Navigation Links
BRAF inhibitor treatment causes melanoma cells to shift how they produce energy
Date:3/8/2013

A multi-institutional study has revealed that BRAF-positive metastatic malignant melanomas develop resistance to treatment with drugs targeting the BRAF/MEK growth pathway through a major change in metabolism. The findings, which will be published in Cancer Cell and have been released online, suggest a strategy to improve the effectiveness of currently available targeted therapies.

"We were surprised to find that melanoma cells treated with the BRAF inhibitor vemurafenib dramatically change the way they produce energy to stay alive," says David E. Fisher, MD, PhD, chief of Dermatology at Massachusetts General Hospital (MGH) and a co-corresponding author of the Cancer Cell paper. "While current BRAF inhibitor treatment is a major improvement shrinking tumors in most patients and extending survival for several months patients eventually relapse. So there is an ongoing need to improve both the magnitude and durability of these responses."

In about half the cases of malignant melanoma the most deadly form of skin cancer tumor growth is driven by mutations in the BRAF gene. Research by investigators at the MGH Cancer Center and elsewhere has shown that treatment with drugs that block BRAF activity temporarily halts tumor growth. Combining a BRAF inhibitor with a drug that targets MEK, another protein in the same growth pathway, strengthens and extends the antitumor response. The current study was designed to investigate how BRAF inhibition changes metabolic activity within melanoma cells and to find other possible treatment targets.

The most common way that cells convert glucose into energy is called oxidative phosphorylation and largely relies on the activity of the cellular structures called mitochondria. Many cancer cells use an alternative mechanism that produces the energy compound ATP without involving mitochondria. A series of experiments by the MGH team revealed that the elevated BRAF activity in BRAF-positive m
'/>"/>

Contact: Michelle Marcella
mmarcella@partners.org
617-724-2755
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
2. VyGone Inhibitor Zapper: The Brand New Solution For the Safe Treatment Of Sores, Warts and Herpes
3. Inhibitors of shuttle molecule show promise in acute leukemia
4. Leukemia inhibitory factor may be a promising target against pancreatic cancer
5. Uncommon BRAF mutation in melanoma sensitive to MEK inhibitor drug therapy
6. Preclinical data support ongoing clinical trials testing IDO inhibitors as a treatment for cancer
7. PARP inhibitors may have clinical utility in HER2-positive breast cancers
8. New mechanism of action for PARP inhibitors discovered
9. PI3-kinase and PARP inhibitor combo may offer new treatment option for triple-neg breast cancers
10. Scientists at Mainz University identify inhibitor of myelin formation in the central nervous system
11. New small molecule inhibitor could be a safe and first-line treatment for metastatic breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2015)... York, New York (PRWEB) April 19, 2015 ... Panel on Multidistrict Litigation (JPML) indicate that Lipitor lawsuits ... litigation underway in U.S. District Court, District of South ... 2,185 new cases have been filed in the proceeding ... diabetes due to their use of the cholesterol-lowering statin. ...
(Date:4/19/2015)... 19, 2015 Family and friends of Brad ... in Memory of Brad Baddeley event to honor his ... , Bowling for Brains is cheduled to take place on ... Street in Lincoln, Nebraska. Participants may arrive at 12:30pm on ... , The cost is only $4 per game and 100% ...
(Date:4/18/2015)... 2015 Carinsurancequotesinfo.com has released a new ... physical injuries caused by a car accident. ... for a vehicle. A policy can pay for car ... Drivers should always carry appropriate coverage when they are ... be bought with several important riders that offer extra ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 Review of ... hosting a ‘Strategies for Success’ program for cataract surgeons ... meeting in San Diego, where eye surgeon Jeffrey L. ... this invitation-only event. Dr. Martin is the Managing Partner ... of Ophthalmology chose Dr. Martin to lead this year’s ...
(Date:4/18/2015)... York, New York (PRWEB) April 18, 2015 ... ) filed on behalf of individuals who were ... replacement system continue to move forward in the U.S. ... Order dated April 10th, the Court has amended an ... of unrelated cases. Among other things, the new amendment ...
Breaking Medicine News(10 mins):Health News:Lipitor Lawsuits Mount, as New Court Report Shows More Than 100 Filings Added to Federal Litigation Since March 2Health News:Lipitor Lawsuits Mount, as New Court Report Shows More Than 100 Filings Added to Federal Litigation Since March 3Health News:Lincoln, NE’s Bowling for Brains to benefit Renowned Brain Aneurysm Foundation 2Health News:Lincoln, NE’s Bowling for Brains to benefit Renowned Brain Aneurysm Foundation 3Health News:Auto Insurance Plans Can Cover Physical Injuries Caused By An Accident! 2Health News:Dr. Jeffrey Martin Invited to Share Latest Breakthroughs in Cataract Care During Roundtable Discussion at National 2015 ASCRS Meeting In San Diego 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 3
... chiefs have said “negative” to allegations that a perceived problem ... will upset the immunization// schedule of thousands of babies and ... of the Health IT initiative by the Government, to track ... problem, it is estimated that nearly 3,000 children would find ...
... to be believed neural transplants could be used to ... for a number of people came from a group ... provide improvement and a period of stability in Huntington's ... bad thing to happen to anyone. It is a ...
... scientists are of the opinion that women are in a ... that was conducted using rodents they found that female rodents ... shed light on health differences between males and females. ... 120 rats and measured in them what is known as ...
... to disclose the results of study findings with participants ... published in the April 1, 2006 issue of CANCER,// ... that such disclosures may actually do more harm than ... ,Maurie Markman, M.D., of the University of ...
... Claudia Twiby, eighteen months old was kept alive with a Berlin ... ,Four weeks later she received a new donated heart ... Lansdale, 32, and Shaun Twiby, 42. ,Claudia was only ... at London's Great Ormond Street Hospital, which first carried out the ...
... European regulators have not given the green signal to a ... . This is a step retrograde to a budding industry ... animals , ,GTC Biotherapeutics, proponents of this drug, ... the verdict came about only on the basis of a ...
Cached Medicine News:Health News:Men Are Less Capable Of Handling Stress Than Women – New Stud 2Health News:Regulators Object Drug Produced from Genetically Engineered Farm Animals 2
(Date:4/17/2015)... , Apr. 16, 2015 Research and Markets ... the "Corporate Reputation of Pharma in 2014 - ... Edition" report to their offering. For ... opinions on the corporate reputation of the pharmaceutical industry ... health with the views of patient organisations representing all ...
(Date:4/17/2015)... TAIPEI , April 17, 2015 TWi ... fully-owned subsidiary, TWi Pharmaceuticals USA , ... in the United States.  It has been in close ... wholesalers and expects to have its own label specialty ... soon in the U.S. pharma market. According ...
(Date:4/16/2015)... A drug commonly taken to prevent seizures in epilepsy may ... according to a study released today that will be presented ... Washington, DC , April 18 to 25, ... experience at some point in their life a condition called ... the eye to the brain gets inflamed," said study author ...
Breaking Medicine Technology:Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 2Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 3Epilepsy Drug May Preserve Eyesight for People with MS 2
The Valve Mapper Steerocath-Dx has a unique "peanut" shaped tip. It is designed to conform to the anatomy during mapping procedures. Both 8F/8mm and 8F/6mm tips are available....
... Vein Mapping. The LASSO Circular Mapping Catheter ... catheter capable of circumferentially mapping the myocardial ... unique design allows the sequential assessment of ... pulmonary vein isolation. The circular LASSO ...
For Atrial Mapping. Biosense Webster offers a complete line of specialty 20-pole catheters. The CRISTA CATH 20-pole deflectable catheter is designed for positioning along the crista terminals....
Fixed and steerable lumen diagnostic mapping catheters are offered in a variety of catheter configurations...
Medicine Products: