Navigation Links
Autophagic activation with Nimotuzumab enhances chemo-radiosensitivity
Date:5/13/2014

A study which will be published in the May 2014 issue of Experimental Biology and Medicine was aimed at determining whether an EGFR-targeted therapy combined with chemo-radiotherapy can improve local tumor control effectively, compared to cytotoxic agents or irradiation alone. Dr. Haizhu Song and co-workers from Jinling Hospital and the Medical School of Nanjing University in China demonstrated that nimotuzumab could enhance chemo-radiosensitivity by promoting autophagic cell death in esophageal squamous carcinoma (ESCC) cells.

Nimotuzumab is a humanized anti-EGFR monoclonal antibody that inhibits EGF-stimulated receptor autophosphorylation and downstream signaling pathways. The majority of prior investigations have focused on the therapeutic effects of nimotuzumab on cancer cells including cell cycle arrest and the induction of apoptotic cell death. Dr. Chen's laboratory detected the autophagic activity of ESCC cells following a combination of nimotuzumab with paclitaxel, cis-platinum or external beam radiation. These results showed that autophagic activation by nimotuzumab facilitated the antitumor effects of cytotoxic agents and irradiation in ESCC cells with high expression of EGFR. Therefore, nimotuzumab-combined therapy might be more beneficial for treating ESCC patients with a high level of EGFR expression and activation of autophagy; as part of a combined therapy or as an alternative approach to kill cancer cells more efficiently.

"We hope that our study will be meaningful in gaining a mechanistic understanding of nimotuzumab-combined therapy and provide a potential strategy for improving therapeutic efficacy in esophageal squamous cell carcinoma," said Dr. Longbang Chen, corresponding author.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "Song and colleagues provide evidence, worth pursuing, that activation of autophagy by nimotuzumab may provide increased chemosensitivity and radiosensivity in ESCC".


'/>"/>

Contact: Longbang Chen
dr.chenlb@163.com
Society for Experimental Biology and Medicine
Source:Eurekalert

Related medicine news :

1. TGA Premier Junior Golf Launches School Based Activation and Business Model in Canada
2. Panaseeda Golden Flax Seed Oil Review Examines Activation Products Flax Seed Oil
3. Panaseeda White Sesame Oil: Review Examines Activation Products White Sesame Oil
4. Panaseeda: Review Examines Andreas Wecker and Activation Products' Panaseeda Five Oil Blend for Whole Body Health
5. The concussed brain at work: fMRI study documents brain activation during concussion recovery
6. Methylphenidate normalizes activation in key brain areas in kids with ADHD
7. Same protein that fires up cancer-promoting Erk also blocks its activation
8. HPV in older women may be due to reactivation of virus, not new infection
9. Research reveals new understanding of X chromosome inactivation
10. Acupuncture enhances antidepressant effect of Seroxat
11. Its all coming back to me now: Researchers find caffeine enhances memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2017)... ... March 01, 2017 , ... After a long period of ... cleanse. While juice cleanses and workouts top the detox categories, there is a rare ... regime. The Kerry Gaynor Method’s Vital Lung Detox is an herbal-based formula designed to ...
(Date:3/1/2017)... ... March 01, 2017 , ... Look for a new collection ... Roses and Drift Roses. Star Roses and Plants is launching their new Bushel ... The Bushel and Berry Collection makes growing fresh fruit simple with a variety of ...
(Date:3/1/2017)... ... March 01, 2017 , ... Breast Surgeon, Dr. Dennis Holmes of 90210 ... breast cancer and where it fits in the treatment paradigm at Susan G. Komen ... The event brings together leading cancer and wellness experts to share the latest innovations ...
(Date:3/1/2017)... ... March 01, 2017 , ... Granite Peaks Gastroenterology recently announced ... by supporting the 80% by 2018 initiative, led by the American Cancer Society ... Cancer Roundtable (an organization co-founded by ACS and CDC). , “80% by 2018” ...
(Date:3/1/2017)... ... 2017 , ... “There is Comfort for the Soul”: a loving account of ... all-too-brief time together, and the soul-healing comfort provided by God’s presence in the face ... author, Jerie A. Tau, a dog-loving medical professional whose work takes her to remote ...
Breaking Medicine News(10 mins):
(Date:3/1/2017)... Mar 01, 2017 ... Research and Markets has announced ... to 2017" report to their offering. The ... report provides understanding and access to partnering deals and agreements entered ... provides an analysis of partnering deals. The majority of deals are ...
(Date:3/1/2017)... Research and Markets has announced the addition of the ... to their offering. ... This analysis is one of the most accurate studies performed ... financial data derived from varied research sources to present unique and ... market during the next five years, including a deep dive analysis ...
(Date:3/1/2017)... , March 1, 2017  Numotion, the nation,s leading ... availability of Tek RMD ("robotic mobilization device") by Matia ... Tek RMD is a motorized standing movement device that ... manual wheelchair to complete everyday activities from a standing ... a Tek RMD unassisted. Numotion is the exclusive distributor ...
Breaking Medicine Technology: