Navigation Links
Autophagic activation with Nimotuzumab enhances chemo-radiosensitivity
Date:5/13/2014

A study which will be published in the May 2014 issue of Experimental Biology and Medicine was aimed at determining whether an EGFR-targeted therapy combined with chemo-radiotherapy can improve local tumor control effectively, compared to cytotoxic agents or irradiation alone. Dr. Haizhu Song and co-workers from Jinling Hospital and the Medical School of Nanjing University in China demonstrated that nimotuzumab could enhance chemo-radiosensitivity by promoting autophagic cell death in esophageal squamous carcinoma (ESCC) cells.

Nimotuzumab is a humanized anti-EGFR monoclonal antibody that inhibits EGF-stimulated receptor autophosphorylation and downstream signaling pathways. The majority of prior investigations have focused on the therapeutic effects of nimotuzumab on cancer cells including cell cycle arrest and the induction of apoptotic cell death. Dr. Chen's laboratory detected the autophagic activity of ESCC cells following a combination of nimotuzumab with paclitaxel, cis-platinum or external beam radiation. These results showed that autophagic activation by nimotuzumab facilitated the antitumor effects of cytotoxic agents and irradiation in ESCC cells with high expression of EGFR. Therefore, nimotuzumab-combined therapy might be more beneficial for treating ESCC patients with a high level of EGFR expression and activation of autophagy; as part of a combined therapy or as an alternative approach to kill cancer cells more efficiently.

"We hope that our study will be meaningful in gaining a mechanistic understanding of nimotuzumab-combined therapy and provide a potential strategy for improving therapeutic efficacy in esophageal squamous cell carcinoma," said Dr. Longbang Chen, corresponding author.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "Song and colleagues provide evidence, worth pursuing, that activation of autophagy by nimotuzumab may provide increased chemosensitivity and radiosensivity
'/>"/>

Contact: Longbang Chen
dr.chenlb@163.com
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. TGA Premier Junior Golf Launches School Based Activation and Business Model in Canada
2. Panaseeda Golden Flax Seed Oil Review Examines Activation Products Flax Seed Oil
3. Panaseeda White Sesame Oil: Review Examines Activation Products White Sesame Oil
4. Panaseeda: Review Examines Andreas Wecker and Activation Products' Panaseeda Five Oil Blend for Whole Body Health
5. The concussed brain at work: fMRI study documents brain activation during concussion recovery
6. Methylphenidate normalizes activation in key brain areas in kids with ADHD
7. Same protein that fires up cancer-promoting Erk also blocks its activation
8. HPV in older women may be due to reactivation of virus, not new infection
9. Research reveals new understanding of X chromosome inactivation
10. Acupuncture enhances antidepressant effect of Seroxat
11. Its all coming back to me now: Researchers find caffeine enhances memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... St. Joseph, Missouri (PRWEB) October 31, 2014 ... prepare for school, one Midwest optometrist feels they may ... vision problems to affect areas like concentration, school performance ... events may be too brief to identify progressive vision ... Options, St. Joseph, Mo., announces a new initiative: The ...
(Date:10/31/2014)... Oct. 31, 2014 (HealthDay News) -- Surgery for low ... where in the United States you live, a new ... experience low back pain at some point in their ... professional medical care for a spine problem," co-author Brook ... Clinical Practice, said in a college news release. ...
(Date:10/31/2014)... duration of treatment and cost, patients with early ... breast irradiation (APBI) with proton therapy versus whole ... The University of Texas MD Anderson Proton Therapy ... study based on typical patient characteristics, researchers used ... eight different types of partial and whole breast ...
(Date:10/31/2014)... lab device to give cancer researchers an unprecedented microscopic ... spread through the body, causing more than 90 percent ... tumor cells travel, the device could uncover new ways ... the university,s Whiting School of Engineering and its Institute ... new system recently in the journal Cancer Research ...
(Date:10/31/2014)... North Shore Eye Care today announced ... Island and the addition of leading ophthalmologist, William S. ... North Shore Eye Care Medical Director, Jeffrey Martin, MD. ... the Department of Ophthalmology of Winthrop-University Hospital and has ... for more than 30 years. He has been named ...
Breaking Medicine News(10 mins):Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 3Health News:Spinal Surgery Varies by Region in U.S.: Study 2Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 2Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 3Health News:Viewing cancer on the move: New device yields close-up look at metastasis 2Health News:Viewing cancer on the move: New device yields close-up look at metastasis 3Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 2Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 3
... , , SALT LAKE ... it has added 10 new sales representatives to its nationwide direct sales ... , , "We,re thrilled to be adding so ... vice president of sales and marketing at Dynatronics. "This is just ...
... , , EMERYVILLE, Calif., ... ) today announced that it will webcast an investor briefing ... Time. Speakers will review clinical data for Nexavar in breast ... 34th European Society for Medical Oncology (ESMO) Multidisciplinary Congress in ...
... , , C.S. Mott Children,s Hospital ... to have their children vaccinated against H1N1 flu, despite higher disease risk; ... ANN ARBOR, Mich., Sept. 24 With schools back in session, H1N1 ... children. A new vaccine against H1N1 flu -- strongly recommended for kids ...
... , , SAN ... company discovering and developing a new class of naturally occurring ... in Tokyo on Tuesday October 6. Jeff Watkins, CEO of ... product engine, and lead program based on naturally occurring resected ...
... N.J., Sept. 24 Marketing Technology Solutions , ... QualityHealth.com , has today filed a lawsuit alleging that ... misappropriated trade secrets and other confidential information by utilizing MTS-copyrighted online ... a health website owned and operated by MediZine. , , ...
... Singapore and Washington DC (September 24, 2009) There is clear ... cancer, according to a study published in the current issue ... The article "Lifestyle Interventions in the Prevention and Treatment ... common forms of cancer (lung, colorectal, breast, prostate and skin) ...
Cached Medicine News:Health News:Dynatronics Expands Nationwide Direct Sales Force by 25 Percent 2Health News:H1N1 Flu: Are Parents Underestimating Risk to Kids? 2Health News:H1N1 Flu: Are Parents Underestimating Risk to Kids? 3Health News:H1N1 Flu: Are Parents Underestimating Risk to Kids? 4Health News:aTyr Pharma to Present at Japan Biopharma Partnering Conference 2Health News:MediZine Named in Intellectual Property Lawsuit Filed by Marketing Technology Solutions 2
(Date:10/31/2014)... -- Though therapies are in their nascent phase, sales ... annual increase of 16.2% over the 2010-2020 period, reaching ... to Kalorama Information,s report, Stem Cell Therapeutics Markets ... have gained or are expected to gain approval from ... ever more complicated conditions, stem cell therapies hold the ...
(Date:10/30/2014)... 30, 2014 /CNW/ - Atlantic Canadians will save an ... Canada,s provinces and territories and ... of the Canadian Generic Pharmaceutical Association (CGPA), said today. ... speaking at the Atlantic Summit on Healthcare and Drug ... is being hosted by the Public Policy Forum and ...
(Date:10/30/2014)... -- Stryker Orthopaedics, the Official Joint Replacement Products of ... its debut year of the relationship at the Charles ... This marks the eleventh tournament stop along both ... has activated on-site with the "Stryker Mobility Zone" – ... importance of joint health.  The Stryker ...
Breaking Medicine Technology:Report: Stem Cell Technologies Market Growing 2Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 2Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 3Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 2Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 3Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 4
... and Buffalo Grove, Ill. , May 11 Solta ... today announced that they have reached an agreement resolving lawsuits involving certain Thermage® ... , , ... U.S. District Court in Delaware by Alma Lasers seeking a declaration ...
... CrystalGenomics, Inc., a novel drug R&D company announced today that ... antibiotic candidate, CG400549, has been successfully completed in Europe . ... CG400549 is ... which is a critical enzyme in generating bacterial membrane) as it ...
Cached Medicine Technology:Solta Medical and Alma Lasers Resolve Patent Lawsuits 2Solta Medical and Alma Lasers Resolve Patent Lawsuits 3CrystalGenomics Announces Successful Completion of a Phase I SAD Clinical Trial for CG400549, its Novel Antibiotic Candidate 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: