Navigation Links
As colorectal cancer gets more aggressive, treatment with grape seed extract is even more effective
Date:1/17/2013

When the going gets tough, grape seed extract gets going: A University of Colorado Cancer Center study recently published in the journal Cancer Letters shows that the more advanced are colorectal cancer cells, the more GSE inhibits their growth and survival. On the other end of the disease spectrum, GSE leaves healthy cells alone entirely.

"We've known for quite a while that the bioactive compounds in grape seed extract selectively target many types of cancer cells. This study shows that many of the same mutations that allow colorectal cancer cells to metastasize and survive traditional therapies make them especially sensitive to treatment with GSE," says Molly Derry, doctoral candidate in the lab of Rajesh Agarwal, PhD, investigator at the CU Cancer Center and professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences.

Derry notes this is an especially important finding in light of increasing colorectal cancer rates (due in part to increasingly high-fat diets and sedentary lifestyles) and a low screening rate; that means 60 percent of patients diagnosed have already reached the advanced stage of the disease.

"Finding a way to selectively target advanced colorectal cancer cells could have major clinical importance," Derry says.

The group performed their experiments on colorectal cancer cell lines representing various stages of the disease. Whereas it generally takes much more chemotherapy to kill a stage IV cancer cell than a stage II cancer cell, Derry saw that the reverse was true with grape seed extract.

"It required less than half the concentration of GSE to suppress cell growth and kill 50 percent of stage IV cells than it did to achieve similar results in the stage II cells," Derry says.

The group also discovered a likely mechanism of GSE's preferential targeting of advanced colorectal cancer cells: when cancer cells were treated with antioxidants the GSE induced cell death was reversed and so Derry and colleagues consider it likely that GSE targets colorectal cancer through inducing oxidative stress that leads to the programmed cell death known as apoptosis.

"A colorectal cancer cell can have upwards of 11,000 genetic mutations differences from the DNA in healthy cells. Traditional chemotherapies may only target a specific mutation and as cancer progresses more mutations occur. These changes can result in cancer that is resistance to chemotherapy. In contrast, the many bioactive compounds of GSE are able to target multiple mutations. The more mutations a cancer presents, the more effective GSE is in targeting them," Derry says.

The Agarwal Lab continues its preclinical work studying the effectiveness and action of dietary compounds against cancer and encourages further exploration of their findings in clinical settings.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. New model may help predict response to chemotherapy for colorectal cancer
2. Surgical-site infections may increase risk of deadly blood clots after colorectal surgery
3. Inclusion of CTC as HEDIS screening modality could increase colorectal cancer screening compliance
4. Multiple sclerosis drug may one day treat colorectal cancer
5. Patients with family history of colorectal cancer may be at risk for aggressive form of the disease
6. Breath test could possibly diagnose colorectal cancer
7. New electrically-conductive polymer nanoparticles can generate heat to kill colorectal cancer cells
8. Gene mutation identifies colorectal cancer patients who live longer with aspirin therapy
9. A recipe for increased colorectal cancer screening rates
10. Surgical patient safety program lowers SSIs by one-third following colorectal operations
11. Colonoscopy screening markedly reduces colorectal cancer incidence and death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... Washington, DC (PRWEB) , ... May 06, 2016 ... ... Blum, Executive Vice President at CareFirst Blue Cross BlueShield and Former Principal Deputy ... Officer at CareMore - an Anthem Company; Steve Ondra, MD, Chief Medical Officer ...
(Date:5/5/2016)... Seattle, WA (PRWEB) , ... May 05, 2016 ... ... one ranking for overall select performance in the industry’s gold standard KLAS ... Expertise? The Epic Consulting report assessed organizations that specialize in consulting services ...
(Date:5/5/2016)... ... 05, 2016 , ... The U.S. Food and Drug Administration ... to submit their products through an arduous federal approval process. The rules, which ... the market since February 15, 2007. That would essentially ban 99 percent of ...
(Date:5/5/2016)... , ... May 05, 2016 , ... TLC Laser Eye ... Diego, California. The laser eye center will now be called “Gordon Schanzlin New Vision ... staff will remain at the full-service facility to ensure that patients continue to receive ...
(Date:5/5/2016)... Kansas (PRWEB) , ... May 05, 2016 , ... ... that some macroalgae can use ultraviolet light A (UV-A) for photosynthesis, researchers Juntian ... of red, green, and brown seaweeds. The pair observed that when photosynthetically active ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... 2016 Research ... the  "Europe Thrombocythemia Market and Competitive ... their offering.       (Logo: ... latest research Europe Thrombocythemia Market and ... comprehensive insights into Thrombocythemia pipeline products, ...
(Date:5/4/2016)... Diversified Holdings (NYSE: CODI ) ("CODI," "we," ... market businesses, announced today its consolidated operating results for ... First Quarter 2016 Highlights , Generated Cash Flow ... of $13.6 million for the first quarter of 2016; ... the first quarter of 2016; , Paid a ...
(Date:5/4/2016)... According to market research "Global Computed ... to 2022 - Industry Insights by Slice Type (High, Mid ... by P&S Market Research, the global computed tomography market ... is expected to grow at a CAGR of 5.0% during ... is expected to witness the faster growth, CAGR of 5.3%, ...
Breaking Medicine Technology: