Navigation Links
Atherosclerosis: Specific microRNAs promote inflammation
Date:3/22/2013

Atherosclerosis, an inflammatory reaction, is at the root of the most common forms of cardiovascular disease. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have now identified a microRNA that plays a prominent role in the process, and offers a promising target for new therapies.

Atherosclerosis otherwise known as hardening of the arteries is a prevalent cause of death in modern societies. The condition arises from the build-up of localized fatty deposits called plaques in the arteries. Macrophages, the phagocytic cells of the immune system, migrate to these sites, inducing chronic inflammation which exacerbates the accumulation of the atherosclerotic lesions. These can lead to obstruction of major vessels, causing heart attack and stroke. A team of medical researchers led by LMU's Professor Andreas Schober has now identified a microRNA (miRNA) that helps initiate the inflammatory process.

miRNAs are short segments of RNA derived from longer precursors transcribed from defined stretches of the genomic DNA. They act as versatile regulators of gene expression in cells, and also control the function of macrophages, in which patterns of gene activity must respond rapidly to changes in the extracellular environment. "However, the miRNAs that control the inflammation process during the various stages of atherosclerosis had not been identified up to now," says Schober.

In an earlier study, Schober and his team had shown that the microRNA miR-155 is a prominent member of the miRNA population in macrophages. The molecule prevents the synthesis of a protein that inhibits the inflammatory reaction, and thus promotes the progression of atherosclerosis. However, miR-155 does not serve as the initiator of inflammation. Schober and his colleagues have now looked at the patterns of microRNA expression in atherosclerotic lesions in the mouse, and noted that levels of a different miRNA, called miR-342-5p, increase in very early plaque
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brain waves challenge area-specific view of brain activity
2. Researchers propose a novel prognostic model for disease-specific survival in BCa patients
3. Stroke risk in elderly treated with antipsychotics is newly linked to specific drug actions
4. US Drug Watchdog Now Urges Personal Injury Law Firms To Help Them Help Injured Individuals Of A Transvaginal Mesh Failure With A State Specific Approach-The Worst Victims
5. US Drug Watchdog Now Urges Top Personal Injury Trial Lawyers To Join Their State Specific Effort To Help Victims Of A Severe Transvaginal Mesh Failure To Get Compensation
6. US Drug Watchdog Now Invites Top Personal Injury Law Firms To Join Them In A State Specific Effort To Identify And Help Victims Of A Severe Transvaginal Mesh Failure
7. US Drug Watchdog Now Urges AV Rated Law Firms To Help Them Help More Victims Of A Severe Transvaginal Mesh Failure With A State Specific Approach
8. US Drug Watchdog Now Urges Trial Law Firms To Join Them In Their Effort To Help Severely Injured Victims Of A Transvaginal Mesh Failure-With A State Specific Approach
9. Prostate-specific antigen screening: Values and techniques shape decisions
10. Specific warning signs of complications in colorectal surgical patients released
11. US Drug Watchdog Now Urges All US Recipients of All Metal Hip Implants to Get a Blood Test For Cobalt-Chromium Levels and They Offer Specific Law Firms For Failure Victims
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2014)... Pro Ace Care, a renowned Vancouver hot water tank company, ... 8 year warranty on its selected hot water tanks. As ... to the impending winter season, it was important for Pro ... that the company provides. As a result, Pro Ace will ... Bradford hot water tanks. , “Every installer who works ...
(Date:11/23/2014)... 2014 (HealthDay News) -- The holidays can be a ... overload can trigger major meltdowns, an expert says. ... of circumstances, but when you have children with special ... occupational therapy professor at University of the Sciences in ... best to let your hosts or visitors know what ...
(Date:11/23/2014)... To show thanks to new and old ... white evening dresses for weddings. Customers who need ... iFitDress.com is a distinguished dress manufacturer, and it is among ... customers for a very long time. The CEO of this ... will be able to buy not only a beautiful dress, ...
(Date:11/23/2014)... AngelWeddingDress.com has recently updated its online store, ... dresses. “If you are looking for gorgeous beach wedding ... possible. Here you can enjoy 70% off discounts and ... a big marriage ceremony is the most important dream ... dress is uppermost priority. Ophelia, one of customers, said, ...
(Date:11/23/2014)... The FDA is Watching: , What ... Webinar**, Dec. 11, 2014 ? Any Time at Your ... on promotional activities is no longer limited to magazine ... at websites, Twitter, journal articles, TV appearances, Facebook and ... 11, for On-Demand access to Timothy Ayers and Michelle ...
Breaking Medicine News(10 mins):Health News:Pro Ace Care Now Gives 8 Year Guarantee on Selected Vancouver Hot Water Tanks 2Health News:Holidays Can Be Sensory Overload for Kids With Autism 2Health News:iFitDress.com: Wonderful White Evening Dresses Now Available 2Health News:Beach Wedding Dresses Added to Outstanding Online Dress Company AngelWeddingDress.com 2Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 2Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 3Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 4Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 5
... A parliamentary panel has recommended that the Indian Army ... to de-stress them.// ,"There is also imperative need ... de-stress our jawans in field units. Immediate steps may ... defence said in its "Review of medical services and ...
... and flossing. A new study in published in the ... common tasks are vital. In the study, researchers found ... flossing routinely was responsible for 38 percent reduction in ... reduced. In the group that did not floss as ...
... yes; but researchers say it could also keep brain ... were found to boost brain activity in much the ... of Massachusetts Lowell (UML). The animal research found that ... brain of the essential neurotransmitter acetylcholine. This in turn ...
... asked the present generation not to be under the wrong ... cured//. ,They said that the anti retroviral (ARV) ... the worst side effects of the ARVs. The drugs prescribed ... off ARVs. All these drugs have different toxicity levels and ...
... Medication in treating major depression is only one of ... a newly published UCLA study.// ,Published ... of Psychiatry, the study used electroencephalogram (EEG) measurements to ... changes in brain activity during a placebo lead-in phase ...
... been linked to an increased risk of stroke in ... which has added to the growing evidence of possible ... which appear in the August issue of Human Molecular ... 100 percent depending on the particular genetic variation. ...
Cached Medicine News:Health News:Yoga to De-stress Indian Army Soldiers 2Health News:Apple Juice May Keep Alzheimer's Away 2Health News:Depression - a Puzzle of Many Pieces 2Health News:Stroke Risk Higher with Gene Variations 2
(Date:11/21/2014)... 2014  World Hemp Oil, an importer of oil ... are now offering legal, organic oil with high CBD ... grown in medical marijuana states. People suffering from epileptic ... Parkinson,s, MS, and spinal cord injury, no longer have ... imported CBD Oil Is legal in all states. ...
(Date:11/21/2014)... , 21. November 2014 /PRNewswire/ ... hat heute bekannt gegeben, dass die ... EMA) die Kennzeichnung als Orphan-Medizinprodukt an ... des Unternehmens zur Behandlung von Fibrodysplasia ... seltene, stark beeinträchtigende genetische Krankheit, die ...
(Date:11/21/2014)...  Market research firm Kalorama information says that 2014 ... in the medical device industry.  The firm thinks the ... just 3% growth this year, which led firms to ... lines and entrance by acquisition into new competitive zones. ... The Global Market for Medical Devices, 5 th ...
Breaking Medicine Technology:New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 2New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 3Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 2Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 3Kalorama: 2014 The "Year of The Buy" in Medical Device Industry 2
... COLUMBUS, Ohio, June 1, 2011 EndoSphere Inc., a ... devices for the treatment of metabolic diseases, including obesity ... a highly oversubscribed Series A Preferred Financing round led ...  EndoSphere Inc., which holds 23 U.S. and international issued ...
... 2011 Mettler-Toledo International Inc. (NYSE: MTD ) ... Global Healthcare Conference in New York on Wednesday, June 8, ... webcast of the presentation, visit the investor relations page on ... of the webcast will be available for seven days. ...
Cached Medicine Technology:EndoSphere Inc. Announces Pivotal Financing Led by Broadline Capital 2
The Select 3D Arterial cannulae from Medtronic features a tip configuration which diffuses the flow through multiple outlets. This unique tip design provides reduced velocity with one central and thr...
The Medtronic EOPA CAP® arterial cannula provides a simple solution to obtaining accurate arterial pressure readings....
Intermittent catheter...
Intermittent catheter...
Medicine Products: