Navigation Links
BRAF inhibitor treatment causes melanoma cells to shift how they produce energy
Date:3/8/2013

elanoma cells suppresses oxidative phosphorylation by reducing expression of a transcription factor called MITF. Suppressing production of MITF reduced levels of a protein called PGC1α that regulates the generation and function of mitochondria. But melanoma cells treated with a BRAF inhibitor showed elevated MITF activity, along with increased expression of oxidative phosphorylation genes and greater numbers of mitochondria. By switching to oxidative phosphorylation to supply the energy they need, the tumor cells increased their ability to survive in spite of BRAF inhibitor treatment.

"These findings suggest that combination treatment with mitochondrial inhibitors could improve the efficacy of BRAF inhibitors in malignant melanoma," says Fisher, the Wigglesworth Professor of Dermatology at Harvard Medical School. "Several small molecules that target mitochondrial metabolism have been identified by investigators here at the MGH and elsewhere, and laboratory investigations of specific combinations of BRAF inhibitors with mitochondrial antagonists are currently underway."


'/>"/>

Contact: Michelle Marcella
mmarcella@partners.org
617-724-2755
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
2. VyGone Inhibitor Zapper: The Brand New Solution For the Safe Treatment Of Sores, Warts and Herpes
3. Inhibitors of shuttle molecule show promise in acute leukemia
4. Leukemia inhibitory factor may be a promising target against pancreatic cancer
5. Uncommon BRAF mutation in melanoma sensitive to MEK inhibitor drug therapy
6. Preclinical data support ongoing clinical trials testing IDO inhibitors as a treatment for cancer
7. PARP inhibitors may have clinical utility in HER2-positive breast cancers
8. New mechanism of action for PARP inhibitors discovered
9. PI3-kinase and PARP inhibitor combo may offer new treatment option for triple-neg breast cancers
10. Scientists at Mainz University identify inhibitor of myelin formation in the central nervous system
11. New small molecule inhibitor could be a safe and first-line treatment for metastatic breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... (PRWEB) July 23, 2014 Recently, iFitDress.com, a ... women, has announced its new selection of white party ... announced that custom made outfits are now available on its ... order before the end of July can get a discounted ... company’s products are popular among international customers, so its marketing ...
(Date:7/22/2014)... Marietta, Georgia and surrounding areas have more rescue dogs ... to lower population of needy pets; Marietta Vet Clinic, Julian ... have joined forces. Local businesses are being asked to ... presented to the Tigg Neuter Project. , The pet ... to attend and host the event. Local business as ...
(Date:7/22/2014)... Obtaining a bachelor’s degree in nursing just became ... medical experience. The School of Nursing at The University ... of an accelerated nursing degree program that provides course ... UNCG Veterans Access Program (VAP), will start January 2015 ... prior college credit, veterans who are RNs can earn ...
(Date:7/22/2014)... 22, 2014 Dr. Jeremy K. Ueno, ... colleagues, have recently discussed the reasons for an increase ... the periodontics profession are seeing the amount of referrals ... In fact, one surgeon reported that over 50% of ... dental implants have a very high success rate of ...
(Date:7/22/2014)... New York, NY (PRWEB) July 22, 2014 ... ( http://www.xareltolawsuitcenter.com/ ) that alleges the death ... bleeding caused by the blood thinner, Bernstein Liebhard LLP ... the U.S. District Court for the Southern District ... Xarelto in January 2012, and suffered a subdural hemorrhage ...
Breaking Medicine News(10 mins):Health News:Elegant White Party Dresses Now Provided by Distinguished Company iFitDress.com 2Health News:Marietta Vet Clinic Hosts 2014 Dog Days of Summer Pet Rescue Event 2Health News:UNCG School of Nursing Fast-Tracks Medically Trained Veterans 2Health News:Dr. Jeremy Ueno Can Help Treat Patients That Have Failing Implants 2Health News:Dr. Jeremy Ueno Can Help Treat Patients That Have Failing Implants 3Health News:Xarelto Lawsuit Filed by Florida Woman Alleges Uncontrollable Bleeding Led to Husband’s Death, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuit Filed by Florida Woman Alleges Uncontrollable Bleeding Led to Husband’s Death, Bernstein Liebhard LLP Reports 3
... BioSpecifics,Technologies Corp. (OTC Bulletin Board: BSTC.OB), a biopharmaceutical,company ... BioSpecifics, President, Tom Wegman, will present a,corporate overview ... Healthcare,Conference on Wednesday, November 12, 2008, at 10:20am ... York, NY., A live webcast of the ...
... Nov. 7 Eric Abrue (30), a,quadriplegic patient who is ... a historic and highly successful LASIK procedure performed,by Drs. Jeffrey ... in a,playground in 1986, breaking his neck and severing his ... unable to move any,part of his body below his upper ...
... Power and Associates Also Names Kaiser Permanente "Highest ... DENVER, Nov. 7 Kaiser Permanente Colorado is ... plan in,Colorado according to a joint ranking by ... for Quality Assurance (NCQA)., To view the ...
... Study finds these doctors have better results, including survival ... heart surgeons may be the best choice for adults ... new study suggests. , A congenital heart defect occurs ... blood vessels near the heart. , The researchers analyzed ...
... Children under the age of three who had hernia surgery ... later compared to children who had not undergone the surgery, ... School of Public Health and the College of Physicians and ... into the New York State Medicaid system between 1999 and ...
... Show at Nassau Coliseum, NEW YORK, Nov. 7 ... 2009 Concert Series -- a Valentine,s Day show,with Barry Manilow, ... will be held on February 14th, 2009 at Nassau Coliseum, ... 10th at 10am,through Ticketmaster.com or by calling Stand Up for ...
Cached Medicine News:Health News:Historic LASIK Surgery Performed on Quadriplegic Patient to Preserve his Communication Abilities 2Health News:Audio: Kaiser Permanente is Colorado's Top Commercial and Medicare Plan on U.S. News & World Report/NCQA 'America's Best Health Plans' List 2Health News:Audio: Kaiser Permanente is Colorado's Top Commercial and Medicare Plan on U.S. News & World Report/NCQA 'America's Best Health Plans' List 3Health News:Pediatric Heart Surgeons May Be Best Choice for Adults 2Health News:General anesthesia for hernia surgery in children and risk of later developmental problems 2Health News:Barry Manilow Brings Valentine's and Music to New York With Concert to Raise Funds for Breast Cancer Research 2
(Date:7/22/2014)... July 22, 2014  A central ... temporary Total Artificial Heart implant is ... Hospital with the Freedom® portable driver to wait ... a 64-year-old retiree from a Syracuse architectural hardware ... the condition with medications, an implantable defibrillator and ...
(Date:7/22/2014)...  July 22, 2014 The ... Reuters , the world,s leading provider of ... announced Cortellis Clinical Trials Intelligence , ... industry-first milestone with the documentation of more ... professionals with greater and quicker access to ...
(Date:7/22/2014)... PharmaTech (Cayman) Inc. (NYSE: WX ), a leading ... in China and the ... financial results for the second quarter of 2014 after the ... (which will be Thursday morning, August 14, 2014 Shanghai time). ... section of the Company,s website at http://www.wuxiapptec.com . ...
Breaking Medicine Technology:'I'm a Heartless SOB' Jokes Patient Discharged from Strong Memorial Hospital without a Human Heart 2'I'm a Heartless SOB' Jokes Patient Discharged from Strong Memorial Hospital without a Human Heart 3Thomson Reuters Cortellis Clinical Trials Intelligence Reaches Industry Milestone with 180,000 Clinical Trials 2Thomson Reuters Cortellis Clinical Trials Intelligence Reaches Industry Milestone with 180,000 Clinical Trials 3WuXi PharmaTech Schedules Second-Quarter 2014 Earnings Release 2
... Acute Myeloid ... ... the U.S. Food & Drug Administration (FDA) has granted orphan,drug designation ... (AML)., Celator is currently preparing to conduct two randomized Phase ...
... in ,The Lancet, and Presented at ESC Congress-, ... new international,study, the GISSI Heart Failure (GISSI-HF) study, ... esters reduced all cause mortality and hospital,admissions for ... findings are published in this week,s online version ...
Cached Medicine Technology:Celator Pharmaceuticals Receives Orphan Drug Designation for Anticancer Agent CPX-351 2New Data Shows Prescription Omega-3 Acid Ethyl Esters Reduced the Incidence of Death in Heart Failure Patients 2New Data Shows Prescription Omega-3 Acid Ethyl Esters Reduced the Incidence of Death in Heart Failure Patients 3New Data Shows Prescription Omega-3 Acid Ethyl Esters Reduced the Incidence of Death in Heart Failure Patients 4
Used following hysterectomy procedure. Often attached to Bard bile bag....
Used following open gallbladder procedure to drain bile. Often attached to Bard bile bag....
Silicone Flat Hubless Drains...
Siliconized PVC drains...
Medicine Products: