Navigation Links
Cancer-linked FAM190A gene found to regulate cell division
Date:7/3/2013

Johns Hopkins cancer scientists have discovered that a little-described gene known as FAM190A plays a subtle but critical role in regulating the normal cell division process known as mitosis, and the scientists' research suggests that mutations in the gene may contribute to commonly found chromosomal instability in cancer.

In laboratory studies of cells, investigators found that knocking down expression of FAM190A disrupts mitosis. In three pancreatic cancer-cell lines and a standard human-cell line engineered to be deficient in FAM190A, researchers observed that cells often had difficulty separating at the end of mitosis, creating cells with two or more nuclei. The American Journal of Pathology published a description of the work online May 17, which comes nearly a century after German scientist Theodor Boveri linked abnormal mitosis to cancer. Until now, there had been no common gene alteration identified as the culprit for cancer-linked mitosis.

"These cells try to divide, and it looks like they succeed, except they wind up with a strand that connects them," explains Scott Kern, M.D., professor of oncology and pathology at Johns Hopkins University School of Medicine and its Kimmel Cancer Center. "The next time they try to divide, all the nuclei come together, and they try to make four cells instead of two. Subsequently, they try to make eight cells, and so on." Movies of the process taken by Kern's laboratory are available on the journal Web site.

Kern's group previously reported that deletions in the FAM190A gene could be found in nearly 40 percent of human cancers. That report, published in 2011 in the journal Oncotarget, and the current one are believed to be the only published papers focused solely on FAM190A, which is frequently altered in human cancers but whose function has been unknown. Alterations in FAM190A messages may be the third most common in human cancers after those for the more well-known genes p53 a
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2914
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. More Fake Avastin Found in U.S., FDA Says
2. Kessler Foundation names Dr. John Whyte recipient of Foundations 2nd Annual DeLisa Award
3. History of abandoned urban sites found stored in soil
4. Wilderness Medicine founder offers health tips for summer season
5. Concerns about MRSA for expectant mothers may be unfounded
6. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
7. Clues to Slacker Behavior Found in Brain, Study Says
8. Kessler Foundation researchers present at first International Congress on Cognition in MS
9. Biomedical researchers receive Hartwell Foundation awards
10. Fewer prostate cancer surgery complications found in teaching hospitals with fellowship programs
11. Breast cancer effectively treated with chemical found in celery, parsley by MU researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... TheHardwareCity.com is the place to purchase home ... space heaters are available at the online store. Now, ... 1500w portable electric space heater. , The space heater ... an energy efficient way to heat a small space ... produce 1500 Watts, ensuring a quick warm up period. ...
(Date:10/31/2014)... Prevention Research Center for Healthy Neighborhoods (PRCHN) at ... a key player in nearly $13.32 million in ... Northeast Ohio. , The Centers for Disease Control ... $4.35 million over five years. The funds will ... and disseminating individual, environmental, and policy interventions that ...
(Date:10/31/2014)... Thousand Oaks, CA (PRWEB) October 31, 2014 ... flat tummy also has amazing health effects for ... were created by a Doctor of Science and ... discovered through his dedication to pelvic floor reeducation ... incidence of urinary incontinence, Diastasis Recti, Prolepses, etc. ...
(Date:10/31/2014)... -- Surgery for low back pain caused by spinal ... you live, a new report says. "Nearly 80 ... some point in their lives, and about 30 million ... spine problem," co-author Brook Martin, of the Dartmouth Institute ... college news release. In spinal stenosis, thickening of ...
(Date:10/31/2014)... of four older Americans say that either they or ... treatment, according to the latest issue of The Gerontological ... ( PP&AR ), which goes on to show ... fail to honor patients, end-of-life health care wishes. , ... Issues and Options ," features 12 articles that present ...
Breaking Medicine News(10 mins):Health News:Big Heat 1500w Electric Space Heater Now Available at TheHardwareCity.com 2Health News:Case Western Reserve, Cuyahoga County, YMCA of greater Cleveland: Public health grants 2Health News:Case Western Reserve, Cuyahoga County, YMCA of greater Cleveland: Public health grants 3Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 3Health News:Spinal Surgery Varies by Region in U.S.: Study 2Health News:Advance directives can benefit patients, families, and health care system 2
... potential benefits of human papillomavirus (HPV) vaccinations or frequent HPV ... concludes a new study published online February 15 in the ... found that the rate of new infections preventable by vaccination ... any age typically do not progress to cervical intraepithelial neoplasia ...
... skull bone appear to be a durable treatment option that ... according to a report in the February issue of ... of the JAMA/Archives journals. , Single-sided deafness, also ... percent and 3 percent of children, according to background information ...
... and lungs suffer, study finds , MONDAY, Feb. 15 (HealthDay ... pipes or cigars instead of cigarettes are kidding themselves, a ... means is deleterious," said Dr. R. Graham Barr, assistant professor ... lead author of a report in the Feb. 16 issue ...
... further problems, experts say, , MONDAY, Feb. 15 (HealthDay News) ... are likely to have another stroke soon after the initial ... according to a new study by researchers from the Medical ... importance of recognizing that anyone who has had a stroke ...
... As more people undergo bariatric procedures, use of revisions ... News) -- Repeat weight-loss surgery carries a higher risk ... has found. , The surgical treatment, known as bariatric ... loss in severely obese people. Rates of repeat bariatric ...
... Small study shows patients with ocular type benefit from ... toxin type A (Botox), the drug that can temporarily ... migraines, a small study suggests. , Specifically, Botox may ... as crushing or eye-popping, otherwise known as ocular migraines. ...
Cached Medicine News:Health News:News brief: Benefit of HPV Vaccination, Frequent Screening for Women over 41 is Likely to be Low 2Health News:Bone-anchored hearing aids help youth with single-sided deafness 2Health News:Cigars, Pipes No 'Healthy' Alternative to Cigarettes 2Health News:Cigars, Pipes No 'Healthy' Alternative to Cigarettes 3Health News:After a Stroke, High Risk for a Recurrence 2Health News:After a Stroke, High Risk for a Recurrence 3Health News:Repeated Weight-Loss Surgery Carries Added Risks 2Health News: Botox May Prevent Some Migraines 2Health News: Botox May Prevent Some Migraines 3
(Date:10/31/2014)... Oct. 31, 2014  Australian biopharmaceutical company Specialised Therapeutics ... (nanoparticle albumin-bound paclitaxel) in combination with gemcitabine, will be ... with metastatic pancreatic cancer from 1 November. ... is the 5 th most common cause of ... cancer deaths, with the lowest 5-year survival of all ...
(Date:10/31/2014)... -- Investor-Edge has initiated coverage on the ... Isis Pharmaceuticals Inc. (NASDAQ: ISIS ), Halozyme ... Inc. (NASDAQ: ACAD ), and Synta Pharmaceuticals ... can be accessed at: http://investor-edge.com/register . ... at 4,566.14, up 0.37%, the Dow Jones Industrial Average ...
(Date:10/31/2014)... Australia and BARCELONA , October ... Ltd (Multigate) was found to infringe two Australian patents of ... for sale in Australia safety IV ... 17.10.14 in Federal Court of Australia ... http://www.austlii.edu.au/au/cases/cth/FCA/2014/1110.html . In the detailed judgment, ...
Breaking Medicine Technology:Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 2Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 3Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 4Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 5Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 6Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 7Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 8Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 2Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 3Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 4Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 5B. Braun Wins Patent Disputes Against Poly Medicure Ltd's Australian Distributor Multigate Medical Devices Pty. Ltd. and Spanish Distributor Dextromédica S. L. 2
... Beshear announced yesterday that most of Kentucky,s Medicaid program ... $375 million. In modernizing the state,s Medicaid pharmacy benefits, ... pharmacy benefit managers (PBMs) to lower prescription drug costs, ... "Governor Beshear has done the right thing ...
... 8, 2011 Stryker Joint Preservation, a business unit ... American Orthopaedic Society for Sports Medicine meeting that it ... to distribute Stryker,s RegenKit-THT, a one-step system designed for ... (A-PRP) from a small sample of blood at the ...
Cached Medicine Technology:Modernizing Medicaid Rx with 'Innovative' PBM Tools Will Help Kentucky Save $375 Million 2Stryker Announces Exclusive Collaboration With RegenLab 2
Advanced operating microscope with high-resolution apochromatic optics. Senso-servo drive to keep the microscope in perfect balance even if parts are moved or mounted elsewhere....
Opmi Vario/S88 system surgical microscope. It is applicable for neurosurgery, spinal, ENT and P&R surgery....
The Horizontal-Vertical (H/V) lumbar valve system is the only differential pressure valve for lumbo-peritoneal shunting, which addresses orthostatic overdrainage....
Curved left, Hardy Curettes, bayonet, working distance 120 mm, total length 241 mm....
Medicine Products: