Navigation Links
Cancer scientists discover genetic diversity in leukemic propagating cells
Date:1/19/2011

y have one set of genetic abnormalities while other families are very rare, explaining why they had never been seen before.

The study results provide data linking genetic events in ALL taken from patients when first diagnosed to their future clinical survival. In the lab, the researchers reproduced human ALL in mice transplanted with patient leukemia samples. Sometimes the dominant genetic family would grow in the mice while in other mice the rarer families would grow.

"By looking at the genetic signatures of the leukemia cells in the different mice we were able to figure out their genetic ancestry and the evolutionary trajectory that that particular leukemia took. We found that if a particular gene family was mutated, the tumours were aggressive when grown in the mice. The patients with the corresponding tumours had poorer survival showing that the human-mouse transplant system could be very useful in predicting patient outcome."

This insight into genetic diversity has positive implications for cancer treatment, says Dr. Dick. "Understanding the complexity of cellular relationships and the existence of distinct genetic families of leukemia cells will shed light on why some cells of the cancer are not killed by the therapy and eventually regrow resulting in disease relapse, and help accelerate the development of tailored therapies to wipe out all the unwanted branches in the genetic tree."

Research collaborator Dr. Charles Mullighan, a hematologist at St. Jude Children's Research Hospital, adds: "Overall, the study proved that many leukemias comprise multiple subpopulations with different genetic alterations, and that these genetic alterations may evolve over time. The main clinical implication is that we now need to extend this work to identify genetic changes at low levels at diagnosis that confer a high risk of treatment failure and relapse and find ways of targeting them."

The current research builds from earlier
'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.on.ca
416-946-2846
University Health Network
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
3. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
4. Low forms of cyclin E reduce breast cancer drugs effectiveness
5. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
6. Soft drinks may increase risk of pancreatic cancer
7. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
8. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
9. Single gene mutation induces endometrial cancer
10. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
11. Molecular pathways linked to sex, age affect outcomes in lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... (PRWEB) July 24, 2014 Memantine was initially ... first marketed in Germany under the brand name Akatinol; it ... nations as Ebixa and in the USA to Forest Labs ... 420 million in 2013. In the US, Forest reported Namenda ... protection expiry in Canada, Australia and the European region has ...
(Date:7/24/2014)... Rockville, MD (PRWEB) July 24, 2014 ... women are looking to egg freezing as a way ... potential which would otherwise decline with advancing reproductive age. ... embryos, is a cutting edge medical technology that allows ... ovaries during her peak fertility years, which are then ...
(Date:7/24/2014)... with high-throughput data generated by breast cancer biologists ... computational method to determine how gene networks are ... as they respond to potential cancer therapy agents., ... each other in laboratory-grown cells is described in ... PLOS Computational Biology . , The method ...
(Date:7/24/2014)... July 24, 2014 In a recent report ... has officially put an end to criminal penalties associated with ... new era for marijuana reform in Washington DC, giving it ... new law replaces criminal penalties for possession of one ounce ... and the possession of more than an ounce of marijuana ...
(Date:7/24/2014)... New research from Penn Medicine shows that ... length of hospital stay by 30 percent and ... when compared with conventional transfemoral TAVR, which requires ... is available in the current issue of ... replacement of the aortic valve without a traditional ...
Breaking Medicine News(10 mins):Health News:Memantine Discussed in New Comprehensive Patent Search Report by Ark Patent Intelligence Published at MarketPublishers.com 2Health News:Memantine Discussed in New Comprehensive Patent Search Report by Ark Patent Intelligence Published at MarketPublishers.com 3Health News:Expanded Financial Options for Women Interested in Proactive Egg Freezing at Shady Grove Fertility 2Health News:Expanded Financial Options for Women Interested in Proactive Egg Freezing at Shady Grove Fertility 3Health News:Expanded Financial Options for Women Interested in Proactive Egg Freezing at Shady Grove Fertility 4Health News:Gene changes in breast cancer cells pinpointed with new computational method 2Health News:Gene changes in breast cancer cells pinpointed with new computational method 3Health News:Washington D.C. Decriminalizes Marijuana 2Health News:Penn study: Incisionless transcatheter aortic valve replacement surgery cuts hospital length of stay 2
... ,Bad, Children Can Survive - and Thrive , ... The holidays should bring peace, harmony, and treasured memories, ... difficult, even disorderly conduct among troubled children. Tantrums, defiant reactions, ... leave parents asking, "What did I do wrong?" , ...
... 18 A simple and inexpensive,developmental diagnostic assay ... to be highly accurate for rapid detection,of serious ... susceptibility. The research was reported in three ... Agents,and Chemotherapy (ICAAC). , ...
... an increasingly important part of patient consultations. , ... ... reveals physicians are accessing online clinical resources more than ever, and ... through Internet searches. Epocrates, Inc., developer of mobile and ...
... of fruit, it doesn,t seem very difficult to recognize a ... to "feature binding" a process by which our brain combines ... us a complete and unified picture of it. For example, ... to work, connecting (or binding) information about each fruit,s shape ...
... signs aren,t just for newlyweds anymore. , They are also ... sexual expression, according to Kansas State University aging experts. , ... can offer residents some privacy," said Gayle Doll, who directs ... a problem for nursing home residents who want to engage ...
... years old, close to 90 percent of children have at ... night terrors, teeth-grinding and bed-wetting. , For the majority, ... percent of children in this age group have difficulties sleeping ... slumber or they can,t stay asleep. While the effects of ...
Cached Medicine News:Health News:New Site DrNorm.com Offers Hope and Healing to Parents of 'Difficult' Children During Holiday Season & Beyond 2Health News:New Site DrNorm.com Offers Hope and Healing to Parents of 'Difficult' Children During Holiday Season & Beyond 3Health News:New Research Shows MicroPhage Test Accurately and Rapidly Detects Serious Bacterial Infections 2Health News:New Research Shows MicroPhage Test Accurately and Rapidly Detects Serious Bacterial Infections 3Health News:Epocrates Survey Identifies Trends in Online Resource Use Among Physicians 2Health News:Epocrates Survey Identifies Trends in Online Resource Use Among Physicians 3Health News:Bound by attention: Bringing rats and humans together 2Health News:K-State helps nursing home staff become comfortable with residents' sexual expression 2Health News:26 percent of sleepless children become overweight 2
(Date:7/24/2014)... 2014  Abaxis, Inc. (NasdaqGS: ABAX ), ... today reported financial results for the first fiscal quarter ... , Revenues of $47.5 million, up 10% over ... $0.21, up 50% over last year,s comparable quarter. ... $7.2 million, up 20% over last year,s comparable quarter. ...
(Date:7/24/2014)... 24, 2014 Amgen (NASDAQ: AMGN ) ... results on Tuesday, July 29, 2014, after the close of ... a conference call with the investment community at 2 p.m. ... Robert A. Bradway , chairman and chief executive officer, and ... audio of the conference call will be simultaneously broadcast over ...
(Date:7/24/2014)...  IGI Laboratories, Inc. (NYSE MKT: IG), a New Jersey ... financial results for the second quarter ended June 30, 2014. ... revenues of $6.5 million in the second quarter of 2014, ... , Total revenues of $13.3 million for the six ... the same period in 2013 , Total revenues generated ...
Breaking Medicine Technology:Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 2Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 3Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 4Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 5Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 6Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 7Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 8Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 9Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 10Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 11Amgen Announces Webcast of 2014 Second Quarter Financial Results 2IGI Laboratories Announces Second Quarter 2014 Results 2IGI Laboratories Announces Second Quarter 2014 Results 3IGI Laboratories Announces Second Quarter 2014 Results 4IGI Laboratories Announces Second Quarter 2014 Results 5IGI Laboratories Announces Second Quarter 2014 Results 6IGI Laboratories Announces Second Quarter 2014 Results 7
... SOUTH SAN FRANCISCO, Calif., Oct. 21 NGM Biopharmaceuticals, ... and development of novel biotherapeutics for the treatment of ... that Arthur D. Levinson, Ph.D., the Chairman of Genentech,s ... of Directors. Under Dr. Levinson,s leadership as Chairman ...
... PharmaNet Development Group, Inc., a leading provider of clinical ... device companies, today announced its participation at the 8th ... the World Trade Center in Rotterdam, The Netherlands from ... top management will discuss some of the most important ...
Cached Medicine Technology:NGM Biopharmaceuticals Appoints Dr. Arthur D. Levinson, Former Genentech CEO, to its Board of Directors 2NGM Biopharmaceuticals Appoints Dr. Arthur D. Levinson, Former Genentech CEO, to its Board of Directors 3PharmaNet Development Group Management Participates in the 8th Annual Partnerships in Clinical Trials Conference in Rotterdam 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: