Navigation Links
Body Mass Index gain throughout adulthood may increase risk of postmenopausal breast cancer
Date:4/20/2010

WASHINGTON, D.C. Reported mid-life increase in body mass index (BMI) may lead to substantially higher risk of postmenopausal breast cancer, according to results of a prospective cohort study presented at the American Association for Cancer Research 101st Annual Meeting 2010, held here April 17-21.

In previous studies, excess weight has been linked with increased risk of postmenopausal breast cancer. Scientists have speculated that in postmenopausal women, estrogen produced in adipose tissue, or body fat, may promote breast cell proliferation. Relatively few studies have looked specifically at increase in BMI and its timing in relation to postmenopausal breast cancer risk, which this study investigated.

The researchers analyzed information from 72,007 women in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial cohort, who were 55 to 74 years old at study entry. The analysis included 3,677 cases of postmenopausal breast cancer, which makes this one of the larger studies of its kind, according to the researchers.

The researchers observed the strongest associations among women who had never used menopausal hormone therapy; results were shown only for this group of women.

"Compared with women who maintained approximately the same BMI, those who had an increase of 5 kg/m2 or more between age 20 and study entry had a nearly twofold increased risk of breast cancer," said Laura Sue, M.P.H., a cancer research fellow at the National Cancer Institute (NCI).

Results showed that nearly 57 percent of the study population's BMI increased 5 kg/m2 or more between age 20 and study entry. A BMI increase of 5 kg/m2 is equivalent to a woman of average height, 5'4", gaining approximately 30 pounds.

Women who reported a BMI increase of 5 kg/m2 or more between age 20 and 50 were at an 88 percent increased risk of developing postmenopausal breast cancer, compared with women who reported a stable BMI. For women who reported a BMI increase of 5 kg/m2 or more between age 50 and study entry, risk increased 56 percent, compared with women who maintained BMI. BMI gain both before and after age 50 independently contribute to increased risk of postmenopausal breast cancer.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Human development index linked to stem cell transplant rates and success in leukemia patients
2. LocumTenens.com Online Job Index Continues Rise in First Quarter 2010
3. New clinical prediction index to help patients considering kidney transplant
4. Tickerspy.com Announces New Stock Index Tracking Chinese Healthcare Stocks
5. Chindex International, Inc. Reports Third Quarter Fiscal Year 2010 Financial Results
6. MIB Life Index Reports North American Life Insurance Activity Up 3.9% in November
7. Study finds changes in fetal epigenetics throughout pregnancy
8. Educational Toy Franchise Expects Continued Growth Throughout Colorado in 2010
9. Toys"R"Us, Inc. Expands its Support of Autism Speaks Throughout North America
10. Study shows genital herpes virus reactivates widely throughout genital tract
11. Why symptoms of schizophrenia emerge in young adulthood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of ... its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his ... July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the Law ... organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our ... a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... New York, NY (PRWEB) , ... October 13, 2017 , ... ... most influential people in business to advocate for action towards gender equality at their ... 18,000 views from around the globe, and reached a social audience of over 3 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, Inc. ... earnings conference call and webcast on Friday, November 3, ... (EDT) and ending at approximately 8:30 a.m. (CDT) / ... the company,s 2017 financial performance and guidance for 2018, ... initiatives to enhance operational performance, and long-range financial outlook ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
(Date:9/19/2017)... Sept. 19, 2017   ZirMed Inc ., a recognized ... announced that it has been ranked #1 by its users ... Rankings 2017 User Survey. ZirMed was recognized as the ... hospitals and medical centers over 200 beds and holds one ... technology user survey history. ...
Breaking Medicine Technology: