Navigation Links
Atherosclerosis: Specific microRNAs promote inflammation
Date:3/22/2013

Atherosclerosis, an inflammatory reaction, is at the root of the most common forms of cardiovascular disease. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have now identified a microRNA that plays a prominent role in the process, and offers a promising target for new therapies.

Atherosclerosis otherwise known as hardening of the arteries is a prevalent cause of death in modern societies. The condition arises from the build-up of localized fatty deposits called plaques in the arteries. Macrophages, the phagocytic cells of the immune system, migrate to these sites, inducing chronic inflammation which exacerbates the accumulation of the atherosclerotic lesions. These can lead to obstruction of major vessels, causing heart attack and stroke. A team of medical researchers led by LMU's Professor Andreas Schober has now identified a microRNA (miRNA) that helps initiate the inflammatory process.

miRNAs are short segments of RNA derived from longer precursors transcribed from defined stretches of the genomic DNA. They act as versatile regulators of gene expression in cells, and also control the function of macrophages, in which patterns of gene activity must respond rapidly to changes in the extracellular environment. "However, the miRNAs that control the inflammation process during the various stages of atherosclerosis had not been identified up to now," says Schober.

In an earlier study, Schober and his team had shown that the microRNA miR-155 is a prominent member of the miRNA population in macrophages. The molecule prevents the synthesis of a protein that inhibits the inflammatory reaction, and thus promotes the progression of atherosclerosis. However, miR-155 does not serve as the initiator of inflammation. Schober and his colleagues have now looked at the patterns of microRNA expression in atherosclerotic lesions in the mouse, and noted that levels of a different miRNA, called miR-342-5p, increase in very early plaque
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brain waves challenge area-specific view of brain activity
2. Researchers propose a novel prognostic model for disease-specific survival in BCa patients
3. Stroke risk in elderly treated with antipsychotics is newly linked to specific drug actions
4. US Drug Watchdog Now Urges Personal Injury Law Firms To Help Them Help Injured Individuals Of A Transvaginal Mesh Failure With A State Specific Approach-The Worst Victims
5. US Drug Watchdog Now Urges Top Personal Injury Trial Lawyers To Join Their State Specific Effort To Help Victims Of A Severe Transvaginal Mesh Failure To Get Compensation
6. US Drug Watchdog Now Invites Top Personal Injury Law Firms To Join Them In A State Specific Effort To Identify And Help Victims Of A Severe Transvaginal Mesh Failure
7. US Drug Watchdog Now Urges AV Rated Law Firms To Help Them Help More Victims Of A Severe Transvaginal Mesh Failure With A State Specific Approach
8. US Drug Watchdog Now Urges Trial Law Firms To Join Them In Their Effort To Help Severely Injured Victims Of A Transvaginal Mesh Failure-With A State Specific Approach
9. Prostate-specific antigen screening: Values and techniques shape decisions
10. Specific warning signs of complications in colorectal surgical patients released
11. US Drug Watchdog Now Urges All US Recipients of All Metal Hip Implants to Get a Blood Test For Cobalt-Chromium Levels and They Offer Specific Law Firms For Failure Victims
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... diabetes face a number of challenges over the holidays, but ... "With the holidays coming, take some time to think ... be visiting and all of the to-dos," Joan Bardsley, president ... association news release. "By planning ahead. you can enjoy the ... make a healthy eating contract with yourself. Before a big ...
(Date:11/28/2014)... Agein.com, the Internet’s premier anti-aging web site ... the foremost experts in the industry, is releasing its top ... winter. , “The official start of winter is still three ... hit with an icy blast. After one of the worst ... will usher in another brutal winter,” says Dr. Kevin J. ...
(Date:11/28/2014)... BambooFlooringChina.com has been recognized as a ... the business has announced its new strand woven ... discount on these new models. , Based on the ... without carpenter machines involved. It is crafted on strand ... for do-it-yourselfers without hard work on installation, also available ...
(Date:11/28/2014)... Now that the holiday season is here, ... nation's leading cash-for-junk-cars companies, is improving their cash offers ... competitive and help bring a little bit more joy ... year. , Along with purchasing expensive gifts for family ... deal with large travel expenses during the holiday season. ...
(Date:11/28/2014)... 28, 2014 Dr. Diane Walder, one ... announced the addition of Dr. Bridgit Nolan to her ... practice after having completed her dermatology residency at the ... Walder invited Dr. Nolan to join her ... and cosmetic dermatology. Not only does Dr. Nolan strive ...
Breaking Medicine News(10 mins):Health News:Holiday Eating Tips for People With Diabetes 2Health News:Agein Corporation, a Leading Anti-Aging Company, Releases Top Diet and Personal Care Tips for Preventing Dry Skin this Season 2Health News:BambooFlooringChina.com Introduces Its New Strand Woven Bamboo Flooring Collection 2Health News:Rusty's Auto Salvage Increasing Their Cash Offers to Help Drivers Save Throughout the Busy Holiday Season 2Health News:Dr. Diane Walder Welcomes New Cosmetic Dermatologist to Practice 2
... Treatment ... Worldwide, LOS ANGELES, Nov. ... develop an AIDS vaccine have,announced that their efforts have stumbled or, in ... was halted last week,when its vaccine was suspected of actually making some ...
... erosive gastroesophageal reflux disease ... (GERD) who cannot swallow tablets, COLLEGEVILLE, Pa., ... WYE ), announced today that the,U.S. Food and Drug Administration ... new addition,to the Protonix family of prescription medications. "The ...
... The prognosis for individuals with metastatic melanoma (MM) is ... have some clinical benefit; however, most patients eventually succumb ... known as dendritic cells (DCs) fail to sustain an ... in vitro using human melanoma cell lines and resected ...
... YORK, Nov. 15 Danny Wright, Chief Executive ... (http://www.alliancehealthcard.com ) will be featured in an exclusive ... at 2 p.m. EST. The interview,will be posted ... on November 16. The interview will cover ...
... will serve as Digital,s Medical Director for ... Ophthalmology, ... company specializing in retinal risk assessment for diabetics,announced today that Suber S. ... provide the company expert,advice and counsel regarding product development and development. ...
... consumption of these foods lowered odds up to 60%, study ... that includes plenty of fish, omega-3 rich oils, fruits and ... while high intake of omega-6 rich oils may boost the ... They looked at the diets of 8,085 people older than ...
Cached Medicine News:Health News:AIDS Vaccine Failures Highlight Need to Focus on Lifesaving Treatment, Says AHF 2Health News:Wyeth Receives FDA Approval of Protonix for Delayed-Release Oral Suspension 2Health News:Wyeth Receives FDA Approval of Protonix for Delayed-Release Oral Suspension 3Health News:WallSt.net Announces Upcoming Interview With CEO of Alliance HealthCard 2Health News:Digital Healthcare Announces Appointment of Dr. Suber Huang as Medical Director 2Health News:Digital Healthcare Announces Appointment of Dr. Suber Huang as Medical Director 3Health News:Fish, Fruits, Veggies May Cut Dementia Risk 2
(Date:11/28/2014)... -- Chinese magnesium alloy maker DongGuan Eontec Co., Ltd ... bone fixation screw has received Chinese regulatory inspection approval ... and that the company acknowledges receipt of the approval ... and Technology Daily journalists Wang Xiangming and ... Professor Li Yangde , has been a pioneer ...
(Date:11/27/2014)... - New Solution That Makes JINS MEME,s Raw ... Ltd. will launch JINS MEME "ACADEMIC PACK" in late April, ... (without tax /including two pairs of JINS MEME and designated ... of "JINS MEME" to academic researchers, and it enables them ... and six-axis sensors without API. (*Physiological data that can be ...
(Date:11/26/2014)... Company plc ("Perrigo") (NYSE: PRGO ; TASE), ... today announced the closing of Perrigo,s previously announced registered ... shares at a public offering price of $152.00 per ... purchase up to an additional 888,157 ordinary shares by ... representatives of the several underwriters. Perrigo ...
Breaking Medicine Technology:Chinese magnesium alloy manufacturer Eontec expects to have its medical magnesium alloy available for clinical trial in 2015 2Chinese magnesium alloy manufacturer Eontec expects to have its medical magnesium alloy available for clinical trial in 2015 3Chinese magnesium alloy manufacturer Eontec expects to have its medical magnesium alloy available for clinical trial in 2015 4JIN to Launch JINS MEME ACADEMIC PACK in Late April 2015 2JIN to Launch JINS MEME ACADEMIC PACK in Late April 2015 3Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 2Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 3Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 4
... Texas, Nov. 18, 2010 OCuSOFT, Inc., an ... to announce that ZYTAZE™ is now available in ... but are not limited to: Walgreens, CVS, Wal-Mart, ... In an early pilot study, ZYTAZE™ demonstrated marked ...
... FORD, Pa., Nov. 18, 2010 Endo Pharmaceuticals Holdings ... it priced $400 million aggregate principal amount of 7.00% ... of 99.10 percent in connection with its previously announced ... of the Company and will be guaranteed by certain ...
Cached Medicine Technology:Endo Pharmaceuticals Holdings Inc. Announces Pricing of Private Offering of Senior Notes 2
... Practice management software for eyecare ... true multi-tasking, multi-office practice management ... database technology- Winx Pro is ... assist you in effectively managing ...
... Working with over 2,500 ... proud to serve one ... client bases in the ... PM Ophthalmology, we are ...
... EMR Ophthalmology is a comprehensive electronic ... for ophthalmology practices. Intuition EMR Ophthalmology ... provides the tools to evaluate your ... to make better decisions and to ...
... in advanced cartridge mixing and delivery systems. ... mechanically injects all types of bone cement ... line-up includes a large selection of nozzles ... difficult to access areas. A new, anatomically ...
Medicine Products: