Navigation Links
Blood Disorder Cases Tied to Prescription Painkiller Abuse
Date:1/10/2013

By Steven Reinberg
HealthDay Reporter

THURSDAY, Jan. 10 (HealthDay News) -- Tennessee health officials report cases of a rare blood-clotting problem among people who injected the painkiller Opana ER (extended release) after crushing pills meant to be taken by mouth.

Thrombotic thrombocytopenic purpura (TTP) is a disorder that causes blood clots to form in small blood vessels around the body and is usually seen in about one in 100,000 people. From August to October, however, there were 15 cases seen in Tennessee. All were associated with intravenous drug abuse, with 14 specifically related to Opana ER.

"I don't think anybody has a figure for the percentage of people who are crushing these drugs to inject them; nobody really knows how commonly people do that," said Dr. Leonard Paulozzi, a medical epidemiologist at the U.S. Centers for Disease Control and Prevention.

There are, however, many reports of people crushing these pills to make them injectable, said Paulozzi, who works in the division of unintentional injury prevention at the CDC's National Center for Injury Prevention and Control.

Abusers crush these drugs to be able to snort them or cook them into a liquid so they can be injected.

"The advantage is it gets into the bloodstream faster," Paulozzi said. "Apparently, the amount of euphoria associated with the drug is associated with how fast the drug level rises in your bloodstream."

If left untreated, the clotting disorder can be fatal. None of the Tennessee patients died, but 12 tested positive for hepatitis C and seven were treated for sepsis, which is a toxic condition that can cause vital organs to shut down.

The report was published in the Jan. 11 issue of the journal Morbidity and Mortality Weekly Report.

In February, a new formulation of Opana ER designed to be more difficult to abuse became available, according to the CDC. This new formulation is gradually replacing the original one, the agency said. As with OxyContin, the new formulation is meant to prevent pulverizing the pills or dissolving them for injection.

The new formulation, however, didn't prevent the Tennessee incidents, a health official noted.

It isn't clear why this blood condition is associated with Opana ER, said Dr. David Kirschke, deputy state epidemiologist for the Tennessee Department of Health. He speculated that something in the drug when injected might have an effect on reducing platelets.

Reformulating these drugs to make them harder to tamper with may reduce the abuse of them, Kirschke said. "Unfortunately, in this case, the condition appears to be associated specifically with the reformulated version of the medication," he said. "It could be that something was done to the pill, which may be what's causing actual illness when they do abuse it."

In light of this report, the CDC is asking doctors to ask patients with TTP-like illness about injection-drug abuse. Also, doctors who prescribe Opana and pharmacists who fill prescriptions for it should tell patients about the risks when the drug is used other than as prescribed.

Abuse of narcotic prescription painkillers is a major public health problem in the United States, according to the U.S. Substance Abuse and Mental Health Services Administration.

Since 2002, some 22 million Americans have begun abusing prescription painkillers, the agency reports.

In 2009 there were nearly 425,000 emergency department visits involving nonmedical or inappropriate use of narcotic painkillers and an estimated 15,600 deaths involving these drugs, according to Dr. Douglas Throckmorton, deputy director for regulatory programs at the Center for Drug Evaluation and Research of the U.S. Food and Drug Administration.

The FDA recently released proposed guidelines to help drug makers develop more tamper-resistant formulas of their narcotic pain drugs.

More information

For more facts on prescription drug abuse, visit the U.S. National Library of Medicine.

SOURCES: Leonard Paulozzi, M.D., M.P.H., medical epidemiologist, division of unintentional injury prevention, National Center for Injury Prevention and Control, U.S. Centers for Disease Control and Prevention; David Kirschke, M.D., deputy state epidemiologist, Tennessee Department of Health; Jan. 11, 2013, Morbidity and Mortality Weekly Report


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. This week in Blood: Jan. 10, 2013
2. US Drug Watchdog Now Urges DePuy Pinnacle Metal Hip Recipients To Get A Blood Test and to Call Them For The Names Of The Best Lawyers If Their Metals Levels Are Elevated
3. Microscopic blood in urine unreliable indicator of urinary tract cancer
4. US Drug Watchdog Now Urges All Recipients Of A All Metal Hip Implant to Get A Blood Test Out of New Concerns About Side Effects and They Name Law Firms To Help Victims
5. ARUP Laboratories Introduces Blood Test to Aid in the Early Detection of Lung Cancer
6. U-M sibling study discovers genetic region linked to control of key blood-clotting protein
7. US Drug Watchdog Now Urges a Blood Test for All DePuy Pinnacle Hip Implant Recipients and They Suggest Law Firms to Help Victims of a Failure Get Compensated
8. Common Blood Pressure Drugs Might Lower Dementia Risk
9. Low Wages Linked to Raised Risk for High Blood Pressure
10. US Drug Watchdog Now Urges All Zimmer Stryker, Biomet, Wright and DePuy All Metal Hip Implant Recipients to Get A Blood Test For A Failure-Don't Get Left Holding the Bag
11. US Drug Watchdog will Expand Their Initiative Focused on Helping Recipients of a Failed DePuy Pinnacle All Metal Hip Implant with a New Emphasis on Blood Testing in 2013
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blood Disorder Cases Tied to Prescription Painkiller Abuse
(Date:3/28/2017)... ... 2017 , ... Tuesday, March 28, 2017, is the annual American Diabetes Association ... Test to find out if they are at risk for developing Type 2 diabetes. ... evening sky by programming the LAX pylons the color red. Downtown’s U.S. Bank Tower ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... team. Ruel Williamson brings his extensive knowledge of appraisals, property values, ad valorem ... the real estate valuation industry for more than 40 years. , “Ruel is ...
(Date:3/28/2017)... ... 2017 , ... The Thyroid Secret is a specialized 9-part ... program was recently launched on March 1, and Dr. Wentz discussed varied benefits ... Dr. Izabella Wentz is a licensed pharmacist and a foremost thyroid specialist. After ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... software and services, is proud to announce it has joined the National Association ... representing the interests of chronically ill, disabled, and dying Americans of all ages ...
(Date:3/28/2017)... ... March 28, 2017 , ... Alert Sentry Group LLC., ... (Mobile Personal Emergency Response Systems), the iSAFE and the iSAFE Plus. These iSAFE products ... first of their kind, the iSAFE and iSAFE Plus offer direct GPS Location and ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... March 29, 2017  NuVasive, Inc. (NASDAQ: NUVA), ... spine surgery with minimally disruptive, procedurally-integrated solutions, today ... clearance of the CoRoent® Small Interbody™ System indicated ... in the cervical spine. This marks the first ... used at up to four contiguous levels. ...
(Date:3/29/2017)... , March 29, 2017 NetworkNewsWire ... ... the public safety in regulating marijuana, but economic arguments also ... creation, and reduced law enforcement costs. However, to legalize and ... provided by SinglePoint, Inc. (OTC: SING) ( SING Profile ), ...
(Date:3/29/2017)... - Medicure Inc. ("Medicure") (TSXV:MPH, OTC:MCUJF), a specialty pharmaceutical ... ended December 31, 2016 after market close on ... released later than the previous fiscal year,s results ... and balances of Apicore from the acquisition date ... date meets TSX Venture Exchange listed company requirements. ...
Breaking Medicine Technology: