Navigation Links
Capturing circulating cancer cells could provide insights into how disease spreads
Date:12/11/2012

ANN ARBORA glass plate with a nanoscale roughness could be a simple way for scientists to capture and study the circulating tumor cells that carry cancer around the body through the bloodstream.

Engineering and medical researchers at the University of Michigan have devised such a set-up, which they say takes advantage of cancer cells' stronger drive to settle and bind compared with normal blood cells.

Circulating tumor cells are believed to contribute to cancer metastasis, the grim process of the disease spreading from its original site to distant tissues. Blood tests that count these cells can help doctors predict how long a patient with widespread cancer will live.

As important as the castaway cells are, scientists don't know a lot about them. They're rare, at about one per billion blood cells. And they are not all identical, even if they come from the same tumor. Existing tools for isolating them only catch certain types of cellsthose that express specific surface proteins or are larger than normal blood cells.

For example, the commonly used, FDA-approved CellSearch system uses antibody- coated magnetic beads to seek out tumor cells and bind to them. But not all circulating tumor cells express the proteins these antibodies recognize. It is possible that the most dangerous ones, known as cancer stem or progenitor cells, may have shed that tell-tale coat, thereby evading approaches that rely on antibodies.

The researchers say their system could likely trap these stealth cancer stem cellsa feat no research team has accomplished yet.

"Our system can capture the majority of circulating tumor cells regardless of their surface proteins or their physical sizes, and this could include cancer progenitor or initiating cells," said Jianping Fu, assistant professor of mechanical engineering and biomedical engineering and a senior author of a paper on the technique published online in ACS Nano.

Fu
'/>"/>

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-7087
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Coffee May Lower Risk of Death From Mouth Cancer: Study
2. The current state of lung cancer treatment
3. Children born prematurely are at higher risk of esophageal inflammation, cancer
4. FDA OKs Expanded Use of Prostate Cancer Drug
5. Prostate cancer now detectable by imaging-guided biopsy
6. Targeted prostate biopsy has potential to improve diagnosis of prostate cancer
7. UCLA cancer scientists identify liposarcoma tumors that respond to chemotherapy
8. The Project for Natural Health Choices Inc. Issues an Advisory for Men to Consume Flavonoids in their Diet to Protect Against Prostate Cancer
9. To fight incurable metastatic breast cancer, resistance must be broken
10. Caffeinated coffee may reduce the risk of oral cancers
11. Abnormal DNA maintenance related to cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 17, 2014 A group of 127 scientists ... today, in reaction to a recent statement by the center ... training and derogated the efficacy of all brain exercises. , ... the parts of the center’s statement critical of brain exercise ... had also overstated its case, in a document it had ...
(Date:12/17/2014)... 2014 Project Veritas is releasing a ... of MIT economist and Obamacare architect Jonathan Gruber to ... conducted the interview, which is being distributed on YouTube. ... intentional mislabeling in the Affordable Care Act in order ... two-hundred-and-fifty billion dollar per year tax grab. , “President ...
(Date:12/17/2014)... -- Poor students get more fruits and vegetables at school ... But, the opposite is true for students from wealthier families. ... school may give a healthy boost to poor students, diets, ... family income level, students all ate a similar amount of ... study was published recently in the journal Preventive Medicine ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. ... in America, and work commitment is a big reason why, ... killer," said Dr. Mathias Basner, an assistant professor of sleep ... School of Medicine. A time-use survey of nearly 125,000 ... the main activity exchanged for sleep. Short sleepers -- those ...
(Date:12/15/2014)... Main Street Dental Team ( http://www.MainStreetDentalTeam.com ), Unionville’s first ... study providing evidence on the impact of 100% pure ... Sufficient enough evidence already exists showing a negative link ... with the onset of tooth decay. One question that ... 100% fruit juice, meaning it is completely natural with ...
Breaking Medicine News(10 mins):Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 3Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 4Health News:Project Veritas: James O’Keefe Interviews the Man Who Discovered Jonathan Gruber Videos 2Health News:Poor Students Eat Healthier Foods at School, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:Main Street Dental Team, Unionville’s Most Innovative Dental Clinic, Comments on New Study Relating Pure Fruit Juice to Poor Oral Hygiene 2
... Australia, Fremantle, for the patients with type II diabetes, the ... if they self-monitor their blood glucose levels. ,Dr. ... the journal Diabetes Care, explained that they conducted their study ... the Fremantle Diabetes Study. It was reported that a total ...
... in Toronto will begin on Sunday, bringing together over 20,000 ... play a more active role in the battle with this ... hard around the world especially in sub-Saharan Africa which is ... that nearly 9 out of 10 children diagnosed with HIV/AIDS ...
... new study published in the September issue of the ... identified the genes //responsible for preserving cognition even at ... of Pittsburgh are the first to identify the genetic ... has been defined in many ways, however, we focused ...
... expect far more from the children than their ... to a study that has been published in ... are increasingly being expected to provide an adult-level ... professor in McMaster University's Department of Psychology, Neuroscience ...
... diagnosed with prostate cancer three years ago is now ... Hospital. ,In a statement released by the Tannadice ... his illness were released putting an end to the ... ,The new treatment began at Ninewells Hospital ...
... workers against any pandemic or influenza outbreak, South Australia ... Mr. John Hill said//. The fund would assist in ... would be necessary to fight a potential influenza outbreak. ... the outbreak was uncontrollable, nearly 25% of South Australians ...
Cached Medicine News:Health News:Study Finds No Benefits On Self Monitoring Blood Glucose levels 2Health News:Church to Have an Active Role in the Prevention of AIDS 2Health News:Genes And Aging 2Health News:Please Give Kids a Break!! 2
(Date:12/17/2014)... , December 17, 2014 Revenue and ... expenditure on research and development In the past ... revenue by two percent to EUR 4.287 billion (last year: ... by 14 percent to EUR 360 million. "Overall, 2013/14 was ... Michael Kaschke , President and CEO of Carl Zeiss ...
(Date:12/17/2014)...  Beamz Interactive, Inc. (OTCQB: BZIC), a leading ... that it has signed an agreement with RSL ... innovative prosthetic, orthotic and assistive technology products and ... RSL Steeper will promote and supply the Beamz ... within UK residential care facilities through its Assistive ...
(Date:12/17/2014)... Dec. 17, 2014  RXi Pharmaceuticals Corporation (NASDAQ: ... on discovering, developing and commercializing innovative therapies addressing ... completion of enrollment in its first Phase 2a ... observations confirmed the 1-month findings that were reported ... Logo - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO , ...
Breaking Medicine Technology:ZEISS Asserts its Position in Difficult Environment 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5
... MYL ) today announced that its subsidiary Mylan ... and Drug Administration (FDA) for its Abbreviated New Drug Application ... mg, 10 mg, 15 mg, and 20 mg. This product ... ® , which is indicated for the treatment of schizophrenia ...
... Young Innovations, Inc. (NASDAQ: YDNT ) today announced sales ... Sales for the first quarter of 2012 were ... the first quarter of 2011. Income from operations increased 5.3% to ... in the first quarter of 2011. Net income increased 5.6% to ...
Cached Medicine Technology:Mylan Launches Generic Version of Zyprexa® Tablets 2Young Innovations, Inc. Announces Record Sales and EPS for the Quarter Ended March 31, 2012 2Young Innovations, Inc. Announces Record Sales and EPS for the Quarter Ended March 31, 2012 3Young Innovations, Inc. Announces Record Sales and EPS for the Quarter Ended March 31, 2012 4
Achievement, available exclusively from Art Optical, is a unique RGP lens design with a patented junctionless back surface and a controlled edge lift....
... is designed using sophisticated lathing techniques, intrinsically ... lenses feature a center thickness of just ... all plus powered Thinsite lenses maintain a ... designs. The unique design eliminates stress points ...
... is a simultaneous vision lens ... Through a series of front ... LifeStyle Gp delivers up to ... its multi-aspheric center-distance design works ...
Boston Multivision design is manufactured in Boston ES material for early presbyope patients. Boston Multivision lens provides crisp, clear vision at near, intermediate, and far distances and excelle...
Medicine Products: