Navigation Links
Are intravenous treatments safe? New research raises doubts
Date:8/31/2009

German scientists have identified a serious and previously misunderstood contaminant that brings the safety and efficacy of intravenous treatments into question. In a report published in the September 2009 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org), they show how a common intravenous treatment used to boost blood pressure in ailing patients also contains substances called "advanced glycation end products," which trigger inflammation. These substances result from reactions that occur among the various proteins (called "posttranslational modification") within the intravenous fluid after it has been formulated for use. This study directly challenges today's prevalent belief that advanced glycation end products are not contaminants.

"Improving the quality of infusion solutions by accounting for posttranslational modification of proteins could lead to better clinical outcomes for patients, such as those treated solutions containing albumin," said Angelika Bierhaus, senior scientist and co-study author from the University of Heidelberg in Germany.

To make their discovery, Bierhaus and colleagues detected advanced glycation end products in several currently available albumin infusion solutions and injected separate groups of mice with solutions containing both high and low amounts of this substance. The mice receiving the high levels of advanced glycation end products experienced significantly higher inflammation and death rates than the mice receiving solutions with low levels of advanced glycation end products. This suggests that screening infusion solutions for posttranslational protein modifications and then removing the compounds may improve patient outcomes, especially treatments requiring albumin infusions.

"It is always difficult to learn that what was once thought safe might have more risk than previously appreciated, especially when it relates to treatments mea
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. FDA Clears MDN-CGS(R) Intravenous Insulin Dosing Software
2. BioCryst Reports Positive Results From a Phase 2 Study of Intravenous Peramivir for Outpatient Influenza
3. Most Important Factors Driving Usage of Antibiotics in the ICU Setting are Availability in Intravenous Formulation, Activity Against Key Gram Negative Pathogens, Drug Interactions and Bactericidal Activity
4. New form of intravenous iron treats anemia in chronic kidney disease patients on dialysis
5. Number of cardiovascular risk factors could determine safety of intravenous gammaglobulin treatment
6. New Bill Offers Medicare Reimbursement Fix for Intravenous Immune Globulin
7. Availability in Both Intravenous and Oral Formulation is a Leading Drug Attribute Surveyed Physicians Prefer for the Treatment of Urinary Tract Infections in the Hospital Setting
8. Intravenous Immune Biologics Will Suffer from the Pending Shift in Coverage from the Medical to the Pharmacy Benefit
9. Drug-free treatments offer hope for older people in pain
10. Updated Brochure on Gynecologic Cancer Treatments Now Available
11. Plastic Surgery 2007: Where Truth Behind Emerging Cosmetic Treatments Meets Amazing Reconstructive Advances
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... Youngsters who enter puberty early are at increased risk ... was linked with a number of factors associated with ... according to the researchers. Early puberty was also linked ... peers, and having friends who were prone to getting ... found an association between early puberty and these factors, ...
(Date:11/26/2014)... -- Teens prescribed anti-anxiety or sleep medications are ... other teens, a new study warns. The ... assessments on teenagers before prescribing these drugs to ... don,t realize the abuse potential," said lead researcher ... Michigan School of Nursing. "These drugs produce highly ...
(Date:11/26/2014)... News) -- Exposure to peanut protein in household dust ... with the skin condition eczema, a new study reveals. ... United States are allergic to peanuts. And severe eczema ... peanut allergy, the researchers noted. The new study ... The researchers examined the amount of peanut protein the ...
(Date:11/26/2014)... HealthDay Reporter TUESDAY, Nov. 25, 2014 ... may disrupt the makeup of bacteria in the digestive system, ... small new study suggests. The research doesn,t confirm ... ill, and study authors aren,t recommending that anyone stop taking ... be used at the lowest dose that provides adequate relief ...
(Date:11/24/2014)... ( http://www.fecbek.com ), a leading online shopping mall in the ... the Black Friday to its fans worldwide. , ... Black Friday! It is a shopping day popular among Americans ... everyone knows the history of the Special Friday. Fecbek.com tells ... The fourth Friday in November is the date of the ...
Breaking Medicine News(10 mins):Health News:Early Puberty Linked to Increased Risk of Depression in Teens 2Health News:Teens Given Anxiety, Sleep Meds May Be at Risk for Drug Abuse 2Health News:Infants With Eczema May Be More Prone to Peanut Allergy: Study 2Health News:Could Popular Heartburn Drugs Upset Your 'Good' Gut Bugs? 2Health News:Could Popular Heartburn Drugs Upset Your 'Good' Gut Bugs? 3
... with sound advice may help them identify hearing loss ... therefore untreated. ,Hearing loss in children often remain ... and lead to deficiency in attending, difficulty in attending ... to the researcher Judith Gravel from The Children's Hospital ...
... Adjuvant chemotherapy with epirubicin and cyclophosphamide for early ... myeloid leukemia or Myelodysplastic syndrome. ,Recent study ... early breast cancer patients undergoing chemotherapy with higher ... have an increased risk of developing Acute myeloid ...
... Heidelberg in Mannheim, concludes that women appear to develop alcoholic ... that women become dependant on alcohol not as frequently as ... on the general alcohol consumption pattern if men and women. ... and before pregnancy. It might have adverse effects on the ...
... plays an important role in increasing death risk.// It is ... that can kill him. ,Depression had long been taken ... disease. Now the team of researchers from Washington University School ... rate variability is the prime cause for such a case. ...
... sterols might help to lower your "bad" LDL cholesterol ... been shown to block cholesterol's absorption, lower blood cholesterol ... intestines. , ,The study had 29 participants, all ... type 2 diabetes and were slightly overweight. Participants were ...
... popular form of ancient Indian exercise and meditation for the ... healing properties and is popularly used to relieve people of ... trauma and anxiety in patients with breast cancer., ... Yoga therapy treated over 400 patients with breast cancer with ...
Cached Medicine News:Health News:High-Dosage of Epirubicin and Cyclophosphamide may cause AML 2Health News:Yoga Can Be Good For Breast Cancer Patients 2
(Date:11/24/2014)... Nov. 24, 2014 Juno Therapeutics today ... Designation to the company,s JCAR015 chimeric antigen receptor ... of relapsed or refractory B-cell acute lymphoblastic leukemia ... Sloan Kettering Cancer Center, where Phase 1 clinical ... FDA,s action is important news for patients who ...
(Date:11/24/2014)... 2014  Marta Rendon, MD, founder of the Rendon Center ... , FL and international key opinion leader in dermatology, was one ... United States to attend the international Aesthetic Experts ... . Here, at this gathering of over 600 physicians from ... plastic surgery experts from Asia and ...
(Date:11/24/2014)... , Nov. 24, 2014  AiCure, an ... motion-sensing technology to monitor medication ingestion, has announced ... monitor and intervene with patients receiving medication as ... Fatal overdoses from prescription opiates have quadrupled in ... deaths per year than heroin, cocaine and benzodiazepines ...
Breaking Medicine Technology:Juno T Cell Therapy For Leukemia Granted FDA Breakthrough Therapy Designation 2Juno T Cell Therapy For Leukemia Granted FDA Breakthrough Therapy Designation 3Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 2Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 3Can artificial intelligence solve the $55 billion problem of opioid abuse? 2
... well-tolerated with signs of durable,disease control in advanced ... /PRNewswire-FirstCall/ -- IDM,Pharma, Inc. today presented preliminary results ... trial (DC-MEL-202). The,results showed that UVIDEM was well ... response in patients with,progressive metastatic melanoma. , The ...
... trial presented at ENDO 2007 , ,- Regulatory approvals ... recruitment in Europe , ,MONTREAL, QUEBEC -- (MARKET WIRE) ... that 26-week data from,its first Phase 3 study testing ... ENDO, the 89th,annual meeting of the Endocrine Society. The ...
Cached Medicine Technology:IDM Pharma Presents Preliminary Results from Phase II UVIDEM,Melanoma Vaccine Clinical Trial 2IDM Pharma Presents Preliminary Results from Phase II UVIDEM,Melanoma Vaccine Clinical Trial 3IDM Pharma Presents Preliminary Results from Phase II UVIDEM,Melanoma Vaccine Clinical Trial 4IDM Pharma Presents Preliminary Results from Phase II UVIDEM,Melanoma Vaccine Clinical Trial 5Theratechnologies: TH9507 Phase 3 Clinical Update 2Theratechnologies: TH9507 Phase 3 Clinical Update 3
...
...
... an easy way to eliminate paper ECG ... money. This Windows-based tool dramatically streamlines ECG ... and the hospital emergency department. You can ... Review high-resolution waveforms on-screen. Edit patient information, ...
... communications software, including Remote Link and Central ... you the tools and choices to effectively ... Send patient tests via email, LAN or ... Philips Zymed Holter analysis applications are used. ...
Medicine Products: