Navigation Links
Are intravenous treatments safe? New research raises doubts
Date:8/31/2009

German scientists have identified a serious and previously misunderstood contaminant that brings the safety and efficacy of intravenous treatments into question. In a report published in the September 2009 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org), they show how a common intravenous treatment used to boost blood pressure in ailing patients also contains substances called "advanced glycation end products," which trigger inflammation. These substances result from reactions that occur among the various proteins (called "posttranslational modification") within the intravenous fluid after it has been formulated for use. This study directly challenges today's prevalent belief that advanced glycation end products are not contaminants.

"Improving the quality of infusion solutions by accounting for posttranslational modification of proteins could lead to better clinical outcomes for patients, such as those treated solutions containing albumin," said Angelika Bierhaus, senior scientist and co-study author from the University of Heidelberg in Germany.

To make their discovery, Bierhaus and colleagues detected advanced glycation end products in several currently available albumin infusion solutions and injected separate groups of mice with solutions containing both high and low amounts of this substance. The mice receiving the high levels of advanced glycation end products experienced significantly higher inflammation and death rates than the mice receiving solutions with low levels of advanced glycation end products. This suggests that screening infusion solutions for posttranslational protein modifications and then removing the compounds may improve patient outcomes, especially treatments requiring albumin infusions.

"It is always difficult to learn that what was once thought safe might have more risk than previously appreciated, especially when it relates to treatments mea
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. FDA Clears MDN-CGS(R) Intravenous Insulin Dosing Software
2. BioCryst Reports Positive Results From a Phase 2 Study of Intravenous Peramivir for Outpatient Influenza
3. Most Important Factors Driving Usage of Antibiotics in the ICU Setting are Availability in Intravenous Formulation, Activity Against Key Gram Negative Pathogens, Drug Interactions and Bactericidal Activity
4. New form of intravenous iron treats anemia in chronic kidney disease patients on dialysis
5. Number of cardiovascular risk factors could determine safety of intravenous gammaglobulin treatment
6. New Bill Offers Medicare Reimbursement Fix for Intravenous Immune Globulin
7. Availability in Both Intravenous and Oral Formulation is a Leading Drug Attribute Surveyed Physicians Prefer for the Treatment of Urinary Tract Infections in the Hospital Setting
8. Intravenous Immune Biologics Will Suffer from the Pending Shift in Coverage from the Medical to the Pharmacy Benefit
9. Drug-free treatments offer hope for older people in pain
10. Updated Brochure on Gynecologic Cancer Treatments Now Available
11. Plastic Surgery 2007: Where Truth Behind Emerging Cosmetic Treatments Meets Amazing Reconstructive Advances
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Most mommy blogs are simple family journals, ... to attract all mothers from all walks of life. ... whether its high fashion or child rearing. When Felicia ... the Internet was so segmented. “I found myself visiting ... and then search Google to get information on another. ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 A ... Music” EXPO in Hollywood introduced country artist/writer-producer Jimmy ... products for musicians. Etymotic is an innovator in ... Earplugs. Since their introduction in 2012, Etymotic’s Music•PRO® ... adapting to unsafe sound levels and restoring natural ...
(Date:7/31/2014)... (HealthDay News) -- Transplant surgeons often feel emotionally ... burnout, a new study suggests. Nearly half ... having a low sense of personal accomplishment and ... exhausted, researchers found. "Burnout is common in ... co-author Dr. Marwan Abouljoud, director of the Henry ...
(Date:7/31/2014)... Joseph M. Lee, M.D., M.S., R.P.V.I, has ... leading provider of quality cardiovascular and internal medicine services ... Lee is a board certified cardiologist with a focus ... to his position at CDHV, Dr. Lee is an ... University Medical Center. Dr. Lee is board certified in ...
(Date:7/31/2014)... Women in the Los Angeles area ... financial future. The Independent Woman , a leader ... 6 upcoming Los Angeles area events. , These ... input from Kim Kiyosaki, a successful investor, entrepreneur, and ... is passionate about women’s financial education. , Now, the ...
Breaking Medicine News(10 mins):Health News:Mommylish Launches Its Website 2Health News:Country Star Jimmy Robbins Now Using Etymotic’s MusicPRO Electronic Earplugs 2Health News:Burnout Common Among Transplant Surgeons, Study Reveals 2Health News:ColumbiaDoctors of the Hudson Valley Welcomes Joseph M. Lee, M.D., M.S., R.P.V.I. 2Health News:ColumbiaDoctors of the Hudson Valley Welcomes Joseph M. Lee, M.D., M.S., R.P.V.I. 3Health News:The Independent Woman to Offer Financial Workshops in the Los Angeles Area - Developed by Women for Women 2
... HealthDay Reporter , MONDAY, May 2 (HealthDay News) ... infants is a surprisingly common practice, new research finds, but ... babies. The study, conducted by the U.S. Food ... are given botanical supplements or teas during their first year ...
... long sought a way to directly measure the brain,s temperature ... developed a way to get the brain,s precise temperature with ... a patient,s head, according to findings presented May 1 at ... "This is the first time that anyone has presented ...
... all counts, the 54-year-old man who collapsed on a ... died. He,d suffered a heart attack, and even though ... shocks with a defibrillator, the man was without a ... cardiac arrest ( http://www.mayoclinic.org/heart-attack/ ), reported first in ...
... , MONDAY, May 2 (HealthDay News) -- Exercising ... finds. The researchers looked at students in grades 1 ... who took part in a program that incorporated physical activity ... a week. Before the study, the students had 40 minutes ...
... have shown that blood-thinning medications, such as aspirin, can ... rising prostate-specific antigen (PSA) levelthe risk of metastasis and ... although very telling, have all emphasized the need for ... Cancer Center having concluded the largest study on this ...
... April 30 (HealthDay News) -- A new study finds that ... may predict increased arterial stiffness, which is associated with cardiovascular ... to pump blood and are also associated with a buildup ... flow and lead to a heart attack. In this ...
Cached Medicine News:Health News:Study Questions Giving Babies Botanical Supplements, Teas 2Health News:Study Questions Giving Babies Botanical Supplements, Teas 3Health News:Researchers develop device to measures brain temperature non-invasively 2Health News:Mayo Clinic CPR efforts successful on man with no pulse for 96 minutes 2Health News:Exercising While Learning Boosts Test Scores, Study Finds 2Health News:Researchers find that aspirin reduces the risk of cancer recurrence in prostate cancer patients 2
(Date:7/31/2014)... Calif., July 31, 2014 STAAR Surgical Company ... and marketer of implantable lenses and delivery systems for ... ended July 4, 2014 of $20.0 million, a 10% ... of 2013. On a constant currency basis, revenues grew ... the second quarter of 2013.  The effect of foreign ...
(Date:7/31/2014)... 2014 Pharmacyclics, Inc. (the "Company") (Nasdaq: ... the quarter ended June 30, 2014. Financial Results ... Revenue Total revenue for the quarter ended June 30, ... quarter ended June 30, 2013 primarily due to IMBRUVICA ® ... Total revenue for the six months ended June 30, ...
(Date:7/31/2014)... -- UBM Medica US announces that Cancer Network ... exclusive slide shows dealing with communication in the oncology ... Cancer Network, the online home ... and podcasts about the latest clinical findings. Among the ... , End-of-life care is challenging for even the most ...
Breaking Medicine Technology:STAAR Surgical Reports 10% Second Quarter Revenue Growth 2STAAR Surgical Reports 10% Second Quarter Revenue Growth 3STAAR Surgical Reports 10% Second Quarter Revenue Growth 4STAAR Surgical Reports 10% Second Quarter Revenue Growth 5STAAR Surgical Reports 10% Second Quarter Revenue Growth 6STAAR Surgical Reports 10% Second Quarter Revenue Growth 7STAAR Surgical Reports 10% Second Quarter Revenue Growth 8STAAR Surgical Reports 10% Second Quarter Revenue Growth 9STAAR Surgical Reports 10% Second Quarter Revenue Growth 10STAAR Surgical Reports 10% Second Quarter Revenue Growth 11STAAR Surgical Reports 10% Second Quarter Revenue Growth 12STAAR Surgical Reports 10% Second Quarter Revenue Growth 13STAAR Surgical Reports 10% Second Quarter Revenue Growth 14STAAR Surgical Reports 10% Second Quarter Revenue Growth 15STAAR Surgical Reports 10% Second Quarter Revenue Growth 16STAAR Surgical Reports 10% Second Quarter Revenue Growth 17STAAR Surgical Reports 10% Second Quarter Revenue Growth 18STAAR Surgical Reports 10% Second Quarter Revenue Growth 19STAAR Surgical Reports 10% Second Quarter Revenue Growth 20STAAR Surgical Reports 10% Second Quarter Revenue Growth 21STAAR Surgical Reports 10% Second Quarter Revenue Growth 22STAAR Surgical Reports 10% Second Quarter Revenue Growth 23STAAR Surgical Reports 10% Second Quarter Revenue Growth 24STAAR Surgical Reports 10% Second Quarter Revenue Growth 25STAAR Surgical Reports 10% Second Quarter Revenue Growth 26STAAR Surgical Reports 10% Second Quarter Revenue Growth 27STAAR Surgical Reports 10% Second Quarter Revenue Growth 28STAAR Surgical Reports 10% Second Quarter Revenue Growth 29STAAR Surgical Reports 10% Second Quarter Revenue Growth 30STAAR Surgical Reports 10% Second Quarter Revenue Growth 31Pharmacyclics Reports Second Quarter 2014 Results 2Pharmacyclics Reports Second Quarter 2014 Results 3Pharmacyclics Reports Second Quarter 2014 Results 4Pharmacyclics Reports Second Quarter 2014 Results 5Pharmacyclics Reports Second Quarter 2014 Results 6
... Imaging announced today that it has received FDA 510(k) ... Analyzer® System to assess coronary branch vessels in addition ... artery disease (CAD). The clearance is the third for ... tool that automatically detects significant (50 percent and over) ...
... Medical, Inc., a private sports medicine device company specializing ... immediately, David B. Springer will succeed James Hart as ... Executive Chairman due to health reasons. Hart, ... CEO since the company,s inception in 2005, will continue ...
Cached Medicine Technology:Rcadia COR Analyzer System Receives Expanded FDA Clearance to Rule Out Coronary Artery Disease in Coronary Branch Vessels 2Cayenne Medical, Inc. Appoints David B. Springer President & CEO 2Cayenne Medical, Inc. Appoints David B. Springer President & CEO 3
... Independent controls for Digital ... stainless steel front. Anodized aluminum ends. ... stainless steel floor. , Oversized refrigeration ... 10C , Positive seal self-closing doors. ...
... The F340 is a basic laboratory ... compensated pH results can be obtained when ... a 3-in-1 electrode. • Fast and easy ... buffer recognition for five buffers (pH 1.68, ...
... The F340 is a basic laboratory ... compensated pH results can be obtained when ... a 3-in-1 electrode. • Fast and easy ... buffer recognition for five buffers (pH 1.68, ...
... dual-monochromator, multi-detection microplate reader with a ... reading capability. Detection modalities include absorbance ... and have optical performance comparable to ... Endpoint, kinetic, spectrum and area-well scanning ...
Medicine Products: