Navigation Links
CT angiography helps predict heart attack risk
Date:2/18/2013

OAK BROOK, Ill. Coronary computed tomography angiography (CCTA) is an effective tool for determining the risk of heart attacks and other adverse cardiac events in patients with suspected coronary artery disease but no treatable risk factors, such as high cholesterol or high blood pressure, according to a new study published online in the journal Radiology.

"CCTA should be considered as an appropriate first- line test for patients with atypical chest pain and suspected but not confirmed coronary artery disease," said the study's lead author, Jonathon Leipsic, M.D., FRCPC, from the University of British Columbia in Vancouver.

Heart disease is the leading cause of death in the U.S., according to the Centers for Disease Control and Prevention. Treatment often involves addressing modifiable cardiovascular risk factors such as elevated cholesterol, high blood pressure, diabetes and smoking. However, some risk factors, like family history, are not modifiable, and no risk models exist to help guide clinicians to identify those symptomatic patients without cardiac risk factors who are at an increased risk of death and myocardial infarction.

"This scenario, where patients are symptomatic but have no cardiac risk factors, comes up often in clinical practice," Dr. Leipsic said. "We lack a good tool to stratify these patients into risk groups."

CCTA is a noninvasive test that has shown high accuracy for the diagnosis or exclusion of coronary artery disease in individuals. However, referral for patients with suspected coronary artery disease is often based on clinical risk factor scoring. Less is known about the prognostic value of CCTA in individuals with no medically modifiable risk factors.

In the first study of its kind, Dr. Leipsic and colleagues correlated CCTA findings with the risk of major adverse cardiac events in 5,262 patients with suspected coronary artery disease but no medically modifiable risk factors. They culled the data from the Coronary CT Angiography Evaluation For Clinical Outcomes: An International Multicenter (CONFIRM) registry.

After an average follow-up of 2.3 years, 104 patients had experienced a major adverse cardiovascular event. The researchers identified a high prevalence of coronary artery disease in the study group, despite the absence of modifiable risk factors. More than one-quarter of the patients had non-obstructive disease or disease related to the buildup of plaque in the arteries, and another 12 percent had obstructive disease with a greater than 50 percent narrowing in a coronary artery.

"We found that patients with narrowing of the coronary arteries on CT had a much higher risk of an adverse cardiac event," Dr. Leipsic said. "This was true even for those without a family history of heart disease."

Both symptomatic and asymptomatic patients with obstructive disease faced an increased risk for a major cardiac event. In contrast, the absence of coronary artery disease on CCTA was associated with a very low risk of a major event.

The findings highlight the need for refinement in the evaluation of individuals who may be missed by traditional methods of coronary artery disease evaluation.

"If a patient shows up with vague symptoms and no medically modifiable risk factors, doctors often dismiss them or do a treadmill test, which won't identify atherosclerosis and only has a modest sensitivity for detecting obstructive disease," Dr. Leipsic said.

CCTA could help address this problem, Dr. Leipsic added, by helping to diagnose or rule out coronary artery disease and identifying those who may benefit from more intensive therapy.

The researchers continue to study the CONFIRM data with the aim to learn more about the relationship between plaque and heart attacks and the longer-term outlook for patients with coronary artery disease.

"We are now collecting data to determine the prognostic value of CCTA after five years or more of follow-up, which will be very important for the field," Dr. Leipsic said.


'/>"/>
Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Positive stress helps protect eye from glaucoma
2. Exercise helps smokers to quit smoking, to remain smoke-free and to reduce the risk of death
3. Unusual protein helps regulate key cell communication pathway
4. Equal access to care helps close survival gap for young African-American cancer patients
5. First-of-its-kind Menopause Map helps women navigate treatment
6. Palliative care resource helps ease changes
7. Fertilizing bone marrow helps answer why some cancers spread to bones
8. Two-Drug Combo Helps Teens With Migraines
9. Experimental Drug Helps Fight Some Childhood Cancers, Study Finds
10. Breast MRI helps predict chemotherapys effectiveness
11. Cooling Helps Oxygen-Deprived Newborns: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... ... Elder-Beerman, Herberger’s and Younkers department stores, announced it has raised $176,000 to benefit ... Center, Holden Comprehensive Cancer Center at the University of Iowa, The Lynn Sage ...
(Date:2/9/2016)... ... 09, 2016 , ... METTLER TOLEDO has published a new ... basic understanding of the techniques they use so they can more easily spot ... waste and rework to create a leaner overall lab experience. , The ...
(Date:2/9/2016)... ... 2016 , ... United Methodist Communications collaborated with Chocolate Moose ... video designed to prevent the next widespread Ebola outbreak from occurring ... distributed throughout Togo, Liberia, Sierra Leone, Nigeria, Côte d’Ivoire and other African countries, ...
(Date:2/9/2016)... Petersburg, FL (PRWEB) , ... February 09, 2016 , ... Shark Finds and ... a new DRTV campaign with GRIP-DRY. , GRIP-DRY is a newly patented product that has ... Golfers who play in the wet and early morning dew or right after a rain ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Federal Laboratory ... federallabs.org . The site houses a wealth of federal resources that businesses can ... process called technology transfer (T2). As a network of over 300 federal laboratories, ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016  Increasingly, health care ... their vital signs with wireless technology. With the Vios ... automate patient oversight and remotely detect problems before they ... signs across in-hospital environments. the United ... United States . --> The ...
(Date:2/9/2016)... Feb. 9, 2016 The new report " Global Fetal ... Spearhead Acuity Business Research & Consulting group reveals that ... market with a share of 36.4% in 2014 that translated into ... , the report also covers market analysis for Fetal and Neonatal ... , Asia-Pacific , Latin America ...
(Date:2/9/2016)... , Feb. 9, 2016  Bluestar Silicones will promote ... line for long-term implant applications and announce certification ... & Manufacturing (MD&M) West Conference (Booth #1759), February ... --> --> Available in ... LSRs offer outstanding physical properties enabling our customers ...
Breaking Medicine Technology: