Navigation Links
Autophagic activation with Nimotuzumab enhances chemo-radiosensitivity
Date:5/13/2014

A study which will be published in the May 2014 issue of Experimental Biology and Medicine was aimed at determining whether an EGFR-targeted therapy combined with chemo-radiotherapy can improve local tumor control effectively, compared to cytotoxic agents or irradiation alone. Dr. Haizhu Song and co-workers from Jinling Hospital and the Medical School of Nanjing University in China demonstrated that nimotuzumab could enhance chemo-radiosensitivity by promoting autophagic cell death in esophageal squamous carcinoma (ESCC) cells.

Nimotuzumab is a humanized anti-EGFR monoclonal antibody that inhibits EGF-stimulated receptor autophosphorylation and downstream signaling pathways. The majority of prior investigations have focused on the therapeutic effects of nimotuzumab on cancer cells including cell cycle arrest and the induction of apoptotic cell death. Dr. Chen's laboratory detected the autophagic activity of ESCC cells following a combination of nimotuzumab with paclitaxel, cis-platinum or external beam radiation. These results showed that autophagic activation by nimotuzumab facilitated the antitumor effects of cytotoxic agents and irradiation in ESCC cells with high expression of EGFR. Therefore, nimotuzumab-combined therapy might be more beneficial for treating ESCC patients with a high level of EGFR expression and activation of autophagy; as part of a combined therapy or as an alternative approach to kill cancer cells more efficiently.

"We hope that our study will be meaningful in gaining a mechanistic understanding of nimotuzumab-combined therapy and provide a potential strategy for improving therapeutic efficacy in esophageal squamous cell carcinoma," said Dr. Longbang Chen, corresponding author.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "Song and colleagues provide evidence, worth pursuing, that activation of autophagy by nimotuzumab may provide increased chemosensitivity and radiosensivity
'/>"/>

Contact: Longbang Chen
dr.chenlb@163.com
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. TGA Premier Junior Golf Launches School Based Activation and Business Model in Canada
2. Panaseeda Golden Flax Seed Oil Review Examines Activation Products Flax Seed Oil
3. Panaseeda White Sesame Oil: Review Examines Activation Products White Sesame Oil
4. Panaseeda: Review Examines Andreas Wecker and Activation Products' Panaseeda Five Oil Blend for Whole Body Health
5. The concussed brain at work: fMRI study documents brain activation during concussion recovery
6. Methylphenidate normalizes activation in key brain areas in kids with ADHD
7. Same protein that fires up cancer-promoting Erk also blocks its activation
8. HPV in older women may be due to reactivation of virus, not new infection
9. Research reveals new understanding of X chromosome inactivation
10. Acupuncture enhances antidepressant effect of Seroxat
11. Its all coming back to me now: Researchers find caffeine enhances memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... May 22, 2015 “It’s like ... SLP, RAC-CT, CHHRP-QT, Vice President of Clinical Operations/Education ... important ‘language’ that impacts how care is coded ... in long term care reimbursement, operations and compliance ... and talent management, launches a new series of ...
(Date:5/22/2015)... May 22, 2015 According to a new ... generations are equally as likely to worry about what will ... Gen X, 77% Boomers, 69% Silent Generation), which may help ... are scared of aging, particularly Millennials (47%), Gen X’ers (51%), ... Poll in April, 2015 among more than 2,000 U.S. adults ...
(Date:5/22/2015)... The dentist in West ... they are now offering complimentary consultations to patients ... At consultations, patients can discuss their candidacy for ... treatments can achieve and whether alternative options are ... appointment. If treatments are chosen, patients can start ...
(Date:5/22/2015)... May 22, 2015 Wimbledon Health Partners, ... electrocardiogram (EKG), echocardiogram and NCV testing , is ... highly respected All American National athlete, to the Wimbledon ... find the high level of testing and information it ... and their athletic trainers, this way they can focus ...
(Date:5/22/2015)... In April 2006, Veatch Consulting opened ... years they have concentrated their focus to working with ... Because of this growth and their goals to better ... Denver, Colorado, Cleveland, Ohio, Houston, Texas and now Dallas, ... dental offices, dental start ups, orthodontic practices, pediatric dental ...
Breaking Medicine News(10 mins):Health News:Harmony Healthcare International Takes the Lead in Launching ICD-10 Coding Transition in Post-Acute Care 2Health News:Harmony Healthcare International Takes the Lead in Launching ICD-10 Coding Transition in Post-Acute Care 3Health News:New Study Reveals America’s Fear of Aging 2Health News:New Study Reveals America’s Fear of Aging 3Health News:West Hollywood Dental Office, Sunset Plaza Dental is Now Offering Complimentary Consultations 2Health News:Wimbledon Athletics Recruits Team USA Athlete 2Health News:Wimbledon Athletics Recruits Team USA Athlete 3
... smaller babies tend to have lower IQs.While the differences are ... of importance at a population level.// , ... at age seven to study the relationship between birth weight ... is directly related to birth weight, while factors such as ...
... testing is a useful way of pinpointing those at ... disease have no obvious symptoms like chest pain or ... hidden weaknesses long before heart problems become obvious. ... and 3,000 women given treadmill testing and then followed ...
... a more extensive biopsy detecting technique for prostate cancers has ... the traditional examination. In the traditional exam for prostate cancer, ... , At Ohio State University, researchers said that it ... his team, called this the extended sector biopsy. ...
... deal with stress. There has been quite a bit of ... and mental ill health. , , Researchers at West Virginia ... meditation programme called 'mindfulness training' can help people who describe ... a half hour classes once a week for eight weeks, ...
... is usually indicated by itchy flaky scalp to give it ... can treat dandruff by using a medicated shampoo, but be aware ... as individual products may lose their effectiveness. Ideally, wash your hair ... actually comes into contact with your scalp by leaving it for ...
... the market with an advertising blitz--but no proof it ... allergies, one tiny blue pill," proclaim ads from //manufacturer ... prescription allergy drug. In November, the Food and Drug ... A month's supply, which now costs about $85, could ...
Cached Medicine News:
(Date:5/22/2015)... , May 22, 2015 According ... Market by Product (Consumables, Instruments, Services), by Test Type ... Chromatography, Flow Cytometry), by End Users - Global Forecast ... Market is expected to reach $736.85 Million by 2020 ... of 10.25%. Browse 71 market data ...
(Date:5/22/2015)... , May 22, 2015 Research and Markets ... addition of the "Latest Regulations on Pharmaceutical ... to their offering. This is first ... a guidance on international multi-center clinical trials of ... has begun to be implemented on March 1, ...
(Date:5/22/2015)... , May 22, 2015 ... clinical research unit with a worldwide reputation for ... its frequent publications in peer reviewed medical journals. ... stakeholders and regulators in discussions about rules for ...      (Logo: http://photos.prnewswire.com/prnh/20150522/745125) , Clinical ...
Breaking Medicine Technology:Oxidative Stress Assays Market Worth $736.85 Million by 2020 2Oxidative Stress Assays Market Worth $736.85 Million by 2020 3Oxidative Stress Assays Market Worth $736.85 Million by 2020 42015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2
... NEW YORK, Sept. 28, 2011 The Prix Galien USA ... of human health last night during the fifth annual Prix ... Prix Galien USA 2011 Awards for best biotechnology product and ... the Museum of Natural History in New York City.   ...
... Sept. 28, 2011 Tengion, Inc. (Nasdaq: TNGN ... Flora to its Board of Directors. Mr. Flora brings to ... successful wound healing and surgical device businesses.  He most recently ... Covidien. Tengion also announced today that Gary ...
Cached Medicine Technology:Excellence in Scientific Innovation and Humanitarian Efforts Honored at 2011 Prix Galien Award Ceremony 2Tengion Appoints Scott Flora to Board of Directors 2Tengion Appoints Scott Flora to Board of Directors 3Tengion Appoints Scott Flora to Board of Directors 4
... SurgiGraphic 1027, with a Carbon Fiber ... designed for superior C-arm access, safety ... design means C-Arm utilization is quick ... exposure is minimized resulting in a ...
... The SurgiGraphic 6000 ... the tabletop for precise ... Float allows for immediate ... moving the C-Arm, making ...
... IMPLANT SYSTEM is a unique three-piece implant ... 1st metatarsal phalangeal joint resulting from osteoarthritis, ... a previous arthroplasty. The implant is ... superior function and longevity. With a ...
... play an important part in our daily ... rheumatic changes can cause severe handicaps. A ... finger-joint prostheses was to produce a reconstructed ... function as nearly possible.,The cementless RM Finger ...
Medicine Products: