Navigation Links
Cancer scientists discover genetic diversity in leukemic propagating cells
Date:1/19/2011

(Toronto, Canada January 20, 2011) Cancer scientists led by Dr. John Dick at the Ontario Cancer Institute (OCI) and collaborators at St Jude Children's Research Hospital (Memphis) have found that defective genes and the individual leukemia cells that carry them are organized in a more complex way than previously thought.

The findings, published today in Nature (DOI:10.1038/nature09733), challenge the conventional scientific view that cancer progresses as a linear series of genetic events and that all the cells in a tumour share the same genetic abnormalities and the same growth properties.

"Our results show this is not the case and open the way to discover how genetic abnormalities transform normal cells into leukemic cells and the steps that have to happen to make the leukemic cells increasingly abnormal and aggressive, how leukemic cells at different steps of genetic evolution (or progression) respond to therapy, or contribute to relapse," says Dr. Dick, Senior Scientist at OCI's Campbell Family Institute for Cancer Research, the research arm of Princess Margaret Hospital, and the McEwen Centre for Regenerative Medicine at University Health Network. Dr. Dick is also a Professor in the Department of Molecular Genetics, University of Toronto, and Director of the Cancer Stem Cell Program at the Ontario Institute for Cancer Research.

The research team found that the leukemia cells taken from patients with acute lymphoblastic leukemia (ALL) are actually composed of multiple families of genetically distinct leukemia cells. They looked at how these families developed and retraced the ALL "family tree" back to its origins. They discovered that the so-called black sheep the cells that propagate the disease and potentially survive therapy persist through generations, and even branch off and evolve to form genetically distinct cancer families. Some of these genetic families dominate, making it appear that the leukemia cells onl
'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.on.ca
416-946-2846
University Health Network
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
3. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
4. Low forms of cyclin E reduce breast cancer drugs effectiveness
5. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
6. Soft drinks may increase risk of pancreatic cancer
7. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
8. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
9. Single gene mutation induces endometrial cancer
10. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
11. Molecular pathways linked to sex, age affect outcomes in lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... July 03, 2015 , ... ... place on June 25, 2015 at 1:00pm. The Association welcomed speaker C. Daniel ... to injured bicyclists and practical points of investigating these types of cases. , ...
(Date:7/3/2015)... ... July 03, 2015 , ... " Selfie on a Stick ” ... latest and coolest technology products available to consumers. Amanda Forstrom, a technology expert and ... sticks are great for documenting memories. , Almost every smartphone has an incredibly powerful ...
(Date:7/2/2015)... ... , ... sweetFrog Enterprises, LLC. is pleased to announce the opening of its newest location in ... State. The premium frozen yogurt chain was listed as #22 on the Inc. 500 list ... Village at Bachman Lake, is located at:, 3701 W. Northwest Highway, STE 430, Dallas, TX ...
(Date:7/2/2015)... ... 2015 , ... Many Fourth of July celebrations will include fireworks this summer, ... is sharing some tips to promote the proper use of fireworks. , According to ... room daily with fireworks-related injuries in the month surrounding the Fourth of July. Amica ...
(Date:7/2/2015)... ... July 02, 2015 , ... Get ready ... SIGVARIS PERFORMANCE SOCKS. Since the socks were first introduced, they have rapidly been ... popularity has inspired four new, fun shades including: blue, lime, pink and red. ...
Breaking Medicine News(10 mins):Health News:Attorney from William Mattar Leads Discussion on Bicycle Accidents 2Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:sweetFrog Opens 18th Location in the Lone Star State 2Health News:6 Fireworks Safety Tips from Amica Insurance 2Health News:SIGVARIS is Sporting Four Brand New Colors in the Popular PERFORMANCE SOCK Product Line 2
... management technology, aggressive fever control may improve neurologic ... 25 The nation,s top-rated neurology programs cool ... with the non-invasive, safe and technologically advanced ... 80 percent, or 23 of the 30 top-ranked ...
... CompleteM.E. Healthcare Education Solution Streamlines Student Evaluations and Consolidates Scheduling ... ... BC (PRWEB) March 25, 2009 -- one45 Software, a leading ... subsidiary of Cytiva Software Inc. (CRX:TSX.V), announced today the selection ...
... Professional is less invasive than blood tests at detecting lead levels in ... ... Until now, determining a person,s lead exposure has been an invasive procedure ... Professional, a new saliva-based lead test that screens for lead ...
... of the Program in Clinical Effectiveness (PCE), which has ... 1986, have achieved significant success in receiving grant support ... funders, along with other accomplishments considered key to establishing ... a joint program of Brigham and Women,s Hospital ...
... Lifestyle, age and weight have all been considered as risk ... open access journal Breast Cancer Research has found ... three times the risk of developing an aggressive ,triple negative ... In the US, which has the highest rate of breast ...
... BioHorizons announces today that its 2009 Global Symposium ... May 2, at the Hilton Chicago. This educational ... dentistry, treatment planning, implant surface treatments, tissue regeneration ... the outstanding and diverse expertise of top dental ...
Cached Medicine News:Health News:Top Neurology Programs Control Fever with Arctic Sun Cooling Technology 2Health News:Top Neurology Programs Control Fever with Arctic Sun Cooling Technology 3Health News:Texas A&M Health Science Center College of Medicine Selects one45 Software's Healthcare Education Suite 2Health News:Texas A&M Health Science Center College of Medicine Selects one45 Software's Healthcare Education Suite 3Health News:Texas A&M Health Science Center College of Medicine Selects one45 Software's Healthcare Education Suite 4Health News:The First Oral Based Lead Test, LeadConfirm Professional, Makes Getting The Lead Out Easier 2Health News:The First Oral Based Lead Test, LeadConfirm Professional, Makes Getting The Lead Out Easier 3Health News:The First Oral Based Lead Test, LeadConfirm Professional, Makes Getting The Lead Out Easier 4Health News:Intensive summer program helps physicians build clinical research careers 2Health News:Intensive summer program helps physicians build clinical research careers 3Health News:BioHorizons Announces Its 2009 Global Symposium: Bringing Together Top Thought Leaders in the Dental Implant Industry to Provide Insight on Integrating Technology into the Continuum of Care 2
(Date:7/2/2015)... Conn. , July 2, 2015 Numotion,s ... Executive Officer announced that Tamas Feitel has ... Feitel joins Numotion after a highly successful 18 year ... leadership roles driving strategy, profitability, and productivity to result ... most recent position was Chief Financial Officer for GE ...
(Date:7/2/2015)... July 2, 2015 The report ... Heterofermentative), Species (Lactobacillus, Pediococcus & Enterococcus), Enzymes (Fibre-digesting & ... to 2020", Silage Inoculants & Enzymes Market is expected ... of 4.0% from 2015 to 2020. ... spread through 194 P ages and ...
(Date:7/2/2015)... julio de 2015 BGI anunció hoy que ... alto rendimiento en Hong Kong ... (CAP). La instalación de BGI en Hong Kong ... próxima generación que recibe la certificación CAP en ... en prácticas de laboratorio clínico. Junto con el exitoso ...
Breaking Medicine Technology:Numotion Names Tamas Feitel Chief Financial Officer 2Silage Inoculants & Enzymes Market Worth $489.05 Million by 2020 2Silage Inoculants & Enzymes Market Worth $489.05 Million by 2020 3Silage Inoculants & Enzymes Market Worth $489.05 Million by 2020 4BGI recibe la acreditación del College of American Pathologists (CAP) 2
... NAGOYA, Japan, June 23 Although previous studies,suggest ... length,growth of the eye in children with progressing ... evident. Using a rigorous study design,and precise optical ... in Madrid are undertaking the Myopia Control with,Orthokeratology ...
... Calif., June 23 Alexza,Pharmaceuticals, Inc. (Nasdaq: ... of its Phase 2a clinical trial of Staccato(R) ... the 50th Annual Scientific Meeting of,the American Headache ... Place in Boston, MA. The oral platform abstract ...
Cached Medicine Technology:Menicon Undertakes With the Novovision Clinic a Paediatric Myopia Control Clinical Trial 2Alexza Pharmaceuticals to Present AZ-104 Phase 2a Clinical Data at the American Headache Society Annual Scientific Meeting 2
Sharp tipped scissors angled 135 from the shaft with a horizontal cutting action. For cutting in the plane parallel to the retina and cutting membranes adherent to the retinal surface (delamination)....
Sharp tipped illuminated scissors with a curvature of 12 mm to follow the contour of the retina. For cutting in the plane parallel to the retina, cutting membranes adherent to the retinal surface and...
Microscissors : Horizontal Scissors...
Sharp tipped scissors with a vertical cutting action. Rounded lower edge of scissors blade minimizes unintentional engagement of retina....
Medicine Products: