Navigation Links
Capturing circulating cancer cells could provide insights into how disease spreads
Date:12/11/2012

ANN ARBORA glass plate with a nanoscale roughness could be a simple way for scientists to capture and study the circulating tumor cells that carry cancer around the body through the bloodstream.

Engineering and medical researchers at the University of Michigan have devised such a set-up, which they say takes advantage of cancer cells' stronger drive to settle and bind compared with normal blood cells.

Circulating tumor cells are believed to contribute to cancer metastasis, the grim process of the disease spreading from its original site to distant tissues. Blood tests that count these cells can help doctors predict how long a patient with widespread cancer will live.

As important as the castaway cells are, scientists don't know a lot about them. They're rare, at about one per billion blood cells. And they are not all identical, even if they come from the same tumor. Existing tools for isolating them only catch certain types of cellsthose that express specific surface proteins or are larger than normal blood cells.

For example, the commonly used, FDA-approved CellSearch system uses antibody- coated magnetic beads to seek out tumor cells and bind to them. But not all circulating tumor cells express the proteins these antibodies recognize. It is possible that the most dangerous ones, known as cancer stem or progenitor cells, may have shed that tell-tale coat, thereby evading approaches that rely on antibodies.

The researchers say their system could likely trap these stealth cancer stem cellsa feat no research team has accomplished yet.

"Our system can capture the majority of circulating tumor cells regardless of their surface proteins or their physical sizes, and this could include cancer progenitor or initiating cells," said Jianping Fu, assistant professor of mechanical engineering and biomedical engineering and a senior author of a paper on the technique published online in ACS Nano.

Fu
'/>"/>

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-7087
University of Michigan
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Coffee May Lower Risk of Death From Mouth Cancer: Study
2. The current state of lung cancer treatment
3. Children born prematurely are at higher risk of esophageal inflammation, cancer
4. FDA OKs Expanded Use of Prostate Cancer Drug
5. Prostate cancer now detectable by imaging-guided biopsy
6. Targeted prostate biopsy has potential to improve diagnosis of prostate cancer
7. UCLA cancer scientists identify liposarcoma tumors that respond to chemotherapy
8. The Project for Natural Health Choices Inc. Issues an Advisory for Men to Consume Flavonoids in their Diet to Protect Against Prostate Cancer
9. To fight incurable metastatic breast cancer, resistance must be broken
10. Caffeinated coffee may reduce the risk of oral cancers
11. Abnormal DNA maintenance related to cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2013)... Ill. The distribution of white matter brain abnormalities ... closely resembles that found in early Alzheimer,s dementia, according ... Radiology . , "Findings of MTBI bear ... dementia," said the study,s lead author, Saeed Fakhran, M.D., ... at the University of Pittsburgh School of Medicine. "Additional ...
(Date:6/17/2013)... (PRWEB) June 17, 2013 Daily Gossip ... therefore, publish a thorough review of the Tinnitus ... Daily Gossip presents the natural treatment that ... patients who have tested it. , Based on the ... natural Tinnitus treatment suggested by Thomas Coleman ...
(Date:6/17/2013)... New York, New York (PRWEB) June 17, 2013 ... associated with products manufactured by C.R. Bard, Inc. ... underway in New Jersey’s Atlantic County Superior Court, Bernstein ... a new Consent Order that set forth protocols for ... samples for the litigation’s bellwether cases. Court documents ...
(Date:6/17/2013)... The producers of Impact with Martin ... reports highlighting how sustainable farming techniques are helping the ... their demand on food supplies. , Impact Martin ... airing in markets around the country on public television. ... who is marking the start of his second half-century ...
(Date:6/17/2013)... 17, 2013 Ayurveda Chile is ... "knowledge or wisdom of life." As a mind-body-spirit medicine, its ... transformation of consciousness. Its fundamental philosophy is that disease is ... environment. In order to re-establish optimal health, one must discover ... a life style which brings us back into perfect harmony ...
Breaking Medicine News(10 mins):Health News:Concussion patients show Alzheimer's-like brain abnormalities 2Health News:Concussion patients show Alzheimer's-like brain abnormalities 3Health News:Thomas Coleman's Tinnitus Miracle Treatment Review Discloses Alternative Natural Cure 2Health News:Transvaginal Mesh Lawyers at Bernstein Liebhard LLP Note New Order in New Jersey C.R. Bard Litigation Concerning Handling of Explants and Tissue Samples 2Health News:Transvaginal Mesh Lawyers at Bernstein Liebhard LLP Note New Order in New Jersey C.R. Bard Litigation Concerning Handling of Explants and Tissue Samples 3Health News:Ayurveda Chile Program Offered by Escuela Ayurveda de California in August, 2013 2
... of nearly 150 randomized controlled trials on children all ... 60 percent of the studies either failed to take steps ... describe those measures. A report of the team,s findings ... experimental trials sponsored by pharmaceutical or medical-device makers, along with ...
... touchscreens, housed in computer kiosks at clinics and ... School of Medicine and clinicians at local health ... diverse language, literacy and computer skills. The ... and collect patient data. Each piece of text ...
... ... ... policies that would meet people’s needs and improve their lives, according to Thoraya Ahmed Obaid, ... can better track and make greater progress to achieve the Millennium Development Goals ...
... and Geneva, Switzerland -- The International AIDS Society (IAS) ... access to the XVIII International AIDS Conference (AIDS 2010) ... -- an independent operating foundation and non-partisan source of ... USA -- is the official webcaster for AIDS 2010, ...
... ... calls on the public to share their personal stories and utilizes social media to spread the ... Newcastle, ME (Vocus) July ... society has resulted in a special video project and upcoming book. The Social Security Stories ...
... ... to improve fertility in women with diminished ovarian reserve further confirms Center For Human ... ... Shulman, MD and co-workers of Tel Aviv University in Tel Aviv, Israel, confirmed previously ...
Cached Medicine News:Health News:Pediatric clinical studies appear prone to bias, Hopkins review shows 2Health News:Pediatric clinical studies appear prone to bias, Hopkins review shows 3Health News:Talking touchscreens aid patients 2Health News:Everyone Counts: Quality Data Essential to Improving People's Lives, Says UNFPA 2Health News:Online coverage of XVIII International AIDS Conference to include daily webcasts, live coverage, podcasts and news recaps 2Health News:Project captures Social Security "Stories," Seeks Additional Submissions from Public 2Health News:Project captures Social Security "Stories," Seeks Additional Submissions from Public 3Health News:Tel Aviv University Fertility Research Confirms New York Center's DHEA Findings 2Health News:Tel Aviv University Fertility Research Confirms New York Center's DHEA Findings 3
(Date:6/17/2013)... , June 17, 2013  Ochsner Health ... technologies that will help improve medication safety by ... its health system. The CareFusion ... of hardware and software that helps hospitals significantly ... and administer medications because of simpler, more efficient ...
(Date:6/17/2013)... 17, 2013 /PRNewswire-iReach/ -- MicroTechnologies recently was awarded a significant ... devices at its Costa Rica facility. ... new Life Science division and will serve to greatly advance ... a major step forward, both for our company and ... remain confidential) has put their faith in the country and ...
(Date:6/17/2013)... 2013   Life Technologies Corporation (NASDAQ: ... Epi5™ Episomal iPSC Reprogramming Vectors , the world,s first ... won its developers a Nobel Prize in 2012 for ... an early embryonic state. Scientists use induced ... patient-derived adult somatic cells. The iPSCs can then be ...
Breaking Medicine Technology:Ochsner Health System Improves Safety Through Advanced Medication Management Technology 2Ochsner Health System Improves Safety Through Advanced Medication Management Technology 3Ochsner Health System Improves Safety Through Advanced Medication Management Technology 4Ochsner Health System Improves Safety Through Advanced Medication Management Technology 5MicroTechnologies Announces Award of Medical Device Contract Manufacturing Line 2Life Technologies Expands Range of Stem Cell Reprogramming Solutions 2Life Technologies Expands Range of Stem Cell Reprogramming Solutions 3
... 23 Neurobiological Technologies, Inc. (Nasdaq: NTII ) ("NTI") ... extraordinary dividend of $0.18 per share of common stock, which ... record as of November 30, 2009. The December 9, 2009 ... pursuant to a plan of complete liquidation and dissolution and ...
... Calif., Nov. 23 Advanced Sterilization Products (ASP), ... today the acquisition by its French affiliate, Apsis ... of innovative disinfection processes and technologies to prevent ... disclosed. , Gloster Europe designs and markets ...
Cached Medicine Technology:Neurobiological Technologies Announces Extraordinary Dividend of $0.18 per Share 2ASP Announces Acquisition of Gloster Europe to Help Reduce Infections in Healthcare Facilities 2
... PreserVision® AREDS formula is the one and ... in the National Eye Institute's age-related eye ... day format. The 10-year clinical Age-Related ... Eye Institute (a division of the National ...
... OcularProtect is a scientifically advanced ... for visual and full body ... key nutrients, including a diverse ... FloraGLO lutein, lycopene and OptiBerry ...
... vitamin and mineral supplements offer everything ... plus more. Ocuvite Extra contains ... levels of vitamins C versus the ... other antioxidants and minerals traditionally found ...
HydroEye is an exclusive formulation designed to provide dry eye relief and support the body's natural tear formation. Like all ScienceBased Health formulations, it is produced in softgel form for ma...
Medicine Products: