Navigation Links
Cancer-linked FAM190A gene found to regulate cell division
Date:7/3/2013

Johns Hopkins cancer scientists have discovered that a little-described gene known as FAM190A plays a subtle but critical role in regulating the normal cell division process known as mitosis, and the scientists' research suggests that mutations in the gene may contribute to commonly found chromosomal instability in cancer.

In laboratory studies of cells, investigators found that knocking down expression of FAM190A disrupts mitosis. In three pancreatic cancer-cell lines and a standard human-cell line engineered to be deficient in FAM190A, researchers observed that cells often had difficulty separating at the end of mitosis, creating cells with two or more nuclei. The American Journal of Pathology published a description of the work online May 17, which comes nearly a century after German scientist Theodor Boveri linked abnormal mitosis to cancer. Until now, there had been no common gene alteration identified as the culprit for cancer-linked mitosis.

"These cells try to divide, and it looks like they succeed, except they wind up with a strand that connects them," explains Scott Kern, M.D., professor of oncology and pathology at Johns Hopkins University School of Medicine and its Kimmel Cancer Center. "The next time they try to divide, all the nuclei come together, and they try to make four cells instead of two. Subsequently, they try to make eight cells, and so on." Movies of the process taken by Kern's laboratory are available on the journal Web site.

Kern's group previously reported that deletions in the FAM190A gene could be found in nearly 40 percent of human cancers. That report, published in 2011 in the journal Oncotarget, and the current one are believed to be the only published papers focused solely on FAM190A, which is frequently altered in human cancers but whose function has been unknown. Alterations in FAM190A messages may be the third most common in human cancers after those for the more well-known genes p53 a
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2914
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. More Fake Avastin Found in U.S., FDA Says
2. Kessler Foundation names Dr. John Whyte recipient of Foundations 2nd Annual DeLisa Award
3. History of abandoned urban sites found stored in soil
4. Wilderness Medicine founder offers health tips for summer season
5. Concerns about MRSA for expectant mothers may be unfounded
6. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
7. Clues to Slacker Behavior Found in Brain, Study Says
8. Kessler Foundation researchers present at first International Congress on Cognition in MS
9. Biomedical researchers receive Hartwell Foundation awards
10. Fewer prostate cancer surgery complications found in teaching hospitals with fellowship programs
11. Breast cancer effectively treated with chemical found in celery, parsley by MU researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... Minneapolis, Minnesota (PRWEB) March 02, 2015 ... a new strategic relationship with First Protective Insurance ... new initiative will allow First Protective affiliated advisors ... and implementation support that Secura Consultants delivers. ... is a national leader in the design and ...
(Date:3/1/2015)... Excellence is pleased to announce the addition of a digital ... are over 75 terms and phrases available for viewing, with more ... patients a better understanding of what our Providers are talking about ... With this resource, our patients are able to go back to ... that they may not remember or comprehend at the time of ...
(Date:3/1/2015)... Researchers say working around asbestos-containing construction products may ... contract malignant mesothelioma. Surviving Mesothelioma has just posted the ... Click here to read it now. , Scientists ... 17,345 sheet metal workers from 1986 to 2010 and ... mesothelioma or another asbestos-related disease . , “Significant ...
(Date:3/1/2015)... (PRWEB) March 01, 2015 Indiana ... Network Service Provider, announces NewWays Networking, LLC (NewWays) ... “By working with IFN, NewWays is well positioned ... client’s demand for Internet bandwidth in rural parts ... , According to Cory Childs IFN Enterprise Sales ...
(Date:3/1/2015)... CrossFit Attollo is a CrossFit gym located in Vancouver ... to new members. Now through the end of March ... will receive their fourth month half off. , ... The three month contract is only $264, dropping the price ... comes in at only $55. The special saves new members ...
Breaking Medicine News(10 mins):Health News:Secura Consultants and First Protective Insurance Group Announce Strategic Relationship 2Health News:New Study Finds Indirect Asbestos Exposure Can Raise Mesothelioma Risk for Sheet Metal Workers, According to Surviving Mesothelioma 2Health News:NewWays Networking Selects Indiana Fiber Network, LLC as Fiber Transport Provider 2Health News:CrossFit Gym in Vancouver WA Offers Spring Special 2
... "As a physician,you hear all sorts of excuses ... Hashey, Medical Director of First Coast Family Medicine and ... most common that Dr. Hashey reports is the excuse ... "That couldn,t be farther from the truth.,The flu shot ...
... for ... Cardiac Rehabilitation, BOTHELL, Wash., ... global leader in advanced cardiac monitoring,and defibrillation products, announced today ... has seamless connectivity with LUMEDX,CardioWellness(TM) data management software. (Logo: ...
... patient outcomes at Houston Northwest Medical ... among nation,s best for several service lines, ... Annual,HealthGrades Hospital Quality in America Study issued today, ... several service,lines including overall gastrointestinal services, gastrointestinal,surgery, stroke, ...
... Oct. 17 /PRNewswire/ - The numbers are staggering --,over ... have a,disability. "It,s not the impairment or disability ... their exclusion from mainstream,social, economic and political opportunities," says ... have to work together to stand up and speak ...
... methicillin-resistant Staphylococcus aureus Infections in the, United States, shows that hospital-caused MRSA ... and Prevention have,consistently understated the size of the problem and have failed ... protect patients from these ... infections., NEW ...
... hold a press availability tomorrow, Wednesday, October 17, at 10:30,a.m. ... 2-year-old,from Tampa, Fla., who was born with a serious heart ... is on Capitol Hill urging Members of,Congress to vote to ... 10 million children., WHO: Speaker Nancy ...
Cached Medicine News:Health News:Flu Myths Abound in Flu Season 2Health News:Cardiac Science Announces Data Connectivity with LUMEDX 2Health News:Cardiac Science Announces Data Connectivity with LUMEDX 3Health News:Cardiac Science Announces Data Connectivity with LUMEDX 4Health News:Houston Northwest Medical Center's Patient Outcomes Superior 2Health News:Houston Northwest Medical Center's Patient Outcomes Superior 3Health News:CBM USA stands up and speaks out to world leaders on the International Day for the Eradication of Poverty 2Health News:The Journal of the American Medical Association (JAMA) Article Reveals Scope of MRSA Infections 2
(Date:2/27/2015)... 2015  Pomerantz LLP is investigating claims on behalf ... "Company") (NASDAQ: VTAE ).  Such investors are ... rswilloughby@pomlaw.com or 888-476-6529, ext. 237. ... officers and/or directors have violated Sections 10(b) and 20(a) ... On February 27, 2015, the Company announced that ...
(Date:2/27/2015)... Securities lawyers at Dunnam & Dunnam ... (NASDAQ: SLXP ) in connection with a ... are encouraged to contact attorney Hamilton Lindley by ... upon the shareholder value of the transaction. Under terms ... $158.00 per share in cash. At least one analyst ...
(Date:2/27/2015)... LONDON , February 27, 2015 ... - new study showing you trends, R&D progress, and ... medicine heading? What are the commercial prospects for ... shows you potential revenues and other trends to 2025, ... ,s report lets you assess regenerative medicine : ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Vitae Pharmaceuticals, Inc. - VTAE 2Translational Regenerative Medicine: Market Prospects 2015-2025 2Translational Regenerative Medicine: Market Prospects 2015-2025 3Translational Regenerative Medicine: Market Prospects 2015-2025 4Translational Regenerative Medicine: Market Prospects 2015-2025 5Translational Regenerative Medicine: Market Prospects 2015-2025 6Translational Regenerative Medicine: Market Prospects 2015-2025 7Translational Regenerative Medicine: Market Prospects 2015-2025 8
... Tolerability and,Additive Antiviral Activity of HCV-796 -, EXTON, ... announced additional data from a Phase 1b study,of ... virus (HCV),polymerase inhibitor at the 42nd Annual Meeting ... Liver (EASL). This meeting is,being held in Barcelona, ...
... Data on Innovative Oncology Compounds at the,American ... PARK, Ill., April 13, 2007 /PRNewswire-FirstCall/ -- ... that target,cancer. Researchers now know that cancer ... new blood vessels to deliver oxygen,and nutrients ...
Cached Medicine Technology:ViroPharma Announces Presentation of Additional HCV-796 Data at,Meeting of The European Association for the Study of the Liver 2ViroPharma Announces Presentation of Additional HCV-796 Data at,Meeting of The European Association for the Study of the Liver 3ViroPharma Announces Presentation of Additional HCV-796 Data at,Meeting of The European Association for the Study of the Liver 4ViroPharma Announces Presentation of Additional HCV-796 Data at,Meeting of The European Association for the Study of the Liver 5ViroPharma Announces Presentation of Additional HCV-796 Data at,Meeting of The European Association for the Study of the Liver 6Abbott Researchers Focus on New Cutting-Edge Approaches in the,Fight Against Cancer 2Abbott Researchers Focus on New Cutting-Edge Approaches in the,Fight Against Cancer 3Abbott Researchers Focus on New Cutting-Edge Approaches in the,Fight Against Cancer 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: