Navigation Links
Androgen receptor may explain male dominance in liver cancer
Date:5/19/2010

in the journal Nature Medicine. The drug is a synthetic compound loosely based on the compounds found in curcumin, the polyphenol that gives the spice tumeric its yellow color. It has been used for centuries as a folk medicine in Asia and India. In this case, however, scientists significantly altered the natural substance to be more powerful, and are carefully screening it for safety and effectiveness.

AndroScience Corp., a biotech company founded by Chang and others in 2000, is evaluating ASC-J9 in several clinical settings, although not yet in the treatment of liver cancer, Chang said. The URMC owns a stake in AndroScience, and has licensed several of Chang's research findings.

In the current study, researchers found that AR cooperates with the hepatitis B virus to trigger the expression of several oncogenes, resulting in normal liver cells transforming into cancer cells. Furthermore, they showed that liver tumors without the AR had fewer proliferating cancer cells, which helps to explain the gender disparity in the disease.

Some of the findings are in agreement with earlier studies by Chang's lab on the role of AR in prostate cancer. Just as in prostate cancer, the liver tumor microenvironment is rich in various cell types, each of which has a distinct role in promoting the cancer.

"It will be interesting to see if targeting AR at different stages or in different liver cancer cell types may also lead to differential effects during the progression of cancer," the paper concluded.

The hepatitis B and C viruses account for approximately 80 percent of primary liver cancer cases worldwide. Newborn vaccines and screenings for HBV and HCV, particularly in Asian and African countries, have reduced the incidence of liver cancer in later years. Still, an estimated 560,000 new cases are diagnosed annually. In high-risk areas such as China, Japan and sub-Saharan Africa the male-to-female ratio of liver cancer can be as high a
'/>"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Intermittent androgen deprivation at least as effective as continuous androgen deprivation
2. Brain dopamine receptor density correlates with social status
3. Pharmacokinetic/Pharmacodynamic Data Support Further Development of Tobiras Next-Generation CCR5 Receptor Antagonist
4. New Guidelines Issued on Hormone Receptor Testing for Breast Cancer
5. Cell study finds receptor can fight tamoxifen-resistant breast cancer cells
6. Estrogen receptor status of HER2+ breast cancer correlates with response to anti-HER therapies
7. Scientist Who Helps Explain Pain Wins Grawemeyer Award
8. Study explains why light worsens migraine headaches
9. Three Anticoagulant Studies May Change Current Medical Practice Including New Data Revealing That Preventative Use of Aspirin and Heparin is Not Effective in Reducing Recurrent, Unexplained Miscarriages
10. Fish Oil Explained Thanks To Unveiling of New Website “fishoil.com”
11. Personal Injury Attorney David Perecman Explains the Possible Legal Consequences of Fatal 911 Operator Error in New York
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... November 26, 2014 Increasing demand ... include image guided surgeries has paved way for ... Rising incidence of various types of cancers and ... increase in demand for these owing to their ... contrast media injectors market can also be attributed ...
(Date:11/26/2014)... November 26, 2014 German scientists say ... science can cause mesothelioma that looks and acts similar ... new article on the research. Click here to ... Institute for Toxicology and Experimental Medicine in Hannover injected ... all of the rats eventually developed mesothelioma , ...
(Date:11/26/2014)... November 26, 2014 For its ... published The AIS Report on Blue Cross and Blue ... Inc. on the varied strategies the two Blues plans ... compliance with treatments for sleep apnea, ranging from brick-and-mortar ... because it’s linked to increased rates of a variety ...
(Date:11/26/2014)... November 26, 2014 With Thousand Oaks ... dollars, the prosthodontists at the Anacapa Dental Art Institute in ... procedures can be daunting for some. , That is why ... procedures they offer. , “No dentist wants cost to come ... of teeth,” said Dr. Mamaly Reshad, partner in the Anacapa ...
(Date:11/26/2014)... 26, 2014 Sonru, the video interviewing ... Chief Operating Officer and Chief Marketing Officer, in addition ... , Jeff Jones has been appointed as Chief ... takes the role of Chief Marketing Officer. , Mr ... whose 25-year career includes senior roles with The Walt ...
Breaking Medicine News(10 mins):Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 2Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 3Health News:Multi-walled Nanotubes Linked to Mesothelioma in New Study, According to Surviving Mesothelioma 2Health News:AIS Newsletter Reports on Strategies Blues Plans Are Implementing to Combat Sleep Apnea 2Health News:AIS Newsletter Reports on Strategies Blues Plans Are Implementing to Combat Sleep Apnea 3Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 2Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 3Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 4Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 5Health News:Sonru Expansion continues with appointment of new executive team and opening of new London base 2
... Plan Members Drop Coverage for multiple Reasons; Integrated Retention Strategy ... Balance Sheet. , ... Orlando, FL ... of ConnextionsHealth provides both good and bad news for health ...
... U.S, NAPWA and POZ reinvigorate AIDS activism -WASHINGTON, March ... (NAPWA) and POZ magazine today announced the ... Principles Project. The project aims to encourage a ... self-empowerment manifesto written in 1983 by a group of ...
... Lead Lilly USA Business-to-Business Organization and Oversee Sales and ... Include Lilly USA Diabetes Business UnitINDIANAPOLIS, March 2 ... today announced that Alex M. Azar II, currently senior ... the top leadership role in Lilly,s U.S. Business-to-Business organization. ...
... its part to help fight AIDS in Africa with ... of National Sleep Awareness Week, Coherence Resources, Inc. provided ... they need: adequate sleep. Malaria medications taken by ... from Coherence Resources helps the volunteers cope with the ...
... Milan, Italy----Cowen and Company 29th Annual Health Care Conference in ... (Nasdaq: TSPT ) announced today that the Company ... , Glenn A. Oclassen, ... 2009, to be held at the Milano Convention Centre (MIC) ...
... Industries, Inc. (Nasdaq: HRLY ) announced today that ... $1 million from the U. S. Air Force for the ... The awards are for the production of transmit microwave assemblies ... components for use in the APG-68 radar system on various ...
Cached Medicine News:Health News:Common Approaches to Member Retention by Health Insurance Plans are Ineffective, New Study Shows 2Health News:Common Approaches to Member Retention by Health Insurance Plans are Ineffective, New Study Shows 3Health News:The National Association of People with AIDS (NAPWA) and POZ Magazine Partner to Launch The Denver Principles Project 2Health News:The National Association of People with AIDS (NAPWA) and POZ Magazine Partner to Launch The Denver Principles Project 3Health News:Lilly Announces Leadership Changes 2Health News:Lilly Announces Leadership Changes 3Health News:Sleepless in Botswana 2Health News:Sleepless in Botswana 3Health News:Transcept Pharmaceuticals to Present at Two Upcoming Conferences 2Health News:Transcept Pharmaceuticals to Present at Two Upcoming Conferences 3Health News:Herley Lancaster Awarded $1.0 Million in New Contracts 2
(Date:11/26/2014)... 25, 2014  goBalto, Inc., the leading provider of ... a winner of Red Herring,s Top 100 Global ... North America award in 2013, marking its emergence as ... Red Herring,s Top 100 Global list has become ... and entrepreneurs. Red Herring editors were among the first ...
(Date:11/26/2014)... , Nov. 25, 2014  Unilife Corporation (NASDAQ: UNIS, ... drug delivery systems, today announced that its Chairman and ... at the Piper Jaffray 26th Annual Healthcare Conference at ... on Tuesday, December 2, 2014. The ... a "live" listen only Webcast. To listen, please go ...
(Date:11/26/2014)... HERZLIYA PITUACH, Israel, Nov. 25, 2014 Immune ... a clinical stage biopharmaceutical company that engages in ... the treatment of inflammatory diseases and cancer, today ... public offering of 3,450,000 units, with each unit ... stock, par value $0.0001 per share, and one ...
Breaking Medicine Technology:goBalto Selected as a 2014 Red Herring Top 100 Global Company 2goBalto Selected as a 2014 Red Herring Top 100 Global Company 3Unilife to Present at the Piper Jaffray 26th Annual Healthcare Conference on December 2nd 2Immune Pharmaceuticals Inc. Announces Closing Of Public Offering Of Common Stock And Warrants 2Immune Pharmaceuticals Inc. Announces Closing Of Public Offering Of Common Stock And Warrants 3Immune Pharmaceuticals Inc. Announces Closing Of Public Offering Of Common Stock And Warrants 4Immune Pharmaceuticals Inc. Announces Closing Of Public Offering Of Common Stock And Warrants 5
... Aug. 8, 2011 Endologix, Inc. (Nasdaq: ... for aortic disorders, announced today that the first U.S. ... was performed at Edward Hines, Jr. VA Hospital in ... M.D., F.A.C.S., Associate Professor and Chief of Vascular Surgery ...
... leading manufacturer of integrated medical imaging display and communication systems, ... Medical achieved significant growth in sales and an expansion of ... with record second quarter sales, Carrot surpassed its revenue mark ... now well positioned for the third straight year of triple ...
Cached Medicine Technology:Endologix Announces First U.S. Implant of AFX™ Endovascular AAA System 2Carrot Medical Positioned for Third Straight Year of Triple Digit Growth 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: