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Cardiovascular issues up mortality rates in patients with advanced fibrosis
Date:4/10/2013

New research reveals that advanced fibrosis is a significant predictor of mortality in patients with nonalcoholic fatty liver disease (NAFLD), largely brought about by cardiovascular causes. NAFLD alone was not associated with increased mortality according to findings published in the April issue of Hepatology, a journal of the American Association for the Study of Liver Diseases.

With super-sized portions, sugary soft drinks and physical inactivity, obesity is on the rise and showing no sign of slowing. Studies report that the prevalence of obesity has doubled in the U.S. over the past 25 years. As obesity rates have soared, so has the incidence of NAFLD, making it the most prevalent liver disease in the U.S.

NAFLD is a chronic form of liver disease that includes such conditions as steatosis without fibrosis, nonalcoholic steatohepatitis (NASH) with fibrosis, and cirrhosis. Fibrosis is the progressive scarring of the liver with stages ranging from zero to four (cirrhosis). Medical evidence has found that patients with simple steatosis have a better prognosis than those with NASH, which could progress to end-stage liver disease.

Lead investigator Dr. W. Kim Ray from the Mayo Clinic in Rochester, Minn. explains, "The effect of NAFLD on public health is not well understood. Large, population-based studies, which can provide insight into disease activity, present some difficulty given that liver biopsy is required to confirm NAFLD."

To investigate the long-term impact of NAFLD on mortality, the team used data from the National Health and Nutrition Examination Survey (NHANES)a survey by the National Center for Health Statistics in conjunction with the Centers for Disease Control and Prevention (CDC) that was conducted from 1988 to 1994 with mortality follow-up through 2006. NAFLD was diagnosed by ultrasound and severity of fibrosis was measured by non-invasive fibrosis markers such as the NAFLD fibrosis score (NFS). '/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

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