Navigation Links
Antidepressants show potential for postoperative pain
Date:8/29/2014

After a systematic review of clinical trials based on administering antidepressants for acute and chronic postsurgical pain, researchers have concluded that more trials are needed to determine whether these drugs should be prescribed for postsurgical pain on a regular basis.

Dr. Ian Gilron, a professor and director of clinical pain research in the Department of Anesthesiology, and his team of seven researchers reviewed 15 trials to determine whether the use of antidepressants for pain relief post-surgery would work more effectively than painkillers such as opioids, local anesthetics, or acetaminophen.

Clinical trials are often used to answer questions about the efficacy of the off-label uses of drugs. In the case of antidepressants, their effects on postsurgical pain continue to be an area of research interest.

"For the past 50 years, it's been observed that antidepressants for other chronic pain conditions relieve pain independently of their effect on depression," says Dr. Gilron, who also works as an attending anesthesiologist at Kingston General Hospital (KGH). "Even with the best available medicines, there are still many people who experience postoperative pain. Reviewing the use of antidepressants to manage this pain was definitely an opportunity to be seized."

Pain around a surgical site can interfere with normal activities like walking, it can prolong recovery from surgery.

After searching through three databases of trials, first author of the paper and fifth year anesthesiology resident Karen Wong sifted through 1,350 records from three different research databases to select the 15 trials for detailed review.

Trials were selected for review based on a patient's pain at rest and with movement, adverse effects of antidepressants, and other outcomes of using antidepressants for postsurgical pain.

Just over half of the trials examined showed a reduction in pain after use of antidepressants.

"These results are more than a coincidence," says Dr. Gilron. "We can conclude from this research review that, while it's premature to formally recommend these drugs be prescribed for pain, more definitive studies on these medications are necessary."


'/>"/>

Contact: Rosie Hales
rosie.hales@queensu.ca
Queen's University
Source:Eurekalert

Related medicine news :

1. Minorities, Medicare Recipients Less Likely to Get Antidepressants
2. Newer Antidepressants May Be Safe for Parkinsons Patients
3. Publication Bias Casts Doubt on Value of Antidepressants for Autism
4. Medicare Coverage Gap May Cause Seniors to Forgo Antidepressants
5. Common Antidepressants Too Risky During Pregnancy, Researchers Say
6. Common Antidepressants Tied to Higher Bleeding Risk in Warfarin Users: Study
7. When Antidepressants Dont Work, Give Counseling a Try
8. Prenatal Antidepressants Dont Raise Fetal, Infant Death Risk: Study
9. Antidepressants Celexa, Lexapro Tied to Irregular Heartbeat: Study
10. Antidepressants for pregnant moms dont affect infants growth
11. Some Antidepressants Linked to Bleeding Risk With Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2019)... ... February 19, 2019 , ... ... experience to The Oncology Institute of Hope and Innovation. , Dr. Lombardi completed ... cum laude. He received his medical degree from the University of Rochester School ...
(Date:2/19/2019)... ... February 19, 2019 , ... ClearHealth Quality ... Foley & Lardner LLP, as Recognized Consultants. The CHQI Recognized Consultant Program trains ... pursuing CHQI accreditation. , Ms. Wein and Mr. Einhorn are part of ...
(Date:2/19/2019)... , ... February 18, 2019 , ... ... nation to test the PathO3Gen Solutions Footwear Sanitizing Stations to maximize infection control ... TechnologyTM to kill superbugs such as MRSA and C. difficile, which can be ...
(Date:2/19/2019)... ... ... The San Diego Superior Court has entered a judgment approving the class action ... class of approximately 14,100 patients who were admitted in-patient to one of its hospital, ... a class action case (Santana, et al. v. Rady Children’s Hospital – San Diego, ...
(Date:2/16/2019)... ... February 15, 2019 , ... SurgCenter Development ( http://www.surgcenter.com ... the U.S., celebrates the formation of its 200th ASC partnership in its 26-year ... year. , “We continue to see the demand increase from patients who want ...
Breaking Medicine News(10 mins):
(Date:2/19/2019)... ... February 19, 2019 , ... Nativis, Inc., ... cancers and other serious diseases, today announced the publication of a second study ... suggesting that the Nativis Voyager device is safe for treatment of rGBM. ...
(Date:2/19/2019)... ... 2019 , ... The Jean Griswold Foundation, a nonprofit named for the founder ... the lives of seniors and others in the communities in which Griswold Home Care ... otherwise couldn’t afford them. , “Each of these organizations have made such ...
(Date:2/16/2019)... ... February 15, 2019 , ... In observance of Gum ... are urging patients to take their oral health seriously. With recent suggested links ... and risk of pre-term birth, there is plenty to be concerned about along ...
Breaking Medicine Technology: