Navigation Links
Battery of tests on cancer cells shows them as 'squishy,' yet tactically strong
Date:4/26/2013

ndakumar, Laimonas Kelbauskas, Patti Senechal, Courtney Hemphill, Roger H. Johnson and Deirdre Meldrum.

"We compared the stiffness of normal breast cells and highly metastatic breast cancer cells, and found the cancer cells to be significantly more 'squishy' or deformable," Staunton said. "This makes sense because in order for a cell to metastasize, it has to squeeze through tight passages in the lymphatics and microvasculature, so being squishy helps cancer cells spread through the body."

"We also looked at the morphology of their nuclei," he added. "The cancer cell nuclei were found to have a characteristic 'crushed beach-ball' shape that might correspond to the abnormal chromosomal rearrangements associated with cancer."

"Finally, we took individual cells, put each one in an airtight chamber, and measured how much oxygen they consumed," Staunton said. "This tells us about their metabolism. We found the cancer cells use less oxygen, relying more on glycolysis, kind of like what bacteria and yeast do."

Taken together, researchers at the 12 PSOC's used some 20 distinct techniques, including atomic force microscopy, ballistic intracellular nano-rheology, cell surface receptor expression levels, differential interference contrast microscopy, micro-patterning and extracellular matrix secretion, and traction force microscopy.

The work has enabled a comprehensive cataloging and comparison of the physical characteristics of non-malignant and metastatic cells, and the molecular signatures associated with those characteristics. This made it possible to identify unique relationships between observations, Staunton said.

"We were surprised that even though the cancer cells are softer, they are able to exert more contractile forces on the fibers surrounding them which was determined at the Cornell University PSOC by a method called traction force microscopy. This pair of characteristics is somewhat contradictory from a
'/>"/>

Contact: Skip Derra
skip.derra@asu.edu
480-965-4823
Arizona State University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Battery-Operated Skin Patch Offers New Option for Migraine Sufferers
2. Thin Film & Printed Battery Market Growing at CAGR of 46.14% to Reach $1,210.3 Million by 2017 - New Report by MarketsandMarkets
3. Device Offers Hope for Battery-Free Pacemakers
4. Study finds number of battery-related emergency department visits by children more than doubles
5. PeopleKeys Personality Tests Give Job Seekers a Competitive Advantage
6. Doctors Order Fewer Lab Tests When They Know the Cost
7. Naturally-occurring substance proves effective against deadly skin cancer in laboratory tests
8. Most Men Dont Need PSA Tests, Doctors Group Says
9. Blood tests can provide fuller picture of mutations in cancer than traditional biopsies do
10. Breast Cancer Gene Tests Wont Help Most Women: Report
11. Researchers tackle physician challenge of correctly ordering laboratory tests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... On Saturday, October 25, 2014, the Brownsville Community ... and fitness fair ¡Vive tu vida! Get Up! Get Moving!®. ... for better health and wellness for people of all ages ... to the public, will be held at Dean Porter Park, ... 1:00 pm. , “¡Vive tu Vida! Get Up! Get ...
(Date:10/22/2014)... 2014 Isabel Healthcare will ... Professions (ASAHP) Conference on October 22-24 in Las Vegas, ... in a panel discussion on Technology in Health Professions ... provides a diagnostic decision support tool and clinical education ... of students and clinical learners. The Isabel tools help ...
(Date:10/22/2014)... News) -- The United States is now mandating ... of West Africa land at one of five ... the virus. In a statement released Tuesday, ... percent of air passengers from Guinea, Liberia and ... five airports -- New York City,s Kennedy International ...
(Date:10/22/2014)... California (PRWEB) October 22, 2014 Hay House ... Move Beyond Addiction and Upgrade Your Life (Paperback; $10.82) written ... of Yoga & Recovery. This book is meant to ... in a life of recovery. , Recovery 2.0 is ... 12 Steps; Recovery 2.0 is a guide for what comes ...
(Date:10/22/2014)... Best Cheap Hosting USA is among the most ... recently announced that iPower ( http://www.best-cheap-hosting-usa.com/go/iPower/ ) is the ... the world. , “iPower is one of the most ... various kinds of useful products for new and old ... customer service and a number of features which will ...
Breaking Medicine News(10 mins):Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 3Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 4Health News:Isabel Healthcare to Participate in The Association of Schools of Allied Health Professions (ASAHP) 2014 Conference 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2
... Inc. (Nasdaq and SWX: BMRN) announced today that Emil,Kakkis, ... a,company update at the Bear Stearns 20th Annual Healthcare ... at 3:00 p.m. ET. Interested parties may access ... section of the BioMarin website, http://www.BMRN.com . A,replay ...
... Dismisses Rationale for,Proposed California Toy Ban, SACRAMENTO, ... of scientific research has conclusively determined,that a type ... risk to children when,it is used in toys, ... from the Toy Industry Association (TIA), which commissioned,the ...
... Ind., Sept. 4 Symmetry Medical Inc.,(NYSE: ... the global orthopedic,device industry and other medical markets, ... acquisition of Specialty Surgical,Instruments (SSI) and Ultra Containers ... instruments and sterilization containers. About Symmetry Medical ...
... LAFAYETTE, Ind. - A new technology for cancer detection ... developed by Purdue University researchers. , Researchers from ... of Biomedical Engineering collaborated with cancer and biotechnology experts ... tumor cells within the human body. By shining a ...
... been known that countries with rapidly developing economies may ... overnutrition. People living in poverty experience diseases that result ... suffer from diseases that result from an abundance of ... Health (HSPH) and the University of Bristol have examined ...
... kills 70,000 every year in developing countries worldwide can be ... always fatal when it reaches the brain. , But ... have shown how a type of bat rabies infection can ... the brain, when it is most lethal. They found that ...
Cached Medicine News:Health News:'Study of Studies' Finds No Risk to Children From Phthalates in Toys 2Health News:Symmetry Medical Completes Acquisition Of Specialty Surgical Instruments 2Health News:Purdue researchers develop technology to detect cancer by scanning surface veins 2Health News:Purdue researchers develop technology to detect cancer by scanning surface veins 3Health News:Income inequality associated with overnourishment and undernourishment in India 2Health News:Jefferson immunology researchers halt lethal rabies infection in brain 2Health News:Jefferson immunology researchers halt lethal rabies infection in brain 3
(Date:10/22/2014)... Influenza will affect as many as 200,000 people this year ... as high as 49,000 people.  The main way ... to person in respiratory droplets of coughs and sneezes. ... kills much fewer people each year than the Flu. The ... sweat, saliva, blood and other bodily fluids. The Ebola virus ...
(Date:10/22/2014)... Mass. , Oct. 22, 2014 InVivo ... Cambridge, MA is revolutionizing spinal cord injury ... has been shown to outperform in tissue regrowth in ... the scaffold.  Made from an FDA approved polymer, the ... making it harmless to the human body. NVIV has ...
(Date:10/22/2014)... Calif. , Oct. 22, 2014 WHEN: ... EDTLOCATION: Online, complimentary registration available at: ... Leader Archana Vidyasekar and Visionary Innovation Research ... WiFi-like wireless electricity, self-assembling materials, nanobots and ... technologies which will transform our lives in ...
Breaking Medicine Technology:WholeHealth Products is proud to be releasing its Influenza A and B combo test, on the heels of the announcing of its phase 2 completion of the Rapid Ebola Test 2InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 2InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 3Futuristic Technologies That Will Transform Our World Beyond 2030 2Futuristic Technologies That Will Transform Our World Beyond 2030 3Futuristic Technologies That Will Transform Our World Beyond 2030 4
... Specialty Pharma Association announces its Fall Conference - Complementing Your ... Marriott Marquis Hotel & Marina Guest Speakers ... RPh President National Community Pharmacists Association ... President TenStep, Inc. ...
... Etymotic Research , an innovator in ... the GunSport*PRO line of high-definition electronic earplugs.  Designed ... shooters, the GunSport*PRO allows users to hear their ... sudden, loud blasts.  The GunSport*PRO is priced at ...
Cached Medicine Technology:Etymotic Debuts GunSport*PRO High Definition Electronic Earplugs 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: