Navigation Links
Cancer patients' quality of life directly relates to their survival
Date:5/16/2008

ROCHESTER, Minn. -- Patients who feel better live longer, say Mayo Clinic researchers, working with the North Central Cancer Treatment Group (NCCTG), in study results released May 15 as part of the 44th Annual Meeting of the American Society of Clinical Oncology (ASCO).

Mayo Clinic cancer researcher and the studys lead author, Angelina Tan, says the results show quality of life is an independent factor in survival.

Quality of life appears to affect the survival of cancer patients, says Tan. If physicians can identify patients who are not doing well, they will be able to intervene and, we hope, improve not only their patients sense of well-being, but also their length of life.

The researchers compared overall survival with responses from 3,704 patients to one question -- On a scale of 0 to 10, how would you rate your quality of life? Patients had a variety of cancer types, and the question was asked during their participation in one of 24 different NCCTG clinical trials. The unifying factor for the patients was that all had late-stage disease. All results were converted to a 100-point scale.

The team found that baseline quality of life was a strong predictor of survival. They found a distinct difference when dividing patients by the median score of 83 (6.1 months increased survival time for those with scores greater than or equal to 83). The investigators also divided the group into those with scores of more than 50 and 50 or less, defining those in the 50 or less category as having clinically deficient quality of life. In this analysis, the results were even more striking, with increased survival of 7.5 months for the non-clinically deficient patients. The investigators determined that these numbers were independent of performance status (a traditionally used survival prediction method evaluating a patients ambulatory status).

This study is one of several similar quality of life studies that are being presented by Mayo Clinic researchers at the ASCO annual meeting.

Quality of life research is a priority at Mayo, says Jeff Sloan, Ph.D., a cancer researcher at Mayo and the studys primary investigator. While doctors know that a patients quality of life is important, these studies show that measuring it is necessary and can predict how patients will do.

Dr. Sloan, Tan and their colleagues at Mayo Clinic and NCCTG hope current and future research will identify both how and when clinicians can best support their patients feelings of well-being. For example, if the quality of life deficit was identified to be related to patient fatigue and emotional distress, interventions (pharmaceutical, psychosocial, etc.) could be offered to improve patient well-being.

If quality of life deficits can be identified routinely in clinical practice, it will help patients, says Tan. Physicians can address the issues leading to a decrease in quality of life, and ideally these interventions will extend survival.

Other researchers included Paul Novotny; Judith Kaur, M.D.; and Jan Buckner, M.D., all from Mayo Clinic. NCCTG researchers included Paul Schaefer, M.D., Toledo Community Hospital Oncology Program, Toledo, Ohio; Philip Stella, M.D., St. Joseph Mercy Health System, Ann Arbor, Mich.; and John Kuebler, M.D., Columbus Community Clinical Oncology Program, Columbus, Ohio.

Related quality of life studies being presented at ASCO include:

Baseline quality of life is a strong prognostic factor for overall survival in patients with advanced stage non-small cell lung cancer, Schild et al.

A quality-of-life assessment of patients participating in phase I clinical trials confirms a decrease during treatment, Atherton et al.

Baseline quality of life is a strong and performance status-independent prognostic factor for overall survival in patients with metastatic colorectal cancer, Turja et al.

Tumor burden is not related to quality of life in patients with metastatic colorectal cancer, Sloan et al.


'/>"/>

Contact: Traci Klein
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th Annual ... Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised funds ... been wounded in battle and their families. Venture Construction Group is a 2016 Silver ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... innovative inhaled drugs, announced today that it was added ... reconstituted its comprehensive set of U.S. and global ... is an important milestone for Pulmatrix," said Chief Executive ... awareness of our progress in developing drugs for crucial ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
Breaking Medicine Technology: