Navigation Links
Body Mass Index gain throughout adulthood may increase risk of postmenopausal breast cancer
Date:4/20/2010

WASHINGTON, D.C. Reported mid-life increase in body mass index (BMI) may lead to substantially higher risk of postmenopausal breast cancer, according to results of a prospective cohort study presented at the American Association for Cancer Research 101st Annual Meeting 2010, held here April 17-21.

In previous studies, excess weight has been linked with increased risk of postmenopausal breast cancer. Scientists have speculated that in postmenopausal women, estrogen produced in adipose tissue, or body fat, may promote breast cell proliferation. Relatively few studies have looked specifically at increase in BMI and its timing in relation to postmenopausal breast cancer risk, which this study investigated.

The researchers analyzed information from 72,007 women in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial cohort, who were 55 to 74 years old at study entry. The analysis included 3,677 cases of postmenopausal breast cancer, which makes this one of the larger studies of its kind, according to the researchers.

The researchers observed the strongest associations among women who had never used menopausal hormone therapy; results were shown only for this group of women.

"Compared with women who maintained approximately the same BMI, those who had an increase of 5 kg/m2 or more between age 20 and study entry had a nearly twofold increased risk of breast cancer," said Laura Sue, M.P.H., a cancer research fellow at the National Cancer Institute (NCI).

Results showed that nearly 57 percent of the study population's BMI increased 5 kg/m2 or more between age 20 and study entry. A BMI increase of 5 kg/m2 is equivalent to a woman of average height, 5'4", gaining approximately 30 pounds.

Women who reported a BMI increase of 5 kg/m2 or more between age 20 and 50 were at an 88 percent increased risk of developing postmenopausal breast cancer, compared with women who reported a stable BMI. For women who reported a BMI increase of 5 kg/m2 or more between age 50 and study entry, risk increased 56 percent, compared with women who maintained BMI. BMI gain both before and after age 50 independently contribute to increased risk of postmenopausal breast cancer.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Human development index linked to stem cell transplant rates and success in leukemia patients
2. LocumTenens.com Online Job Index Continues Rise in First Quarter 2010
3. New clinical prediction index to help patients considering kidney transplant
4. Tickerspy.com Announces New Stock Index Tracking Chinese Healthcare Stocks
5. Chindex International, Inc. Reports Third Quarter Fiscal Year 2010 Financial Results
6. MIB Life Index Reports North American Life Insurance Activity Up 3.9% in November
7. Study finds changes in fetal epigenetics throughout pregnancy
8. Educational Toy Franchise Expects Continued Growth Throughout Colorado in 2010
9. Toys"R"Us, Inc. Expands its Support of Autism Speaks Throughout North America
10. Study shows genital herpes virus reactivates widely throughout genital tract
11. Why symptoms of schizophrenia emerge in young adulthood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... Bill Mull Agencies, ... owners in and around central Kansas, is joining the Youth Horizons organization for ... region. , Headquartered in Wichita, Youth Horizons works to empower area children from ...
(Date:12/7/2016)... ... ... Kenall Manufacturing, a leader in sealed healthcare lighting for more than 30 ... sealed, LED luminaire that meets the needs of everyone in the patient room by ... , A 2’ x 4’ model features four modes: reading, ambient, standard and high ...
(Date:12/7/2016)... ... December 07, 2016 , ... OC87 Recovery Diaries ... schizophrenic mother in a unique, personal perspective through animation. , That woman ... addictive disorders at her private psychotherapy practice. Sheri’s mother, Pearl, lived with schizophrenia. ...
(Date:12/7/2016)... ... 07, 2016 , ... Castle Dermatology Institute is now offering liquid facelifts with ... youthful appearance to the face. Dr. Peyman Ghasri and Dr. Pedram Ghasri, San ... treatments, to rejuvenate and renew the facial appearance. , Sculptra is a highly ...
(Date:12/7/2016)... Fl (PRWEB) , ... December 07, 2016 , ... When it came time to blow ... heart. Just 40 minutes later, the Pediatric Heart Transplant team at Joe DiMaggio ... making the Weston teen the hospital’s 30th heart transplant recipient. , “He was playing ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... MOINES, Iowa , Dec. 8, 2016 /PRNewswire/ ... a pharmaceutical company advancing technologies designed to address ... appointment of Chitra Edwin , Ph.D., RAC, ... Compliance. Dr. Edwin will provide leadership for all ... for regulatory approvals, preparation of regulatory submissions, serving ...
(Date:12/7/2016)... , Dec. 7, 2016  Urinary catheters are ... retention and other urological disorders. Urinary catheters include ... (condom) catheter. Indwelling or Foley catheter is a ... type of catheter is inserted into the bladder ... A tiny balloon attachment at one end of ...
(Date:12/7/2016)... 2016  Palatin Technologies, Inc. ("Palatin") (NYSE MKT: ... previously disclosed underwritten public offering of units with ... sole book-running manager, Roth Capital Partners acted as ... co-manager for the offering. "This financing ... proceeds, allowing us to continue advancing bremelanotide for ...
Breaking Medicine Technology: