Navigation Links
As colorectal cancer gets more aggressive, treatment with grape seed extract is even more effective
Date:1/17/2013

When the going gets tough, grape seed extract gets going: A University of Colorado Cancer Center study recently published in the journal Cancer Letters shows that the more advanced are colorectal cancer cells, the more GSE inhibits their growth and survival. On the other end of the disease spectrum, GSE leaves healthy cells alone entirely.

"We've known for quite a while that the bioactive compounds in grape seed extract selectively target many types of cancer cells. This study shows that many of the same mutations that allow colorectal cancer cells to metastasize and survive traditional therapies make them especially sensitive to treatment with GSE," says Molly Derry, doctoral candidate in the lab of Rajesh Agarwal, PhD, investigator at the CU Cancer Center and professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences.

Derry notes this is an especially important finding in light of increasing colorectal cancer rates (due in part to increasingly high-fat diets and sedentary lifestyles) and a low screening rate; that means 60 percent of patients diagnosed have already reached the advanced stage of the disease.

"Finding a way to selectively target advanced colorectal cancer cells could have major clinical importance," Derry says.

The group performed their experiments on colorectal cancer cell lines representing various stages of the disease. Whereas it generally takes much more chemotherapy to kill a stage IV cancer cell than a stage II cancer cell, Derry saw that the reverse was true with grape seed extract.

"It required less than half the concentration of GSE to suppress cell growth and kill 50 percent of stage IV cells than it did to achieve similar results in the stage II cells," Derry says.

The group also discovered a likely mechanism of GSE's preferential targeting of advanced colorectal cancer cells: when cancer cells were treated with antioxidants the GSE induced cell death was reversed and so Derry and colleagues consider it likely that GSE targets colorectal cancer through inducing oxidative stress that leads to the programmed cell death known as apoptosis.

"A colorectal cancer cell can have upwards of 11,000 genetic mutations differences from the DNA in healthy cells. Traditional chemotherapies may only target a specific mutation and as cancer progresses more mutations occur. These changes can result in cancer that is resistance to chemotherapy. In contrast, the many bioactive compounds of GSE are able to target multiple mutations. The more mutations a cancer presents, the more effective GSE is in targeting them," Derry says.

The Agarwal Lab continues its preclinical work studying the effectiveness and action of dietary compounds against cancer and encourages further exploration of their findings in clinical settings.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. New model may help predict response to chemotherapy for colorectal cancer
2. Surgical-site infections may increase risk of deadly blood clots after colorectal surgery
3. Inclusion of CTC as HEDIS screening modality could increase colorectal cancer screening compliance
4. Multiple sclerosis drug may one day treat colorectal cancer
5. Patients with family history of colorectal cancer may be at risk for aggressive form of the disease
6. Breath test could possibly diagnose colorectal cancer
7. New electrically-conductive polymer nanoparticles can generate heat to kill colorectal cancer cells
8. Gene mutation identifies colorectal cancer patients who live longer with aspirin therapy
9. A recipe for increased colorectal cancer screening rates
10. Surgical patient safety program lowers SSIs by one-third following colorectal operations
11. Colonoscopy screening markedly reduces colorectal cancer incidence and death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... Medic CE , a Career Step ... Pediatric Septic Shock” hosted by the Journal of Emergency Medical Services (JEMS). The free ... will be presented by Captain Rommie Duckworth, LP, a career fire captain as well ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... holistic pediatric dentistry options for its patients on Long Island, New York. ... physical well being, and is one of the biggest trends in dentistry today. ...
(Date:5/24/2017)... ... May 24, 2017 , ... Fiberstar, Inc., ... the food and beverage industry offers Citri-Fi®, a natural citrus fiber, to improve ... decision process. As a result, labels need to deliver simple, transparent and clear ...
(Date:5/23/2017)... ... May 23, 2017 , ... MDLand International (MDLand), ... announced today that its iClinic V12.2 solution has achieved approval from National Center ... introduced PCMH 2017 standards which emphasize team-based care with a significant focus on ...
(Date:5/23/2017)... NEW YORK, NY (PRWEB) , ... May 23, ... ... decision makers in the pharmaceutical and medical device sectors, today announced the winners ... • Transformers • Entrepreneurs) represent the most influential people in the healthcare industry ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... 2017  Demonstrating its commitment to representing research- ... the Pharmaceutical Research and Manufacturers of America (PhRMA) ... will now have to meet new research and ... to join PhRMA. "By putting in ... a clear message that being a member of ...
(Date:5/8/2017)... May 8, 2017 MACRA replaces the ... fee for service reimbursement. Black Book Research crowdsource-surveyed 8,845 ... 1.       The Market for MIPS Compliance Technology is ... physician practices with 3 or more clinicians seek to ... Q4. "Given the magnitude of the changes, the hunt ...
(Date:5/6/2017)... 5, 2017  May is Stroke Awareness Month and ... most important methods to prevent a stroke: monitor and ... Disease Control and Prevention, undetected and uncontrolled hypertension is ... the global leader in personal heart health technology, recently ... heart attack and stroke and is advancing a national ...
Breaking Medicine Technology: