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Battery of tests on cancer cells shows them as 'squishy,' yet tactically strong
Date:4/26/2013

purely physical perspective, but it makes sense for a cancer cell, since both traits improve their chances of metastasizing. Understanding why is still an active area of research," explained Staunton, who is working towards his doctorate in physics.

"Another interesting finding was that a protein called CD44, which doubles as a cancer stem cell marker and as a molecule that helps the cell stick to certain fibers in the extracellular matrix, is equally abundant in the normal and cancer cells. But in the cancer cells the proteins don't make it to the cell surface," he added.

"For some reason they stay inside the cytoplasm, so the cancer cells are not as sticky," added Staunton whose hometown is Buffalo, N.Y. "This is another trait that contributes to their ability to spread through the body."

The PSOC network went to great lengths to have all of the studies performed under comparable conditions. While the cell lines studied are well understood, part of the effort for the network was to prove they could consistently coordinate the research.

Staunton, who has been involved in ASU's center since its inception, says the experience has helped his growth as a researcher.

"It is the perfect habitat for budding scientists and for transdisciplinary collaborations," he said.


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Contact: Skip Derra
skip.derra@asu.edu
480-965-4823
Arizona State University
Source:Eurekalert

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