Navigation Links
Cancer-linked FAM190A gene found to regulate cell division
Date:7/3/2013

Johns Hopkins cancer scientists have discovered that a little-described gene known as FAM190A plays a subtle but critical role in regulating the normal cell division process known as mitosis, and the scientists' research suggests that mutations in the gene may contribute to commonly found chromosomal instability in cancer.

In laboratory studies of cells, investigators found that knocking down expression of FAM190A disrupts mitosis. In three pancreatic cancer-cell lines and a standard human-cell line engineered to be deficient in FAM190A, researchers observed that cells often had difficulty separating at the end of mitosis, creating cells with two or more nuclei. The American Journal of Pathology published a description of the work online May 17, which comes nearly a century after German scientist Theodor Boveri linked abnormal mitosis to cancer. Until now, there had been no common gene alteration identified as the culprit for cancer-linked mitosis.

"These cells try to divide, and it looks like they succeed, except they wind up with a strand that connects them," explains Scott Kern, M.D., professor of oncology and pathology at Johns Hopkins University School of Medicine and its Kimmel Cancer Center. "The next time they try to divide, all the nuclei come together, and they try to make four cells instead of two. Subsequently, they try to make eight cells, and so on." Movies of the process taken by Kern's laboratory are available on the journal Web site.

Kern's group previously reported that deletions in the FAM190A gene could be found in nearly 40 percent of human cancers. That report, published in 2011 in the journal Oncotarget, and the current one are believed to be the only published papers focused solely on FAM190A, which is frequently altered in human cancers but whose function has been unknown. Alterations in FAM190A messages may be the third most common in human cancers after those for the more well-known genes p53 a
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2914
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. More Fake Avastin Found in U.S., FDA Says
2. Kessler Foundation names Dr. John Whyte recipient of Foundations 2nd Annual DeLisa Award
3. History of abandoned urban sites found stored in soil
4. Wilderness Medicine founder offers health tips for summer season
5. Concerns about MRSA for expectant mothers may be unfounded
6. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
7. Clues to Slacker Behavior Found in Brain, Study Says
8. Kessler Foundation researchers present at first International Congress on Cognition in MS
9. Biomedical researchers receive Hartwell Foundation awards
10. Fewer prostate cancer surgery complications found in teaching hospitals with fellowship programs
11. Breast cancer effectively treated with chemical found in celery, parsley by MU researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... (PRWEB) November 23, 2014 A classic black ... of the most famous dress suppliers, has unveiled its new ... new dresses are now offered at a big discount, up ... special offer. , The new black prom dresses, made ... order to meet the needs of all customers, the company ...
(Date:11/22/2014)... (PRWEB) November 23, 2014 BambooFlooringChina.com ... the company has proudly released its new collection of ... discounted rates, up to 29% off. , According ... and sturdy tree-like grass, making it a highly renewable resource. ... products have a mixing color which comes from natural bamboo ...
(Date:11/22/2014)... NY (PRWEB) November 22, 2014 ... Goods Administration (TGA) approved it for use “as ... approved and listed within the Therapeutic Goods (Listing) ... , Kyowa Hakko’s Setria® Glutathione will be ... biotech specialist that sources and imports fine chemicals ...
(Date:11/22/2014)... 2014 Discount-Dress.com is an important ... firm is to increase the company’s online market share by ... selection of bridesmaid dresses and announced a bridesmaid dress promotion ... until Dec. 30, 2014. All the dresses from this company ... , In fact, Discount-Dress.com is very good at manufacturing wedding ...
(Date:11/22/2014)... Nocturia is defined by the ... the individual has to wake at night one ... – Pipeline Review, H2 2014” provides comprehensive information ... comparative analysis at various stages, therapeutics assessment by ... administration (RoA) and molecule type, along with latest ...
Breaking Medicine News(10 mins):Health News:New Black Prom Dresses from BellasDress.com 2Health News:Trendy Bamboo Mats Online Now By BambooFlooringChina.com 2Health News:Setria® Glutathione Now Available in Australia 2Health News:Setria® Glutathione Now Available in Australia 3Health News:Bridesmaid Dresses Introduced by Famous Company Discount-Dress.com For The New Year 2015 2Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 2Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 3Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 4
... Karen Ignagni, President and CEO of America,s Health Insurance ... the President,s budget:"Today,s budget submission sends a signal to ... prioritizing health care. We applaud the President for ... resources to put our nation on a path towards ...
... SEO Online PR & Marketing Consultancy, is pleased to announce the ... successful Industry Directory, offering free listings to relevant specialist industries. ... ... B2B, SEO Online PR & Marketing Consultancy , is pleased ...
... N.C., Feb. 26 Arbor Pharmaceuticals, a specialty,pharmaceutical ... the company has launched XYLAREX - a first-in-class ... media (middle ear,infections). XYLAREX is a novel ... the number of ear infections children experience. ...
... Feb. 26 A lawsuit was filed today by ... who contracted salmonella poisoning,after eating at a Blueberry Hill ... child was hospitalized for three days as a result ... Cook County Department of Health,after the Communicable Disease Unit ...
... groups nationwide to receive National Autism Conference DVD ... Association (NAA) today announced its receipt of a ... (CWF) to disseminate DVD sets of complete presentations ... organizations throughout the United States, U.S. territories, and ...
... to continuing multi-pronged effort to raise awarenessWASHINGTON, Feb. 26 ... for a Drug-Free America offers some promising news regarding ... According to the 20th annual Partnership Attitude Tracking Survey ... about drugs and alcohol, an increased number of teens ...
Cached Medicine News:Health News:AHIP Statement on the President's Budget 2Health News:Simply Marcomms Launch New Specialist Online Industry Directories 2Health News:Arbor Pharmaceuticals Announces the Launch of XYLAREX(TM) - A New Nonantibiotic Product for the Dietary Management of Recurrent Ear Infections in Children 2Health News:National Autism Association Announces American Legion Child Welfare Grant for Autism Outreach 2Health News:New Partnership for a Drug-Free America 20th Annual Study Shows Progress in Teens Recognizing Dangers of OTC Cough Medicine Abuse 2Health News:New Partnership for a Drug-Free America 20th Annual Study Shows Progress in Teens Recognizing Dangers of OTC Cough Medicine Abuse 3
(Date:11/21/2014)... , Nov. 20, 2014  RedRick Technologies, ... solutions and reading room environment guidance, has helped ... musculoskeletal radiology reading room, which may also serve ... at Penn Medicine. "In line ... American College of Radiology,s Imaging 3.0 ™ ...
(Date:11/21/2014)... Depomed, Inc. (NASDAQ: DEPO ) today announced ... Annual Healthcare Conference in New York City ... scheduled for 8:00 am EST (5:00 am PST) on Tuesday December ... be accessed via the Investor Relations page of the Depomed website ... archived for 30 days on the company,s website. ...
(Date:11/21/2014)... Texas , Nov. 21, 2014  Lexicon Pharmaceuticals, ... pricing of its previously announced underwritten public offering of ... an effective shelf registration statement. The offering will consist ... offering price of $1.005 per share.  Lexicon has also ... to 7,462,687 additional shares of common stock.  All of ...
Breaking Medicine Technology:RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 2RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 3Depomed To Present At Piper Jaffray 26th Annual Healthcare Conference 2Lexicon Announces Pricing Of Common Stock Offering 2Lexicon Announces Pricing Of Common Stock Offering 3
... BRISTOL, Tenn., May 22, 2007,/PRNewswire-FirstCall/ -- Palatin ... that data from Study 16 and,Study 17 ... evaluating,bremelanotide in men with erectile dysfunction (ED) ... (AUA) Annual,Meeting (AUA 2007) held in Anaheim, ...
... Abuse-Related Effects For OROS(r),Methylphenidate , Two New ... , SAN DIEGO, CA, May 22, 2007 ... for parents and physicians who prescribe,medications to ... on Tuesday at the 160th Annual Meeting ...
Cached Medicine Technology:Palatin Technologies and King Pharmaceuticals Report Data Showing,Improvements in Sexual Relationship and Self-Esteem in Patients,with Erectile Dysfunction Treated with Bremelanotide 2Palatin Technologies and King Pharmaceuticals Report Data Showing,Improvements in Sexual Relationship and Self-Esteem in Patients,with Erectile Dysfunction Treated with Bremelanotide 3Palatin Technologies and King Pharmaceuticals Report Data Showing,Improvements in Sexual Relationship and Self-Esteem in Patients,with Erectile Dysfunction Treated with Bremelanotide 4Palatin Technologies and King Pharmaceuticals Report Data Showing,Improvements in Sexual Relationship and Self-Esteem in Patients,with Erectile Dysfunction Treated with Bremelanotide 5Palatin Technologies and King Pharmaceuticals Report Data Showing,Improvements in Sexual Relationship and Self-Esteem in Patients,with Erectile Dysfunction Treated with Bremelanotide 6Palatin Technologies and King Pharmaceuticals Report Data Showing,Improvements in Sexual Relationship and Self-Esteem in Patients,with Erectile Dysfunction Treated with Bremelanotide 7New Data Focuses on Abuse of Stimulant Medication 2New Data Focuses on Abuse of Stimulant Medication 3New Data Focuses on Abuse of Stimulant Medication 4New Data Focuses on Abuse of Stimulant Medication 5
... (PAPP-A) is a large placenta-derived glycoprotein ... concentrations by placental trophoblast cells, and ... in increasing concentrations throughout gestation until ... to pregnancy since measurable levels have ...
... proteohormone with a molecular weight of 16 kDa. ... and produced by adipocytes [1,2]. Leptin is thought ... body weight [1-3]. In the human, leptin levels ... women [4]. A relationship between serum leptin levels ...
... primary known naturally-occurring stimulant of red blood ... human EPO is 18.2 kDa. Due to ... an estimated molecular mass of ~30.5 kDa. ... unique structure, the EPO receptor bears some ...
... Alpha Fetoprotein (AFP) is a 68 kDa protein, ... the fetal liver and yolk sac [1]. ... weeks gestation, and production rates reach 19-26 g/min ... and estimates of total fetal AFP continue to ...
Medicine Products: