Navigation Links
Biphasic electrical stimulation: A strategy may bring hope to spinal cord injury patients
Date:8/23/2013

Researchers at the Beihang University School of Biological Science and Medical Engineering, led by Dr. Yubo Fan, have discovered that Biphasic Electrical stimulation (BES), a non-chemical procedure, may be used as a strategy for preventing cell apoptosis in stem cell-based transplantation therapy. The article describing their studies will be published in the August 2013 issue of Experimental Biology and Medicine. The scientists believe that their technique will be used for spinal cord injury patients in the future.

Spinal cord injury (SCI) is a serious disease of the central nervous system. According to Spinal Cord Injury Facts & Statistics, 250,000 Americans are spinal cord injured patients. Approximately 52% of spinal cord injured individuals are considered as paraplegic, and 47% patients are quadriplegic. In addition, 11,000 new injuries occur each year, and 82% are male.

Transplantation of Stem Cells is a potential clinical therapy for repair and regeneration of injured spinal cord, and brings new hope for patients. However, the survival rate of transplanted cells is relatively low because the cells are particularly vulnerable to apoptosis in the spinal cord. Factors proposed for causing such low survival include immune reactions, limited trophic factors and hypoxia. It appears that a lack of adequate growth factors plays an important role in the survival of transplanted cells. "We've shown for the very first time that BES may provide insight into preventing growth factor deprivation-triggered apoptosis in olfactory bulb neural precursor cells (OB NPCs)," said Yubo Fan, professor of Biological Science and Medical Engineering at Beihang and senior author. "These findings suggest that BES may thus be used as a strategy to improve cell survival and prevent cell apoptosis in stem cell-based transplantation therapies," Fan explained. The results may guide future efforts to restore functions lost after spinal cord injury.

The team of researchers investigated the protective effects of BES on growth factor-deprived apoptosis in OB NPCs. The NPCs were exposed to 12 h of BES. The results were that BES enhanced cell survival and prevented the apoptosis of NPCs caused by growth factor deprivation. The anti-apoptotic effect of BES was dependent on the activation of the PI3K/Akt signaling cascade and an increase in brain-derived neurotrophic factor (BDNF) production. "What was especially surprising and exciting was that a non-chemical procedure can prevent apoptosis in stem cells therapy for spinal cord injury patients," Fan said. "How BES precisely regulates the survival of exogenous stem cells is still unknown, but will be an extremely novel area of research on spinal cord injury in the future," Dr. Fan added.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "The fact that Biphasic Electrical Stimulation can improve the survival of neural precursor cells is truly exciting and will provide the basis for future studies that could lead to novel therapies for patients with spinal cord injury. I look forward to future advances in this field".


'/>"/>

Contact: Dr. Yubo Fan
yubofan@buaa.edu.cn
Society for Experimental Biology and Medicine
Source:Eurekalert

Related medicine news :

1. Parker Waichman LLP Responds to an Intuitive Surgical Notice that the da Vinci Surgical Robot, Due to a Defect, Can Electrically Burn a Patient During Surgery
2. Electrical pulse treatment pokes holes in hard-to-treat tumors
3. Electrical Stimulation Could Zap the Need for Physical Therapy Following Knee Replacement
4. Functional electrical stimulation cycling promotes recovery in chronic spinal cord injury
5. Electrical Brain Stimulation Plus Drug Fights Depression: Study
6. After 100 years, understanding the electrical role of dendritic spines
7. New electrically-conductive polymer nanoparticles can generate heat to kill colorectal cancer cells
8. Electrical characteristics of printed products determined in a snap
9. Electrical Brain Stimulation Curbs Epileptic Seizures in Rats
10. Unprecedented accuracy in locating brain electrical activity with new device
11. Electrical brain stimulation can alleviate swallowing disorders after stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... Francisco Canales, MD and Heather ... Napa Valley office. The technique utilizes the body’s own healing abilities to quickly ... Furnas, are part of only a select few cosmetic surgeons bringing this procedure ...
(Date:2/5/2016)... , ... February 05, 2016 , ... ... devoted exclusively to funding innovative lymphoma research and serving the lymphoma community through ... poised to once again host, Swirl, A Wine Tasting Event at the La ...
(Date:2/5/2016)... York (PRWEB) , ... February 05, 2016 , ... Regular ... and find themselves having to wait longer to access the treadmills. It’s a predictable ... Year’s resolutions to lose weight and get in shape by joining gyms, starting new ...
(Date:2/5/2016)... New York, New York (PRWEB) , ... February 05, 2016 , ... ... (APDA) announced the election of Patrick McDermott as Chairman of the National Board of ... welcome Pat as Chairman of the Board,” stated Leslie A. Chambers , APDA ...
(Date:2/5/2016)... ... ... Colorize is a web theme package created exclusively for Final ... dynamic moving camera. Colorize is perfect for personal and web related videos and its ... to 5 focus points per scene, stage floor scene presets that are great for ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... 2016 France , Germany ... UK, and Israel ). It includes a 10-year epidemiology ... GD, segmented by age and sex in these markets. GD epidemiology report ... is in-depth, high quality, transparent and market-driven, providing expert analysis of disease ... Germany , Italy , Spain ...
(Date:2/4/2016)... LONDON , Feb. 4, 2016 ... to achieve significant growth as next generation systems ... and use radiology for cancer surgery. New systems ... radiological overdosing that has been such a problem ... be delivered. Radiosurgery robots take cancer surgery far ...
(Date:2/4/2016)... , Feb. 4, 2016 Summary ... common cancer and the most common cancer in women ... the disease exceedingly prevalent. The number of women diagnosed ... decades, but the number of deaths has declined due ... cancer treatment has been revolutionized in the past four ...
Breaking Medicine Technology: