Navigation Links
BRAF inhibitor treatment causes melanoma cells to shift how they produce energy
Date:3/8/2013

elanoma cells suppresses oxidative phosphorylation by reducing expression of a transcription factor called MITF. Suppressing production of MITF reduced levels of a protein called PGC1α that regulates the generation and function of mitochondria. But melanoma cells treated with a BRAF inhibitor showed elevated MITF activity, along with increased expression of oxidative phosphorylation genes and greater numbers of mitochondria. By switching to oxidative phosphorylation to supply the energy they need, the tumor cells increased their ability to survive in spite of BRAF inhibitor treatment.

"These findings suggest that combination treatment with mitochondrial inhibitors could improve the efficacy of BRAF inhibitors in malignant melanoma," says Fisher, the Wigglesworth Professor of Dermatology at Harvard Medical School. "Several small molecules that target mitochondrial metabolism have been identified by investigators here at the MGH and elsewhere, and laboratory investigations of specific combinations of BRAF inhibitors with mitochondrial antagonists are currently underway."


'/>"/>

Contact: Michelle Marcella
mmarcella@partners.org
617-724-2755
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
2. VyGone Inhibitor Zapper: The Brand New Solution For the Safe Treatment Of Sores, Warts and Herpes
3. Inhibitors of shuttle molecule show promise in acute leukemia
4. Leukemia inhibitory factor may be a promising target against pancreatic cancer
5. Uncommon BRAF mutation in melanoma sensitive to MEK inhibitor drug therapy
6. Preclinical data support ongoing clinical trials testing IDO inhibitors as a treatment for cancer
7. PARP inhibitors may have clinical utility in HER2-positive breast cancers
8. New mechanism of action for PARP inhibitors discovered
9. PI3-kinase and PARP inhibitor combo may offer new treatment option for triple-neg breast cancers
10. Scientists at Mainz University identify inhibitor of myelin formation in the central nervous system
11. New small molecule inhibitor could be a safe and first-line treatment for metastatic breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... unrelated donors was safe and effective in treating ... Clostridium difficile , according to a new pilot ... and available online. Known as fecal microbiota transplantation, ... a colonoscope or a nasogastric tube. The findings ... more readily available to patients. , A growing ...
(Date:4/23/2014)... National Institute of Arthritis and Musculoskeletal and Skin Diseases ... Ross Prize in Molecular Medicine, conferred by the Feinstein ... award will be given on June 9 at the ... scientific presentations by Dr. O,Shea and other prominent researchers. ... , The award, which includes a $50,000 prize from ...
(Date:4/23/2014)... - Purdue University researchers have developed a way to ... by using tiny gold particles with tails of synthetic ... agricultural and biological engineering, used gold nanoparticles to target ... BRCA1 messenger RNA splice variants, which can indicate the ... these mRNA splice variants in a cell can be ...
(Date:4/23/2014)... Rochelle, NY, April 23, 2014Men whose testosterone falls below ... and to be overweight and have heart disease and ... to identify testosterone-deficient men for further testing and possible ... of Men,s Health , a peer-reviewed publication from Mary ... on the Journal of Men,s Health website ...
(Date:4/23/2014)... health benefits of probiotics, antioxidants and other nutritional compounds, ... chemical industry is getting in on the action. But ... so the industry is responding with clinical research to ... in Chemical & Engineering News (C&EN), the ... Melody M. Bomgardner, a senior editor at C&EN, writes ...
Breaking Medicine News(10 mins):Health News:Pilot study suggests ways to widen access to fecal transplants for C. diff infections 2Health News:NIH scientist to receive Ross Prize in Molecular Medicine 2Health News:Gold nanoparticles help target, quantify breast cancer segments in a living cell 2
... are not as stringent as with new medications , TUESDAY, ... Administration may not be as stringent in evaluating devices as ... report in the Dec. 23/30 issue of the Journal ... often sails through based on studies that are not randomized ...
... exist both indoors and outdoors, experts say , TUESDAY, Dec. ... can be challenging for anyone, but they pose extra hazards ... cause of injury-related deaths for adults over age 65 in ... older were treated in emergency departments for falls in 2005, ...
... happen outside the lab, expert says , TUESDAY, Dec. ... disinfectant could cause some germs to develop resistance to ... been proven outside of the laboratory and they don,t ... used properly. "It is OK to use disinfectants. Just ...
... Blood Today, Boost Community Supply and Help Save Lives! , ... its divisions in Manhattan, Long Island, Hudson Valley, Brooklyn/Staten Island, and ... recognition of National Blood Donor Month, and to help save lives. ... Americans would die each year without it, and the only place ...
... , , ... Alcohol Recovery (NIFAR®) is launching a global recovery and ... alcohol abuse. Social media websites and educational web videos ... and evaluate their drinking behavior. , (Photo: ...
... -- The role of pharmacists hasn,t received much attention ... But national and regional studies show that when pharmacists ... costs and improve outcomes. A study on diabetic patients ... Pharmaceutical Sciences identified cost savings with improvements in a ...
Cached Medicine News:Health News:Study Questions FDA Approvals of Cardiac Devices 2Health News:Study Questions FDA Approvals of Cardiac Devices 3Health News:Study Questions FDA Approvals of Cardiac Devices 4Health News:Caution Can Help Keep Elderly Safe During Winter 2Health News:Disinfectant Misuse Might Help Germs Resist Antibiotics 2Health News:Disinfectant Misuse Might Help Germs Resist Antibiotics 3Health News:January Is National Blood Donor Month 2Health News:January Is National Blood Donor Month 3Health News:New 'STOP DRINKING 411' Campaign Promotes Alcohol Recovery and Prevention Via Web Social Media 2Health News:New 'STOP DRINKING 411' Campaign Promotes Alcohol Recovery and Prevention Via Web Social Media 3Health News:Pharmacists improve care of diabetics while cutting costs, UB research shows 2Health News:Pharmacists improve care of diabetics while cutting costs, UB research shows 3
(Date:1/15/2014)...  In an unprecedented effort to curb the spread of "superbugs" such ... vehicles, an advanced and portable UV germicidal lamp manufactured by MRSA-UV ... In order to prevent EMS paramedics and transport ... West Palm Beach Fire Rescue is the first in ...
(Date:1/15/2014)... R.I. , Jan. 15, 2014 MultiCell Technologies, ... filed a U.S. provisional patent application concerning composition of ... to achieve targeted tumor cell death.  ... small noncoding double stranded RNA molecules (VSRNAs) which interfere ...
(Date:1/15/2014)... , Jan. 15, 2014 The Cadence Fitness ... Fitness Center by the Medical Fitness Association, a non-profit ... achieve their full potential. The Cadence Fitness & Health ... western suburbs and second in the Chicagoland area. ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3
... China Nuvo Solar Energy, Inc. (OTCQB: CNUV) today ... Bluewater Surgical, Inc. to a western distributorship. Bluewater surgical ... medicine, trauma surgery and more to acute care hospitals ... the high priced medical device providers in the marketplace. ...
... 4, 2011 Scrip , a leading global ... philanthropic foundation, the Abbott Fund, with a 2011 ... Scrip,s seventh annual awards ceremony in London ... of the significant results achieved through a decade-long, public-private ...
Cached Medicine Technology:China Nuvo Solar Energy, Inc. Announces Third-Party Distribution Agreement With Bluewater Surgical, Inc. 2China Nuvo Solar Energy, Inc. Announces Third-Party Distribution Agreement With Bluewater Surgical, Inc. 3Abbott Honored With Scrip Award for Leadership in Corporate Social Responsibility 2Abbott Honored With Scrip Award for Leadership in Corporate Social Responsibility 3Abbott Honored With Scrip Award for Leadership in Corporate Social Responsibility 4
Stainless steel lockable wall display for up to 12 frames....
Omni labs carries an extensive line of frames, lenses, soft contacts, RGP lenses, and many other products and services. It supports Zeiss, American optical, Sola, Rodenstock, Zylowear, Eyewear design...
A compact showcase unit. Made with tempered glass, one, two or three adjustable shelves, a door with a safety lock. Equipped with fluorescent lighting and levelers. Display is available in various si...
Classic is proud to provide top-quality vision eyewear to physicians, health maintenance organizations (HMOs), and numerous state and federal government programs. Classic Laboratory produces over 150...
Medicine Products: