Navigation Links
Cancer scientists discover genetic diversity in leukemic propagating cells
Date:1/19/2011

(Toronto, Canada January 20, 2011) Cancer scientists led by Dr. John Dick at the Ontario Cancer Institute (OCI) and collaborators at St Jude Children's Research Hospital (Memphis) have found that defective genes and the individual leukemia cells that carry them are organized in a more complex way than previously thought.

The findings, published today in Nature (DOI:10.1038/nature09733), challenge the conventional scientific view that cancer progresses as a linear series of genetic events and that all the cells in a tumour share the same genetic abnormalities and the same growth properties.

"Our results show this is not the case and open the way to discover how genetic abnormalities transform normal cells into leukemic cells and the steps that have to happen to make the leukemic cells increasingly abnormal and aggressive, how leukemic cells at different steps of genetic evolution (or progression) respond to therapy, or contribute to relapse," says Dr. Dick, Senior Scientist at OCI's Campbell Family Institute for Cancer Research, the research arm of Princess Margaret Hospital, and the McEwen Centre for Regenerative Medicine at University Health Network. Dr. Dick is also a Professor in the Department of Molecular Genetics, University of Toronto, and Director of the Cancer Stem Cell Program at the Ontario Institute for Cancer Research.

The research team found that the leukemia cells taken from patients with acute lymphoblastic leukemia (ALL) are actually composed of multiple families of genetically distinct leukemia cells. They looked at how these families developed and retraced the ALL "family tree" back to its origins. They discovered that the so-called black sheep the cells that propagate the disease and potentially survive therapy persist through generations, and even branch off and evolve to form genetically distinct cancer families. Some of these genetic families dominate, making it appear that the leukemia cells onl
'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.on.ca
416-946-2846
University Health Network
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
3. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
4. Low forms of cyclin E reduce breast cancer drugs effectiveness
5. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
6. Soft drinks may increase risk of pancreatic cancer
7. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
8. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
9. Single gene mutation induces endometrial cancer
10. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
11. Molecular pathways linked to sex, age affect outcomes in lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... September 03, 2015 , ... E-Volve ... a leading national healthcare solutions organization, to provide electronic medical record (EMR) consulting ... agreement, Amerinet members will receive negotiated pricing on E-Volve Health’s Epic EMR consulting, ...
(Date:9/3/2015)... Rhinebeck, NY (PRWEB) , ... September 03, 2015 ... ... Kitslaar when he made the company the final destination of his six-month, 10,000 ... , During the trek—which he calls the “Connecting Las Americas” ...
(Date:9/3/2015)... ... September 03, 2015 , ... Results of a ... Healthcare Research and Policy Analysis has found physician leadership development training programs to ... percent of respondents said their organizations conduct some kind of physician leadership development ...
(Date:9/3/2015)... ... September 03, 2015 , ... Hope For The Warriors® is ... Scholarships are awarded two times each year to spouses or caregivers of post-9/11 ... dedicated to restoring a sense of self, restoring the family unit, and restoring ...
(Date:9/3/2015)... ... September 03, 2015 , ... Today, Splashtop announced availability ... as part of the LANDESK One Partner program. Splashtop remote desktop ... mobile user experience in remote access and control:, , ...
Breaking Medicine News(10 mins):Health News:E-Volve Health to Offer EMR Consulting Solutions to Amerinet Members 2Health News:Topical BioMedics Announces Visit from Max Wohlgemuth Kitslaar, Ending his Six-Month, 10,000 Mile Journey from Chile to New York on a 1976 Moto Guzzi Motorcycle 2Health News:Topical BioMedics Announces Visit from Max Wohlgemuth Kitslaar, Ending his Six-Month, 10,000 Mile Journey from Chile to New York on a 1976 Moto Guzzi Motorcycle 3Health News:Topical BioMedics Announces Visit from Max Wohlgemuth Kitslaar, Ending his Six-Month, 10,000 Mile Journey from Chile to New York on a 1976 Moto Guzzi Motorcycle 4Health News:Topical BioMedics Announces Visit from Max Wohlgemuth Kitslaar, Ending his Six-Month, 10,000 Mile Journey from Chile to New York on a 1976 Moto Guzzi Motorcycle 5Health News:Topical BioMedics Announces Visit from Max Wohlgemuth Kitslaar, Ending his Six-Month, 10,000 Mile Journey from Chile to New York on a 1976 Moto Guzzi Motorcycle 6Health News:Survey finds growing movement for physician leadership training 2Health News:Survey finds growing movement for physician leadership training 3Health News:Hope For The Warriors Spouse/Caregiver Scholarships Now Open for Spring 2016 2Health News:Splashtop Partners with LANDESK to Deliver High Performance Remote Access and Remote Support to and from Mobile Devices and Chromebook 2Health News:Splashtop Partners with LANDESK to Deliver High Performance Remote Access and Remote Support to and from Mobile Devices and Chromebook 3Health News:Splashtop Partners with LANDESK to Deliver High Performance Remote Access and Remote Support to and from Mobile Devices and Chromebook 4
... Boston, MA--Researchers from Boston Medical Centers (BMC) New ... proportion of their centenarian subjects, avoiding age-related diseases ... the key to their longevity; rather, the avoidance ... their exceptional survival. These findings appear in the ...
... DIEGO, Feb. 11 SpectraScience, Inc. (OTC,Bulltetin ... devices company, today,announced that it has retained ... consulting firm to provide strategic investor relations,services., ... SpectraScience, stated, "We,have selected Hayden Communications because ...
... Funding Totals $60,000; Emergency Call Center Activated ... to Support ... the corporate philanthropy organization of AT&T Inc. (NYSE: T ... In further support of the victims of this disaster, AT&T ...
... new thin-film coating developed at MIT can deliver controlled ... implantation, essentially serving as a micro pharmacy. , The ... cancer, epilepsy, diabetes and other diseases. It is among ... by applying a small electric field. , You can ...
... (Nasdaq:,ICAD), an industry-leading provider of Computer-Aided Detection (CAD),solutions ... that the,Company,s fourth quarter and year end 2007 ... Thursday, March 6, 2008. iCAD management,will discuss the ... am,ET., Shareholders and other interested parties may ...
... Conversion of Shelled Space an Integral Part of MedCath,s ... Corporation,(Nasdaq: MDTH ) and its physician partners today ... TexSAn Heart Hospital, San Antonio, Texas,creating a 120-bed acute ... approximately 36,130 square feet of shelled,space into 60 inpatient ...
Cached Medicine News:Health News:Researchers at BMC find disability does not necessarily follow disease in living to old age 2Health News:SpectraScience, Inc. Retains Hayden Communications 2Health News:AT&T Tennessee Supports Local Disaster Relief Efforts 2Health News:AT&T Tennessee Supports Local Disaster Relief Efforts 3Health News:MIT develops thin-film 'micro pharmacy' 2Health News:iCAD To Release Fourth Quarter and Year End 2007 Financial Results on Thursday, March 6, 2008 2Health News:iCAD To Release Fourth Quarter and Year End 2007 Financial Results on Thursday, March 6, 2008 3Health News:MedCath Plans 60-bed Expansion at TexSAn Heart Hospital 2Health News:MedCath Plans 60-bed Expansion at TexSAn Heart Hospital 3
(Date:9/3/2015)... YORK , Sept. 3, 2015 ... glucose device is a home-based electronic device. It ... that transmits information about glucose levels through radiowaves ... is displayed. The regular usage of self-monitoring blood ... prompt an individual to undergo proper diabetes treatment. ...
(Date:9/3/2015)... , Sept. 3, 2015 About dry eye syndrome ... eyes due to deficient tear production or quick tear ... of two types: aqueous tear deficient dry eye and ... lacrimal glands do not produce enough tears, whereas meibomian ... secrete lipids to slow tear evaporation and maintain tear ...
(Date:9/3/2015)... VIEJO, Calif. , Sept. 3, 2015 /PRNewswire/ ... global pharmaceutical company, and AqueSys, Inc. a private ... ocular implants that reduce intraocular pressure (IOP) associated ... into an agreement under which Allergan will acquire ... of the agreement, Allergan will acquire AqueSys for ...
Breaking Medicine Technology:Global Self-monitoring Blood Glucose Devices Market 2015-2019 2Global Dry Eye Syndrome Market 2015-2019 2Allergan to Acquire Glaucoma Treatment Company AqueSys to Add Minimally Invasive Implantable Shunt to Eye Care Offering 2Allergan to Acquire Glaucoma Treatment Company AqueSys to Add Minimally Invasive Implantable Shunt to Eye Care Offering 3Allergan to Acquire Glaucoma Treatment Company AqueSys to Add Minimally Invasive Implantable Shunt to Eye Care Offering 4Allergan to Acquire Glaucoma Treatment Company AqueSys to Add Minimally Invasive Implantable Shunt to Eye Care Offering 5Allergan to Acquire Glaucoma Treatment Company AqueSys to Add Minimally Invasive Implantable Shunt to Eye Care Offering 6
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: