Drug Candidate BLU-554 Induces Significant Tumor Regression in Models of Hepatocellular Carcinoma 2Blueprint Medicines Presents New Preclinical Data Demonstrating Its Drug Candidate BLU-554 Induces Significant Tumor Regression in Models of Hepatocellular Carcinoma 3ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 11ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 12ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 13
... INC. (NYSE: RMD ), announced today that on ... the third quarter and nine months of fiscal year 2011, ... will be issued after 1:00 p.m. Pacific Time and the ... its results, market trends, and future outlook. (Logo: ...
... NeuroVasx announced today that the FDA has approved ... Device (HDE) for the treatment of large, giant and ... to treat.  The HDE allows for the treatment of ... (Logo: http://photos.prnewswire.com/prnh/20110405/CG77724LOGO ) Christopher ...
Cached Medicine Technology:ResMed Announces Conference Call and Webcast to Discuss Third Quarter 2011 Results 2NeuroVasx Receives FDA Approval for cPAX Aneurysm Treatment System 2
This camouflaging lens features the solid black stripes of the lightning fast African zebra, on a white iris background....
Sphere Introducer...
Reusable cannula with .90 mm (20 g) shaft, tapering to .30 mm (30 g). Angled 125 3 mm from tip and flattened for easy insertion into the subretinal space....
... tip cannula allows atraumatic access ... for aspiration of subretinal fluids. ... beyond end of cannula. ... secure connection to a backflush ...
Medicine Products: